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Items: 1 to 50 of 187

1.

ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation.

Salmon M, Schaheen B, Spinosa M, Montgomery W, Pope NH, Davis JP, Johnston WF, Sharma AK, Owens GK, Merchant JL, Zehner ZE, Upchurch GR Jr, Ailawadi G.

Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):73-88. doi: 10.1161/ATVBAHA.118.311136.

PMID:
30580567
2.

Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds.

Newman AA, Baylis RA, Hess DL, Griffith SD, Shankman LS, Cherepanova OA, Owens GK.

JCI Insight. 2018 Aug 9;3(15). pii: 121017. doi: 10.1172/jci.insight.121017. [Epub ahead of print]

3.

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.

Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C, Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK.

Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038/s41591-018-0124-5. Epub 2018 Jul 23.

4.

Klf4 has an unexpected protective role in perivascular cells within the microvasculature.

Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H402-H414. doi: 10.1152/ajpheart.00084.2018. Epub 2018 Apr 6.

PMID:
29631369
5.

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.

Starke RM, Thompson JW, Ali MS, Pascale CL, Martinez Lege A, Ding D, Chalouhi N, Hasan DM, Jabbour P, Owens GK, Toborek M, Hare JM, Dumont AS.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):610-621. doi: 10.1161/ATVBAHA.117.310478. Epub 2018 Jan 18.

PMID:
29348119
6.

The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology.

Baylis RA, Gomez D, Mallat Z, Pasterkamp G, Owens GK.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):e174-e177. doi: 10.1161/ATVBAHA.117.310097. Epub 2017 Sep 28. No abstract available.

7.

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis.

Murgai M, Ju W, Eason M, Kline J, Beury DW, Kaczanowska S, Miettinen MM, Kruhlak M, Lei H, Shern JF, Cherepanova OA, Owens GK, Kaplan RN.

Nat Med. 2017 Oct;23(10):1176-1190. doi: 10.1038/nm.4400. Epub 2017 Sep 18.

8.

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. doi: 10.1152/ajpheart.00029.2017. Epub 2017 Mar 10.

9.

Shifting the Focus of Preclinical, Murine Atherosclerosis Studies From Prevention to Late-Stage Intervention.

Baylis RA, Gomez D, Owens GK.

Circ Res. 2017 Mar 3;120(5):775-777. doi: 10.1161/CIRCRESAHA.116.310101. No abstract available.

10.

"Attack of the Clones": Commonalities Between Cancer and Atherosclerosis.

DiRenzo D, Owens GK, Leeper NJ.

Circ Res. 2017 Feb 17;120(4):624-626. doi: 10.1161/CIRCRESAHA.116.310091. No abstract available.

11.

Reconciling Smooth Muscle Cell Oligoclonality and Proliferative Capacity in Experimental Atherosclerosis.

Gomez D, Owens GK.

Circ Res. 2016 Dec 9;119(12):1262-1264. No abstract available.

12.

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective.

Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Bekiranov S, Connelly JJ, Tomilin A, Owens GK.

Nat Med. 2016 Jun;22(6):657-65. doi: 10.1038/nm.4109. Epub 2016 May 16.

13.

Vascular Smooth Muscle Cells in Atherosclerosis.

Bennett MR, Sinha S, Owens GK.

Circ Res. 2016 Feb 19;118(4):692-702. doi: 10.1161/CIRCRESAHA.115.306361. Review.

14.

Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK.

Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217a. No abstract available.

15.

Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.

Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG.

Hypertension. 2016 Feb;67(2):461-8. doi: 10.1161/HYPERTENSIONAHA.115.06123. Epub 2015 Dec 22.

16.

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.

Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E.

EMBO Mol Med. 2016 Jan 1;8(1):6-24. doi: 10.15252/emmm.201505433.

17.

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory.

Gomez D, Swiatlowska P, Owens GK.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2508-16. doi: 10.1161/ATVBAHA.115.305044. Epub 2015 Oct 8. Review.

18.

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap.

Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T.

Genom Data. 2015 Sep 1;5:36-37.

19.

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.

Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T.

PLoS Genet. 2015 May 28;11(5):e1005155. doi: 10.1371/journal.pgen.1005155. eCollection 2015 May.

20.

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK.

Nat Med. 2015 Jun;21(6):628-37. doi: 10.1038/nm.3866. Epub 2015 May 18. Erratum in: Nat Med. 2016 Feb;22(2):217.

21.

Recent insights into the cellular biology of atherosclerosis.

Tabas I, García-Cardeña G, Owens GK.

J Cell Biol. 2015 Apr 13;209(1):13-22. doi: 10.1083/jcb.201412052. Review.

