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Items: 1 to 50 of 99

1.

The Face of Chromatin Variants.

Flaus A, Owen-Hughes T.

Cell. 2019 Sep 5;178(6):1284-1286. doi: 10.1016/j.cell.2019.08.024.

PMID:
31491382
2.

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhöfer-Wölfer K, Wöhrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB, Ciulli A.

Nat Chem Biol. 2019 Aug;15(8):846. doi: 10.1038/s41589-019-0329-z.

PMID:
31267096
3.

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhöfer-Wölfer K, Wöhrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB, Ciulli A.

Nat Chem Biol. 2019 Jul;15(7):672-680. doi: 10.1038/s41589-019-0294-6. Epub 2019 Jun 10. Erratum in: Nat Chem Biol. 2019 Jul 2;:.

4.

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation.

Gali VK, Dickerson D, Katou Y, Fujiki K, Shirahige K, Owen-Hughes T, Kubota T, Donaldson AD.

PLoS Genet. 2018 Nov 12;14(11):e1007783. doi: 10.1371/journal.pgen.1007783. eCollection 2018 Nov.

5.

Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC.

Yoshikawa H, Larance M, Harney DJ, Sundaramoorthy R, Ly T, Owen-Hughes T, Lamond AI.

Elife. 2018 Aug 10;7. pii: e36530. doi: 10.7554/eLife.36530.

6.

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome.

Sundaramoorthy R, Hughes AL, El-Mkami H, Norman DG, Ferreira H, Owen-Hughes T.

Elife. 2018 Aug 6;7. pii: e35720. doi: 10.7554/eLife.35720.

7.

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.

Sundaramoorthy R, Hughes AL, Singh V, Wiechens N, Ryan DP, El-Mkami H, Petoukhov M, Svergun DI, Treutlein B, Quack S, Fischer M, Michaelis J, Böttcher B, Norman DG, Owen-Hughes T.

Elife. 2017 Mar 23;6. pii: e22510. doi: 10.7554/eLife.22510.

8.

Deciphering Subunit-Specific Functions within SWI/SNF Complexes.

Hughes AL, Owen-Hughes T.

Cell Rep. 2017 Feb 28;18(9):2075-2076. doi: 10.1016/j.celrep.2017.02.045. Review.

9.

Unlocking the nucleosome.

Flaus A, Owen-Hughes T.

Science. 2017 Jan 20;355(6322):245-246. doi: 10.1126/science.aam5403. No abstract available.

PMID:
28104852
10.

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates.

Hauer MH, Seeber A, Singh V, Thierry R, Sack R, Amitai A, Kryzhanovska M, Eglinger J, Holcman D, Owen-Hughes T, Gasser SM.

Nat Struct Mol Biol. 2017 Feb;24(2):99-107. doi: 10.1038/nsmb.3347. Epub 2017 Jan 9.

PMID:
28067915
11.

Erratum: How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Schurch NJ, Schofield P, Gierliński M, Cole C, Sherstnev A, Singh V, Wrobel N, Gharbi K, Simpson GG, Owen-Hughes T, Blaxter M, Barton GJ.

RNA. 2016 Oct;22(10):1641. doi: 10.1261/rna.058339.116. No abstract available.

12.

High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.

Dickerson D, Gierliński M, Singh V, Kitamura E, Ball G, Tanaka TU, Owen-Hughes T.

BMC Cell Biol. 2016 Sep 8;17(1):33. doi: 10.1186/s12860-016-0111-y.

13.

Establishment of a promoter-based chromatin architecture on recently replicated DNA can accommodate variable inter-nucleosome spacing.

Fennessy RT, Owen-Hughes T.

Nucleic Acids Res. 2016 Sep 6;44(15):7189-203. doi: 10.1093/nar/gkw331. Epub 2016 Apr 22.

14.

The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3-H4 tetramers and Asf1-H3-H4 complexes.

Hammond CM, Sundaramoorthy R, Larance M, Lamond A, Stevens MA, El-Mkami H, Norman DG, Owen-Hughes T.

Nucleic Acids Res. 2016 Jul 27;44(13):6157-72. doi: 10.1093/nar/gkw209. Epub 2016 Apr 1.

15.

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Schurch NJ, Schofield P, Gierliński M, Cole C, Sherstnev A, Singh V, Wrobel N, Gharbi K, Simpson GG, Owen-Hughes T, Blaxter M, Barton GJ.

RNA. 2016 Jun;22(6):839-51. doi: 10.1261/rna.053959.115. Epub 2016 Mar 28. Erratum in: RNA. 2016 Oct;22(10 ):1641.

16.

The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors.

Wiechens N, Singh V, Gkikopoulos T, Schofield P, Rocha S, Owen-Hughes T.

PLoS Genet. 2016 Mar 28;12(3):e1005940. doi: 10.1371/journal.pgen.1005940. eCollection 2016 Mar. Erratum in: PLoS Genet. 2016 May;12(5):e1006086.

