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Items: 1 to 50 of 105

1.

Predatory bacteria can protect SKH-1 mice from a lethal plague challenge.

Findlay JS, Flick-Smith HC, Keyser E, Cooper IA, Williamson ED, Oyston PCF.

Sci Rep. 2019 May 10;9(1):7225. doi: 10.1038/s41598-019-43467-1.

2.

Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles.

Whelan AO, Flick-Smith HC, Homan J, Shen ZT, Carpenter Z, Khoshkenar P, Abraham A, Walker NJ, Levitz SM, Ostroff GR, Oyston PCF.

PLoS One. 2018 Oct 8;13(10):e0200213. doi: 10.1371/journal.pone.0200213. eCollection 2018.

3.

Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures.

Parnell AE, Mordhorst S, Kemper F, Giurrandino M, Prince JP, Schwarzer NJ, Hofer A, Wohlwend D, Jessen HJ, Gerhardt S, Einsle O, Oyston PCF, Andexer JN, Roach PL.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3350-3355. doi: 10.1073/pnas.1710741115. Epub 2018 Mar 12.

5.

An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.

Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, Atkins TP, Atkins HS, Soyer OS, Titball RW.

BMC Microbiol. 2017 Jul 21;17(1):163. doi: 10.1186/s12866-017-1073-8.

6.

Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interaction.

Male AL, Forafonov F, Cuda F, Zhang G, Zheng S, Oyston PCF, Chen PR, Williamson ED, Tavassoli A.

Sci Rep. 2017 Jun 8;7(1):3104. doi: 10.1038/s41598-017-03253-3.

7.

A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis.

Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PC, Atkins TP, Titball RW.

Sci Rep. 2017 Feb 6;7:41923. doi: 10.1038/srep41923.

8.

YPTB3816 of Yersinia pseudotuberculosis strain IP32953 is a virulence-related metallo-oligopeptidase.

Atas A, Seddon AM, Ford DC, Cooper IA, Wren BW, Oyston PC, Karlyshev AV.

BMC Microbiol. 2016 Nov 25;16(1):282.

9.

Biochemical and structural characterization of polyphosphate kinase 2 from the intracellular pathogen Francisella tularensis.

Batten LE, Parnell AE, Wells NJ, Murch AL, Oyston PC, Roach PL.

Biosci Rep. 2015 Nov 18;36(1):e00294. doi: 10.1042/BSR20150203.

10.

Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis.

Wilkinson RC, Batten LE, Wells NJ, Oyston PC, Roach PL.

Biosci Rep. 2015 Oct 8;35(6). pii: e00268. doi: 10.1042/BSR20150229.

11.

Evaluating the role of phage-shock protein A in Burkholderia pseudomallei.

Southern SJ, Male A, Milne T, Sarkar-Tyson M, Tavassoli A, Oyston PC.

Microbiology. 2015 Nov;161(11):2192-203. doi: 10.1099/mic.0.000175. Epub 2015 Sep 14.

12.

The importance of the magnesium transporter MgtB for virulence of Yersinia pseudotuberculosis and Yersinia pestis.

Ford DC, Joshua GW, Wren BW, Oyston PC.

Microbiology. 2014 Dec;160(Pt 12):2710-7. doi: 10.1099/mic.0.080556-0. Epub 2014 Sep 18.

PMID:
25234474
13.

Construction of an inducible system for the analysis of essential genes in Yersinia pestis.

Ford DC, Ireland PM, Bullifent HL, Saint RJ, McAlister EV, Sarkar-Tyson M, Oyston PC.

J Microbiol Methods. 2014 May;100:1-7. doi: 10.1016/j.mimet.2014.01.017. Epub 2014 Feb 11.

PMID:
24524852
14.

In vivo manipulation of γ9(+) T cells in the common marmoset (Callithrix Jacchus) with phosphoantigen and effect on the progression of respiratory melioidosis.