22.

Response to letter regarding article, "Inhibition of interleukin-1β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysm".

Johnston WF, Salmon M, Pope NH, Meher A, Su G, Stone ML, Lu G, Owens GK, Upchurch GR Jr, Ailawadi G.

Circulation. 2015 Apr 7;131(14):e400. doi: 10.1161/CIRCULATIONAHA.115.014726. No abstract available.

PMID:
25847985
23.

5-Lipoxygenase pathway in experimental abdominal aortic aneurysms.

Bhamidipati CM, Whatling CA, Mehta GS, Meher AK, Hajzus VA, Su G, Salmon M, Upchurch GR Jr, Owens GK, Ailawadi G.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2669-78. doi: 10.1161/ATVBAHA.114.304016. Epub 2014 Oct 16.

24.

Inhibition of interleukin-1β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms.

Johnston WF, Salmon M, Pope NH, Meher A, Su G, Stone ML, Lu G, Owens GK, Upchurch GR Jr, Ailawadi G.

Circulation. 2014 Sep 9;130(11 Suppl 1):S51-9. doi: 10.1161/CIRCULATIONAHA.113.006800.

25.

Critical role of TNF-α in cerebral aneurysm formation and progression to rupture.

Starke RM, Chalouhi N, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Wada K, Shimada K, Hasan DM, Greig NH, Owens GK, Dumont AS.

J Neuroinflammation. 2014 Apr 16;11:77. doi: 10.1186/1742-2094-11-77.

26.

Therapeutic implications of estrogen for cerebral vasospasm and delayed cerebral ischemia induced by aneurysmal subarachnoid hemorrhage.

Ding D, Starke RM, Dumont AS, Owens GK, Hasan DM, Chalouhi N, Medel R, Lin CL.

Biomed Res Int. 2014;2014:727428. doi: 10.1155/2014/727428. Epub 2014 Mar 2. Review.

27.

Vascular smooth muscle cells in cerebral aneurysm pathogenesis.

Starke RM, Chalouhi N, Ding D, Raper DM, Mckisic MS, Owens GK, Hasan DM, Medel R, Dumont AS.

Transl Stroke Res. 2014 Jun;5(3):338-46. doi: 10.1007/s12975-013-0290-1. Epub 2013 Oct 10. Review.

PMID:
24323713
28.

Tumor necrosis factor-α modulates cerebral aneurysm formation and rupture.

Starke RM, Raper DM, Ding D, Chalouhi N, Owens GK, Hasan DM, Medel R, Dumont AS.

Transl Stroke Res. 2014 Apr;5(2):269-77. doi: 10.1007/s12975-013-0287-9. Epub 2013 Sep 20. Review.

PMID:
24323710
29.

KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation.

Salmon M, Johnston WF, Woo A, Pope NH, Su G, Upchurch GR Jr, Owens GK, Ailawadi G.

Circulation. 2013 Sep 10;128(11 Suppl 1):S163-74. doi: 10.1161/CIRCULATIONAHA.112.000238.

30.

Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease.

Starke RM, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez F, Hasan DM, Rosenwasser RH, Owens GK, Koch WJ, Dumont AS.

PLoS One. 2013 Aug 14;8(8):e71954. doi: 10.1371/journal.pone.0071954. eCollection 2013.

31.

TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology.

Ali MS, Starke RM, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Owens GK, Koch WJ, Greig NH, Dumont AS.

J Cereb Blood Flow Metab. 2013 Oct;33(10):1564-73. doi: 10.1038/jcbfm.2013.109. Epub 2013 Jul 17.

32.

Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms.

Bhamidipati CM, Mehta GS, Moehle CW, Meher AK, Su G, Vigneshwar NG, Barbery C, Sharma AK, Kron IL, Laubach VE, Owens GK, Upchurch GR Jr, Ailawadi G.

FASEB J. 2013 Jun;27(6):2122-31. doi: 10.1096/fj.12-214197. Epub 2013 Feb 14.

33.

Detection of histone modifications at specific gene loci in single cells in histological sections.

Gomez D, Shankman LS, Nguyen AT, Owens GK.

Nat Methods. 2013 Feb;10(2):171-7. doi: 10.1038/nmeth.2332. Epub 2013 Jan 13.

34.

Genetic and pharmacologic disruption of interleukin-1β signaling inhibits experimental aortic aneurysm formation.

Johnston WF, Salmon M, Su G, Lu G, Stone ML, Zhao Y, Owens GK, Upchurch GR Jr, Ailawadi G.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):294-304. doi: 10.1161/ATVBAHA.112.300432. Epub 2013 Jan 3.

