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Thermal constraints on in vivo optogenetic manipulations.

Owen SF, Liu MH, Kreitzer AC.

Nat Neurosci. 2019 Jun 17. doi: 10.1038/s41593-019-0422-3. [Epub ahead of print]


Pharmacology beyond the patient - The environmental risks of human drugs.

Gunnarsson L, Snape JR, Verbruggen B, Owen SF, Kristiansson E, Margiotta-Casaluci L, Österlund T, Hutchinson K, Leverett D, Marks B, Tyler CR.

Environ Int. 2019 Aug;129:320-332. doi: 10.1016/j.envint.2019.04.075. Epub 2019 May 28.


The Use of Molecular Descriptors To Model Pharmaceutical Uptake by a Fish Primary Gill Cell Culture Epithelium.

Chang ED, Hogstrand C, Miller TH, Owen SF, Bury NR.

Environ Sci Technol. 2019 Feb 5;53(3):1576-1584. doi: 10.1021/acs.est.8b04394. Epub 2019 Jan 15.


Environmental risk assessment of metformin and its transformation product guanylurea: II. Occurrence in surface waters of Europe and the United States and derivation of predicted no-effect concentrations.

Caldwell DJ, D'Aco V, Davidson T, Kappler K, Murray-Smith RJ, Owen SF, Robinson PF, Simon-Hettich B, Straub JO, Tell J.

Chemosphere. 2019 Feb;216:855-865. doi: 10.1016/j.chemosphere.2018.10.038. Epub 2018 Oct 15.


Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, Moger J, Randall AD, Tyler CR.

Sci Rep. 2018 Oct 23;8(1):15903. doi: 10.1038/s41598-018-32731-5.


An open-source control system for in vivo fluorescence measurements from deep-brain structures.

Owen SF, Kreitzer AC.

J Neurosci Methods. 2019 Jan 1;311:170-177. doi: 10.1016/j.jneumeth.2018.10.022. Epub 2018 Oct 17.


Machine Learning for Environmental Toxicology: A Call for Integration and Innovation.

Miller TH, Gallidabino MD, MacRae JI, Hogstrand C, Bury NR, Barron LP, Snape JR, Owen SF.

Environ Sci Technol. 2018 Nov 20;52(22):12953-12955. doi: 10.1021/acs.est.8b05382. Epub 2018 Oct 19. No abstract available.


Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model.

Langan LM, Owen SF, Trznadel M, Dodd NJF, Jackson SK, Purcell WM, Jha AN.

Front Pharmacol. 2018 Aug 22;9:947. doi: 10.3389/fphar.2018.00947. eCollection 2018.


Prediction of bioconcentration factors in fish and invertebrates using machine learning.

Miller TH, Gallidabino MD, MacRae JI, Owen SF, Bury NR, Barron LP.

Sci Total Environ. 2019 Jan 15;648:80-89. doi: 10.1016/j.scitotenv.2018.08.122. Epub 2018 Aug 10.


A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice.

Sun F, Zeng J, Jing M, Zhou J, Feng J, Owen SF, Luo Y, Li F, Wang H, Yamaguchi T, Yong Z, Gao Y, Peng W, Wang L, Zhang S, Du J, Lin D, Xu M, Kreitzer AC, Cui G, Li Y.

Cell. 2018 Jul 12;174(2):481-496.e19. doi: 10.1016/j.cell.2018.06.042.


A review of the pharmaceutical exposome in aquatic fauna.

Miller TH, Bury NR, Owen SF, MacRae JI, Barron LP.

Environ Pollut. 2018 Aug;239:129-146. doi: 10.1016/j.envpol.2018.04.012. Epub 2018 Apr 10. Review.


Establishment and long-term maintenance of primary intestinal epithelial cells cultured from the rainbow trout, Oncorhynchus mykiss.

Langan LM, Owen SF, Jha AN.

Biol Open. 2018 Mar 7;7(3). pii: bio032870. doi: 10.1242/bio.032870.


Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish.

Green JM, Lange A, Scott A, Trznadel M, Wai HA, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR.

Sci Rep. 2018 Feb 9;8(1):2699. doi: 10.1038/s41598-018-20922-z.


Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning.

Owen SF, Berke JD, Kreitzer AC.

Cell. 2018 Feb 8;172(4):683-695.e15. doi: 10.1016/j.cell.2018.01.005.


Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies.

Langan LM, Arossa S, Owen SF, Jha AN.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Feb;826:53-64. doi: 10.1016/j.mrgentox.2017.12.009. Epub 2017 Dec 24.


ECOdrug: a database connecting drugs and conservation of their targets across species.

Verbruggen B, Gunnarsson L, Kristiansson E, Österlund T, Owen SF, Snape JR, Tyler CR.

