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Items: 1 to 50 of 54


Water content, not stiffness, dominates Brillouin spectroscopy measurements in hydrated materials.

Wu PJ, Kabakova IV, Ruberti JW, Sherwood JM, Dunlop IE, Paterson C, Török P, Overby DR.

Nat Methods. 2018 Aug;15(8):561-562. doi: 10.1038/s41592-018-0076-1. No abstract available.


Effect of phacoemulsification on facility of outflow.

Alaghband P, Beltran-Agulló L, Galvis EA, Overby DR, Lim KS.

Br J Ophthalmol. 2018 Nov;102(11):1520-1526. doi: 10.1136/bjophthalmol-2017-311548. Epub 2018 Apr 13.


Pharmacological regulation of outflow resistance distal to Schlemm's canal.

McDonnell F, Dismuke WM, Overby DR, Stamer WD.

Am J Physiol Cell Physiol. 2018 Jul 1;315(1):C44-C51. doi: 10.1152/ajpcell.00024.2018. Epub 2018 Apr 6.


Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.

Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD.

Exp Eye Res. 2018 Jun;171:164-173. doi: 10.1016/j.exer.2018.03.001. Epub 2018 Mar 9. Review.


Quantification of Scleral Biomechanics and Collagen Fiber Alignment.

Campbell IC, Sherwood JM, Overby DR, Hannon BG, Read AT, Raykin J, Ethier CR.

Methods Mol Biol. 2018;1695:135-159. doi: 10.1007/978-1-4939-7407-8_13.


Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents.

Roy Chowdhury U, Rinkoski TA, Bahler CK, Millar JC, Bertrand JA, Holman BH, Sherwood JM, Overby DR, Stoltz KL, Dosa PI, Fautsch MP.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5731-5742. doi: 10.1167/iovs.17-22538.


Direct measurement of pressure-independent aqueous humour flow using iPerfusion.

Madekurozwa M, Reina-Torres E, Overby DR, Sherwood JM.

Exp Eye Res. 2017 Sep;162:129-138. doi: 10.1016/j.exer.2017.07.008. Epub 2017 Jul 16.


Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration.

Chang JYH, Chow LW, Dismuke WM, Ethier CR, Stevens MM, Stamer WD, Overby DR.

Adv Healthc Mater. 2017 Aug;6(16). doi: 10.1002/adhm.201700383. Epub 2017 May 17.


VEGF as a Paracrine Regulator of Conventional Outflow Facility.

Reina-Torres E, Wen JC, Liu KC, Li G, Sherwood JM, Chang JY, Challa P, Flügel-Koch CM, Stamer WD, Allingham RR, Overby DR.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1899-1908. doi: 10.1167/iovs.16-20779. Erratum in: Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2817.


Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.

Wen JC, Reina-Torres E, Sherwood JM, Challa P, Liu KC, Li G, Chang JY, Cousins SW, Schuman SG, Mettu PS, Stamer WD, Overby DR, Allingham RR.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1893-1898. doi: 10.1167/iovs.16-20786. Erratum in: Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2816.


Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.

Chandrawati R, Chang JYH, Reina-Torres E, Jumeaux C, Sherwood JM, Stamer WD, Zelikin AN, Overby DR, Stevens MM.

Adv Mater. 2017 Apr;29(16). doi: 10.1002/adma.201604932. Epub 2017 Feb 21.


Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.

O'Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Stamer WD, Overby DR, O'Brien C, Tam LCS, Humphries P.

Hum Mol Genet. 2017 Apr 1;26(7):1230-1246. doi: 10.1093/hmg/ddx028.


Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.

Tam LC, Reina-Torres E, Sherwood JM, Cassidy PS, Crosbie DE, Lütjen-Drecoll E, Flügel-Koch C, Perkumas K, Humphries MM, Kiang AS, O'Callaghan J, Callanan JJ, Read AT, Ethier CR, O'Brien C, Lawrence M, Campbell M, Stamer WD, Overby DR, Humphries P.

