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Items: 1 to 50 of 114

1.

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.

Wrobel AG, Kadlecova Z, Kamenicky J, Yang JC, Herrmann T, Kelly BT, McCoy AJ, Evans PR, Martin S, Müller S, Sroubek F, Neuhaus D, Höning S, Owen DJ.

Dev Cell. 2019 Aug 19;50(4):494-508.e11. doi: 10.1016/j.devcel.2019.07.017.

2.

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.

Kovtun O, Leneva N, Bykov YS, Ariotti N, Teasdale RD, Schaffer M, Engel BD, Owen DJ, Briggs JAG, Collins BM.

Nature. 2018 Sep;561(7724):561-564. doi: 10.1038/s41586-018-0526-z. Epub 2018 Sep 17.

3.

Influence of methods of joint inspection during tibial plateau leveling osteotomy on the radiographic appearance of the patellar tendon.

Owen DJ, Manley R, Casale SA.

Vet Surg. 2018 Oct;47(7):916-922. doi: 10.1111/vsu.12942. Epub 2018 Sep 4.

PMID:
30180275
4.

Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.

Mehta D, Leong N, McLeod VM, Kelly BD, Pathak R, Owen DJ, Porter CJH, Kaminskas LM.

Mol Pharm. 2018 Oct 1;15(10):4568-4576. doi: 10.1021/acs.molpharmaceut.8b00581. Epub 2018 Sep 13.

PMID:
30107748
5.

Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats.

Leong NJ, Mehta D, McLeod VM, Kelly BD, Pathak R, Owen DJ, Porter CJH, Kaminskas LM.

J Pharm Sci. 2018 Sep;107(9):2509-2513. doi: 10.1016/j.xphs.2018.05.013. Epub 2018 May 29.

PMID:
29852134
6.

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.

Ryan GM, McLeod VM, Mehta D, Kelly BD, Stanislawski PC, Owen DJ, Kaminskas LM, Porter CJH.

Nanomedicine. 2017 Nov;13(8):2485-2494. doi: 10.1016/j.nano.2017.08.003. Epub 2017 Aug 15.

PMID:
28821463
7.

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.

Navarro Negredo P, Edgar JR, Wrobel AG, Zaccai NR, Antrobus R, Owen DJ, Robinson MS.

J Cell Biol. 2017 Sep 4;216(9):2927-2943. doi: 10.1083/jcb.201602058. Epub 2017 Jul 25.

8.

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers.

Haque S, McLeod VM, Jones S, Fung S, Whittaker M, McIntosh M, Pouton C, Owen DJ, Porter CJH, Kaminskas LM.

Eur J Pharm Biopharm. 2017 Oct;119:408-418. doi: 10.1016/j.ejpb.2017.07.005. Epub 2017 Jul 13.

PMID:
28713018
9.

Erratum: Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.

De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel AG, Wilson TA, Pouwels J, Montagnac G, Owen DJ, Ivaska J.

Nat Struct Mol Biol. 2017 Feb 6;24(2):194. doi: 10.1038/nsmb0217-194b. No abstract available.

PMID:
28169997
10.

Dual Function of the pUL7-pUL51 Tegument Protein Complex in Herpes Simplex Virus 1 Infection.

Albecka A, Owen DJ, Ivanova L, Brun J, Liman R, Davies L, Ahmed MF, Colaco S, Hollinshead M, Graham SC, Crump CM.

J Virol. 2017 Jan 3;91(2). pii: e02196-16. doi: 10.1128/JVI.02196-16. Print 2017 Jan 15.

11.

Social stress predicts preterm birth in twin pregnancies.

Owen DJ, Wood L, Tomenson B, Creed F, Neilson JP.

J Psychosom Obstet Gynaecol. 2017 Mar;38(1):63-72. doi: 10.1080/0167482X.2016.1235146. Epub 2016 Oct 11.

PMID:
27728996
12.

BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers.

