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Physician Time Spent Using the Electronic Health Record During Outpatient Encounters: A Descriptive Study.

Overhage JM, Jr DM.

Ann Intern Med. 2020 Jan 14. doi: 10.7326/M18-3684. [Epub ahead of print]


Technology-Enabled Clinical Trials: Transforming Medical Evidence Generation.

Marquis-Gravel G, Roe MT, Turakhia MP, Boden W, Temple R, Sharma A, Hirshberg B, Slater P, Craft N, Stockbridge N, McDowell B, Waldstreicher J, Bourla A, Bansilal S, Wong JL, Meunier C, Kassahun H, Coran P, Bataille L, Patrick-Lake B, Hirsch B, Reites J, Mehta R, Muse ED, Chandross KJ, Silverstein JC, Silcox C, Overhage JM, Califf RM, Peterson ED.

Circulation. 2019 Oct 22;140(17):1426-1436. doi: 10.1161/CIRCULATIONAHA.119.040798. Epub 2019 Oct 21.


A systematic comparison of contemporary automatic speech recognition engines for conversational clinical speech.

Kodish-Wachs J, Agassi E, Kenny P 3rd, Overhage JM.

AMIA Annu Symp Proc. 2018 Dec 5;2018:683-689. eCollection 2018.


Biomimetic 3D in vitro model of biofilm triggered osteomyelitis for investigating hematopoiesis during bone marrow infections.

Raic A, Riedel S, Kemmling E, Bieback K, Overhage J, Lee-Thedieck C.

Acta Biomater. 2018 Jun;73:250-262. doi: 10.1016/j.actbio.2018.04.024. Epub 2018 Apr 19.


Novel roles for two-component regulatory systems in cytotoxicity and virulence-related properties in Pseudomonas aeruginosa.

Gellatly SL, Bains M, Breidenstein EBM, Strehmel J, Reffuveille F, Taylor PK, Yeung ATY, Overhage J, Hancock REW.

AIMS Microbiol. 2018 Mar 8;4(1):173-191. doi: 10.3934/microbiol.2018.1.173. eCollection 2018.


Factors Influencing Progress of Health Information Exchange Organizations in the United States.

Overhage LM, Covich-Bordenick J, Li X, Overhage JM.

Stud Health Technol Inform. 2017;245:1236.


The Impact of Censoring Drug Switching in Medication Adherence Measures of Chronic Single Ingredient Oral Drugs.

Zhu VJ, Overhage JM, Ma Q, Ryan PB.

Stud Health Technol Inform. 2017;245:1200-1204.


The Oxidative Stress Agent Hypochlorite Stimulates c-di-GMP Synthesis and Biofilm Formation in Pseudomonas aeruginosa.

Strempel N, Nusser M, Neidig A, Brenner-Weiss G, Overhage J.

Front Microbiol. 2017 Nov 22;8:2311. doi: 10.3389/fmicb.2017.02311. eCollection 2017.


A new data processing routine facilitating the identification of surface adhered proteins from bacterial conditioning films via QCM-D/MALDI-ToF/MS.

Hohmann S, Neidig A, Kühl B, Kirschhöfer F, Overhage J, Brenner-Weiß G.

Anal Bioanal Chem. 2017 Oct;409(25):5965-5974. doi: 10.1007/s00216-017-0521-5. Epub 2017 Aug 11.


The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence.

Clamens T, Rosay T, Crépin A, Grandjean T, Kentache T, Hardouin J, Bortolotti P, Neidig A, Mooij M, Hillion M, Vieillard J, Cosette P, Overhage J, O'Gara F, Bouffartigues E, Dufour A, Chevalier S, Guery B, Cornelis P, Feuilloley MG, Lesouhaitier O.

Sci Rep. 2017 Jan 24;7:41178. doi: 10.1038/srep41178.


Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability.

Tettmann B, Niewerth C, Kirschhöfer F, Neidig A, Dötsch A, Brenner-Weiss G, Fetzner S, Overhage J.

Front Microbiol. 2016 Dec 9;7:1978. doi: 10.3389/fmicb.2016.01978. eCollection 2016.


Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa.