17.

Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment.

Gierliński M, Cole C, Schofield P, Schurch NJ, Sherstnev A, Singh V, Wrobel N, Gharbi K, Simpson G, Owen-Hughes T, Blaxter M, Barton GJ.

Bioinformatics. 2015 Nov 15;31(22):3625-30. doi: 10.1093/bioinformatics/btv425. Epub 2015 Jul 23.

18.

Modelling multi-protein complexes using PELDOR distance measurements for rigid body minimisation experiments using XPLOR-NIH.

Hammond CM, Owen-Hughes T, Norman DG.

Methods. 2014 Dec;70(2-3):139-53. doi: 10.1016/j.ymeth.2014.10.028. Epub 2014 Nov 18.

19.

The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement.

El Mkami H, Ward R, Bowman A, Owen-Hughes T, Norman DG.

J Magn Reson. 2014 Nov;248:36-41. doi: 10.1016/j.jmr.2014.09.010. Epub 2014 Sep 28.

20.

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.

Bowman A, Hammond CM, Stirling A, Ward R, Shang W, El-Mkami H, Robinson DA, Svergun DI, Norman DG, Owen-Hughes T.

Nucleic Acids Res. 2014 May;42(9):6038-51. doi: 10.1093/nar/gku232. Epub 2014 Mar 31.

21.

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.

Di Cerbo V, Mohn F, Ryan DP, Montellier E, Kacem S, Tropberger P, Kallis E, Holzner M, Hoerner L, Feldmann A, Richter FM, Bannister AJ, Mittler G, Michaelis J, Khochbin S, Feil R, Schuebeler D, Owen-Hughes T, Daujat S, Schneider R.

Elife. 2014 Mar 25;3:e01632. doi: 10.7554/eLife.01632.

22.

PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

Biebricher A, Hirano S, Enzlin JH, Wiechens N, Streicher WW, Huttner D, Wang LH, Nigg EA, Owen-Hughes T, Liu Y, Peterman E, Wuite GJL, Hickson ID.

Mol Cell. 2013 Sep 12;51(5):691-701. doi: 10.1016/j.molcel.2013.07.016. Epub 2013 Aug 22.

23.

Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes.

Narlikar GJ, Sundaramoorthy R, Owen-Hughes T.

Cell. 2013 Aug 1;154(3):490-503. doi: 10.1016/j.cell.2013.07.011. Review.

24.

A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones.

Allan J, Fraser RM, Owen-Hughes T, Docherty K, Singh V.

J Mol Biol. 2013 Nov 15;425(22):4206-22. doi: 10.1016/j.jmb.2013.07.019. Epub 2013 Jul 18.

25.

CENP-A confers a reduction in height on octameric nucleosomes.

Miell MD, Fuller CJ, Guse A, Barysz HM, Downes A, Owen-Hughes T, Rappsilber J, Straight AF, Allshire RC.

Nat Struct Mol Biol. 2013 Jun;20(6):763-5. doi: 10.1038/nsmb.2574. Epub 2013 May 5.

26.

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.

Zhang W, Tyl M, Ward R, Sobott F, Maman J, Murthy AS, Watson AA, Fedorov O, Bowman A, Owen-Hughes T, El Mkami H, Murzina NV, Norman DG, Laue ED.

Nat Struct Mol Biol. 2013 Jan;20(1):29-35. doi: 10.1038/nsmb.2446. Epub 2012 Nov 25.

27.

Evolutionary insights into genome-wide nucleosome positioning.

Singh V, Owen-Hughes T.

Genome Biol. 2012;13(9):170.

28.

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED.

J Mol Biol. 2012 Sep 7;422(1):3-17. doi: 10.1016/j.jmb.2012.04.031. Epub 2012 May 7.

29.

Making sense of transcribing chromatin.

Owen-Hughes T, Gkikopoulos T.

Curr Opin Cell Biol. 2012 Jun;24(3):296-304. doi: 10.1016/j.ceb.2012.02.003. Epub 2012 Mar 10. Review.

30.

Micrococcal nuclease does not substantially bias nucleosome mapping.

Allan J, Fraser RM, Owen-Hughes T, Keszenman-Pereyra D.

J Mol Biol. 2012 Mar 30;417(3):152-64. doi: 10.1016/j.jmb.2012.01.043. Epub 2012 Jan 30.

31.

Sulfyhydryl-reactive site-directed cross-linking as a method for probing the tetrameric structure of histones H3 and H4.

Bowman A, Owen-Hughes T.

Methods Mol Biol. 2012;833:373-87. doi: 10.1007/978-1-61779-477-3_22.

PMID:
22183605
32.

A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization.

Gkikopoulos T, Schofield P, Singh V, Pinskaya M, Mellor J, Smolle M, Workman JL, Barton GJ, Owen-Hughes T.

Science. 2011 Sep 23;333(6050):1758-60. doi: 10.1126/science.1206097.

33.

