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Items: 1 to 50 of 60

1.

Can Arginase Inhibitors Be the Answer to Therapeutic Challenges in Alzheimer's Disease?

Ovsepian SV, O'Leary VB.

Neurotherapeutics. 2018 Sep 21. doi: 10.1007/s13311-018-0668-6. [Epub ahead of print]

PMID:
30242774
2.

Neurobiology and therapeutic applications of neurotoxins targeting transmitter release.

Ovsepian SV, O'Leary VB, Ayvazyan NM, Al-Sabi A, Ntziachristos V, Dolly JO.

Pharmacol Ther. 2018 Aug 25. pii: S0163-7258(18)30154-2. doi: 10.1016/j.pharmthera.2018.08.016. [Epub ahead of print] Review.

PMID:
30149105
3.

Amyloid Plaques of Alzheimer's Disease as Hotspots of Glutamatergic Activity.

Ovsepian SV, O'Leary VB, Zaborszky L, Ntziachristos V, Dolly JO.

Neuroscientist. 2018 Jul 27:1073858418791128. doi: 10.1177/1073858418791128. [Epub ahead of print]

PMID:
30051750
4.

Extended Near-Infrared Optoacoustic Spectrometry for Sensing Physiological Concentrations of Glucose.

Ghazaryan A, Ovsepian SV, Ntziachristos V.

Front Endocrinol (Lausanne). 2018 Mar 19;9:112. doi: 10.3389/fendo.2018.00112. eCollection 2018.

5.

Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy.

Berezhnoi A, Schwarz M, Buehler A, Ovsepian SV, Aguirre J, Ntziachristos V.

J Biophotonics. 2018 Nov;11(11):e201700359. doi: 10.1002/jbio.201700359. Epub 2018 Jul 18.

PMID:
29573174
6.

Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients.

Reber J, Willershäuser M, Karlas A, Paul-Yuan K, Diot G, Franz D, Fromme T, Ovsepian SV, Bézière N, Dubikovskaya E, Karampinos DC, Holzapfel C, Hauner H, Klingenspor M, Ntziachristos V.

Cell Metab. 2018 Mar 6;27(3):689-701.e4. doi: 10.1016/j.cmet.2018.02.002.

PMID:
29514074
7.

Synaptic vesicle cycle and amyloid β: Biting the hand that feeds.

Ovsepian SV, O'Leary VB, Zaborszky L, Ntziachristos V, Dolly JO.

Alzheimers Dement. 2018 Apr;14(4):502-513. doi: 10.1016/j.jalz.2018.01.011. Epub 2018 Mar 1. Review.

PMID:
29494806
8.

Alleviation of Trigeminal Nociception Using p75 Neurotrophin Receptor Targeted Lentiviral Interference Therapy.

O'Leary VB, O'Connell M, Antyborzec I, Ntziachristos V, Oliver Dolly J, Ovsepian SV.

Neurotherapeutics. 2018 Apr;15(2):489-499. doi: 10.1007/s13311-018-0608-5.

PMID:
29427180
9.

Pushing the Boundaries of Neuroimaging with Optoacoustics.

Ovsepian SV, Olefir I, Westmeyer G, Razansky D, Ntziachristos V.

Neuron. 2017 Dec 6;96(5):966-988. doi: 10.1016/j.neuron.2017.10.022. Review.

PMID:
29216459
10.

The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients.

O'Leary VB, Maugg D, Smida J, Baumhoer D, Nathrath M, Ovsepian SV, Atkinson MJ.

Oncotarget. 2017 Sep 19;8(50):87431-87441. doi: 10.18632/oncotarget.21086. eCollection 2017 Oct 20.

11.

The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response.

O'Leary VB, Smida J, Matjanovski M, Brockhaus C, Winkler K, Moertl S, Ovsepian SV, Atkinson MJ.

Oncotarget. 2017 Jul 13;8(45):78397-78409. doi: 10.18632/oncotarget.19228. eCollection 2017 Oct 3.

12.

Multispectral Optoacoustic Tomography (MSOT) of Human Breast Cancer.

Diot G, Metz S, Noske A, Liapis E, Schroeder B, Ovsepian SV, Meier R, Rummeny E, Ntziachristos V.

Clin Cancer Res. 2017 Nov 15;23(22):6912-6922. doi: 10.1158/1078-0432.CCR-16-3200. Epub 2017 Sep 12.

13.

PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome.

O'Leary VB, Smida J, Buske FA, Carrascosa LG, Azimzadeh O, Maugg D, Hain S, Tapio S, Heidenreich W, Kerr J, Trau M, Ovsepian SV, Atkinson MJ.

Sci Rep. 2017 Aug 2;7(1):7163. doi: 10.1038/s41598-017-07295-5.

14.

The birth of the synapse.

Ovsepian SV.

Brain Struct Funct. 2017 Nov;222(8):3369-3374. doi: 10.1007/s00429-017-1459-2. Epub 2017 Jun 13. Review.