Sci Rep. 2017 Jan 16;7:40717. doi: 10.1038/srep40717.


The Value of Mouse Models for Glaucoma Drug Discovery.

Dismuke WM, Overby DR, Civan MM, Stamer WD.

J Ocul Pharmacol Ther. 2016 Oct;32(8):486-487. Epub 2016 Mar 16. No abstract available.


Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes.

Li G, Mukherjee D, Navarro I, Ashpole NE, Sherwood JM, Chang J, Overby DR, Yuan F, Gonzalez P, Kopczynski CC, Farsiu S, Stamer WD.

Eur J Pharmacol. 2016 Sep 15;787:20-31. doi: 10.1016/j.ejphar.2016.04.002. Epub 2016 Apr 13.


Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop.

Martella A, Silvestri C, Maradonna F, Gioacchini G, Allarà M, Radaelli G, Overby DR, Di Marzo V, Carnevali O.

Endocrinology. 2016 May;157(5):1751-63. doi: 10.1210/en.2015-1384. Epub 2016 Mar 25.


Measurement of Outflow Facility Using iPerfusion.

Sherwood JM, Reina-Torres E, Bertrand JA, Rowe B, Overby DR.

PLoS One. 2016 Mar 7;11(3):e0150694. doi: 10.1371/journal.pone.0150694. eCollection 2016.


Unconventional aqueous humor outflow: A review.

Johnson M, McLaren JW, Overby DR.

Exp Eye Res. 2017 May;158:94-111. doi: 10.1016/j.exer.2016.01.017. Epub 2016 Feb 2. Review.


Physical Factors Affecting Outflow Facility Measurements in Mice.

Boussommier-Calleja A, Li G, Wilson A, Ziskind T, Scinteie OE, Ashpole NE, Sherwood JM, Farsiu S, Challa P, Gonzalez P, Downs JC, Ethier CR, Stamer WD, Overby DR.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8331-9. doi: 10.1167/iovs.15-17106.


Transport across Schlemm's canal endothelium and the blood-aqueous barrier.

Braakman ST, Moore JE Jr, Ethier CR, Overby DR.

Exp Eye Res. 2016 May;146:17-21. doi: 10.1016/j.exer.2015.11.026. Epub 2015 Dec 13. Review.


Animal models of glucocorticoid-induced glaucoma.

Overby DR, Clark AF.

Exp Eye Res. 2015 Dec;141:15-22. doi: 10.1016/j.exer.2015.06.002. Epub 2015 Jun 4. Review.


Role of nitric oxide in murine conventional outflow physiology.

Chang JY, Stamer WD, Bertrand J, Read AT, Marando CM, Ethier CR, Overby DR.

Am J Physiol Cell Physiol. 2015 Aug 15;309(4):C205-14. doi: 10.1152/ajpcell.00347.2014. Epub 2015 Jun 3.


Colocalization of outflow segmentation and pores along the inner wall of Schlemm's canal.

Braakman ST, Read AT, Chan DW, Ethier CR, Overby DR.

Exp Eye Res. 2015 Jan;130:87-96. doi: 10.1016/j.exer.2014.11.008. Epub 2014 Nov 13.


Shear stress-triggered nitric oxide release from Schlemm's canal cells.

Ashpole NE, Overby DR, Ethier CR, Stamer WD.

Invest Ophthalmol Vis Sci. 2014 Nov 13;55(12):8067-76. doi: 10.1167/iovs.14-14722.


Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction.

Stamer WD, Braakman ST, Zhou EH, Ethier CR, Fredberg JJ, Overby DR, Johnson M.

Prog Retin Eye Res. 2015 Jan;44:86-98. doi: 10.1016/j.preteyeres.2014.08.002. Epub 2014 Sep 16. Review.


Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma.

