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Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats.

McClenahan SJ, Kormos CM, Gunnell M, Hambuchen MD, Lamb P, Carroll FI, Lewin AH, Peterson EC, Owens SM.

Vaccine. 2019 Oct 16. pii: S0264-410X(19)31371-4. doi: 10.1016/j.vaccine.2019.10.008. [Epub ahead of print]


Ecological and Genomic Attributes of Novel Bacterial Taxa That Thrive in Subsurface Soil Horizons.

Brewer TE, Aronson EL, Arogyaswamy K, Billings SA, Botthoff JK, Campbell AN, Dove NC, Fairbanks D, Gallery RE, Hart SC, Kaye J, King G, Logan G, Lohse KA, Maltz MR, Mayorga E, O'Neill C, Owens SM, Packman A, Pett-Ridge J, Plante AF, Richter DD, Silver WL, Yang WH, Fierer N.

MBio. 2019 Oct 1;10(5). pii: e01318-19. doi: 10.1128/mBio.01318-19.


Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE.

Stevens MW, Rüedi-Bettschen D, Gunnell MG, Tawney R, West CM, Owens SM.

Drug Alcohol Depend. 2019 Aug 30;204:107484. doi: 10.1016/j.drugalcdep.2019.05.016. [Epub ahead of print]


Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats.

Hambuchen MD, Berquist MD, Simecka CM, McGill MR, Gunnell MG, Hendrickson HP, Owens SM.

J Pharm Pharm Sci. 2019;22(1):301-312. doi: 10.18433/jpps30471.


In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome.

Griffin BA, Caperton CO, Russell LN, Cabanlong CV, Wilson CD, Urquhart KR, Martins BS, Zita MD, Patton AL, Alund AW, Owens SM, Fantegrossi WE, Moran JH, Brents LK.

J Pharmacol Exp Ther. 2019 Jul;370(1):9-17. doi: 10.1124/jpet.118.254219. Epub 2019 Apr 26.


Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats.

McClenahan SJ, Hambuchen MD, Simecka CM, Gunnell MG, Berquist MD, Owens SM.

Drug Alcohol Depend. 2019 Feb 1;195:140-147. doi: 10.1016/j.drugalcdep.2018.12.006. Epub 2019 Jan 4.


Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.

Schwartz MH, Wang H, Pan JN, Clark WC, Cui S, Eckwahl MJ, Pan DW, Parisien M, Owens SM, Cheng BL, Martinez K, Xu J, Chang EB, Pan T, Eren AM.

Nat Commun. 2018 Dec 17;9(1):5353. doi: 10.1038/s41467-018-07675-z.


Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis.

Ahmed I, Roy BC, Raach RT, Owens SM, Xia L, Anant S, Sampath V, Umar S.

PLoS One. 2018 Nov 1;13(11):e0206701. doi: 10.1371/journal.pone.0206701. eCollection 2018.


Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse.

Hay CE, Gonzalez GA 3rd, Ewing LE, Reichard EE, Hambuchen MD, Nanaware-Kharade N, Alam S, Bolden CT, Owens SM, Margaritis P, Peterson EC.

PLoS One. 2018 Jun 29;13(6):e0200060. doi: 10.1371/journal.pone.0200060. eCollection 2018.


Parallelized, Aerobic, Single Carbon-Source Enrichments from Different Natural Environments Contain Divergent Microbial Communities.

Flynn TM, Koval JC, Greenwald SM, Owens SM, Kemner KM, Antonopoulos DA.

Front Microbiol. 2017 Nov 28;8:2321. doi: 10.3389/fmicb.2017.02321. eCollection 2017.


A communal catalogue reveals Earth's multiscale microbial diversity.

Thompson LR, Sanders JG, McDonald D, Amir A, Ladau J, Locey KJ, Prill RJ, Tripathi A, Gibbons SM, Ackermann G, Navas-Molina JA, Janssen S, Kopylova E, Vázquez-Baeza Y, González A, Morton JT, Mirarab S, Zech Xu Z, Jiang L, Haroon MF, Kanbar J, Zhu Q, Jin Song S, Kosciolek T, Bokulich NA, Lefler J, Brislawn CJ, Humphrey G, Owens SM, Hampton-Marcell J, Berg-Lyons D, McKenzie V, Fierer N, Fuhrman JA, Clauset A, Stevens RL, Shade A, Pollard KS, Goodwin KD, Jansson JK, Gilbert JA, Knight R; Earth Microbiome Project Consortium.