Laws TR, Nelson M, Bonnafous C, Sicard H, Taylor C, Salguero FJ, Atkins TP, Oyston PC, Rowland CA.

PLoS One. 2013 Sep 30;8(9):e74789. doi: 10.1371/journal.pone.0074789. eCollection 2013.

15.

Prophylaxis and therapy of plague.

Oyston PC, Williamson ED.

Expert Rev Anti Infect Ther. 2013 Aug;11(8):817-29. doi: 10.1586/14787210.2013.814432. Review.

PMID:
23977937
16.

Synthetic biology: biology by design.

Roberts MA, Cranenburgh RM, Stevens MP, Oyston PC.

Microbiology. 2013 Jul;159(Pt 7):1219-20. doi: 10.1099/mic.0.069724-0. Epub 2013 Jun 6. No abstract available.

17.

Protecting against plague: towards a next-generation vaccine.

Williamson ED, Oyston PC.

Clin Exp Immunol. 2013 Apr;172(1):1-8. doi: 10.1111/cei.12044. Review.

18.

Induction of the Yersinia pestis PhoP-PhoQ regulatory system in the flea and its role in producing a transmissible infection.

Rebeil R, Jarrett CO, Driver JD, Ernst RK, Oyston PC, Hinnebusch BJ.

J Bacteriol. 2013 May;195(9):1920-30. doi: 10.1128/JB.02000-12. Epub 2013 Feb 22.

19.

An assessment of common marmoset (Callithrix jacchus) γ9(+) T cells and their response to phosphoantigen in vitro.

Rowland CA, Laws TR, Oyston PC.

Cell Immunol. 2012 Dec;280(2):132-7. doi: 10.1016/j.cellimm.2012.12.002. Epub 2012 Dec 19.

PMID:
23399838
20.

Targeting the "cytokine storm" for therapeutic benefit.

D'Elia RV, Harrison K, Oyston PC, Lukaszewski RA, Clark GC.

Clin Vaccine Immunol. 2013 Mar;20(3):319-27. doi: 10.1128/CVI.00636-12. Epub 2013 Jan 2. Review.

21.

Structure and function of cytidine monophosphate kinase from Yersinia pseudotuberculosis, essential for virulence but not for survival.

Walker NJ, Clark EA, Ford DC, Bullifent HL, McAlister EV, Duffield ML, Acharya KR, Oyston PC.

Open Biol. 2012 Dec 5;2(12):120142. doi: 10.1098/rsob.120142.

22.

Modern Advances against Plague.

Oyston PC, Williamson ED.

Adv Appl Microbiol. 2012;81:209-41. doi: 10.1016/B978-0-12-394382-8.00006-X.

PMID:
22958531
23.

Inhibition of Yersinia pestis DNA adenine methyltransferase in vitro by a stibonic acid compound: identification of a potential novel class of antimicrobial agents.

McKelvie JC, Richards MI, Harmer JE, Milne TS, Roach PL, Oyston PC.

Br J Pharmacol. 2013 Jan;168(1):172-88. doi: 10.1111/j.1476-5381.2012.02134.x.

24.

Development of rationally designed DNA N6 adenine methyltransferase inhibitors.

Hobley G, McKelvie JC, Harmer JE, Howe J, Oyston PC, Roach PL.

Bioorg Med Chem Lett. 2012 May 1;22(9):3079-82. doi: 10.1016/j.bmcl.2012.03.072. Epub 2012 Mar 27.

PMID:
22483584
25.

The natural history and incidence of Yersinia pestis and prospects for vaccination.

Williamson ED, Oyston PC.

J Med Microbiol. 2012 Jul;61(Pt 7):911-8. doi: 10.1099/jmm.0.037960-0. Epub 2012 Mar 22. Review.

PMID:
22442294
26.

A Toll/interleukin (IL)-1 receptor domain protein from Yersinia pestis interacts with mammalian IL-1/Toll-like receptor pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague.