Dennis MK, Delevoye C, Acosta-Ruiz A, Hurbain I, Romao M, Hesketh GG, Goff PS, Sviderskaya EV, Bennett DC, Luzio JP, Galli T, Owen DJ, Raposo G, Marks MS.

J Cell Biol. 2016 Aug 1;214(3):293-308. doi: 10.1083/jcb.201605090.

13.

Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.

Ma L, Umasankar PK, Wrobel AG, Lymar A, McCoy AJ, Holkar SS, Jha A, Pradhan-Sundd T, Watkins SC, Owen DJ, Traub LM.

Dev Cell. 2016 Jun 6;37(5):428-43. doi: 10.1016/j.devcel.2016.05.003. Epub 2016 May 26.

14.

Using selenomethionyl derivatives to assign sequence in low-resolution structures of the AP2 clathrin adaptor.

Kelly BT, Graham SC, Owen DJ.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):336-45. doi: 10.1107/S2059798315021580. Epub 2016 Mar 1.

15.

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.

De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel AG, Wilson TA, Pouwels J, Montagnac G, Owen DJ, Ivaska J.

Nat Struct Mol Biol. 2016 Feb;23(2):172-9. doi: 10.1038/nsmb.3161. Epub 2016 Jan 18. Erratum in: Nat Struct Mol Biol. 2017 Feb 6;24(2):194.

16.

Structural basis for the binding of tryptophan-based motifs by δ-COP.

Suckling RJ, Poon PP, Travis SM, Majoul IV, Hughson FM, Evans PR, Duden R, Owen DJ.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14242-7. doi: 10.1073/pnas.1506186112. Epub 2015 Nov 2.

17.

A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep.

Ryan GM, Bischof RJ, Enkhbaatar P, McLeod VM, Chan LJ, Jones SA, Owen DJ, Porter CJ, Kaminskas LM.

Pharm Res. 2016 Feb;33(2):510-25. doi: 10.1007/s11095-015-1806-z. Epub 2015 Oct 20.

PMID:
26486513
18.

Tegument Assembly and Secondary Envelopment of Alphaherpesviruses.

Owen DJ, Crump CM, Graham SC.

Viruses. 2015 Sep 18;7(9):5084-114. doi: 10.3390/v7092861. Review.

19.

A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.

Nahorski MS, Al-Gazali L, Hertecant J, Owen DJ, Borner GH, Chen YC, Benn CL, Carvalho OP, Shaikh SS, Phelan A, Robinson MS, Royle SJ, Woods CG.

Brain. 2015 Aug;138(Pt 8):2147-60. doi: 10.1093/brain/awv149. Epub 2015 Jun 11.

20.

CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

Miller SE, Mathiasen S, Bright NA, Pierre F, Kelly BT, Kladt N, Schauss A, Merrifield CJ, Stamou D, Höning S, Owen DJ.

Dev Cell. 2015 Apr 20;33(2):163-75. doi: 10.1016/j.devcel.2015.03.002.

21.

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

Kaminskas LM, McLeod VM, Ascher DB, Ryan GM, Jones S, Haynes JM, Trevaskis NL, Chan LJ, Sloan EK, Finnin BA, Williamson M, Velkov T, Williams ED, Kelly BD, Owen DJ, Porter CJ.

Mol Pharm. 2015 Feb 2;12(2):432-43. doi: 10.1021/mp500531e. Epub 2015 Jan 20.

PMID:
25485615
22.

Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch.

Kelly BT, Graham SC, Liska N, Dannhauser PN, Höning S, Ungewickell EJ, Owen DJ.

Science. 2014 Jul 25;345(6195):459-63. doi: 10.1126/science.1254836.

23.

VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.

Hesketh GG, Pérez-Dorado I, Jackson LP, Wartosch L, Schäfer IB, Gray SR, McCoy AJ, Zeldin OB, Garman EF, Harbour ME, Evans PR, Seaman MNJ, Luzio JP, Owen DJ.

Dev Cell. 2014 Jun 9;29(5):591-606. doi: 10.1016/j.devcel.2014.04.010. Epub 2014 May 22.

24.

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.