Snf2-family proteins: chromatin remodellers for any occasion.

Ryan DP, Owen-Hughes T.

Curr Opin Chem Biol. 2011 Oct;15(5):649-56. doi: 10.1016/j.cbpa.2011.07.022. Epub 2011 Aug 20. Review.

34.

Mechanisms for ATP-dependent chromatin remodelling: the means to the end.

Flaus A, Owen-Hughes T.

FEBS J. 2011 Oct;278(19):3579-95. doi: 10.1111/j.1742-4658.2011.08281.x. Epub 2011 Sep 8. Review.

35.

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains.

Ryan DP, Sundaramoorthy R, Martin D, Singh V, Owen-Hughes T.

EMBO J. 2011 May 27;30(13):2596-609. doi: 10.1038/emboj.2011.166.

36.

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.

Gkikopoulos T, Singh V, Tsui K, Awad S, Renshaw MJ, Scholfield P, Barton GJ, Nislow C, Tanaka TU, Owen-Hughes T.

EMBO J. 2011 May 18;30(10):1919-27. doi: 10.1038/emboj.2011.112. Epub 2011 Apr 19.

37.

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation.

Bowman A, Ward R, Wiechens N, Singh V, El-Mkami H, Norman DG, Owen-Hughes T.

Mol Cell. 2011 Feb 18;41(4):398-408. doi: 10.1016/j.molcel.2011.01.025.

38.

DNA repair factor APLF is a histone chaperone.

Mehrotra PV, Ahel D, Ryan DP, Weston R, Wiechens N, Kraehenbuehl R, Owen-Hughes T, Ahel I.

Mol Cell. 2011 Jan 7;41(1):46-55. doi: 10.1016/j.molcel.2010.12.008.

39.

ATRX: Put me on repeat.

Whitehouse I, Owen-Hughes T.

Cell. 2010 Oct 29;143(3):335-6. doi: 10.1016/j.cell.2010.10.021.

40.

EPR distance measurements in deuterated proteins.

Ward R, Bowman A, Sozudogru E, El-Mkami H, Owen-Hughes T, Norman DG.

J Magn Reson. 2010 Nov;207(1):164-7. doi: 10.1016/j.jmr.2010.08.002. Epub 2010 Aug 11.

41.

The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme.

Awad S, Ryan D, Prochasson P, Owen-Hughes T, Hassan AH.

J Biol Chem. 2010 Mar 26;285(13):9477-84. doi: 10.1074/jbc.M109.082149. Epub 2010 Jan 14.

42.

Probing the (H3-H4)2 histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling.

Bowman A, Ward R, El-Mkami H, Owen-Hughes T, Norman DG.

Nucleic Acids Res. 2010 Jan;38(2):695-707. doi: 10.1093/nar/gkp1003. Epub 2009 Nov 13.

43.

A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.

Neumann H, Hancock SM, Buning R, Routh A, Chapman L, Somers J, Owen-Hughes T, van Noort J, Rhodes D, Chin JW.

Mol Cell. 2009 Oct 9;36(1):153-63. doi: 10.1016/j.molcel.2009.07.027.

44.

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ.

Science. 2009 Sep 4;325(5945):1240-3. doi: 10.1126/science.1177321. Epub 2009 Aug 6.

45.

SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter.

Gkikopoulos T, Havas KM, Dewar H, Owen-Hughes T.

Mol Cell Biol. 2009 Aug;29(15):4057-66. doi: 10.1128/MCB.00400-09. Epub 2009 May 26.

46.

Phosphorylation of histone H3 Thr-45 is linked to apoptosis.

Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I, Kouzarides T.

J Biol Chem. 2009 Jun 12;284(24):16575-83. doi: 10.1074/jbc.M109.005421. Epub 2009 Apr 10.

47.

ATP-dependent looping of DNA by ISWI.

Lia G, Indrieri M, Owen-Hughes T, Finzi L, Podesta A, Milani P, Dunlap D.

J Biophotonics. 2008 Sep;1(4):280-6. doi: 10.1002/jbio.200810027.

48.

Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions.

Somers J, Owen-Hughes T.

Nucleic Acids Res. 2009 May;37(8):2504-13. doi: 10.1093/nar/gkp114. Epub 2009 Mar 5.

49.

FACT facilitates chromatin transcription by RNA polymerases I and III.

Birch JL, Tan BC, Panov KI, Panova TB, Andersen JS, Owen-Hughes TA, Russell J, Lee SC, Zomerdijk JC.

EMBO J. 2009 Apr 8;28(7):854-65. doi: 10.1038/emboj.2009.33. Epub 2009 Feb 12.

50.

Nucleosomes can invade DNA territories occupied by their neighbors.

Engeholm M, de Jager M, Flaus A, Brenk R, van Noort J, Owen-Hughes T.

Nat Struct Mol Biol. 2009 Feb;16(2):151-8. doi: 10.1038/nsmb.1551. Epub 2009 Feb 1.

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