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Items: 1 to 50 of 143

1.

In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni Hypoxanthine-guanine phosphoribosyltransferases.

Romanello L, Zeraik AE, de Freitas Fernandes A, Torini JR, Bird LE, Nettleship JE, Rada H, Reddivari Y, Owens RJ, Serrão VHB, DeMarco R, Brandão-Neto J, Pereira HD.

Mol Biochem Parasitol. 2019 Feb 14. pii: S0166-6851(18)30243-3. doi: 10.1016/j.molbiopara.2019.02.005. [Epub ahead of print]

PMID:
30772423
2.

Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.

Sabaratnam K, Renner M, Paesen G, Harlos K, Nair V, Owens RJ, Grimes JM.

Protein Sci. 2019 Jan 17. doi: 10.1002/pro.3573. [Epub ahead of print]

PMID:
30653278
3.

Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region.

Kim YC, Lopez-Camacho C, Nettleship JE, Rahman N, Hill ML, Silva-Reyes L, Ortiz-Martinez G, Figueroa-Aguilar G, Mar MA, Vivanco-Cid H, Rollier CS, Zitzmann N, Viveros-Sandoval ME, Owens RJ, Reyes-Sandoval A.

Virol J. 2018 Dec 27;15(1):193. doi: 10.1186/s12985-018-1104-6.

4.

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J.

FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23.

PMID:
30430727
5.

Highly stable single-strand-specific 3'-nuclease/nucleotidase from Legionella pneumophila.

Trundová M, Kovaľ T, Owens RJ, Fejfarová K, Dušková J, Kolenko P, Dohnálek J.

Int J Biol Macromol. 2018 Jul 15;114:776-787. doi: 10.1016/j.ijbiomac.2018.03.113. Epub 2018 Mar 23.

PMID:
29580999
6.

CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.

Hardman CS, Chen YL, Salimi M, Jarrett R, Johnson D, Järvinen VJ, Owens RJ, Repapi E, Cousins DJ, Barlow JL, McKenzie ANJ, Ogg G.

Sci Immunol. 2017 Dec 22;2(18). pii: eaan5918. doi: 10.1126/sciimmunol.aan5918.

7.

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.

Robinson JI, Baxter EW, Owen RL, Thomsen M, Tomlinson DC, Waterhouse MP, Win SJ, Nettleship JE, Tiede C, Foster RJ, Owens RJ, Fishwick CWG, Harris SA, Goldman A, McPherson MJ, Morgan AW.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E72-E81. doi: 10.1073/pnas.1707856115. Epub 2017 Dec 15.

8.

Affimer proteins are versatile and renewable affinity reagents.

Tiede C, Bedford R, Heseltine SJ, Smith G, Wijetunga I, Ross R, AlQallaf D, Roberts AP, Balls A, Curd A, Hughes RE, Martin H, Needham SR, Zanetti-Domingues LC, Sadigh Y, Peacock TP, Tang AA, Gibson N, Kyle H, Platt GW, Ingram N, Taylor T, Coletta LP, Manfield I, Knowles M, Bell S, Esteves F, Maqbool A, Prasad RK, Drinkhill M, Bon RS, Patel V, Goodchild SA, Martin-Fernandez M, Owens RJ, Nettleship JE, Webb ME, Harrison M, Lippiat JD, Ponnambalam S, Peckham M, Smith A, Ferrigno PK, Johnson M, McPherson MJ, Tomlinson DC.

Elife. 2017 Jun 27;6. pii: e24903. doi: 10.7554/eLife.24903.

9.

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ, Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F.

Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788d. No abstract available.

PMID:
28586341
10.

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ, Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F.

Nat Med. 2017 May;23(5):579-589. doi: 10.1038/nm.4307. Epub 2017 Apr 3. Erratum in: Nat Med. 2017 Jun 6;23 (6):788.

11.

Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL).

Romanello L, Serrão VHB, Torini JR, Bird LE, Nettleship JE, Rada H, Reddivari Y, Owens RJ, DeMarco R, Brandão-Neto J, Pereira HD.