Krämer A, Herzer J, Overhage J, Meyer-Almes FJ.

BMC Biochem. 2016 Mar 9;17:4. doi: 10.1186/s12858-016-0063-z.


The absence of the Pseudomonas aeruginosa OprF protein leads to increased biofilm formation through variation in c-di-GMP level.

Bouffartigues E, Moscoso JA, Duchesne R, Rosay T, Fito-Boncompte L, Gicquel G, Maillot O, Bénard M, Bazire A, Brenner-Weiss G, Lesouhaitier O, Lerouge P, Dufour A, Orange N, Feuilloley MG, Overhage J, Filloux A, Chevalier S.

Front Microbiol. 2015 Jun 23;6:630. doi: 10.3389/fmicb.2015.00630. eCollection 2015.


Synergistic effect of membrane-active peptides polymyxin B and gramicidin S on multidrug-resistant strains and biofilms of Pseudomonas aeruginosa.

Berditsch M, Jäger T, Strempel N, Schwartz T, Overhage J, Ulrich AS.

Antimicrob Agents Chemother. 2015 Sep;59(9):5288-96. doi: 10.1128/AAC.00682-15. Epub 2015 Jun 15.


Ambulatory Computerized Prescribing and Preventable Adverse Drug Events.

Overhage JM, Gandhi TK, Hope C, Seger AC, Murray MD, Orav EJ, Bates DW.

J Patient Saf. 2016 Jun;12(2):69-74. doi: 10.1097/PTS.0000000000000194.


Authors' reply to Hennessy and Leonard's comment on "Desideratum for evidence-based epidemiology".

Overhage JM, Ryan PB, Schuemie MJ, Stang PE.

Drug Saf. 2015 Jan;38(1):105-7. doi: 10.1007/s40264-014-0254-8. No abstract available.


Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.

Strehmel J, Neidig A, Nusser M, Geffers R, Brenner-Weiss G, Overhage J.

Appl Environ Microbiol. 2015 Feb;81(4):1274-85.


Potential application of antimicrobial peptides in the treatment of bacterial biofilm infections.

Strempel N, Strehmel J, Overhage J.

Curr Pharm Des. 2015;21(1):67-84. Review.


Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest.

Boyce RD, Ryan PB, Norén GN, Schuemie MJ, Reich C, Duke J, Tatonetti NP, Trifirò G, Harpaz R, Overhage JM, Hartzema AG, Khayter M, Voss EA, Lambert CG, Huser V, Dumontier M.

Drug Saf. 2014 Aug;37(8):557-67. doi: 10.1007/s40264-014-0189-0.


Interaction of human plasma proteins with thin gelatin-based hydrogel films: a QCM-D and ToF-SIMS study.

Schönwälder SM, Bally F, Heinke L, Azucena C, Bulut ÖD, Heißler S, Kirschhöfer F, Gebauer TP, Neffe AT, Lendlein A, Brenner-Weiß G, Lahann J, Welle A, Overhage J, Wöll C.

Biomacromolecules. 2014 Jul 14;15(7):2398-406. doi: 10.1021/bm500750v. Epub 2014 Jul 2.


Knockout of extracytoplasmic function sigma factor ECF-10 affects stress resistance and biofilm formation in Pseudomonas putida KT2440.

Tettmann B, Dötsch A, Armant O, Fjell CD, Overhage J.

Appl Environ Microbiol. 2014 Aug;80(16):4911-9. doi: 10.1128/AEM.01291-14. Epub 2014 Jun 6.


The Pseudomonas quinolone signal (PQS) stimulates chemotaxis of polymorphonuclear neutrophils.

Hänsch GM, Prior B, Brenner-Weiss G, Obst U, Overhage J.

J Appl Biomater Funct Mater. 2014 Jun 12;12(1):21-6. doi: 10.5301/jabfm.5000204.


Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.

Yeung AT, Janot L, Pena OM, Neidig A, Kukavica-Ibrulj I, Hilchie A, Levesque RC, Overhage J, Hancock RE.

Infect Immun. 2014 Mar;82(3):1256-67. doi: 10.1128/IAI.01527-13. Epub 2013 Dec 30.


