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Items: 1 to 50 of 132

1.

Using prescribing very short answer questions to identify sources of medication errors: a prospective study in two UK medical schools.

Sam AH, Fung CY, Wilson RK, Peleva E, Kluth DC, Lupton M, Owen DR, Melville CR, Meeran K.

BMJ Open. 2019 Jul 9;9(7):e028863. doi: 10.1136/bmjopen-2018-028863.

2.

Phagocytosis in the Brain: Homeostasis and Disease.

Galloway DA, Phillips AEM, Owen DRJ, Moore CS.

Front Immunol. 2019 Apr 16;10:790. doi: 10.3389/fimmu.2019.00790. eCollection 2019. Review.

3.

Modeling Patient-Specific Dose-Function Response for Enhanced Characterization of Personalized Functional Damage.

Owen DR, Boonstra PS, Viglianti BL, Balter JM, Schipper MJ, Jackson WC, El Naqa I, Jolly S, Ten Haken RK, Kong FS, Matuszak MM.

Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1265-1275. doi: 10.1016/j.ijrobp.2018.05.049. Epub 2018 Jun 1.

PMID:
30108006
4.

Acute Hospital Encounters in Cancer Patients Treated With Definitive Radiation Therapy.

Marar M, Gabriel P, Hwang WT, Owen DR, Ju M, Simone CB 2nd, Christodouleas J, Vapiwala N, Berman AT.

Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):935-944. doi: 10.1016/j.ijrobp.2018.04.025. Epub 2018 Apr 18.

PMID:
29976506
5.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

6.

Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases.

Owen DR, Wong HL, Bonakdar M, Jones M, Hughes CS, Morin GB, Jones SJM, Renouf DJ, Lim H, Laskin J, Marra M, Yip S, Schaeffer DF.

Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: a002535. doi: 10.1101/mcs.a002535. Print 2018 Apr.

7.

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus.

Narayan N, Owen DR, Mandhair H, Smyth E, Carlucci F, Saleem A, Gunn RN, Rabiner EA, Wells L, Dakin SG, Sabokbar A, Taylor PC.

J Nucl Med. 2018 Jul;59(7):1125-1132. doi: 10.2967/jnumed.117.202200. Epub 2018 Jan 4.

8.

Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration.

Scott G, Zetterberg H, Jolly A, Cole JH, De Simoni S, Jenkins PO, Feeney C, Owen DR, Lingford-Hughes A, Howes O, Patel MC, Goldstone AP, Gunn RN, Blennow K, Matthews PM, Sharp DJ.

Brain. 2018 Feb 1;141(2):459-471. doi: 10.1093/brain/awx339.

9.

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.

Owen DR, Fan J, Campioli E, Venugopal S, Midzak A, Daly E, Harlay A, Issop L, Libri V, Kalogiannopoulou D, Oliver E, Gallego-Colon E, Colasanti A, Huson L, Rabiner EA, Suppiah P, Essagian C, Matthews PM, Papadopoulos V.

Biochem J. 2017 Nov 21;474(23):3985-3999. doi: 10.1042/BCJ20170648.

10.

Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.

Fujita M, Kobayashi M, Ikawa M, Gunn RN, Rabiner EA, Owen DR, Zoghbi SS, Haskali MB, Telu S, Pike VW, Innis RB.

EJNMMI Res. 2017 Oct 16;7(1):84. doi: 10.1186/s13550-017-0334-8.

11.

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.

ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. doi: 10.1021/acschembio.7b00481. Epub 2017 Sep 12.

12.

Celiac Disease and Other Causes of Duodenitis.

Owen DR, Owen DA.

Arch Pathol Lab Med. 2018 Jan;142(1):35-43. doi: 10.5858/arpa.2016-0608-RA. Epub 2017 Jul 31. Review.

PMID:
28758791
13.

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.