Mol Biochem Parasitol. 2017 Jun;214:27-35. doi: 10.1016/j.molbiopara.2017.03.006. Epub 2017 Mar 25.

PMID:
28347672
12.

Expression Screening of Integral Membrane Proteins by Fusion to Fluorescent Reporters.

Bird LE, Nettleship JE, Järvinen V, Rada H, Verma A, Owens RJ.

Adv Exp Med Biol. 2016;922:1-11. doi: 10.1007/978-3-319-35072-1_1.

PMID:
27553231
13.

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Data Brief. 2016 Feb 10;7:257-81. doi: 10.1016/j.dib.2016.02.012. eCollection 2016 Jun.

14.

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases.

Roatsch M, Robaa D, Pippel M, Nettleship JE, Reddivari Y, Bird LE, Hoffmann I, Franz H, Owens RJ, Schüle R, Flaig R, Sippl W, Jung M.

Future Med Chem. 2016 Sep;8(13):1553-71. doi: 10.4155/fmc.15.188. Epub 2016 Mar 14.

15.

Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.

Ren J, Nettleship JE, Males A, Stuart DI, Owens RJ.

FEBS Lett. 2016 Jan;590(2):288-97. doi: 10.1002/1873-3468.12054. Epub 2016 Jan 23.

16.

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.

Arena de Souza V, Scott DJ, Nettleship JE, Rahman N, Charlton MH, Walsh MA, Owens RJ.

PLoS One. 2015 Dec 11;10(12):e0143919. doi: 10.1371/journal.pone.0143919. eCollection 2015.

17.

High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate.

Lukacik P, Lobley CM, Bumann M, Arena de Souza V, Owens RJ, O'Toole PW, Walsh MA.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1327-34. doi: 10.1107/S2053230X1501657X. Epub 2015 Sep 23.

18.

A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis.

Liu C, Zhao Y, He W, Wang W, Chen Y, Zhang S, Ma Y, Gohda J, Ishida T, Walter TS, Owens RJ, Stuart DI, Ren J, Gao B.

Sci Rep. 2015 Sep 28;5:14150. doi: 10.1038/srep14150.

19.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Anal Biochem. 2015 Dec 1;490:66-72. doi: 10.1016/j.ab.2015.08.025. Epub 2015 Sep 1.

20.

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.

Beale JH, Parker JL, Samsudin F, Barrett AL, Senan A, Bird LE, Scott D, Owens RJ, Sansom MSP, Tucker SJ, Meredith D, Fowler PW, Newstead S.

Structure. 2015 Oct 6;23(10):1889-1899. doi: 10.1016/j.str.2015.07.016. Epub 2015 Aug 27.

21.

Structural proteomics: high-throughput methods. Preface.

Owens RJ.

Methods Mol Biol. 2015;1261:v. No abstract available.

PMID:
25646554
22.

Green fluorescent protein-based expression screening of membrane proteins in Escherichia coli.

Bird LE, Rada H, Verma A, Gasper R, Birch J, Jennions M, Lӧwe J, Moraes I, Owens RJ.

J Vis Exp. 2015 Jan 6;(95):e52357. doi: 10.3791/52357.

23.

GFP-based expression screening of membrane proteins in insect cells using the baculovirus system.

Hu NJ, Rada H, Rahman N, Nettleship JE, Bird L, Iwata S, Drew D, Cameron AD, Owens RJ.

Methods Mol Biol. 2015;1261:197-209. doi: 10.1007/978-1-4939-2230-7_11.

PMID:
25502201
24.

Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins.

Nettleship JE, Watson PJ, Rahman-Huq N, Fairall L, Posner MG, Upadhyay A, Reddivari Y, Chamberlain JM, Kolstoe SE, Bagby S, Schwabe JW, Owens RJ.

Methods Mol Biol. 2015;1258:209-22. doi: 10.1007/978-1-4939-2205-5_11. Review.

PMID:
25447866
25.