Nature. 2017 Nov 23;551(7681):457-463. doi: 10.1038/nature24621. Epub 2017 Nov 1.


The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats.

Hambuchen MD, Hendrickson HP, Gunnell MG, McClenahan SJ, Ewing LE, Gibson DM, Berquist MD, Owens SM.

Drug Alcohol Depend. 2017 Oct 1;179:347-354. doi: 10.1016/j.drugalcdep.2017.07.011. Epub 2017 Aug 8.


Size, Composition, and Source Profiles of Inhalable Bioaerosols from Colorado Dairies.

Schaeffer JW, Reynolds S, Magzamen S, VanDyke A, Gottel NR, Gilbert JA, Owens SM, Hampton-Marcell JT, Volckens J.

Environ Sci Technol. 2017 Jun 6;51(11):6430-6440. doi: 10.1021/acs.est.7b00882. Epub 2017 May 25.


Chiral determination of 3,4-methylenedioxypyrovalerone enantiomers in rat serum.

Hambuchen MD, Hendrickson HP, Owens SM.

Anal Methods. 2017 Jan 28;9(4):609-617. doi: 10.1039/C6AY03176E. Epub 2016 Dec 22.


Identifying the plant-associated microbiome across aquatic and terrestrial environments: the effects of amplification method on taxa discovery.

Jackrel SL, Owens SM, Gilbert JA, Pfister CA.

Mol Ecol Resour. 2017 Sep;17(5):931-942. doi: 10.1111/1755-0998.12645. Epub 2017 Jan 25.


PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance.

Reichard EE, Nanaware-Kharade N, Gonzalez GA 3rd, Thakkar S, Owens SM, Peterson EC.

Pharm Res. 2016 Dec;33(12):2954-2966. Epub 2016 Sep 12.


Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats.

Owens SM, Pollard GT, Howard JL, Fennell TR, Snyder RW, Carroll FI.

ACS Chem Neurosci. 2016 Dec 21;7(12):1737-1745. doi: 10.1021/acschemneuro.6b00249. Epub 2016 Oct 4.


Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies.

Hambuchen MD, Rüedi-Bettschen D, Gunnell MG, Hendrickson H, Owens SM.

Hum Vaccin Immunother. 2016 Sep;12(9):2240-8. doi: 10.1080/21645515.2016.1179407. Epub 2016 May 10.


Optimization of a methamphetamine conjugate vaccine for antibody production in mice.

Stevens MW, Gunnell MG, Tawney R, Owens SM.

Int Immunopharmacol. 2016 Jun;35:137-141. doi: 10.1016/j.intimp.2016.03.028. Epub 2016 Apr 16.


Spatial scale drives patterns in soil bacterial diversity.

O'Brien SL, Gibbons SM, Owens SM, Hampton-Marcell J, Johnston ER, Jastrow JD, Gilbert JA, Meyer F, Antonopoulos DA.

Environ Microbiol. 2016 Jun;18(6):2039-51. doi: 10.1111/1462-2920.13231. Epub 2016 Mar 21.


Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.

Howe A, Ringus DL, Williams RJ, Choo ZN, Greenwald SM, Owens SM, Coleman ML, Meyer F, Chang EB.

ISME J. 2016 May;10(5):1217-27. doi: 10.1038/ismej.2015.183. Epub 2015 Oct 16.


Correction: The Anti-(+)-Methamphetamine Monoclonal Antibody mAb7F9 Attenuates Acute (+)-Methamphetamine Effects on Intracranial Self-Stimulation in Rats.

Harris AC, LeSage MG, Shelley D, Perry JL, Pentel PR, Owens SM.

PLoS One. 2015 Sep 18;10(9):e0138959. doi: 10.1371/journal.pone.0138959. eCollection 2015. No abstract available.


Athletic equipment microbiota are shaped by interactions with human skin.

Wood M, Gibbons SM, Lax S, Eshoo-Anton TW, Owens SM, Kennedy S, Gilbert JA, Hampton-Marcell JT.

Microbiome. 2015 Jun 19;3:25. doi: 10.1186/s40168-015-0088-3. eCollection 2015.


Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response.

Hambuchen MD, Carroll FI, Rüedi-Bettschen D, Hendrickson HP, Hennings LJ, Blough BE, Brieaddy LE, Pidaparthi RR, Owens SM.

J Med Chem. 2015 Jun 11;58(11):4665-77. doi: 10.1021/acs.jmedchem.5b00220. Epub 2015 May 22.


