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Items: 1 to 50 of 77

1.

Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity.

Chakraborty SK, Basu NK, Jana S, Basu M, Raychoudhuri A, Owens IS.

J Biol Chem. 2012 Jul 13;287(29):24387-96. doi: 10.1074/jbc.M111.335067. Epub 2012 Apr 24.

2.

Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.

Mitra PS, Basu NK, Basu M, Chakraborty S, Saha T, Owens IS.

J Biol Chem. 2011 Jan 14;286(2):1639-48. doi: 10.1074/jbc.M110.165126. Epub 2010 Nov 5.

3.

Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.

Mitra PS, Basu NK, Owens IS.

Biochem Biophys Res Commun. 2009 May 15;382(4):651-6. doi: 10.1016/j.bbrc.2009.03.054. Epub 2009 Mar 14.

4.

Expression of human liver 3, 4-catechol estrogens UDP-Glucuronosyltransferase cDNA in COS 1 cells.

Ahn MR, Owens IS, Sheen YY.

Arch Pharm Res. 1997 Oct;20(5):465-70. doi: 10.1007/BF02973941.

PMID:
18982491
5.

Cloning and expression of human liver UDP-glucuronosyltransferase cDNA, UDPGTh2.

Dong M, Owens IS, Sheen YY.

Arch Pharm Res. 1997 Oct;20(5):459-64. doi: 10.1007/BF02973940.

PMID:
18982490
6.

Comparison of glucuronidating activity of two human cDNAs, UDPGTh1 and UDPGTh2.

Kim SS, Owens IS, Sheen YY.

Arch Pharm Res. 1997 Oct;20(5):454-8. doi: 10.1007/BF02973939.

PMID:
18982489
7.

Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence.

Banerjee R, Pennington MW, Garza A, Owens IS.

Biochemistry. 2008 Jul 15;47(28):7385-92. doi: 10.1021/bi8006127. Epub 2008 Jun 21.

8.

The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C.

Basu NK, Kole L, Basu M, Chakraborty K, Mitra PS, Owens IS.

J Biol Chem. 2008 Aug 22;283(34):23048-61. doi: 10.1074/jbc.M800032200. Epub 2008 Jun 13.

9.

Targeted inhibition of glucuronidation markedly improves drug efficacy in mice - a model.

Basu NK, Kole L, Basu M, McDonagh AF, Owens IS.

Biochem Biophys Res Commun. 2007 Aug 17;360(1):7-13. Epub 2007 Jun 14.

10.

UDP-glucuronosyltransferases: gene structures of UGT1 and UGT2 families.

Owens IS, Basu NK, Banerjee R.

Methods Enzymol. 2005;400:1-22. Review.

PMID:
16399340
11.

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW.

Pharmacogenet Genomics. 2005 Oct;15(10):677-85. Review.

PMID:
16141793
12.

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity.

Basu NK, Kovarova M, Garza A, Kubota S, Saha T, Mitra PS, Banerjee R, Rivera J, Owens IS.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6285-90. Epub 2005 Apr 21.

13.

Human UDP-glucuronosyltransferases show atypical metabolism of mycophenolic acid and inhibition by curcumin.

Basu NK, Kole L, Kubota S, Owens IS.

Drug Metab Dispos. 2004 Jul;32(7):768-73.

PMID:
15205394
14.

Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.

Basu NK, Kubota S, Meselhy MR, Ciotti M, Chowdhury B, Hartori M, Owens IS.

J Biol Chem. 2004 Jul 2;279(27):28320-9. Epub 2004 Apr 26. Erratum in: J Biol Chem. 2004 Dec 24;279(52):54972.

15.

Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

Basu NK, Ciotti M, Hwang MS, Kole L, Mitra PS, Cho JW, Owens IS.

J Biol Chem. 2004 Jan 9;279(2):1429-41. Epub 2003 Oct 13.

16.

Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity.

