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Items: 21


Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer.

Lubbock ALR, Stewart GD, O'Mahony FC, Laird A, Mullen P, O'Donnell M, Powles T, Harrison DJ, Overton IM.

BMC Med. 2017 Jun 26;15(1):118. doi: 10.1186/s12916-017-0874-9.


Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.

Stewart GD, O'Mahony FC, Laird A, Eory L, Lubbock AL, Mackay A, Nanda J, O'Donnell M, Mullen P, McNeill SA, Riddick AC, Berney D, Bex A, Aitchison M, Overton IM, Harrison DJ, Powles T.

Clin Cancer Res. 2015 Sep 15;21(18):4212-23. doi: 10.1158/1078-0432.CCR-15-0207. Epub 2015 May 26.


Carbonic anhydrase 9 expression increases with vascular endothelial growth factor-targeted therapy and is predictive of outcome in metastatic clear cell renal cancer.

Stewart GD, O'Mahony FC, Laird A, Rashid S, Martin SA, Eory L, Lubbock AL, Nanda J, O'Donnell M, Mackay A, Mullen P, McNeill SA, Riddick AC, Aitchison M, Berney D, Bex A, Overton IM, Harrison DJ, Powles T.

Eur Urol. 2014 Nov;66(5):956-63. doi: 10.1016/j.eururo.2014.04.007. Epub 2014 May 10.


The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster.

Li X, Overton IM, Baines RA, Keegan LP, O'Connell MA.

Nucleic Acids Res. 2014 Jan;42(2):1139-51. doi: 10.1093/nar/gkt909. Epub 2013 Oct 16.


TMA Navigator: Network inference, patient stratification and survival analysis with tissue microarray data.

Lubbock AL, Katz E, Harrison DJ, Overton IM.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W562-8. doi: 10.1093/nar/gkt529. Epub 2013 Jun 12.


The use of reverse phase protein arrays (RPPA) to explore protein expression variation within individual renal cell cancers.

O'Mahony FC, Nanda J, Laird A, Mullen P, Caldwell H, Overton IM, Eory L, O'Donnell M, Faratian D, Powles T, Harrison DJ, Stewart GD.

J Vis Exp. 2013 Jan 22;(71). pii: 50221. doi: 10.3791/50221.


Addressing statistical biases in nucleotide-derived protein databases for proteogenomic search strategies.

Blakeley P, Overton IM, Hubbard SJ.

J Proteome Res. 2012 Nov 2;11(11):5221-34. doi: 10.1021/pr300411q. Epub 2012 Oct 15.


Computational approaches to selecting and optimising targets for structural biology.

Overton IM, Barton GJ.

Methods. 2011 Sep;55(1):3-11. doi: 10.1016/j.ymeth.2011.08.014. Epub 2011 Aug 27.


Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus.

Overton IM, Graham S, Gould KA, Hinds J, Botting CH, Shirran S, Barton GJ, Coote PJ.

BMC Syst Biol. 2011 May 12;5:68. doi: 10.1186/1752-0509-5-68.


XANNpred: neural nets that predict the propensity of a protein to yield diffraction-quality crystals.

Overton IM, van Niekerk CA, Barton GJ.

Proteins. 2011 Apr;79(4):1027-33. doi: 10.1002/prot.22914. Epub 2011 Jan 18.


The Scottish Structural Proteomics Facility: targets, methods and outputs.

Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, Kerou M, Weikart ND, Kadi N, Sheikh MA, Schmelz S, Dorward M, Zawadzki M, Cozens C, Falconer H, Powers H, Overton IM, van Niekerk CA, Peng X, Patel P, Garrett RA, Prangishvili D, Botting CH, Coote PJ, Dryden DT, Barton GJ, Schwarz-Linek U, Challis GL, Taylor GL, White MF, Naismith JH.