PMID:
28612096
15.

Long non-coding RNA PARTICLE bridges histone and DNA methylation.

O'Leary VB, Hain S, Maugg D, Smida J, Azimzadeh O, Tapio S, Ovsepian SV, Atkinson MJ.

Sci Rep. 2017 May 11;7(1):1790. doi: 10.1038/s41598-017-01875-1.

16.

Optoacoustic Dermoscopy of the Human Skin: Tuning Excitation Energy for Optimal Detection Bandwidth With Fast and Deep Imaging in vivo.

Schwarz M, Soliman D, Omar M, Buehler A, Ovsepian SV, Aguirre J, Ntziachristos V.

IEEE Trans Med Imaging. 2017 Jun;36(6):1287-1296. doi: 10.1109/TMI.2017.2664142. Epub 2017 Mar 1.

PMID:
28278460
17.

Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo.

Bozhko D, Osborn EA, Rosenthal A, Verjans JW, Hara T, Kellnberger S, Wissmeyer G, Ovsepian SV, McCarthy JR, Mauskapf A, Stein AF, Jaffer FA, Ntziachristos V.

Eur Heart J Cardiovasc Imaging. 2017 Nov 1;18(11):1253-1261. doi: 10.1093/ehjci/jew222.

18.

Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain.

Antyborzec I, O'Leary VB, Dolly JO, Ovsepian SV.

Neurotherapeutics. 2016 Oct;13(4):859-870. doi: 10.1007/s13311-016-0445-3.

19.

Circumventing Brain Barriers: Nanovehicles for Retroaxonal Therapeutic Delivery.

Ovsepian SV, O'Leary VB, Ntziachristos V, Dolly JO.

Trends Mol Med. 2016 Nov;22(11):983-993. doi: 10.1016/j.molmed.2016.09.004. Epub 2016 Oct 5. Review.

PMID:
27720365
20.

Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: use of the multielectrode array as a screening strategy.

Shaban H, O'Connor R, Ovsepian SV, Dinan TG, Cryan JF, Schellekens H.

Drug Discov Today. 2017 Jan;22(1):31-42. doi: 10.1016/j.drudis.2016.09.003. Epub 2016 Sep 12. Review.

PMID:
27634341
21.

Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors.

Ovsepian SV, Blazquez-Llorca L, Freitag SV, Rodrigues EF, Herms J.

Cereb Cortex. 2017 Oct 1;27(10):4733-4749. doi: 10.1093/cercor/bhw267.

PMID:
27600841
22.

High-Resolution Multispectral Optoacoustic Tomography of the Vascularization and Constitutive Hypoxemia of Cancerous Tumors.

Chekkoury A, Nunes A, Gateau J, Symvoulidis P, Feuchtinger A, Beziere N, Ovsepian SV, Walch A, Ntziachristos V.

Neoplasia. 2016 Aug;18(8):459-67. doi: 10.1016/j.neo.2016.06.004.

23.

Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging.

Olefir I, Mercep E, Burton NC, Ovsepian SV, Ntziachristos V.

J Biomed Opt. 2016 Aug 1;21(8):86005. doi: 10.1117/1.JBO.21.8.086005.

PMID:
27533442
24.

Hybrid optical and acoustic resolution optoacoustic endoscopy.

He H, Wissmeyer G, Ovsepian SV, Buehler A, Ntziachristos V.

Opt Lett. 2016 Jun 15;41(12):2708-10. doi: 10.1364/OL.41.002708.

PMID:
27304269
25.

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease.

Ovsepian SV, LeBerre M, Steuber V, O'Leary VB, Leibold C, Oliver Dolly J.

Pharmacol Ther. 2016 Mar;159:93-101. doi: 10.1016/j.pharmthera.2016.01.005. Epub 2016 Jan 26. Review.

PMID:
26825872
26.

Neuronal activity and amyloid plaque pathology: an update.

Ovsepian SV, O'Leary VB.

J Alzheimers Dis. 2016;49(1):13-9. doi: 10.3233/JAD-150544. Review.

PMID:
26444792
27.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

PMID:
26322584
28.

Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission.

Ovsepian SV, O'Leary VB, Zaborszky L.

Neuroscientist. 2016 Jun;22(3):238-51. doi: 10.1177/1073858415588264. Epub 2015 May 22.

29.

PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation.

O'Leary VB, Ovsepian SV, Carrascosa LG, Buske FA, Radulovic V, Niyazi M, Moertl S, Trau M, Atkinson MJ, Anastasov N.

Cell Rep. 2015 Apr 21;11(3):474-85.

30.

Erratum to: Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments.

Ovsepian SV, Bodeker M, O'Leary VB, Lawrence GW, Oliver Dolly J.

Brain Struct Funct. 2015 May;220(3):1839. doi: 10.1007/s00429-015-1030-y. No abstract available.

PMID:
25794534
31.
32.

Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions.

Filser S, Ovsepian SV, Masana M, Blazquez-Llorca L, Brandt Elvang A, Volbracht C, Müller MB, Jung CK, Herms J.