Owen DR, Narayan N, Wells L, Healy L, Smyth E, Rabiner EA, Galloway D, Williams JB, Lehr J, Mandhair H, Peferoen LA, Taylor PC, Amor S, Antel JP, Matthews PM, Moore CS.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2679-2690. doi: 10.1177/0271678X17710182. Epub 2017 May 22.

14.

The anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways.

Dosunmu EF, Emeh RO, Dixit S, Bakeer MK, Coats MT, Owen DR, Pillai SR, Singh SR, Dennis VA.

PLoS One. 2017 May 3;12(5):e0176640. doi: 10.1371/journal.pone.0176640. eCollection 2017.

15.

11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-( R)-PK11195.

Kobayashi M, Jiang T, Telu S, Zoghbi SS, Gunn RN, Rabiner EA, Owen DR, Guo Q, Pike VW, Innis RB, Fujita M.

J Cereb Blood Flow Metab. 2018 Mar;38(3):393-403. doi: 10.1177/0271678X17699223. Epub 2017 Mar 21.

16.

Advances in positron emission tomography for the imaging of rheumatoid arthritis.

Narayan N, Owen DR, Taylor PC.

Rheumatology (Oxford). 2017 Nov 1;56(11):1837-1846. doi: 10.1093/rheumatology/kew484. Review.

17.

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.

Igoe N, Bayle ED, Fedorov O, Tallant C, Savitsky P, Rogers C, Owen DR, Deb G, Somervaille TC, Andrews DM, Jones N, Cheasty A, Ryder H, Brennan PE, Müller S, Knapp S, Fish PV.

J Med Chem. 2017 Jan 26;60(2):668-680. doi: 10.1021/acs.jmedchem.6b01583. Epub 2017 Jan 9.

PMID:
28068087
18.

Microglial positron emission tomography (PET) imaging in epilepsy: Applications, opportunities and pitfalls.

Scott G, Mahmud M, Owen DR, Johnson MR.

Seizure. 2017 Jan;44:42-47. doi: 10.1016/j.seizure.2016.10.023. Epub 2016 Nov 13. Review.

19.

Novel cationic peptide TP359 down-regulates the expression of outer membrane biogenesis genes in Pseudomonas aeruginosa: a potential TP359 anti-microbial mechanism.

Dosunmu EF, Chaudhari AA, Bawage S, Bakeer MK, Owen DR, Singh SR, Dennis VA, Pillai SR.

BMC Microbiol. 2016 Aug 22;16(1):192. doi: 10.1186/s12866-016-0808-2.

20.

New Long-Acting Basal Insulins: Does Benefit Outweigh Cost?

Standl E, Owen DR.

Diabetes Care. 2016 Aug;39 Suppl 2:S172-9. doi: 10.2337/dcS15-3011. No abstract available.

PMID:
27440830
21.

A novel covalent approach to bio-conjugate silver coated single walled carbon nanotubes with antimicrobial peptide.

Chaudhari AA, Ashmore D, Nath SD, Kate K, Dennis V, Singh SR, Owen DR, Palazzo C, Arnold RD, Miller ME, Pillai SR.

J Nanobiotechnology. 2016 Jul 13;14(1):58. doi: 10.1186/s12951-016-0211-z.

22.

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.

Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR.

J Med Chem. 2016 May 26;59(10):4800-11. doi: 10.1021/acs.jmedchem.6b00012. Epub 2016 May 3.

23.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C.

Dev Cell. 2016 Apr 4;37(1):47-57. doi: 10.1016/j.devcel.2016.03.002.

24.

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis.

Colasanti A, Guo Q, Giannetti P, Wall MB, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro PA, Malik O, Owen DR, Young AH, Gunn RN, Piccini P, Matthews PM, Rabiner EA.

Biol Psychiatry. 2016 Jul 1;80(1):62-72. doi: 10.1016/j.biopsych.2015.11.022. Epub 2015 Dec 5.

25.

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S.

Sci Adv. 2015 Nov 13;1(10):e1500723. doi: 10.1126/sciadv.1500723. eCollection 2015 Nov.