Basu NK, Kole L, Owens IS.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):98-104.

PMID:
12646172
17.

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC.

Pharmacogenetics. 2001 Jun;11(4):357-68.

PMID:
11434514
18.

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T.

Hepatology. 2001 May;33(5):1232-8.

PMID:
11343253
19.

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.

Ciotti M, Lakshmi VM, Basu N, Davis BB, Owens IS, Zenser TV.

Carcinogenesis. 1999 Oct;20(10):1963-9.

PMID:
10506112
20.

Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus.

Ciotti M, Basu N, Brangi M, Owens IS.

Biochem Biophys Res Commun. 1999 Jun 24;260(1):199-202.

PMID:
10381366
21.
22.

UDPGT cDNA expression and UDPGT1 in human liver.

Sheen YY, Owens IS, Kim SS, Kim JE.

J Toxicol Sci. 1998 Jul;23 Suppl 2:136-9.

PMID:
9760450
23.
24.

Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease.

Ciotti M, Chen F, Rubaltelli FF, Owens IS.

Biochim Biophys Acta. 1998 Jul 1;1407(1):40-50.

25.

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications.

Ciotti M, Marrone A, Potter C, Owens IS.

Pharmacogenetics. 1997 Dec;7(6):485-95.

PMID:
9429234
26.

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW.

Pharmacogenetics. 1997 Aug;7(4):255-69. Review.

PMID:
9295054
27.

Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis.

Ciotti M, Obaray R, Martín MG, Owens IS.

Am J Med Genet. 1997 Jan 20;68(2):173-8.

PMID:
9028453
28.
30.

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1.

King CD, Green MD, Rios GR, Coffman BL, Owens IS, Bishop WP, Tephly TR.

Arch Biochem Biophys. 1996 Aug 1;332(1):92-100.

PMID:
8806713
31.

Lobular distribution of human liver phenol and bilirubin uridine 5'-diphosphate glucuronosyltransferase messenger RNAs.

Chen F, Zhou J, Ritter JK, Bondy CA, Owens IS.

Gastroenterology. 1996 Aug;111(2):472-80.

PMID:
8690214
32.
33.

Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation.

Owens IS, Ritter JK.

Prog Nucleic Acid Res Mol Biol. 1995;51:305-38. Review. No abstract available.

PMID:
7659777
34.

Human liver glucuronidation of benzidine.

Babu SR, Lakshmi VM, Owens IS, Zenser TV, Davis BB.

Carcinogenesis. 1994 Sep;15(9):2003-7.

PMID:
7923596
35.
36.
37.

Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.

Chen F, Ritter JK, Wang MG, McBride OW, Lubet RA, Owens IS.

Biochemistry. 1993 Oct 12;32(40):10648-57.

PMID:
8399210
41.

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS.

J Biol Chem. 1992 Feb 15;267(5):3257-61.

42.

Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae.

Ritter JK, Owens IS, Negishi M, Nagata K, Sheen YY, Gillette JR, Sasame HA.

Biochemistry. 1991 Dec 3;30(48):11430-7.

PMID:
1742282
43.

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

Ritter JK, Crawford JM, Owens IS.

J Biol Chem. 1991 Jan 15;266(2):1043-7.

44.

Gene expression, ontogeny and transplacental induction of hepatic UDP-glucuronosyl transferase activity in mice.

Chauhan DP, Miller MS, Owens IS, Anderson LM.

Dev Pharmacol Ther. 1991;16(3):139-49.

PMID:
1914788
46.
47.
49.

Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA.

Mackenzie PI, Gonzalez FJ, Owens IS.

J Biol Chem. 1984 Oct 10;259(19):12153-60.

50.

Cleavage of nascent UDP glucuronosyltransferase from rat liver by dog pancreatic microsomes.

Mackenzie PI, Owens IS.

Biochem Biophys Res Commun. 1984 Aug 16;122(3):1441-9.

PMID:
6433911

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