Human Respiratory Coronaviruses Detected In Patients with Influenza-Like Illness in Arkansas, USA.

Silva CS, Mullis LB, Pereira O Jr, Saif LJ, Vlasova A, Zhang X, Owens RJ, Paulson D, Taylor D, Haynes LM, Azevedo MP.

Virol Mycol. 2014 Dec;2014(Suppl 2). pii: 004. Epub 2014 Mar 26.

26.

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.

Tiede C, Tang AA, Deacon SE, Mandal U, Nettleship JE, Owen RL, George SE, Harrison DJ, Owens RJ, Tomlinson DC, McPherson MJ.

Protein Eng Des Sel. 2014 May;27(5):145-55. doi: 10.1093/protein/gzu007. Epub 2014 Mar 25.

27.

Application of In-Fusion™ cloning for the parallel construction of E. coli expression vectors.

Bird LE, Rada H, Flanagan J, Diprose JM, Gilbert RJ, Owens RJ.

Methods Mol Biol. 2014;1116:209-34. doi: 10.1007/978-1-62703-764-8_15.

PMID:
24395367
28.

Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.

Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ.

ChemMedChem. 2013 Dec;8(12):1923-9. doi: 10.1002/cmdc.201300350. Epub 2013 Oct 25.

PMID:
24166830
29.

A streamlined implementation of the glutamine synthetase-based protein expression system.

Knox R, Nettleship JE, Chang VT, Hui ZK, Santos AM, Rahman N, Ho LP, Owens RJ, Davis SJ.

BMC Biotechnol. 2013 Sep 24;13:74. doi: 10.1186/1472-6750-13-74.

30.

Binding of (5S)-penicilloic acid to penicillin binding protein 3.

van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ.

ACS Chem Biol. 2013 Oct 18;8(10):2112-6. doi: 10.1021/cb400200h. Epub 2013 Aug 15.

PMID:
23899657
31.

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ.

J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16.

32.

Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment.

Nettleship JE, Ren J, Scott DJ, Rahman N, Hatherley D, Zhao Y, Stuart DI, Barclay AN, Owens RJ.

BMC Struct Biol. 2013 Jul 4;13:13. doi: 10.1186/1472-6807-13-13.

33.

S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA.

Byrne RT, Whelan F, Aller P, Bird LE, Dowle A, Lobley CM, Reddivari Y, Nettleship JE, Owens RJ, Antson AA, Waterman DG.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1090-8. doi: 10.1107/S0907444913004939. Epub 2013 May 15.

34.

Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology.

Aricescu AR, Owens RJ.

Curr Opin Struct Biol. 2013 Jun;23(3):345-56. doi: 10.1016/j.sbi.2013.04.003. Epub 2013 Apr 25. Review.

35.

Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118.

Lobley CM, Aller P, Douangamath A, Reddivari Y, Bumann M, Bird LE, Nettleship JE, Brandao-Neto J, Owens RJ, O'Toole PW, Walsh MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1427-33. doi: 10.1107/S174430911204273X. Epub 2012 Nov 14.

36.

Structural and functional characterization of the kindlin-1 pleckstrin homology domain.

Yates LA, Lumb CN, Brahme NN, Zalyte R, Bird LE, De Colibus L, Owens RJ, Calderwood DA, Sansom MS, Gilbert RJ.

J Biol Chem. 2012 Dec 21;287(52):43246-61. doi: 10.1074/jbc.M112.422089. Epub 2012 Nov 6.

37.

Outrunning free radicals in room-temperature macromolecular crystallography.

Owen RL, Axford D, Nettleship JE, Owens RJ, Robinson JI, Morgan AW, Doré AS, Lebon G, Tate CG, Fry EE, Ren J, Stuart DI, Evans G.

Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):810-8. doi: 10.1107/S0907444912012553. Epub 2012 Jun 15.

38.

Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis.

Sainsbury S, Ren J, Saunders NJ, Stuart DI, Owens RJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):730-7. doi: 10.1107/S1744309112010603. Epub 2012 Jun 22.