Biol Psychiatry. 2015 Apr 15;77(8):729-39. doi: 10.1016/j.biopsych.2014.10.013. Epub 2014 Oct 29.

PMID:
25599931
33.

Wiring prior to firing: the evolutionary rise of electrical and chemical modes of synaptic transmission.

Ovsepian SV, Vesselkin NP.

Rev Neurosci. 2014;25(6):821-32. doi: 10.1515/revneuro-2014-0037. Review.

PMID:
25051277
34.

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin.

Ochs SM, Dorostkar MM, Aramuni G, Schön C, Filser S, Pöschl J, Kremer A, Van Leuven F, Ovsepian SV, Herms J.

Mol Psychiatry. 2015 Apr;20(4):482-9. doi: 10.1038/mp.2014.55. Epub 2014 Jun 10.

35.

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.

Neuner J, Ovsepian SV, Dorostkar M, Filser S, Gupta A, Michalakis S, Biel M, Herms J.

Nat Commun. 2014 May 28;5:3915. doi: 10.1038/ncomms4915.

36.

Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.

Bagchi B, Al-Sabi A, Kaza S, Scholz D, O'Leary VB, Dolly JO, Ovsepian SV.

PLoS One. 2014 Feb 3;9(2):e87736. doi: 10.1371/journal.pone.0087736. eCollection 2014.

37.

Cholinergic neurons-keeping check on amyloid β in the cerebral cortex.

Ovsepian SV, Herms J.

Front Cell Neurosci. 2013 Dec 11;7:252. doi: 10.3389/fncel.2013.00252. eCollection 2013.

38.

Improved lentiviral transduction of ALS motoneurons in vivo via dual targeting.

O'Leary VB, Ovsepian SV, Bodeker M, Dolly JO.

Mol Pharm. 2013 Nov 4;10(11):4195-206. doi: 10.1021/mp400247t. Epub 2013 Oct 11.

PMID:
24066863
39.

Drain of the brain: low-affinity p75 neurotrophin receptor affords a molecular sink for clearance of cortical amyloid β by the cholinergic modulator system.

Ovsepian SV, Herms J.

Neurobiol Aging. 2013 Nov;34(11):2517-24. doi: 10.1016/j.neurobiolaging.2013.05.005. Epub 2013 Jun 5. Review.

PMID:
23747048
40.

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons.

Ovsepian SV, Antyborzec I, O'Leary VB, Zaborszky L, Herms J, Oliver Dolly J.

Brain Struct Funct. 2014 Sep;219(5):1527-41. doi: 10.1007/s00429-013-0583-x. Epub 2013 May 29.

41.

Therapeutic effectiveness of botulinum neurotoxin A: potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25.

Lawrence GW, Ovsepian SV, Wang J, Aoki KR, Dolly JO.

Neuropharmacology. 2013 Jul;70:287-95. doi: 10.1016/j.neuropharm.2013.02.012. Epub 2013 Feb 26.

PMID:
23485402
42.

A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.

Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO.

J Physiol. 2013 Apr 1;591(7):1771-91. doi: 10.1113/jphysiol.2012.249706. Epub 2013 Jan 14.

43.

Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin.

Edupuganti OP, Ovsepian SV, Wang J, Zurawski TH, Schmidt JJ, Smith L, Lawrence GW, Dolly JO.

FEBS J. 2012 Jul;279(14):2555-67. doi: 10.1111/j.1742-4658.2012.08638.x. Epub 2012 Jun 14.

44.

Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain noncholinergic neurons.

Ovsepian SV, Dolly JO, Zaborszky L.

J Neurophysiol. 2012 Jul;108(2):406-18. doi: 10.1152/jn.00642.2011. Epub 2012 Apr 11.

45.

Dendritic SNAREs add a new twist to the old neuron theory.

Ovsepian SV, Dolly JO.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19113-20. doi: 10.1073/pnas.1017235108. Epub 2011 Nov 11. Review.

46.

Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission.

Lawrence GW, Ovsepian SV, Wang J, Aoki KR, Dolly JO.

Biochem J. 2012 Jan 1;441(1):443-52. doi: 10.1042/BJ20111117.

PMID:
21929507
47.

Innocuous full-length botulinum neurotoxin targets and promotes the expression of lentiviral vectors in central and autonomic neurons.

O'Leary VB, Ovsepian SV, Raghunath A, Huo Q, Lawrence GW, Smith L, Dolly JO.

Gene Ther. 2011 Jul;18(7):656-65. doi: 10.1038/gt.2011.8. Epub 2011 Mar 3.

PMID:
21368902
48.
50.

Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics.

Dolly JO, Lawrence GW, Meng J, Wang J, Ovsepian SV.

Curr Opin Pharmacol. 2009 Jun;9(3):326-35. doi: 10.1016/j.coph.2009.03.004. Epub 2009 Apr 23. Review.

PMID:
19394272

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