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Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy.

Neill T, Sharpe C, Owens RT, Iozzo RV.

J Biol Chem. 2017 Sep 29;292(39):16211-16220. doi: 10.1074/jbc.M116.769950. Epub 2017 Aug 10.


Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin.

Myren M, Kirby DJ, Noonan ML, Maeda A, Owens RT, Ricard-Blum S, Kram V, Kilts TM, Young MF.

Matrix Biol. 2016 May-Jul;52-54:141-150. doi: 10.1016/j.matbio.2016.03.008. Epub 2016 Apr 9. Review.


Reprint of: Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.

Goyal A, Neill T, Owens RT, Schaefer L, Iozzo RV.

Matrix Biol. 2014 Apr;35:42-50. doi: 10.1016/j.matbio.2014.04.002. Epub 2014 Apr 12.


Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.

Goyal A, Neill T, Owens RT, Schaefer L, Iozzo RV.

Matrix Biol. 2014 Feb;34:46-54. doi: 10.1016/j.matbio.2013.12.011. Epub 2014 Jan 26.


Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin.

Neill T, Torres A, Buraschi S, Owens RT, Hoek JB, Baffa R, Iozzo RV.

J Biol Chem. 2014 Feb 21;289(8):4952-68. doi: 10.1074/jbc.M113.512566. Epub 2014 Jan 8.


Biglycan modulates angiogenesis and bone formation during fracture healing.

Berendsen AD, Pinnow EL, Maeda A, Brown AC, McCartney-Francis N, Kram V, Owens RT, Robey PG, Holmbeck K, de Castro LF, Kilts TM, Young MF.

Matrix Biol. 2014 Apr;35:223-31. doi: 10.1016/j.matbio.2013.12.004. Epub 2013 Dec 25.


Biglycan and decorin differentially regulate signaling in the fetal membranes.

Wu Z, Horgan CE, Carr O, Owens RT, Iozzo RV, Lechner BE.

Matrix Biol. 2014 Apr;35:266-75. doi: 10.1016/j.matbio.2013.12.006. Epub 2013 Dec 25.


Decorin causes autophagy in endothelial cells via Peg3.

Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens RT, Schaefer L, Torres A, Iozzo RV.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2582-91. doi: 10.1073/pnas.1305732110. Epub 2013 Jun 24.


Decorin potentiates interferon-γ activity in a model of allergic inflammation.

Bocian C, Urbanowitz AK, Owens RT, Iozzo RV, Götte M, Seidler DG.

J Biol Chem. 2013 May 3;288(18):12699-711. doi: 10.1074/jbc.M112.419366. Epub 2013 Mar 4.


Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1.

Neill T, Jones HR, Crane-Smith Z, Owens RT, Schaefer L, Iozzo RV.

FEBS J. 2013 May;280(10):2353-68. doi: 10.1111/febs.12148. Epub 2013 Feb 15.


The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis.

Jungmann O, Nikolovska K, Stock C, Schulz JN, Eckes B, Riethmüller C, Owens RT, Iozzo RV, Seidler DG.

PLoS One. 2012;7(12):e50809. doi: 10.1371/journal.pone.0050809. Epub 2012 Dec 3.


Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model.

Buraschi S, Neill T, Owens RT, Iniguez LA, Purkins G, Vadigepalli R, Evans B, Schaefer L, Peiper SC, Wang ZX, Iozzo RV.

PLoS One. 2012;7(9):e45559. doi: 10.1371/journal.pone.0045559. Epub 2012 Sep 19.


Biglycan is an extracellular MuSK binding protein important for synapse stability.

Amenta AR, Creely HE, Mercado ML, Hagiwara H, McKechnie BA, Lechner BE, Rossi SG, Wang Q, Owens RT, Marrero E, Mei L, Hoch W, Young MF, McQuillan DJ, Rotundo RL, Fallon JR.

J Neurosci. 2012 Feb 15;32(7):2324-34. doi: 10.1523/JNEUROSCI.4610-11.2012.


Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.

Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV.

J Biol Chem. 2012 Feb 17;287(8):5492-506. doi: 10.1074/jbc.M111.283499. Epub 2011 Dec 22.


Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.

Berendsen AD, Fisher LW, Kilts TM, Owens RT, Robey PG, Gutkind JS, Young MF.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17022-7. doi: 10.1073/pnas.1110629108. Epub 2011 Oct 3.


Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway.

Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ.

Carcinogenesis. 2011 Oct;32(10):1518-24. doi: 10.1093/carcin/bgr132. Epub 2011 Jul 18.


Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.

Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV.

J Biol Chem. 2010 Dec 31;285(53):42075-85. doi: 10.1074/jbc.M110.172841. Epub 2010 Oct 25.


Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer.

Hu Y, Sun H, Owens RT, Gu Z, Wu J, Chen YQ, O'Flaherty JT, Edwards IJ.

Neoplasia. 2010 Oct;12(10):826-36.


Domain structure elucidation of human decorin glycosaminoglycans.

Laremore TN, Ly M, Zhang Z, Solakyildirim K, McCallum SA, Owens RT, Linhardt RJ.

Biochem J. 2010 Oct 15;431(2):199-205. doi: 10.1042/BJ20100788.


Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways.

Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ.

Neoplasia. 2009 Oct;11(10):1042-53.


Decorin is a novel antagonistic ligand of the Met receptor.

Goldoni S, Humphries A, Nyström A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV.

J Cell Biol. 2009 May 18;185(4):743-54. doi: 10.1083/jcb.200901129. Epub 2009 May 11.


A central role for decorin during vertebrate convergent extension.

Zoeller JJ, Pimtong W, Corby H, Goldoni S, Iozzo AE, Owens RT, Ho SY, Iozzo RV.

J Biol Chem. 2009 Apr 24;284(17):11728-37. doi: 10.1074/jbc.M808991200. Epub 2009 Feb 10.


A porcine-derived acellular dermal scaffold that supports soft tissue regeneration: removal of terminal galactose-alpha-(1,3)-galactose and retention of matrix structure.

Xu H, Wan H, Zuo W, Sun W, Owens RT, Harper JR, Ayares DL, McQuillan DJ.

Tissue Eng Part A. 2009 Jul;15(7):1807-19. doi: 10.1089/ten.tea.2008.0384.


Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan.

Zhang G, Chen S, Goldoni S, Calder BW, Simpson HC, Owens RT, McQuillan DJ, Young MF, Iozzo RV, Birk DE.

J Biol Chem. 2009 Mar 27;284(13):8888-97. doi: 10.1074/jbc.M806590200. Epub 2009 Jan 9.


An antimetastatic role for decorin in breast cancer.

Goldoni S, Seidler DG, Heath J, Fassan M, Baffa R, Thakur ML, Owens RT, McQuillan DJ, Iozzo RV.

Am J Pathol. 2008 Sep;173(3):844-55. doi: 10.2353/ajpath.2008.080275. Epub 2008 Aug 7.


Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells.

Zhang J, Noble NA, Border WA, Owens RT, Huang Y.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E810-9. doi: 10.1152/ajpendo.90264.2008. Epub 2008 Jul 29.


Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells.

Sun H, Berquin IM, Owens RT, O'Flaherty JT, Edwards IJ.

Cancer Res. 2008 Apr 15;68(8):2912-9. doi: 10.1158/0008-5472.CAN-07-2305.


Creative saving for college.

Owens RT.

J Okla Dent Assoc. 2006 Nov;96(3):26-7. No abstract available.


Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development.

Rafii MS, Hagiwara H, Mercado ML, Seo NS, Xu T, Dugan T, Owens RT, Hook M, McQuillan DJ, Young MF, Fallon JR.

J Cell Physiol. 2006 Nov;209(2):439-47.


Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation.

Seidler DG, Goldoni S, Agnew C, Cardi C, Thakur ML, Owens RT, McQuillan DJ, Iozzo RV.

J Biol Chem. 2006 Sep 8;281(36):26408-18. Epub 2006 Jul 11.


Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS.

Mercado ML, Amenta AR, Hagiwara H, Rafii MS, Lechner BE, Owens RT, McQuillan DJ, Froehner SC, Fallon JR.