39.

In situ macromolecular crystallography using microbeams.

Axford D, Owen RL, Aishima J, Foadi J, Morgan AW, Robinson JI, Nettleship JE, Owens RJ, Moraes I, Fry EE, Grimes JM, Harlos K, Kotecha A, Ren J, Sutton G, Walter TS, Stuart DI, Evans G.

Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):592-600. doi: 10.1107/S0907444912006749. Epub 2012 Apr 17.

40.

Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.

Wilke S, Groebe L, Maffenbeier V, Jäger V, Gossen M, Josewski J, Duda A, Polle L, Owens RJ, Wirth D, Heinz DW, van den Heuvel J, Büssow K.

PLoS One. 2011;6(12):e27829. doi: 10.1371/journal.pone.0027829. Epub 2011 Dec 9.

41.

Structure of New Delhi metallo-β-lactamase 1 (NDM-1).

Green VL, Verma A, Owens RJ, Phillips SE, Carr SB.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1160-4. doi: 10.1107/S1744309111029654. Epub 2011 Sep 6.

42.

Converting monoclonal antibodies into Fab fragments for transient expression in mammalian cells.

Nettleship JE, Flanagan A, Rahman-Huq N, Hamer R, Owens RJ.

Methods Mol Biol. 2012;801:137-59. doi: 10.1007/978-1-61779-352-3_10.

PMID:
21987252
43.

xtalPiMS: a PiMS-based web application for the management and monitoring of crystallization trials.

Daniel E, Lin B, Diprose JM, Griffiths SL, Morris C, Berry IM, Owens RJ, Blake R, Wilson KS, Stuart DI, Esnouf RM.

J Struct Biol. 2011 Aug;175(2):230-5. doi: 10.1016/j.jsb.2011.05.008. Epub 2011 May 14.

44.

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ.

Nat Struct Mol Biol. 2011 May;18(5):571-6. doi: 10.1038/nsmb.2044. Epub 2011 Apr 24.

45.

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study.

Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, Büssow K, Adamson R, Blagova E, Walton J, Cartwright JL, Bird LE, Owens RJ, Berrow NS, Wilson KS, Sussman JL, Perrakis A, Celie PH.

J Struct Biol. 2011 Aug;175(2):159-70. doi: 10.1016/j.jsb.2011.03.004. Epub 2011 Mar 5.

PMID:
21382497
46.

Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.

Sainsbury S, Bird L, Rao V, Shepherd SM, Stuart DI, Hunter WN, Owens RJ, Ren J.

J Mol Biol. 2011 Jan 7;405(1):173-84. doi: 10.1016/j.jmb.2010.10.024. Epub 2010 Oct 23.

47.

Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.

Bird LE, Ren J, Nettleship JE, Folkers GE, Owens RJ, Stammers DK.

BMC Struct Biol. 2010 May 28;10:13. doi: 10.1186/1472-6807-10-13.

48.

Structural and functional insights of RANKL-RANK interaction and signaling.

Liu C, Walter TS, Huang P, Zhang S, Zhu X, Wu Y, Wedderburn LR, Tang P, Owens RJ, Stuart DI, Ren J, Gao B.

J Immunol. 2010 Jun 15;184(12):6910-9. doi: 10.4049/jimmunol.0904033. Epub 2010 May 14.

49.

The structure of a reduced form of OxyR from Neisseria meningitidis.

Sainsbury S, Ren J, Nettleship JE, Saunders NJ, Stuart DI, Owens RJ.

BMC Struct Biol. 2010 May 17;10:10. doi: 10.1186/1472-6807-10-10.

50.

Improved expression of secreted and membrane-targeted proteins in insect cells.

Hitchman RB, Possee RD, Siaterli E, Richards KS, Clayton AJ, Bird LE, Owens RJ, Carpentier DC, King FL, Danquah JO, Spink KG, King LA.

Biotechnol Appl Biochem. 2010 Jun 21;56(3):85-93. doi: 10.1042/BA20090130.

PMID:
20441568

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