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Items: 1 to 50 of 82

1.

Human antigen R as a therapeutic target in pathological cardiac hypertrophy.

Green LC, Anthony SR, Slone S, Lanzillotta L, Nieman ML, Wu X, Robbins N, Jones SM, Roy S, Owens AP 3rd, Aube J, Xu L, Lorenz JN, Blaxall BC, Rubinstein J, Benoit JB, Tranter M.

JCI Insight. 2019 Feb 21;4(4). pii: 121541. doi: 10.1172/jci.insight.121541. eCollection 2019 Feb 21.

2.

Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases.

Posma JJ, Grover SP, Hisada Y, Owens AP 3rd, Antoniak S, Spronk HM, Mackman N.

Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):13-24. doi: 10.1161/ATVBAHA.118.311655. Review.

PMID:
30580574
3.

Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth.

Sundermann AC, Saum K, Conrad KA, Russell HM, Edwards TL, Mani K, Björck M, Wanhainen A, Owens AP 3rd.

Blood Adv. 2018 Nov 27;2(22):3088-3096. doi: 10.1182/bloodadvances.2017013359.

4.

Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental?

Cameron SJ, Russell HM, Owens AP 3rd.

Blood. 2018 Dec 20;132(25):2619-2628. doi: 10.1182/blood-2017-08-743237. Epub 2018 Sep 18. Review.

PMID:
30228233
5.

Tefillin use induces remote ischemic preconditioning pathways in healthy men.

Owens AP 3rd, Robbins N, Saum K, Jones SM, Kirschner A, Woo JG, McCoy C, Slone S, Rothenberg ME, Urbina EM, Tranter M, Rubinstein J.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1748-H1758. doi: 10.1152/ajpheart.00347.2018. Epub 2018 Sep 14.

6.

Interoceptive inference: From computational neuroscience to clinic.

Owens AP, Allen M, Ondobaka S, Friston KJ.

Neurosci Biobehav Rev. 2018 Jul;90:174-183. doi: 10.1016/j.neubiorev.2018.04.017. Epub 2018 Apr 22. Review.

PMID:
29694845
7.

PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.

Jones SM, Mann A, Conrad K, Saum K, Hall DE, McKinney LM, Robbins N, Thompson J, Peairs AD, Camerer E, Rayner KJ, Tranter M, Mackman N, Owens AP 3rd.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1271-1282. doi: 10.1161/ATVBAHA.117.310082. Epub 2018 Mar 29.

8.

Emotional orienting during interoceptive threat in orthostatic intolerance: Dysautonomic contributions to psychological symptomatology in the postural tachycardia syndrome and vasovagal syncope.

Owens AP, Low DA, Critchley HD, Mathias CJ.

Auton Neurosci. 2018 Jul;212:42-47. doi: 10.1016/j.autneu.2018.01.004. Epub 2018 Jan 31.

PMID:
29519640
9.

Investigating the relationship between cardiac interoception and autonomic cardiac control using a predictive coding framework.

Owens AP, Friston KJ, Low DA, Mathias CJ, Critchley HD.

Auton Neurosci. 2018 Mar;210:65-71. doi: 10.1016/j.autneu.2018.01.001. Epub 2018 Jan 9.

PMID:
29331491
10.

Thrombin promotes diet-induced obesity through fibrin-driven inflammation.

Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ.

J Clin Invest. 2017 Aug 1;127(8):3152-3166. doi: 10.1172/JCI92744. Epub 2017 Jul 24.

11.

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association.

Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular Sciences.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e131-e157. doi: 10.1161/ATV.0000000000000062. Epub 2017 Jul 20. Review.

PMID:
28729366
12.

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association.

Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular Sciences.

Circ Res. 2017 Sep 1;121(6):e53-e79. doi: 10.1161/RES.0000000000000169. Epub 2017 Jul 20. Review.

PMID:
28729353
13.

The genesis and presentation of anxiety in disorders of autonomic overexcitation.

Owens AP, Low DA, Iodice V, Critchley HD, Mathias CJ.

Auton Neurosci. 2017 Mar;203:81-87. doi: 10.1016/j.autneu.2016.10.004. Epub 2016 Oct 19.

PMID:
27865628
14.

Orthostatic intolerance and autonomic dysfunction following bariatric surgery: A retrospective study and review of the literature.

Ponnusamy V, Owens AP, Purkayastha S, Iodice V, Mathias CJ.

Auton Neurosci. 2016 Jul;198:1-7. doi: 10.1016/j.autneu.2016.05.003. Epub 2016 May 31. Review.

PMID:
27292926
15.

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.

Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y.

Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25.

16.

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.

Boulaftali Y, Owens AP 3rd, Beale A, Piatt R, Casari C, Lee RH, Conley PB, Paul DS, Mackman N, Bergmeier W.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):792-9. doi: 10.1161/ATVBAHA.115.306347. Epub 2016 Mar 17.

17.

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury.