J Struct Funct Genomics. 2010 Jun;11(2):167-80. doi: 10.1007/s10969-010-9090-y. Epub 2010 Apr 24.


TarO: a target optimisation system for structural biology.

Overton IM, van Niekerk CA, Carter LG, Dawson A, Martin DM, Cameron S, McMahon SA, White MF, Hunter WN, Naismith JH, Barton GJ.

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W190-6. doi: 10.1093/nar/gkn141. Epub 2008 Apr 2.


ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction.

Overton IM, Padovani G, Girolami MA, Barton GJ.

Bioinformatics. 2008 Apr 1;24(7):901-7. doi: 10.1093/bioinformatics/btn055. Epub 2008 Feb 19.


Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase.

Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter L, Dorward M, Zawadzki M, Overton IM, van Niekirk CA, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ, Naismith JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt 5):452-6. Epub 2007 Apr 28.


The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.

Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ.

J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10.


Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase.

Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter L, Dorward M, Zawadzki M, Overton IM, van Niekirk CA, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ, Naismith JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):488-91. Epub 2007 May 5.


A normalised scale for structural genomics target ranking: the OB-Score.

Overton IM, Barton GJ.

FEBS Lett. 2006 Jul 10;580(16):4005-9. Epub 2006 Jun 16.


Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression.

Stewart-Jones GB, Gillespie G, Overton IM, Kaul R, Roche P, McMichael AJ, Rowland-Jones S, Jones EY.

J Immunol. 2005 Aug 15;175(4):2459-68.


A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms.

Wong GK, Liu B, Wang J, Zhang Y, Yang X, Zhang Z, Meng Q, Zhou J, Li D, Zhang J, Ni P, Li S, Ran L, Li H, Zhang J, Li R, Li S, Zheng H, Lin W, Li G, Wang X, Zhao W, Li J, Ye C, Dai M, Ruan J, Zhou Y, Li Y, He X, Zhang Y, Wang J, Huang X, Tong W, Chen J, Ye J, Chen C, Wei N, Li G, Dong L, Lan F, Sun Y, Zhang Z, Yang Z, Yu Y, Huang Y, He D, Xi Y, Wei D, Qi Q, Li W, Shi J, Wang M, Xie F, Wang J, Zhang X, Wang P, Zhao Y, Li N, Yang N, Dong W, Hu S, Zeng C, Zheng W, Hao B, Hillier LW, Yang SP, Warren WC, Wilson RK, Brandström M, Ellegren H, Crooijmans RP, van der Poel JJ, Bovenhuis H, Groenen MA, Ovcharenko I, Gordon L, Stubbs L, Lucas S, Glavina T, Aerts A, Kaiser P, Rothwell L, Young JR, Rogers S, Walker BA, van Hateren A, Kaufman J, Bumstead N, Lamont SJ, Zhou H, Hocking PM, Morrice D, de Koning DJ, Law A, Bartley N, Burt DW, Hunt H, Cheng HH, Gunnarsson U, Wahlberg P, Andersson L, Kindlund E, Tammi MT, Andersson B, Webber C, Ponting CP, Overton IM, Boardman PE, Tang H, Hubbard SJ, Wilson SA, Yu J, Wang J, Yang H; International Chicken Polymorphism Map Consortium.

Nature. 2004 Dec 9;432(7018):717-22.


Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags.

Hubbard SJ, Grafham DV, Beattie KJ, Overton IM, McLaren SR, Croning MD, Boardman PE, Bonfield JK, Burnside J, Davies RM, Farrell ER, Francis MD, Griffiths-Jones S, Humphray SJ, Hyland C, Scott CE, Tang H, Taylor RG, Tickle C, Brown WR, Birney E, Rogers J, Wilson SA.

Genome Res. 2005 Jan;15(1):174-83. Epub 2004 Dec 8.


A comprehensive collection of chicken cDNAs.

Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ.

Curr Biol. 2002 Nov 19;12(22):1965-9.

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