Nucleic Acids Res. 2018 Jan 4;46(D1):D930-D936. doi: 10.1093/nar/gkx1024.


Investigations to extend viability of a rainbow trout primary gill cell culture.

Maunder RJ, Baron MG, Owen SF, Jha AN.

Ecotoxicology. 2017 Dec;26(10):1314-1326. doi: 10.1007/s10646-017-1856-6. Epub 2017 Nov 11.


Panmixia and Limited Interspecific Introgression in Coyotes (Canis latrans) from West Virginia and Virginia, USA.

Bohling JH, Mastro LL, Adams JR, Gese EM, Owen SF, Waits LP.

J Hered. 2017 Sep 1;108(6):608-617. doi: 10.1093/jhered/esx068.


Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper.

Langan LM, Harper GM, Owen SF, Purcell WM, Jackson SK, Jha AN.

Ecotoxicology. 2017 Oct;26(8):1117-1133. doi: 10.1007/s10646-017-1838-8. Epub 2017 Aug 7.


Species specific anaesthetics for fish anaesthesia and euthanasia.

Readman GD, Owen SF, Knowles TG, Murrell JC.

Sci Rep. 2017 Aug 2;7(1):7102. doi: 10.1038/s41598-017-06917-2.


4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, Moger J, Randall AD, Tyler CR.

Sci Rep. 2017 Jul 26;7(1):6581. doi: 10.1038/s41598-017-06646-6. Erratum in: Sci Rep. 2018 Oct 23;8(1):15903.


Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry.

Miller TH, Bury NR, Owen SF, Barron LP.

Chemosphere. 2017 Sep;183:389-400. doi: 10.1016/j.chemosphere.2017.05.083. Epub 2017 May 13.


The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.

Brockmeier EK, Hodges G, Hutchinson TH, Butler E, Hecker M, Tollefsen KE, Garcia-Reyero N, Kille P, Becker D, Chipman K, Colbourne J, Collette TW, Cossins A, Cronin M, Graystock P, Gutsell S, Knapen D, Katsiadaki I, Lange A, Marshall S, Owen SF, Perkins EJ, Plaistow S, Schroeder A, Taylor D, Viant M, Ankley G, Falciani F.

Toxicol Sci. 2017 Aug 1;158(2):252-262. doi: 10.1093/toxsci/kfx097. Review.


International survey on the use and welfare of zebrafish Danio rerio in research.

Lidster K, Readman GD, Prescott MJ, Owen SF.

J Fish Biol. 2017 May;90(5):1891-1905. doi: 10.1111/jfb.13278. Epub 2017 Feb 20.


Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.

Baron MG, Mintram KS, Owen SF, Hetheridge MJ, Moody AJ, Purcell WM, Jackson SK, Jha AN.

PLoS One. 2017 Jan 3;12(1):e0168837. doi: 10.1371/journal.pone.0168837. eCollection 2017.


Testing the "read-across hypothesis" by investigating the effects of ibuprofen on fish.

Patel A, Panter GH, Trollope HT, Glennon YC, Owen SF, Sumpter JP, Rand-Weaver M.

Chemosphere. 2016 Nov;163:592-600. doi: 10.1016/j.chemosphere.2016.08.041. Epub 2016 Aug 28.


Correction: Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry.

Langan LM, Dodd NJ, Owen SF, Purcell WM, Jackson SK, Jha AN.

PLoS One. 2016 Aug 2;11(8):e0160795. doi: 10.1371/journal.pone.0160795. eCollection 2016.


The First Attempt at Non-Linear in Silico Prediction of Sampling Rates for Polar Organic Chemical Integrative Samplers (POCIS).

Miller TH, Baz-Lomba JA, Harman C, Reid MJ, Owen SF, Bury NR, Thomas KV, Barron LP.

Environ Sci Technol. 2016 Aug 2;50(15):7973-81. doi: 10.1021/acs.est.6b01407. Epub 2016 Jul 18.


Corrigendum: Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.

Margiotta-Casaluci L, Owen SF, Huerta B, Rodríguez-Mozaz S, Kugathas S, Barceló D, Rand-Weaver M, Sumpter JP.

Sci Rep. 2016 Jun 20;6:28122. doi: 10.1038/srep28122. No abstract available.


High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish.

Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR.

Environ Sci Technol. 2016 Jun 21;50(12):6536-45. doi: 10.1021/acs.est.6b01243. Epub 2016 Jun 7.


Individuals Maintain Similar Rates of Protein Synthesis over Time on the Same Plane of Nutrition under Controlled Environmental Conditions.

McCarthy ID, Owen SF, Watt PW, Houlihan DF.

PLoS One. 2016 Mar 28;11(3):e0152239. doi: 10.1371/journal.pone.0152239. eCollection 2016.


Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.