26.

Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity.

Owen DR, Wood DM, Archer JR, Dargan PI.

Drug Alcohol Rev. 2016 Sep;35(5):591-6. doi: 10.1111/dar.12356. Epub 2015 Dec 23.

27.

Corrigendum: The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. No abstract available.

PMID:
26485080
28.

Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [(11)C]PBR28 PET Brain Imaging Study.

Bloomfield PS, Selvaraj S, Veronese M, Rizzo G, Bertoldo A, Owen DR, Bloomfield MA, Bonoldi I, Kalk N, Turkheimer F, McGuire P, de Paola V, Howes OD.

Am J Psychiatry. 2016 Jan;173(1):44-52. doi: 10.1176/appi.ajp.2015.14101358. Epub 2015 Oct 16. Erratum in: Am J Psychiatry. 2017 Apr 1;174(4):402.

29.

Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway.

He S, Owen DR, Jelinsky SA, Lin LL.

Sci Rep. 2015 Oct 5;5:14368. doi: 10.1038/srep14368.

30.

The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added]. Nat Chem Biol. 2015 Nov;11(11):887.

31.

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.

Vangamudi B, Paul TA, Shah PK, Kost-Alimova M, Nottebaum L, Shi X, Zhan Y, Leo E, Mahadeshwar HS, Protopopov A, Futreal A, Tieu TN, Peoples M, Heffernan TP, Marszalek JR, Toniatti C, Petrocchi A, Verhelle D, Owen DR, Draetta G, Jones P, Palmer WS, Sharma S, Andersen JN.

Cancer Res. 2015 Sep 15;75(18):3865-3878. doi: 10.1158/0008-5472.CAN-14-3798. Epub 2015 Jul 2.

32.

Roles of microglia in brain development, tissue maintenance and repair.

Michell-Robinson MA, Touil H, Healy LM, Owen DR, Durafourt BA, Bar-Or A, Antel JP, Moore CS.

Brain. 2015 May;138(Pt 5):1138-59. doi: 10.1093/brain/awv066. Epub 2015 Mar 29. Review.

33.

Intravenous Furosemide for Acute Decompensated Congestive Heart Failure: What Is the Evidence?

Owen DR, MacAllister R, Sofat R.

Clin Pharmacol Ther. 2015 Aug;98(2):119-21. doi: 10.1002/cpt.120. Epub 2015 Jun 30. Review.

34.

Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation.

Moore CS, Cui QL, Warsi NM, Durafourt BA, Zorko N, Owen DR, Antel JP, Bar-Or A.

J Immunol. 2015 Jan 15;194(2):761-72. doi: 10.4049/jimmunol.1401156. Epub 2014 Dec 10.

35.

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8. doi: 10.1073/pnas.1407358111. Epub 2014 Aug 18.

36.

Epigenetic drugs that do not target enzyme activity.

Owen DR, Trzupek JD.

Drug Discov Today Technol. 2014 Jun;12:e29-34. doi: 10.1016/j.ddtec.2012.10.008. Review.

PMID:
25027371
37.

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with (18)F-PBR111 PET.

Colasanti A, Guo Q, Muhlert N, Giannetti P, Onega M, Newbould RD, Ciccarelli O, Rison S, Thomas C, Nicholas R, Muraro PA, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner EA, Matthews PM.

J Nucl Med. 2014 Jul;55(7):1112-8. doi: 10.2967/jnumed.113.135129. Epub 2014 Jun 5.

38.

A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [¹¹C]PBR28 and [¹⁸F]PBR111 for TSPO imaging.

Guo Q, Owen DR, Rabiner EA, Turkheimer FE, Gunn RN.

J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-8. doi: 10.1038/jcbfm.2014.65. Epub 2014 Apr 16.

39.

Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking study.

Owen DR, Guo Q, Kalk NJ, Colasanti A, Kalogiannopoulou D, Dimber R, Lewis YL, Libri V, Barletta J, Ramada-Magalhaes J, Kamalakaran A, Nutt DJ, Passchier J, Matthews PM, Gunn RN, Rabiner EA.

