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Mitochondrial Dysfunction as a Pathogenic Mediator of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.

Ryter SW, Rosas IO, Owen CA, Martinez FJ, Choi ME, Lee CG, Elias JA, Choi AMK.

Ann Am Thorac Soc. 2018 Dec;15(Supplement_4):S266-S272. doi: 10.1513/AnnalsATS.201808-585MG.


A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.

Bazzone LE, King M, MacKay CR, Kyawe PP, Meraner P, Lindstrom D, Rojas-Quintero J, Owen CA, Wang JP, Brass AL, Kurt-Jones EA, Finberg RW.

MBio. 2019 Feb 5;10(1). pii: e02734-18. doi: 10.1128/mBio.02734-18.


Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study.

McNamara JJ, McColley SA, Marigowda G, Liu F, Tian S, Owen CA, Stiles D, Li C, Waltz D, Wang LT, Sawicki GS.

Lancet Respir Med. 2019 Jan 24. pii: S2213-2600(18)30460-0. doi: 10.1016/S2213-2600(18)30460-0. [Epub ahead of print]


Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection.

Rojas-Quintero J, Wang X, Tipper J, Burkett PR, Zuñiga J, Ashtekar AR, Polverino F, Rout A, Yambayev I, Hernández C, Jimenez L, Ramírez G, Harrod KS, Owen CA.

JCI Insight. 2018 Dec 20;3(24). pii: 99022. doi: 10.1172/jci.insight.99022. [Epub ahead of print]


Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.

Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, Wright AL, Halonen M, Martinez FD, Kraft M, Guerra S, Ledford JG.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):302-312. doi: 10.1164/rccm.201807-1345OC.


A Thioredoxin Domain-Containing Protein Interacts with Pepino mosaic virus Triple Gene Block Protein 1.

Mathioudakis MM, Khechmar S, Owen CA, Medina V, Ben Mansour K, Tomaszewska W, Spanos T, Sarris PF, Livieratos IC.

Int J Mol Sci. 2018 Nov 25;19(12). pii: E3747. doi: 10.3390/ijms19123747.


Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia.

Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S.

FASEB J. 2018 Nov 21:fj201802002R. doi: 10.1096/fj.201802002R. [Epub ahead of print]


Dusting Off IL-9 as a New Therapeutic Target for Pulmonary Fibrosis.

Rojas-Quintero J, Wang X, Owen CA.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):141-143. doi: 10.1165/rcmb.2018-0319ED. No abstract available.


Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease.

Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME.

JCI Insight. 2018 Sep 20;3(18). pii: 99592. doi: 10.1172/jci.insight.99592. [Epub ahead of print]


The Course of Lung Function in Middle-aged Heavy Smokers: Incidence and Time to Early Onset of Chronic Obstructive Pulmonary Disease.

Petersen H, Sood A, Polverino F, Owen CA, Pinto-Plata V, Celli BR, Tesfaigzi Y.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1449-1451. doi: 10.1164/rccm.201805-0861LE. No abstract available.


Club cell protein 16 (Cc16) deficiency increases inflamm-aging in the lungs of mice.

Laucho-Contreras ME, Polverino F, Rojas-Quintero J, Wang X, Owen CA.

Physiol Rep. 2018 Aug;6(15):e13797. doi: 10.14814/phy2.13797.


A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD.

Wang X, Polverino F, Rojas-Quintero J, Zhang D, Sánchez J, Yambayev I, Lindqvist E, Virtala R, Djukanovic R, Davies DE, Wilson S, O'Donnell R, Cunoosamy D, Hazon P, Higham A, Singh D, Olsson H, Owen CA.

Am J Respir Crit Care Med. 2018 Jun 4. doi: 10.1164/rccm.201711-2300OC. [Epub ahead of print]


A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.

Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1254-1267. doi: 10.1164/rccm.201707-1331OC.


Gas exchange and breathing pattern in women with postmenopausal bone fragility.

Polverino F, de Torres JP, Santoriello C, Capuozzo A, Mauro I, Rojas-Quintero J, D'Agostino B, Pistolesi M, Celli B, Polverino M, Owen CA.

Respir Med. 2018 Apr;137:141-146. doi: 10.1016/j.rmed.2018.03.006. Epub 2018 Mar 7.


COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series).

Polverino F, Celli BR, Owen CA.

Pulm Circ. 2018 Jan-Mar;8(1):2045894018758528. doi: 10.1177/2045894018758528.


Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype.

Celli BR, Locantore N, Tal-Singer R, Riley J, Miller B, Vestbo J, Yates JC, Silverman EK, Owen CA, Divo M, Pinto-Plata V, Wouters EFM, Faner R, Agusti A; ECLIPSE Study Investigators.