35.

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.

Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, Xu B, Cheng K, Quertermous M, Kundu S, Kortekaas KE, Berzin E, Downing KP, Dalman RL, Tsao PS, Schadt EE, Owens GK, Quertermous T.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):e1-e10. doi: 10.1161/ATVBAHA.112.300399. Epub 2012 Nov 15.

36.

Smooth muscle cell plasticity: fact or fiction?

Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK.

Circ Res. 2013 Jan 4;112(1):17-22. doi: 10.1161/CIRCRESAHA.112.281048. Epub 2012 Oct 23. No abstract available.

37.

Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo.

Salmon M, Gomez D, Greene E, Shankman L, Owens GK.

Circ Res. 2012 Aug 31;111(6):685-96. doi: 10.1161/CIRCRESAHA.112.269811. Epub 2012 Jul 18.

38.

Smooth muscle cell phenotypic switching in atherosclerosis.

Gomez D, Owens GK.

Cardiovasc Res. 2012 Jul 15;95(2):156-64. doi: 10.1093/cvr/cvs115. Epub 2012 Mar 8. Review.

39.

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms.

Alexander MR, Murgai M, Moehle CW, Owens GK.

Physiol Genomics. 2012 Apr 2;44(7):417-29. doi: 10.1152/physiolgenomics.00160.2011. Epub 2012 Feb 7.

40.

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice.

Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK.

J Clin Invest. 2012 Jan;122(1):70-9. doi: 10.1172/JCI43713. Epub 2011 Dec 27. Erratum in: J Clin Invest. 2012 Feb 1;122(2):783.

41.

Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.

Alexander MR, Owens GK.

Annu Rev Physiol. 2012;74:13-40. doi: 10.1146/annurev-physiol-012110-142315. Epub 2011 Oct 10. Review.

PMID:
22017177
42.

Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation.

Moehle CW, Bhamidipati CM, Alexander MR, Mehta GS, Irvine JN, Salmon M, Upchurch GR Jr, Kron IL, Owens GK, Ailawadi G.

J Thorac Cardiovasc Surg. 2011 Dec;142(6):1567-74. doi: 10.1016/j.jtcvs.2011.07.053. Epub 2011 Oct 11.

43.

WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2.

Gan Q, Thiébaud P, Thézé N, Jin L, Xu G, Grant P, Owens GK.

J Biol Chem. 2011 Jun 17;286(24):21853-64. doi: 10.1074/jbc.M111.233098. Epub 2011 Apr 28.

44.

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes.

Hoofnagle MH, Neppl RL, Berzin EL, Teg Pipes GC, Olson EN, Wamhoff BW, Somlyo AV, Owens GK.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1707-21. doi: 10.1152/ajpheart.01192.2010. Epub 2011 Feb 25.

45.

Acceleration of wound healing by growth hormone-releasing hormone and its agonists.

Dioufa N, Schally AV, Chatzistamou I, Moustou E, Block NL, Owens GK, Papavassiliou AG, Kiaris H.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18611-5. doi: 10.1073/pnas.1013942107. Epub 2010 Oct 11.

46.

The actin associated protein palladin is important for the early smooth muscle cell differentiation.

Jin L, Gan Q, Zieba BJ, Goicoechea SM, Owens GK, Otey CA, Somlyo AV.

PLoS One. 2010 Sep 22;5(9):e12823. doi: 10.1371/journal.pone.0012823.

47.

Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation.

Yoshida T, Gan Q, Franke AS, Ho R, Zhang J, Chen YE, Hayashi M, Majesky MW, Somlyo AV, Owens GK.

J Biol Chem. 2010 Jul 2;285(27):21175-84. doi: 10.1074/jbc.M110.112482. Epub 2010 May 3.

48.

Smooth muscle phenotypic modulation is an early event in aortic aneurysms.

Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL, Owens GK.

J Thorac Cardiovasc Surg. 2009 Dec;138(6):1392-9. doi: 10.1016/j.jtcvs.2009.07.075.

49.

Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling.

Nickerson MM, Song J, Meisner JK, Bajikar S, Burke CW, Shuptrine CW, Owens GK, Skalak TC, Price RJ.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1794-801. doi: 10.1161/ATVBAHA.109.194019. Epub 2009 Sep 4.

50.

Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program.

Salmon M, Owens GK, Zehner ZE.

Biochim Biophys Acta. 2009 Jul;1793(7):1144-55. doi: 10.1016/j.bbamcr.2009.01.019. Epub 2009 Feb 14.

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