Kaminskas LM, McLeod VM, Ryan GM, Kelly BD, Haynes JM, Williamson M, Thienthong N, Owen DJ, Porter CJ.

J Control Release. 2014 Jun 10;183:18-26. doi: 10.1016/j.jconrel.2014.03.012. Epub 2014 Mar 14.

PMID:
24637466
25.

Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4482-91. doi: 10.1073/pnas.1313474110. Epub 2013 Nov 5.

26.

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin.

Ryan GM, Kaminskas LM, Bulitta JB, McIntosh MP, Owen DJ, Porter CJH.

J Control Release. 2013 Nov 28;172(1):128-136. doi: 10.1016/j.jconrel.2013.08.004. Epub 2013 Aug 13.

PMID:
23954628
27.

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

Graham SC, Wartosch L, Gray SR, Scourfield EJ, Deane JE, Luzio JP, Owen DJ.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13345-50. doi: 10.1073/pnas.1307074110. Epub 2013 Jul 30.

28.

A critique of current practice of transvaginal pudendal nerve blocks: a prospective audit of understanding and clinical practice.

Ford JM, Owen DJ, Coughlin LB, Byrd LM.

J Obstet Gynaecol. 2013 Jul;33(5):463-5. doi: 10.3109/01443615.2013.771155.

PMID:
23815197
29.

Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent.

Ryan GM, Kaminskas LM, Kelly BD, Owen DJ, McIntosh MP, Porter CJ.

Mol Pharm. 2013 Aug 5;10(8):2986-95. doi: 10.1021/mp400091n. Epub 2013 Jun 26.

PMID:
23750747
30.

Molecular basis for recognition of dilysine trafficking motifs by COPI.

Jackson LP, Lewis M, Kent HM, Edeling MA, Evans PR, Duden R, Owen DJ.

Dev Cell. 2012 Dec 11;23(6):1255-62. doi: 10.1016/j.devcel.2012.10.017. Epub 2012 Nov 21.

31.

The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation.

Schäfer IB, Hesketh GG, Bright NA, Gray SR, Pryor PR, Evans PR, Luzio JP, Owen DJ.

Nat Struct Mol Biol. 2012 Dec;19(12):1300-9. doi: 10.1038/nsmb.2414. Epub 2012 Oct 28.

32.

Are antenatal weight management interventions effective in preventing pre-eclampsia? Systematic review of randomised control trials.

Ho LC, Saunders KA, Owen DJ, Ibrahim UN, Bhattacharya S.

Pregnancy Hypertens. 2012 Oct;2(4):341-9. doi: 10.1016/j.preghy.2012.03.003. Epub 2012 Mar 18. Review.

PMID:
26105601
33.

The effect of praise, positive nonverbal response, reprimand, and negative nonverbal response on child compliance: a systematic review.

Owen DJ, Slep AM, Heyman RE.

Clin Child Fam Psychol Rev. 2012 Dec;15(4):364-85. doi: 10.1007/s10567-012-0120-0. Review.

PMID:
22918669
34.

Structures and mechanisms of vesicle coat components and multisubunit tethering complexes.

Jackson LP, Kümmel D, Reinisch KM, Owen DJ.

Curr Opin Cell Biol. 2012 Aug;24(4):475-83. doi: 10.1016/j.ceb.2012.05.013. Epub 2012 Jun 22. Review.

35.

Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex.

Kent HM, Evans PR, Schäfer IB, Gray SR, Sanderson CM, Luzio JP, Peden AA, Owen DJ.

Dev Cell. 2012 May 15;22(5):979-88. doi: 10.1016/j.devcel.2012.01.018. Epub 2012 Apr 19.

36.

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models.

Kaminskas LM, McLeod VM, Kelly BD, Cullinane C, Sberna G, Williamson M, Boyd BJ, Owen DJ, Porter CJ.

Mol Pharm. 2012 Mar 5;9(3):422-32. doi: 10.1021/mp200522d. Epub 2012 Jan 27.

PMID:
22233281
37.

The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.