FASEB J. 2006 Aug;20(10):1724-6. Epub 2006 Jun 28.


WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan.

Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, Owens RT, Sasaki T, Timpl R, Fitzgerald J.

J Biol Chem. 2006 Mar 17;281(11):7341-9. Epub 2006 Jan 6.


Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.

Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W.

Kidney Int. 2006 Jan;69(1):105-13.


Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins.

Groeneveld TW, Oroszlán M, Owens RT, Faber-Krol MC, Bakker AC, Arlaud GJ, McQuillan DJ, Kishore U, Daha MR, Roos A.

J Immunol. 2005 Oct 1;175(7):4715-23.


Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.

Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV.

J Biol Chem. 2005 Sep 16;280(37):32468-79. Epub 2005 Jul 1.


Decorin prevents metastatic spreading of breast cancer.

Reed CC, Waterhouse A, Kirby S, Kay P, Owens RT, McQuillan DJ, Iozzo RV.

Oncogene. 2005 Feb 3;24(6):1104-10.


Biologically active decorin is a monomer in solution.

Goldoni S, Owens RT, McQuillan DJ, Shriver Z, Sasisekharan R, Birk DE, Campbell S, Iozzo RV.

J Biol Chem. 2004 Feb 20;279(8):6606-12. Epub 2003 Dec 3.


Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.

Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Höök M, Sacchettini JC.

J Biol Chem. 2001 Mar 30;276(13):10010-5. Epub 2001 Jan 3.


Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1.

Xu Y, Gurusiddappa S, Rich RL, Owens RT, Keene DR, Mayne R, Höök A, Höök M.

J Biol Chem. 2000 Dec 15;275(50):38981-9.


Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.

Deivanayagam CC, Rich RL, Carson M, Owens RT, Danthuluri S, Bice T, Höök M, Narayana SV.

Structure. 2000 Jan 15;8(1):67-78.


Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi.

Lawrenz MB, Hardham JM, Owens RT, Nowakowski J, Steere AC, Wormser GP, Norris SJ.

J Clin Microbiol. 1999 Dec;37(12):3997-4004.


Ace is a collagen-binding MSCRAMM from Enterococcus faecalis.

Rich RL, Kreikemeyer B, Owens RT, LaBrenz S, Narayana SV, Weinstock GM, Murray BE, Höök M.

J Biol Chem. 1999 Sep 17;274(38):26939-45.


Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.

Rich RL, Deivanayagam CC, Owens RT, Carson M, Höök A, Moore D, Symersky J, Yang VW, Narayana SV, Höök M.

J Biol Chem. 1999 Aug 27;274(35):24906-13. Erratum in: J Biol Chem 1999 Oct 1;274(40):28836.


Crystallization of ClfA and ClfB fragments: the fibrinogen-binding surface proteins of Staphylococcus aureus.

Deivanayagam CC, Perkins S, Danthuluri S, Owens RT, Bice T, Nanavathy T, Foster TJ, Höök M, Narayana SV.

Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):554-6.


Crystallization and preliminary X-ray analysis of B-domain fragments of a Staphylococcus aureus collagen-binding protein.

Deivanayagam CC, Rich RL, Danthuluri S, Owens RT, Patti JM, Höök M, DeLucas LJ, Narayana SV.

Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):525-7.


Is the sensitivity of cells for FGF-1 and FGF-2 regulated by cell surface heparan sulfate proteoglycans?

Zhou FY, Owens RT, Hermonen J, Jalkanen M, Höök M.

Eur J Cell Biol. 1997 Jun;73(2):166-74.


Heparin-dependent fibroblast growth factor activities: effects of defined heparin oligosaccharides.

Zhou FY, Kan M, Owens RT, McKeehan WL, Thompson JA, Linhardt RJ, Höök M.

Eur J Cell Biol. 1997 May;73(1):71-80.


Proteoglycans produced by cholesterol-enriched macrophages bind plasma low density lipoprotein.

Owens RT, Wagner WD.

Atherosclerosis. 1991 Dec;91(3):229-40.


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