Eur Respir J. 2018 Feb 7;51(2). pii: 1702146. doi: 10.1183/13993003.02146-2017. Print 2018 Feb.


Chronic Obstructive Pulmonary Disease: Breathing New Life into Old Cardiovascular Drugs?

Polverino F, Celli BR, Owen CA.

Ann Am Thorac Soc. 2017 Nov;14(11):1718. doi: 10.1513/AnnalsATS.201707-613LE. No abstract available.


Reply to Voelkel: Cigarette Smoke Is an Endothelial Cell Toxin.

Polverino F, Celli BR, Owen CA.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):274-275. doi: 10.1164/rccm.201707-1381LE. No abstract available.


Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease.

Wan ES, Li Y, Lao T, Qiu W, Jiang Z, Mancini JD, Owen CA, Clish C, DeMeo DL, Silverman EK, Zhou X.

Sci Rep. 2017 May 31;7(1):2504. doi: 10.1038/s41598-017-02701-4.


Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.

Almeida-Reis R, Theodoro-Junior OA, Oliveira BTM, Oliva LV, Toledo-Arruda AC, Bonturi CR, Brito MV, Lopes FDTQS, Prado CM, Florencio AC, Martins MA, Owen CA, Leick EA, Oliva MLV, Tibério IFLC.

Biomed Res Int. 2017;2017:8287125. doi: 10.1155/2017/8287125. Epub 2017 Mar 30.


Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.

Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):47-58. doi: 10.1165/rcmb.2016-0328OC.


A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease.

Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, Divo M, Pinto-Plata V, Chetta A, Tesfaigzi Y, Celli BR, Owen CA.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1464-1476. doi: 10.1164/rccm.201609-1765OC.


Ultrasound-Guided Needle Technique Accuracy: Prospective Comparison of Passive Magnetic Tracking Versus Unassisted Echogenic Needle Localization.

Johnson AN, Peiffer JS, Halmann N, Delaney L, Owen CA, Hersh J.

Reg Anesth Pain Med. 2017 Mar/Apr;42(2):223-232. doi: 10.1097/AAP.0000000000000549.


Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD.

Nakajima T, Nakamura H, Owen CA, Yoshida S, Tsuduki K, Chubachi S, Shirahata T, Mashimo S, Nakamura M, Takahashi S, Minematsu N, Tateno H, Fujishima S, Asano K, Celli BR, Betsuyaku T.

Dis Markers. 2016;2016:4093870. Epub 2016 Nov 22.


The work environment of junior doctors: their perspectives and coping strategies.

Pan TY, Fan HS, Owen CA.

Postgrad Med J. 2017 Jul;93(1101):414-419. doi: 10.1136/postgradmedj-2016-134362. Epub 2016 Dec 1.


Asthma COPD Overlap Syndrome: An Approach to A Real -World Endotype in Obstructive Lung Disease?

Laucho-Contreras M, de Oca MM, Owen CA.

Curr Pharm Des. 2016;22(41):6273-6282. doi: 10.2174/1381612822666160906162441. Review.


B cells in chronic obstructive pulmonary disease: moving to center stage.

Polverino F, Seys LJ, Bracke KR, Owen CA.

Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. doi: 10.1152/ajplung.00304.2016. Epub 2016 Aug 19. Review.


Hhip haploinsufficiency sensitizes mice to age-related emphysema.

Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21.


In Vitro Synthesized RNA Generated from cDNA Clones of Both Genomic Components of Cucurbit yellow stunting disorder virus Replicates in Cucumber Protoplasts.

Owen CA, Moukarzel R, Huang X, Kassem MA, Eliasco E, Aranda MA, Coutts RH, Livieratos IC.

Viruses. 2016 Jun 14;8(6). pii: E170. doi: 10.3390/v8060170.


Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 - April 1, 2016, Tours, France.

Desoubeaux G, Reichert JM, Sleeman M, Reckamp KL, Ryffel B, Adamczewski JP, Sweeney TD, Vanbever R, Diot P, Owen CA, Page C, Lerondel S, Le Pape A, Heuze-Vourc'h N.

MAbs. 2016 Aug-Sep;8(6):999-1009. doi: 10.1080/19420862.2016.1196521. Epub 2016 Jun 6.


Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer?

Polverino F, Laucho-Contreras M, Rojas Quintero J, Divo M, Pinto-Plata V, Sholl L, de-Torres JP, Celli BR, Owen CA.

Multidiscip Respir Med. 2016 Apr 4;11:17. doi: 10.1186/s40248-016-0051-6. eCollection 2016.


A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC.


Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).

Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA.

Expert Opin Ther Targets. 2016 Jul;20(7):869-83. doi: 10.1517/14728222.2016.1139084. Epub 2016 Feb 11. Review.


Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.

Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM.

Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11.


Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis.

Petersen H, Leng S, Belinsky SA, Miller BE, Tal-Singer R, Owen CA, Celli B, Tesfaigzi Y.

Eur Respir J. 2015 Nov;46(5):1501-3. doi: 10.1183/13993003.00682-2015. Epub 2015 Jul 9. No abstract available.


Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.

Lange P, Celli B, Agustí A, Boje Jensen G, Divo M, Faner R, Guerra S, Marott JL, Martinez FD, Martinez-Camblor P, Meek P, Owen CA, Petersen H, Pinto-Plata V, Schnohr P, Sood A, Soriano JB, Tesfaigzi Y, Vestbo J.

N Engl J Med. 2015 Jul 9;373(2):111-22. doi: 10.1056/NEJMoa1411532.


Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis.

Craig VJ, Zhang L, Hagood JS, Owen CA.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):585-600. doi: 10.1165/rcmb.2015-0020TR. Review.


B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.

Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Sholl L, Rosas IO, Agustí A, Celli BR, Owen CA.

Am J Respir Crit Care Med. 2015 Sep 15;192(6):695-705. doi: 10.1164/rccm.201501-0107OC.


Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X.

Genome Med. 2015 Feb 14;7(1):12. doi: 10.1186/s13073-015-0137-3. eCollection 2015.


Protective role for club cell secretory protein-16 (CC16) in the development of COPD.

Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, Divo M, Ashfaq N, Petersen H, Stripp B, Pilon AL, Tesfaigzi Y, Celli BR, Owen CA.

Eur Respir J. 2015 Jun;45(6):1544-56. doi: 10.1183/09031936.00134214. Epub 2015 Feb 19.


Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice.

Laucho-Contreras ME, Taylor KL, Mahadeva R, Boukedes SS, Owen CA.

J Vis Exp. 2015 Jan 16;(95):52236. doi: 10.3791/52236.


A novel nonhuman primate model of cigarette smoke-induced airway disease.

Polverino F, Doyle-Eisele M, McDonald J, Wilder JA, Royer C, Laucho-Contreras M, Kelly EM, Divo M, Pinto-Plata V, Mauderly J, Celli BR, Tesfaigzi Y, Owen CA.

Am J Pathol. 2015 Mar;185(3):741-55. doi: 10.1016/j.ajpath.2014.11.006. Epub 2014 Dec 24.


Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.

Khabibullin D, Medvetz DA, Pinilla M, Hariharan V, Li C, Hergrueter A, Laucho Contreras M, Zhang E, Parkhitko A, Yu JJ, Owen CA, Huang H, Baron RM, Henske EP.

Physiol Rep. 2014 Aug 12;2(8). pii: e12107. doi: 10.14814/phy2.12107. Print 2014 Aug 1.


Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.

Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM.

J Clin Invest. 2014 Sep;124(9):3987-4003. doi: 10.1172/JCI74985. Epub 2014 Aug 1.


ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury.

Roychaudhuri R, Hergrueter AH, Polverino F, Laucho-Contreras ME, Gupta K, Borregaard N, Owen CA.

J Immunol. 2014 Sep 1;193(5):2469-82. doi: 10.4049/jimmunol.1303370. Epub 2014 Jul 25.


Effects of sex hormones on bronchial reactivity during the menstrual cycle.

Matteis M, Polverino F, Spaziano G, Roviezzo F, Santoriello C, Sullo N, Bucci MR, Rossi F, Polverino M, Owen CA, D'Agostino B.

BMC Pulm Med. 2014 Jul 1;14:108. doi: 10.1186/1471-2466-14-108.


Idiopathic pulmonary fibrosis and coronary artery disease.

Cicchitto G, Musella V, Acitorio M, Capuano N, Fiorenzano G, Owen CA, Polverino M, Polverino F.

Multidiscip Respir Med. 2014 May 30;9(1):31. doi: 10.1186/2049-6958-9-31. eCollection 2014.


Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis.

Craig VJ, Polverino F, Laucho-Contreras ME, Shi Y, Liu Y, Osorio JC, Tesfaigzi Y, Pinto-Plata V, Gochuico BR, Rosas IO, Owen CA.

PLoS One. 2014 May 14;9(5):e97485. doi: 10.1371/journal.pone.0097485. eCollection 2014.


Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):262-72. doi: 10.1165/rcmb.2013-0238OC.


Comparison of arterial and venous blood biomarker levels in chronic obstructive pulmonary disease.

Kelly E, Owen CA, Abraham A, Knowlton DL, Celli BR, Pinto-Plata V.

F1000Res. 2013 Apr 19;2:114. doi: 10.12688/f1000research.2-114.v1. eCollection 2013.

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