Miller SE, Sahlender DA, Graham SC, Höning S, Robinson MS, Peden AA, Owen DJ.

Cell. 2011 Nov 23;147(5):1118-31. doi: 10.1016/j.cell.2011.10.038.

38.

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.

Kaminskas LM, McLeod VM, Kelly BD, Sberna G, Boyd BJ, Williamson M, Owen DJ, Porter CJ.

Nanomedicine. 2012 Jan;8(1):103-11. doi: 10.1016/j.nano.2011.05.013. Epub 2011 Jun 23.

PMID:
21704192
39.

Endocytic sorting of transmembrane protein cargo.

Kelly BT, Owen DJ.

Curr Opin Cell Biol. 2011 Aug;23(4):404-12. doi: 10.1016/j.ceb.2011.03.004. Epub 2011 Mar 28. Review.

PMID:
21450449
40.

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.

Kaminskas LM, Kelly BD, McLeod VM, Sberna G, Owen DJ, Boyd BJ, Porter CJ.

J Control Release. 2011 Jun 10;152(2):241-8. doi: 10.1016/j.jconrel.2011.02.005. Epub 2011 Feb 21.

PMID:
21315119
41.

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers.

Kaminskas LM, Kelly BD, McLeod VM, Sberna G, Boyd BJ, Owen DJ, Porter CJ.

Mol Pharm. 2011 Apr 4;8(2):338-49. doi: 10.1021/mp1001872. Epub 2011 Jan 21.

PMID:
21171585
42.

The surgical transversus abdominis plane block--a novel approach for performing an established technique.

Owen DJ, Harrod I, Ford J, Luckas M, Gudimetla V.

BJOG. 2011 Jan;118(1):24-7. doi: 10.1111/j.1471-0528.2010.02779.x. Epub 2010 Nov 18.

43.

Assembly and solution structure of the core retromer protein complex.

Norwood SJ, Shaw DJ, Cowieson NP, Owen DJ, Teasdale RD, Collins BM.

Traffic. 2011 Jan;12(1):56-71. doi: 10.1111/j.1600-0854.2010.01124.x. Epub 2010 Oct 15.

44.

A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.

Jackson LP, Kelly BT, McCoy AJ, Gaffry T, James LC, Collins BM, Höning S, Evans PR, Owen DJ.

Cell. 2010 Jun 25;141(7):1220-9. doi: 10.1016/j.cell.2010.05.006.

45.

Vesicle transport: a new player in APP trafficking.

Owen DJ, Collins BM.

Curr Biol. 2010 May 11;20(9):R413-5. doi: 10.1016/j.cub.2010.03.017.

46.

The association of promised consequences with child compliance to maternal directives.

Owen DJ, Smith Slep AM, Heyman RE.

J Clin Child Adolesc Psychol. 2009 Sep;38(5):639-49. doi: 10.1080/15374410903103510.

PMID:
20183649
47.

Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development.

Edeling MA, Sanker S, Shima T, Umasankar PK, Höning S, Kim HY, Davidson LA, Watkins SC, Tsang M, Owen DJ, Traub LM.

PLoS One. 2009 Dec 3;4(12):e8150. doi: 10.1371/journal.pone.0008150.

48.

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

Adams TE, El Sous M, Hawkins BC, Hirner S, Holloway G, Khoo ML, Owen DJ, Savage GP, Scammells PJ, Rizzacasa MA.

J Am Chem Soc. 2009 Feb 4;131(4):1607-16. doi: 10.1021/ja808402e.

PMID:
19140688
49.

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex.

Kelly BT, McCoy AJ, Späte K, Miller SE, Evans PR, Höning S, Owen DJ.

Nature. 2008 Dec 18;456(7224):976-979. doi: 10.1038/nature07422. No abstract available.

50.

Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.

Pryor PR, Jackson L, Gray SR, Edeling MA, Thompson A, Sanderson CM, Evans PR, Owen DJ, Luzio JP.

Cell. 2008 Sep 5;134(5):817-27. doi: 10.1016/j.cell.2008.07.023.

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