Spear AM, Rana RR, Jenner DC, Flick-Smith HC, Oyston PC, Simpson P, Matthews SJ, Byrne B, Atkins HS.

Microbiology. 2012 Jun;158(Pt 6):1593-606. doi: 10.1099/mic.0.055012-0. Epub 2012 Mar 8.

PMID:
22403187
27.

Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro.

Rowland CA, Hartley MG, Flick-Smith H, Laws TR, Eyles JE, Oyston PC.

Microbes Infect. 2012 Jul;14(7-8):584-9. doi: 10.1016/j.micinf.2012.02.001. Epub 2012 Feb 11.

PMID:
22370220
28.

A Francisella tularensis SCHU S4 mutant deficient in γ-glutamyltransferase activity induces protective immunity: characterization of an attenuated vaccine candidate.

Ireland PM, LeButt H, Thomas RM, Oyston PC.

Microbiology. 2011 Nov;157(Pt 11):3172-9. doi: 10.1099/mic.0.052902-0. Epub 2011 Aug 18.

PMID:
21852349
29.

O-linked glycosylation of the PilA pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide.

Egge-Jacobsen W, Salomonsson EN, Aas FE, Forslund AL, Winther-Larsen HC, Maier J, Macellaro A, Kuoppa K, Oyston PC, Titball RW, Thomas RM, Forsberg Å, Prior JL, Koomey M.

J Bacteriol. 2011 Oct;193(19):5487-97. doi: 10.1128/JB.00383-11. Epub 2011 Jul 29.

30.

Glycosylation of DsbA in Francisella tularensis subsp. tularensis.

Thomas RM, Twine SM, Fulton KM, Tessier L, Kilmury SL, Ding W, Harmer N, Michell SL, Oyston PC, Titball RW, Prior JL.

J Bacteriol. 2011 Oct;193(19):5498-509. doi: 10.1128/JB.00438-11. Epub 2011 Jul 29.

31.

Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis.

Clark EA, Walker N, Ford DC, Cooper IA, Oyston PC, Acharya KR.

J Biol Chem. 2011 Jul 8;286(27):24015-22. doi: 10.1074/jbc.M111.225730. Epub 2011 Apr 29.

32.

Plague: Infections of Companion Animals and Opportunities for Intervention.

Oyston PC, Williamson D.

Animals (Basel). 2011 Jun 21;1(2):242-55. doi: 10.3390/ani1020242. Review.

33.

Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1.

Champion OL, Karlyshev A, Cooper IA, Ford DC, Wren BW, Duffield M, Oyston PC, Titball RW.

Microbiology. 2011 Apr;157(Pt 4):1115-22. doi: 10.1099/mic.0.045807-0. Epub 2010 Dec 23.

PMID:
21183572
34.

Q fever: the neglected biothreat agent.

Oyston PC, Davies C.

J Med Microbiol. 2011 Jan;60(Pt 1):9-21. doi: 10.1099/jmm.0.024778-0. Epub 2010 Oct 28. Review.

PMID:
21030501
35.

Deletion of the Bacillus anthracis capB homologue in Francisella tularensis subspecies tularensis generates an attenuated strain that protects mice against virulent tularaemia.

Michell SL, Dean RE, Eyles JE, Hartley MG, Waters E, Prior JL, Titball RW, Oyston PC.

J Med Microbiol. 2010 Nov;59(Pt 11):1275-84. doi: 10.1099/jmm.0.018911-0. Epub 2010 Jul 22.

PMID:
20651039
36.

Potential of the beta-glucans to enhance innate resistance to biological agents.

Thompson IJ, Oyston PC, Williamson DE.

Expert Rev Anti Infect Ther. 2010 Mar;8(3):339-52. doi: 10.1586/eri.10.10. Review.

PMID:
20192687
37.

A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection.

Oyston PC, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS.