The soil microbiome influences grapevine-associated microbiota.

Zarraonaindia I, Owens SM, Weisenhorn P, West K, Hampton-Marcell J, Lax S, Bokulich NA, Mills DA, Martin G, Taghavi S, van der Lelie D, Gilbert JA.

MBio. 2015 Mar 24;6(2). pii: e02527-14. doi: 10.1128/mBio.02527-14.


The anti-(+)-methamphetamine monoclonal antibody mAb7F9 attenuates acute (+)-methamphetamine effects on intracranial self-stimulation in rats.

Harris AC, LeSage MG, Shelley D, Perry JL, Pentel PR, Owens SM.

PLoS One. 2015 Mar 5;10(3):e0118787. doi: 10.1371/journal.pone.0118787. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138959.


First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers.

Stevens MW, Henry RL, Owens SM, Schutz R, Gentry WB.

MAbs. 2014;6(6):1649-56. doi: 10.4161/19420862.2014.976431.


Pharmacological effects of two anti-methamphetamine monoclonal antibodies. Supporting data for lead candidate selection for clinical development.

Laurenzana EM, Stevens MW, Frank JC, Hambuchen MD, Hendrickson HP, White SJ, Williams DK, Owens SM, Gentry WB.

Hum Vaccin Immunother. 2014;10(9):2638-47. doi: 10.4161/hv.29707. Epub 2014 Nov 1.


Simple radiometric method for accurately quantitating epitope densities of hapten-protein conjugates with sulfhydryl linkages.

Peterson EC, Hambuchen MD, Tawney RL, Gunnell MG, Cowell JL, Lay JO Jr, Blough BE, Carroll FI, Owens SM.

Bioconjug Chem. 2014 Dec 17;25(12):2112-5. doi: 10.1021/bc500456z. Epub 2014 Dec 4.


DNA extraction protocols cause differences in 16S rRNA amplicon sequencing efficiency but not in community profile composition or structure.

Rubin BE, Sanders JG, Hampton-Marcell J, Owens SM, Gilbert JA, Moreau CS.

Microbiologyopen. 2014 Dec;3(6):910-21. doi: 10.1002/mbo3.216. Epub 2014 Sep 26.


Treatment of rats with an anti-(+)-methamphetamine monoclonal antibody shortens the duration of action of repeated (+)-methamphetamine challenges over a one month period.

Hambuchen MD, Rüedi-Bettschen D, Williams DK, Hendrickson H, Owens SM.

Vaccine. 2014 Oct 29;32(47):6213-9. doi: 10.1016/j.vaccine.2014.09.025. Epub 2014 Sep 22.


Longitudinal analysis of microbial interaction between humans and the indoor environment.

Lax S, Smith DP, Hampton-Marcell J, Owens SM, Handley KM, Scott NM, Gibbons SM, Larsen P, Shogan BD, Weiss S, Metcalf JL, Ursell LK, Vázquez-Baeza Y, Van Treuren W, Hasan NA, Gibson MK, Colwell R, Dantas G, Knight R, Gilbert JA.

Science. 2014 Aug 29;345(6200):1048-52. doi: 10.1126/science.1254529.


Understanding cultivar-specificity and soil determinants of the cannabis microbiome.

Winston ME, Hampton-Marcell J, Zarraonaindia I, Owens SM, Moreau CS, Gilbert JA, Hartsel JA, Kennedy SJ, Gibbons SM.

PLoS One. 2014 Jun 16;9(6):e99641. doi: 10.1371/journal.pone.0099641. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e107415. Hartsel, Josh [corrected to Hartsel, Joshua A].


Treatment with a monoclonal antibody against methamphetamine and amphetamine reduces maternal and fetal rat brain concentrations in late pregnancy.

White SJ, Hendrickson HP, Atchley WT, Laurenzana EM, Gentry WB, Williams DK, Owens SM.

Drug Metab Dispos. 2014 Aug;42(8):1285-91. doi: 10.1124/dmd.114.056879. Epub 2014 May 19.


Dinitrogen fixation associated with shoots of aquatic carnivorous plants: is it ecologically important?

Sirová D, Santrůček J, Adamec L, Bárta J, Borovec J, Pech J, Owens SM, Santrůčková H, Schäufele R, Storchová H, Vrba J.

Ann Bot. 2014 Jul;114(1):125-33. doi: 10.1093/aob/mcu067. Epub 2014 May 9.


Restricted streptomycin use in apple orchards did not adversely alter the soil bacteria communities.