Rautou PE, Tatsumi K, Antoniak S, Owens AP 3rd, Sparkenbaugh E, Holle LA, Wolberg AS, Kopec AK, Pawlinski R, Luyendyk JP, Mackman N.

J Hepatol. 2016 Jan;64(1):53-9. doi: 10.1016/j.jhep.2015.08.017. Epub 2015 Aug 29.

18.

Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes.

Østerud B, Unruh D, Olsen JO, Kirchhofer D, Owens AP 3rd, Bogdanov VY.

J Thromb Haemost. 2015 Sep;13(9):1676-82. doi: 10.1111/jth.13041. Epub 2015 Jul 27.

19.

Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.

Owens AP 3rd, Edwards TL, Antoniak S, Geddings JE, Jahangir E, Wei WQ, Denny JC, Boulaftali Y, Bergmeier W, Daugherty A, Sampson UKA, Mackman N.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2032-2041. doi: 10.1161/ATVBAHA.115.305537. Epub 2015 Jul 2. Erratum in: Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):e18.

20.

Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder.

Owens AP, David AS, Low DA, Mathias CJ, Sierra-Siegert M.

Front Neurosci. 2015 Mar 26;9:89. doi: 10.3389/fnins.2015.00089. eCollection 2015.

21.

Neurovisceral phenotypes in the expression of psychiatric symptoms.

Eccles JA, Owens AP, Mathias CJ, Umeda S, Critchley HD.

Front Neurosci. 2015 Feb 10;9:4. doi: 10.3389/fnins.2015.00004. eCollection 2015. Review.

22.

The antithrombotic effects of statins.

Owens AP 3rd, Mackman N.

Annu Rev Med. 2014;65:433-45. doi: 10.1146/annurev-med-051812-145304. Review.

PMID:
24422578
23.

Hyperlipidemia, tissue factor, coagulation, and simvastatin.

Owens AP 3rd, Byrnes JR, Mackman N.

Trends Cardiovasc Med. 2014 Apr;24(3):95-8. doi: 10.1016/j.tcm.2013.07.003. Epub 2013 Sep 7. Review.

24.

Endothelial Shc regulates arteriogenesis through dual control of arterial specification and inflammation via the notch and nuclear factor-κ-light-chain-enhancer of activated B-cell pathways.

Sweet DT, Chen Z, Givens CS, Owens AP, Rojas M, Tzima E.

Circ Res. 2013 Jun 21;113(1):32-39. doi: 10.1161/CIRCRESAHA.113.301407. Epub 2013 May 9.

25.

PAR-1 contributes to the innate immune response during viral infection.

Antoniak S, Owens AP 3rd, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N.

J Clin Invest. 2013 Mar;123(3):1310-22. doi: 10.1172/JCI66125. Epub 2013 Feb 8.

26.

Platelet ITAM signaling is critical for vascular integrity in inflammation.

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware J, Kahn ML, Bergmeier W.

J Clin Invest. 2013 Feb;123(2):908-16. doi: 10.1172/JCI65154. Epub 2013 Jan 25.

27.

Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms.

Poduri A, Owens AP 3rd, Howatt DA, Moorleghen JJ, Balakrishnan A, Cassis LA, Daugherty A.

PLoS One. 2012;7(10):e48462. doi: 10.1371/journal.pone.0048462. Epub 2012 Oct 31.

28.

Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).

Martínez-Botella G, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar S, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA.

J Med Chem. 2012 Nov 26;55(22):10010-21. doi: 10.1021/jm3011806. Epub 2012 Oct 24.

PMID:
23043329
29.

Role of tissue factor in atherothrombosis.

Owens AP 3rd, Mackman N.

Curr Atheroscler Rep. 2012 Oct;14(5):394-401. doi: 10.1007/s11883-012-0269-5. Review.

30.

Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque.

Owens AP 3rd, Mackman N.

Thromb Res. 2012 May;129 Suppl 2:S30-3. doi: 10.1016/j.thromres.2012.02.026. Epub 2012 Mar 22. Review.

31.

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.

Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N.

J Clin Invest. 2012 Feb;122(2):558-68. doi: 10.1172/JCI58969. Epub 2012 Jan 3.

32.

Postural tachycardia syndrome--current experience and concepts.

Mathias CJ, Low DA, Iodice V, Owens AP, Kirbis M, Grahame R.

Nat Rev Neurol. 2011 Dec 6;8(1):22-34. doi: 10.1038/nrneurol.2011.187. Review.

PMID:
22143364
33.

2011 Nobel Prize in Physiology or Medicine: Toll-like receptors, dendritic cells, and their roles in atherosclerosis.

Tedgui A, Owens AP 3rd, Mackman N.

Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2767-8. doi: 10.1161/ATVBAHA.111.240432. No abstract available.

PMID:
22096091
34.

Comment on "tissue factor-dependent chemokine production aggravates experimental colitis".

Gambone JE, Owens AP 3rd, Mackman N.