A Comparison of Data Driven-based Measures of Adherence to Oral Hypoglycemic Agents in Medicaid Patients.

Zhu VJ, Tu W, Rosenman MB, Overhage JM.

AMIA Annu Symp Proc. 2014 Nov 14;2014:1294-301. eCollection 2014.


Human host defense peptide LL-37 stimulates virulence factor production and adaptive resistance in Pseudomonas aeruginosa.

Strempel N, Neidig A, Nusser M, Geffers R, Vieillard J, Lesouhaitier O, Brenner-Weiss G, Overhage J.

PLoS One. 2013 Dec 13;8(12):e82240. doi: 10.1371/journal.pone.0082240. eCollection 2013.


Fabrication of highly uniform gel coatings by the conversion of surface-anchored metal-organic frameworks.

Tsotsalas M, Liu J, Tettmann B, Grosjean S, Shahnas A, Wang Z, Azucena C, Addicoat M, Heine T, Lahann J, Overhage J, Bräse S, Gliemann H, Wöll C.

J Am Chem Soc. 2014 Jan 8;136(1):8-11. doi: 10.1021/ja409205s. Epub 2013 Dec 16.


A comparison of the empirical performance of methods for a risk identification system.

Ryan PB, Stang PE, Overhage JM, Suchard MA, Hartzema AG, DuMouchel W, Reich CG, Schuemie MJ, Madigan D.

Drug Saf. 2013 Oct;36 Suppl 1:S143-58. doi: 10.1007/s40264-013-0108-9.


Managing data quality for a drug safety surveillance system.

Hartzema AG, Reich CG, Ryan PB, Stang PE, Madigan D, Welebob E, Overhage JM.

Drug Saf. 2013 Oct;36 Suppl 1:S49-58. doi: 10.1007/s40264-013-0098-7.


Variation in choice of study design: findings from the Epidemiology Design Decision Inventory and Evaluation (EDDIE) survey.

Stang PE, Ryan PB, Overhage JM, Schuemie MJ, Hartzema AG, Welebob E.

Drug Saf. 2013 Oct;36 Suppl 1:S15-25. doi: 10.1007/s40264-013-0103-1.


Desideratum for evidence based epidemiology.

Overhage JM, Ryan PB, Schuemie MJ, Stang PE.

Drug Saf. 2013 Oct;36 Suppl 1:S5-14. doi: 10.1007/s40264-013-0102-2. Review.


Evaluating the impact of database heterogeneity on observational study results.

Madigan D, Ryan PB, Schuemie M, Stang PE, Overhage JM, Hartzema AG, Suchard MA, DuMouchel W, Berlin JA.

Am J Epidemiol. 2013 Aug 15;178(4):645-51. doi: 10.1093/aje/kwt010. Epub 2013 May 5.


A regional informatics platform for coordinated antibiotic-resistant infection tracking, alerting, and prevention.

Kho AN, Doebbeling BN, Cashy JP, Rosenman MB, Dexter PR, Shepherd DC, Lemmon L, Teal E, Khokar S, Overhage JM.

Clin Infect Dis. 2013 Jul;57(2):254-62. doi: 10.1093/cid/cit229. Epub 2013 Apr 10.


TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa.

Neidig A, Yeung AT, Rosay T, Tettmann B, Strempel N, Rueger M, Lesouhaitier O, Overhage J.

BMC Microbiol. 2013 Apr 9;13:77. doi: 10.1186/1471-2180-13-77.


The role of healthcare IT: becoming a learning organization.

Glaser J, Overhage JM.

Healthc Financ Manage. 2013 Feb;67(2):56-62, 64.


Enhancing patient safety and quality of care by improving the usability of electronic health record systems: recommendations from AMIA.

Middleton B, Bloomrosen M, Dente MA, Hashmat B, Koppel R, Overhage JM, Payne TH, Rosenbloom ST, Weaver C, Zhang J; American Medical Informatics Association.

J Am Med Inform Assoc. 2013 Jun;20(e1):e2-8. doi: 10.1136/amiajnl-2012-001458. Epub 2013 Jan 25.


Online disease management of diabetes: engaging and motivating patients online with enhanced resources-diabetes (EMPOWER-D), a randomized controlled trial.