J Cereb Blood Flow Metab. 2014 Jun;34(6):989-94. doi: 10.1038/jcbfm.2014.46. Epub 2014 Mar 19.

40.

Clinical assessment of carotid atherosclerosis inflammation by positron emission tomography.

Shalhoub J, Oskrochi Y, Davies AH, Owen DR.

Curr Mol Med. 2013 Dec;13(10):1646-52. Review.

PMID:
24206129
41.

Large shift in symbiont assemblage in the invasive red turpentine beetle.

Taerum SJ, Duong TA, de Beer ZW, Gillette N, Sun JH, Owen DR, Wingfield MJ.

PLoS One. 2013 Oct 18;8(10):e78126. doi: 10.1371/journal.pone.0078126. eCollection 2013.

42.

Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding.

Guo Q, Colasanti A, Owen DR, Onega M, Kamalakaran A, Bennacef I, Matthews PM, Rabiner EA, Turkheimer FE, Gunn RN.

J Nucl Med. 2013 Nov;54(11):1915-23. doi: 10.2967/jnumed.113.121020. Epub 2013 Sep 26.

43.

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).

Colasanti A, Owen DR, Grozeva D, Rabiner EA, Matthews PM, Craddock N, Young AH.

Psychoneuroendocrinology. 2013 Nov;38(11):2826-9. doi: 10.1016/j.psyneuen.2013.07.007. Epub 2013 Aug 12.

44.

Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?

Kalk NJ, Owen DR, Tyacke RJ, Reynolds R, Rabiner EA, Lingford-Hughes AR, Parker CA.

Synapse. 2013 Dec;67(12):909-12. doi: 10.1002/syn.21681. Epub 2013 Jun 8. No abstract available.

PMID:
23666806
45.

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.

Picaud S, Da Costa D, Thanasopoulou A, Filippakopoulos P, Fish PV, Philpott M, Fedorov O, Brennan P, Bunnage ME, Owen DR, Bradner JE, Taniere P, O'Sullivan B, Müller S, Schwaller J, Stankovic T, Knapp S.

Cancer Res. 2013 Jun 1;73(11):3336-46. doi: 10.1158/0008-5472.CAN-12-3292. Epub 2013 Apr 10.

46.

The push-pull tactic for mitigation of mountain pine beetle (Coleoptera: Curculionidae) damage in lodgepole and whitebark pines.

Gillette NE, Mehmel CJ, Mori SR, Webster JN, Wood DL, Erbilgin N, Owen DR.

Environ Entomol. 2012 Dec;41(6):1575-86. doi: 10.1603/EN11315.

PMID:
23321106
47.

Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.

Fish PV, Filippakopoulos P, Bish G, Brennan PE, Bunnage ME, Cook AS, Federov O, Gerstenberger BS, Jones H, Knapp S, Marsden B, Nocka K, Owen DR, Philpott M, Picaud S, Primiano MJ, Ralph MJ, Sciammetta N, Trzupek JD.

J Med Chem. 2012 Nov 26;55(22):9831-7. doi: 10.1021/jm3010515. Epub 2012 Nov 8.

48.

Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁).

Owen DR.

ACS Chem Neurosci. 2011 Aug 17;2(8):394-401. doi: 10.1021/cn2000124. Epub 2011 Mar 10. Review.

49.

Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?

Owen DR, Rupprecht R, Nutt DJ.

J Psychopharmacol. 2013 Feb;27(2):119-22. doi: 10.1177/0269881112443746. Epub 2012 Apr 20.

PMID:
22522972
50.

The first total synthesis of (+)-mucosin.

Henderson AR, Stec J, Owen DR, Whitby RJ.

Chem Commun (Camb). 2012 Apr 7;48(28):3409-11. doi: 10.1039/c2cc17915f. Epub 2012 Feb 22.

PMID:
22358150

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