Walsh F, Smith DP, Owens SM, Duffy B, Frey JE.

Front Microbiol. 2014 Jan 31;4:383. doi: 10.3389/fmicb.2013.00383. eCollection 2013.


Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use.

Stevens MW, Tawney RL, West CM, Kight AD, Henry RL, Owens SM, Gentry WB.

MAbs. 2014 Mar-Apr;6(2):547-55. doi: 10.4161/mabs.27620. Epub 2013 Dec 23.


Customizing monoclonal antibodies for the treatment of methamphetamine abuse: current and future applications.

Peterson EC, Gentry WB, Owens SM.

Adv Pharmacol. 2014;69:107-27. doi: 10.1016/B978-0-12-420118-7.00003-2. Review.


Saliva from obese individuals suppresses the release of aroma compounds from wine.

Piombino P, Genovese A, Esposito S, Moio L, Cutolo PP, Chambery A, Severino V, Moneta E, Smith DP, Owens SM, Gilbert JA, Ercolini D.

PLoS One. 2014 Jan 22;9(1):e85611. doi: 10.1371/journal.pone.0085611. eCollection 2014.


Reconstructing the microbial diversity and function of pre-agricultural tallgrass prairie soils in the United States.

Fierer N, Ladau J, Clemente JC, Leff JW, Owens SM, Pollard KS, Knight R, Gilbert JA, McCulley RL.

Science. 2013 Nov 1;342(6158):621-4. doi: 10.1126/science.1243768.


Preparation and metatranscriptomic analyses of host-microbe systems.

Hampton-Marcell JT, Moormann SM, Owens SM, Gilbert JA.

Methods Enzymol. 2013;531:169-85. doi: 10.1016/B978-0-12-407863-5.00009-5.


Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food.

Rüedi-Bettschen D, Wood SL, Gunnell MG, West CM, Pidaparthi RR, Carroll FI, Blough BE, Owens SM.

Vaccine. 2013 Sep 23;31(41):4596-602. doi: 10.1016/j.vaccine.2013.07.038. Epub 2013 Jul 29.


Asymmetric functional divergence of young, dispersed gene duplicates in Arabidopsis thaliana.

Owens SM, Harberson NA, Moore RC.

J Mol Evol. 2013 Feb;76(1-2):13-27. doi: 10.1007/s00239-012-9530-3. Epub 2013 Jan 24.


Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms.

Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Huntley J, Fierer N, Owens SM, Betley J, Fraser L, Bauer M, Gormley N, Gilbert JA, Smith G, Knight R.

ISME J. 2012 Aug;6(8):1621-4. doi: 10.1038/ismej.2012.8. Epub 2012 Mar 8.


Monoclonal antibodies as pharmacokinetic antagonists for the treatment of (+)-methamphetamine addiction.

Owens SM, Atchley WT, Hambuchen MD, Peterson EC, Gentry WB.

CNS Neurol Disord Drug Targets. 2011 Dec;10(8):892-8. Review.


Chronic anti-phencyclidine monoclonal antibody therapy decreases phencyclidine-induced in utero fetal mortality in pregnant rats.

Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM.

Int Immunopharmacol. 2011 Dec;11(12):2181-7. doi: 10.1016/j.intimp.2011.09.016. Epub 2011 Oct 12.


Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines.

Carroll FI, Blough BE, Pidaparthi RR, Abraham P, Gong PK, Deng L, Huang X, Gunnell M, Lay JO Jr, Peterson EC, Owens SM.

J Med Chem. 2011 Jul 28;54(14):5221-8. doi: 10.1021/jm2004943. Epub 2011 Jun 29.


Gestation time-dependent pharmacokinetics of intravenous (+)-methamphetamine in rats.

White S, Laurenzana E, Hendrickson H, Gentry WB, Owens SM.

Drug Metab Dispos. 2011 Sep;39(9):1718-26. doi: 10.1124/dmd.111.039446. Epub 2011 Jun 1.


The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats.

Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM.

J Pharmacol Exp Ther. 2011 Feb;336(2):414-22. doi: 10.1124/jpet.110.175083. Epub 2010 Oct 20.


Development and validation of an LC-MS/MS method for determination of phencyclidine in human serum and its application to human drug abuse cases.

Chimalakonda KC, Hailey C, Black R, Beekman A, Carlisle R, Lowman-Smith E, Singletary H, Owens SM, Hendrickson H.

Anal Methods. 2010 Sep 1;2(9):1249-1254.

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