Tang PC, Overhage JM, Chan AS, Brown NL, Aghighi B, Entwistle MP, Hui SL, Hyde SM, Klieman LH, Mitchell CJ, Perkins AJ, Qureshi LS, Waltimyer TA, Winters LJ, Young CY.

J Am Med Inform Assoc. 2013 May 1;20(3):526-34. doi: 10.1136/amiajnl-2012-001263. Epub 2012 Nov 20.


The Lon protease is essential for full virulence in Pseudomonas aeruginosa.

Breidenstein EB, Janot L, Strehmel J, Fernandez L, Taylor PK, Kukavica-Ibrulj I, Gellatly SL, Levesque RC, Overhage J, Hancock RE.

PLoS One. 2012;7(11):e49123. doi: 10.1371/journal.pone.0049123. Epub 2012 Nov 7.


Empirical assessment of methods for risk identification in healthcare data: results from the experiments of the Observational Medical Outcomes Partnership.

Ryan PB, Madigan D, Stang PE, Overhage JM, Racoosin JA, Hartzema AG.

Stat Med. 2012 Dec 30;31(30):4401-15. doi: 10.1002/sim.5620. Epub 2012 Sep 27.


Data for drugs available through low-cost prescription drug programs are available through pharmacy benefit manager and claims data.

Zhu VJ, Belsito A, Tu W, Overhage JM.

BMC Clin Pharmacol. 2012 Jun 22;12:12. doi: 10.1186/1472-6904-12-12.


Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung.

Breen EC, Malloy JL, Tang K, Xia F, Fu Z, Hancock RE, Overhage J, Wagner PD, Spragg RG.

J Cell Physiol. 2013 Feb;228(2):371-9. doi: 10.1002/jcp.24140.


Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1).

Kahle NA, Brenner-Weiss G, Overhage J, Obst U, Hänsch GM.

Immunobiology. 2013 Feb;218(2):145-51. doi: 10.1016/j.imbio.2012.02.004. Epub 2012 Feb 14.


Race and medication adherence and glycemic control: findings from an operational health information exchange.

Zhu VJ, Tu W, Marrero DG, Rosenman MB, Overhage JM.

AMIA Annu Symp Proc. 2011;2011:1649-57. Epub 2011 Oct 22.


Variability in drug formularies and implications in decision support.

Stephens MJ, Finnell JT, Simonaitis L, Overhage JM.

AMIA Annu Symp Proc. 2011;2011:1327-36. Epub 2011 Oct 22.


All health care is not local: an evaluation of the distribution of Emergency Department care delivered in Indiana.

Finnell JT, Overhage JM, Grannis S.

AMIA Annu Symp Proc. 2011;2011:409-16. Epub 2011 Oct 22.


An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa.

Zaoui C, Overhage J, Löns D, Zimmermann A, Müsken M, Bielecki P, Pustelny C, Becker T, Nimtz M, Häussler S.

Mol Microbiol. 2012 Feb;83(3):536-47. doi: 10.1111/j.1365-2958.2011.07947.x. Epub 2012 Jan 3.


Genotyping of environmental and clinical Stenotrophomonas maltophilia isolates and their pathogenic potential.

Adamek M, Overhage J, Bathe S, Winter J, Fischer R, Schwartz T.

PLoS One. 2011;6(11):e27615. doi: 10.1371/journal.pone.0027615. Epub 2011 Nov 15.


Validation of a common data model for active safety surveillance research.

Overhage JM, Ryan PB, Reich CG, Hartzema AG, Stang PE.

J Am Med Inform Assoc. 2012 Jan-Feb;19(1):54-60. doi: 10.1136/amiajnl-2011-000376. Epub 2011 Oct 28.


Sensible use of observational clinical data.

Overhage JM, Overhage LM.

Stat Methods Med Res. 2013 Feb;22(1):7-13. doi: 10.1177/0962280211403598. Epub 2011 Aug 9.


Facilitating Clinical Research through the Health Information Exchange: Lipid Control as an Example.

Zhu VJ, Tu W, Rosenman MB, Overhage JM.

AMIA Annu Symp Proc. 2010 Nov 13;2010:947-51.

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