Margiotta-Casaluci L, Owen SF, Huerta B, Rodríguez-Mozaz S, Kugathas S, Barceló D, Rand-Weaver M, Sumpter JP.

Sci Rep. 2016 Feb 26;6:21978. doi: 10.1038/srep21978. Erratum in: Sci Rep. 2016 Jun 20;6:28122.


Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry.

Langan LM, Dodd NJ, Owen SF, Purcell WM, Jackson SK, Jha AN.

PLoS One. 2016 Feb 22;11(2):e0149492. doi: 10.1371/journal.pone.0149492. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0160795.


Procedures for the reconstruction, primary culture and experimental use of rainbow trout gill epithelia.

Schnell S, Stott LC, Hogstrand C, Wood CM, Kelly SP, Pärt P, Owen SF, Bury NR.

Nat Protoc. 2016 Mar;11(3):490-8. doi: 10.1038/nprot.2016.029. Epub 2016 Feb 11.


Assessing the reliability of uptake and elimination kinetics modelling approaches for estimating bioconcentration factors in the freshwater invertebrate, Gammarus pulex.

Miller TH, McEneff GL, Stott LC, Owen SF, Bury NR, Barron LP.

Sci Total Environ. 2016 Mar 15;547:396-404. doi: 10.1016/j.scitotenv.2015.12.145. Epub 2016 Jan 12.


Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.

Uchea C, Owen SF, Chipman JK.

Toxicol Res (Camb). 2015 Mar 23;4(2):494-507. Epub 2015 Feb 9.


Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels.

Corcoran J, Winter MJ, Lange A, Cumming R, Owen SF, Tyler CR.

Aquat Toxicol. 2015 Apr;161:127-37. doi: 10.1016/j.aquatox.2015.01.033. Epub 2015 Feb 9.


Climate change and pollution speed declines in zebrafish populations.

Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1237-46. doi: 10.1073/pnas.1416269112. Epub 2015 Mar 2.


Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.

Miller TH, McEneff GL, Brown RJ, Owen SF, Bury NR, Barron LP.

Sci Total Environ. 2015 Apr 1;511:153-60. doi: 10.1016/j.scitotenv.2014.12.034. Epub 2014 Dec 23.


A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.

Stott LC, Schnell S, Hogstrand C, Owen SF, Bury NR.

Aquat Toxicol. 2015 Feb;159:127-37. doi: 10.1016/j.aquatox.2014.12.007. Epub 2014 Dec 16.


Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine.

Margiotta-Casaluci L, Owen SF, Cumming RI, de Polo A, Winter MJ, Panter GH, Rand-Weaver M, Sumpter JP.

PLoS One. 2014 Oct 22;9(10):e110467. doi: 10.1371/journal.pone.0110467. eCollection 2014.


Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio).

Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ.

Aquat Toxicol. 2014 Jul;152:57-65. doi: 10.1016/j.aquatox.2014.03.016. Epub 2014 Mar 29.


A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function.

Parker T, Libourel PA, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ.

J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):30-8. doi: 10.1016/j.vascn.2013.10.002. Epub 2013 Oct 16.


Do fish perceive anaesthetics as aversive?

Readman GD, Owen SF, Murrell JC, Knowles TG.

PLoS One. 2013 Sep 23;8(9):e73773. doi: 10.1371/journal.pone.0073773. eCollection 2013.


The read-across hypothesis and environmental risk assessment of pharmaceuticals.

Rand-Weaver M, Margiotta-Casaluci L, Patel A, Panter GH, Owen SF, Sumpter JP.

Environ Sci Technol. 2013 Oct 15;47(20):11384-95. doi: 10.1021/es402065a. Epub 2013 Sep 30.


Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons.

Owen SF, Tuncdemir SN, Bader PL, Tirko NN, Fishell G, Tsien RW.

Nature. 2013 Aug 22;500(7463):458-62. doi: 10.1038/nature12330. Epub 2013 Aug 4.


Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish.

Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR.

Evol Appl. 2013 Feb;6(2):279-89. doi: 10.1111/j.1752-4571.2012.00288.x. Epub 2012 Aug 30.


Optogenetic identification of striatal projection neuron subtypes during in vivo recordings.

Kravitz AV, Owen SF, Kreitzer AC.

Brain Res. 2013 May 20;1511:21-32. doi: 10.1016/j.brainres.2012.11.018. Epub 2012 Nov 21. Review.


Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes.

Baron MG, Purcell WM, Jackson SK, Owen SF, Jha AN.

Ecotoxicology. 2012 Nov;21(8):2419-29. doi: 10.1007/s10646-012-0965-5. Epub 2012 Jun 26.


Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression.

Wheeler DG, Groth RD, Ma H, Barrett CF, Owen SF, Safa P, Tsien RW.

Cell. 2012 May 25;149(5):1112-24. doi: 10.1016/j.cell.2012.03.041.

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