Microb Pathog. 2010 May;48(5):191-5. doi: 10.1016/j.micpath.2010.01.005. Epub 2010 Jan 22.

38.

Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization.

Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A.

Vaccine. 2010 Feb 17;28(7):1824-31. doi: 10.1016/j.vaccine.2009.12.001. Epub 2009 Dec 16.

39.

Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens.

Stubben CJ, Duffield ML, Cooper IA, Ford DC, Gans JD, Karlyshev AV, Lingard B, Oyston PC, de Rochefort A, Song J, Wren BW, Titball RW, Wolinsky M.

BMC Genomics. 2009 Oct 29;10:501. doi: 10.1186/1471-2164-10-501.

40.

Francisella virulence: significant advances, ongoing challenges and unmet needs.

Oyston PC, Griffiths R.

Expert Rev Vaccines. 2009 Nov;8(11):1575-85. doi: 10.1586/erv.09.114. Review.

PMID:
19863250
41.

Francisella tularensis vaccines.

Oyston PC.

Vaccine. 2009 Nov 5;27 Suppl 4:D48-51. doi: 10.1016/j.vaccine.2009.07.090. Review.

PMID:
19837286
42.

RelA regulates virulence and intracellular survival of Francisella novicida.

Dean RE, Ireland PM, Jordan JE, Titball RW, Oyston PC.

Microbiology. 2009 Dec;155(Pt 12):4104-13. doi: 10.1099/mic.0.031021-0. Epub 2009 Sep 17.

PMID:
19762448
43.

Novel peptide therapeutics for treatment of infections.

Oyston PC, Fox MA, Richards SJ, Clark GC.

J Med Microbiol. 2009 Aug;58(Pt 8):977-87. doi: 10.1099/jmm.0.011122-0. Epub 2009 Jun 15. Review.

PMID:
19528155
44.

Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis.

Champion OL, Cooper IA, James SL, Ford D, Karlyshev A, Wren BW, Duffield M, Oyston PC, Titball RW.

Microbiology. 2009 May;155(Pt 5):1516-22. doi: 10.1099/mic.0.026823-0. Epub 2009 Apr 21.

PMID:
19383703
45.

Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins.

Maddocks SE, Oyston PC.

Microbiology. 2008 Dec;154(Pt 12):3609-23. doi: 10.1099/mic.0.2008/022772-0. Review.

PMID:
19047729
46.

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux.

Stabler RA, Dawson LF, Oyston PC, Titball RW, Wade J, Hinds J, Witney AA, Wren BW.

BMC Microbiol. 2008 Oct 9;8:177. doi: 10.1186/1471-2180-8-177.

47.

An intracellularly inducible gene involved in virulence and polyphosphate production in Francisella.

Richards MI, Michell SL, Oyston PC.

J Med Microbiol. 2008 Oct;57(Pt 10):1183-92. doi: 10.1099/jmm.0.2008/001826-0.

PMID:
18809544
48.

Separated at birth? Microarray analysis of two strikingly similar yersinia species.

Hinchliffe SJ, Isherwood KE, Stabler RA, Oyston PC, Hinds J, Titbal RW, Wren BW.

Comp Funct Genomics. 2002;3(4):355-7. doi: 10.1002/cfg.195. No abstract available.

49.

Francisella tularensis: unravelling the secrets of an intracellular pathogen.

Oyston PC.

J Med Microbiol. 2008 Aug;57(Pt 8):921-30. doi: 10.1099/jmm.0.2008/000653-0. Review.

PMID:
18628490
50.

Protection afforded against aerosol challenge by systemic immunisation with inactivated Francisella tularensis live vaccine strain (LVS).

Eyles JE, Hartley MG, Laws TR, Oyston PC, Griffin KF, Titball RW.

Microb Pathog. 2008 Feb;44(2):164-8. Epub 2007 Aug 21.

PMID:
17904793

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