Mol Med. 2011;17(11-12):1131; author reply 1132. doi: 10.2119/molmed.2011.00303. Epub 2011 Oct 18. No abstract available.

35.

MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4.

Owens AP 3rd, Rateri DL, Howatt DA, Moore KJ, Tobias PS, Curtiss LK, Lu H, Cassis LA, Daugherty A.

Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2813-9. doi: 10.1161/ATVBAHA.111.238642. Epub 2011 Sep 29.

36.

MP's and VTE's: Fact or fiction.

Owens AP 3rd, Mackman N.

Thromb Res. 2011 Dec;128(6):505-6. doi: 10.1016/j.thromres.2011.09.001. Epub 2011 Sep 25. No abstract available.

PMID:
21945232
37.

Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.

Kassel KM, Owens AP 3rd, Rockwell CE, Sullivan BP, Wang R, Tawfik O, Li G, Guo GL, Mackman N, Luyendyk JP.

Am J Pathol. 2011 Nov;179(5):2278-89. doi: 10.1016/j.ajpath.2011.07.015. Epub 2011 Sep 9.

38.

Towards a standardization of the murine ferric chloride-induced carotid arterial thrombosis model.

Owens AP 3rd, Lu Y, Whinna HC, Gachet C, Fay WP, Mackman N.

J Thromb Haemost. 2011 Sep;9(9):1862-3. doi: 10.1111/j.1538-7836.2011.04287.x. No abstract available.

39.

Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity.

Boles JC, Williams JC, Hollingsworth RM, Wang JG, Glover SL, Owens AP 3rd, Barcel DA, Kasthuri RS, Key NS, Mackman N.

Thromb Res. 2012 Feb;129(2):197-203. doi: 10.1016/j.thromres.2011.06.022. Epub 2011 Jul 16.

PMID:
21762960
40.

Microparticles in hemostasis and thrombosis.

Owens AP 3rd, Mackman N.

Circ Res. 2011 May 13;108(10):1284-97. doi: 10.1161/CIRCRESAHA.110.233056. Review.

41.

Clarity and strength of implications for practice in medical journal articles: an exploratory analysis.

Lynn J, Owens AP, Bartunek JM.

BMJ Qual Saf. 2011 Apr;20 Suppl 1:i52-7. doi: 10.1136/bmjqs.2010.046532.

42.

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice.

Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP 3rd, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A.

Circ Res. 2011 Mar 4;108(5):574-81. doi: 10.1161/CIRCRESAHA.110.222844. Epub 2011 Jan 20.

43.

Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice.

Cardenas JC, Owens AP 3rd, Krishnamurthy J, Sharpless NE, Whinna HC, Church FC.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):827-33. doi: 10.1161/ATVBAHA.110.221721. Epub 2011 Jan 13.

44.

Tissue factor and thrombosis: The clot starts here.

Owens AP 3rd, Mackman N.

Thromb Haemost. 2010 Sep;104(3):432-9. doi: 10.1160/TH09-11-0771. Epub 2010 Jun 10. Review.

45.

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice.

Pawlinski R, Wang JG, Owens AP 3rd, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman N.

Blood. 2010 Aug 5;116(5):806-14. doi: 10.1182/blood-2009-12-259267. Epub 2010 Apr 21.

46.

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.

Daugherty A, Rateri DL, Charo IF, Owens AP, Howatt DA, Cassis LA.

Clin Sci (Lond). 2010 Mar 9;118(11):681-9. doi: 10.1042/CS20090372.

47.

Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.

Owens AP 3rd, Subramanian V, Moorleghen JJ, Guo Z, McNamara CA, Cassis LA, Daugherty A.

Circ Res. 2010 Feb 19;106(3):611-9. doi: 10.1161/CIRCRESAHA.109.212837. Epub 2009 Dec 17.

48.

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.

King VL, Lin AY, Kristo F, Anderson TJ, Ahluwalia N, Hardy GJ, Owens AP 3rd, Howatt DA, Shen D, Tager AM, Luster AD, Daugherty A, Gerszten RE.

Circulation. 2009 Jan 27;119(3):426-35. doi: 10.1161/CIRCULATIONAHA.108.785949. Epub 2009 Jan 12.

49.

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.

Goodacre SC, Street LJ, Hallett DJ, Crawforth JM, Kelly S, Owens AP, Blackaby WP, Lewis RT, Stanley J, Smith AJ, Ferris P, Sohal B, Cook SM, Pike A, Brown N, Wafford KA, Marshall G, Castro JL, Atack JR.

J Med Chem. 2006 Jan 12;49(1):35-8.

PMID:
16392789
50.

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.

Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, Bromidge F, Owens AP, Huscroft I, Myers J, Rupniak NM, Patel S, Whiting PJ, Hutson PH, Fone KC, Biello SM, Kulagowski JJ, McAllister G.

Neuropharmacology. 2005 Mar;48(4):492-502.

PMID:
15755477

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