Overby DR, Zhou EH, Vargas-Pinto R, Pedrigi RM, Fuchshofer R, Braakman ST, Gupta R, Perkumas KM, Sherwood JM, Vahabikashi A, Dang Q, Kim JH, Ethier CR, Stamer WD, Fredberg JJ, Johnson M.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13876-81. doi: 10.1073/pnas.1410602111. Epub 2014 Sep 8.


Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells.

Braakman ST, Pedrigi RM, Read AT, Smith JA, Stamer WD, Ethier CR, Overby DR.

Exp Eye Res. 2014 Oct;127:224-35. doi: 10.1016/j.exer.2014.08.003. Epub 2014 Aug 14.


Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice.

Overby DR, Bertrand J, Tektas OY, Boussommier-Calleja A, Schicht M, Ethier CR, Woodward DF, Stamer WD, Lütjen-Drecoll E.

Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):4922-33. doi: 10.1167/iovs.14-14429.


The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice.

Overby DR, Bertrand J, Schicht M, Paulsen F, Stamer WD, Lütjen-Drecoll E.

Invest Ophthalmol Vis Sci. 2014 May 15;55(6):3727-36. doi: 10.1167/iovs.13-13699.


Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT.

Li G, Farsiu S, Chiu SJ, Gonzalez P, Lütjen-Drecoll E, Overby DR, Stamer WD.

Invest Ophthalmol Vis Sci. 2014 Mar 4;55(6):3737-46. doi: 10.1167/iovs.13-13700.


Stimulation of chondrogenic differentiation of adult human bone marrow-derived stromal cells by a moderate-strength static magnetic field.

Amin HD, Brady MA, St-Pierre JP, Stevens MM, Overby DR, Ethier CR.

Tissue Eng Part A. 2014 Jun;20(11-12):1612-20. doi: 10.1089/ten.tea.2013.0307. Epub 2014 Feb 7.


Multi-scale analysis of segmental outflow patterns in human trabecular meshwork with changing intraocular pressure.

Chang JY, Folz SJ, Laryea SN, Overby DR.

J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):213-23. doi: 10.1089/jop.2013.0182. Epub 2014 Jan 23.


Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility.

Dismuke WM, Liang J, Overby DR, Stamer WD.

Exp Eye Res. 2014 Mar;120:28-35. doi: 10.1016/j.exer.2013.12.012. Epub 2013 Dec 27.


The influence of genetic background on conventional outflow facility in mice.

Boussommier-Calleja A, Overby DR.

Invest Ophthalmol Vis Sci. 2013 Dec 19;54(13):8251-8. doi: 10.1167/iovs.13-13025.


The design and development of a high-throughput magneto-mechanostimulation device for cartilage tissue engineering.

Brady MA, Vaze R, Amin HD, Overby DR, Ethier CR.

Tissue Eng Part C Methods. 2014 Feb;20(2):149-59. doi: 10.1089/ten.TEC.2013.0225. Epub 2013 Jul 18.


Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes.

Boussommier-Calleja A, Bertrand J, Woodward DF, Ethier CR, Stamer WD, Overby DR.

Invest Ophthalmol Vis Sci. 2012 Aug 24;53(9):5838-45. doi: 10.1167/iovs.12-9923.


Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography.

Francis AW, Kagemann L, Wollstein G, Ishikawa H, Folz S, Overby DR, Sigal IA, Wang B, Schuman JS.

Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5198-207. doi: 10.1167/iovs.11-9229.


eNOS, a pressure-dependent regulator of intraocular pressure.

Stamer WD, Lei Y, Boussommier-Calleja A, Overby DR, Ethier CR.

Invest Ophthalmol Vis Sci. 2011 Dec 9;52(13):9438-44. doi: 10.1167/iovs.11-7839.


In vitro models for glaucoma research: effects of hydrostatic pressure.

Lei Y, Rajabi S, Pedrigi RM, Overby DR, Read AT, Ethier CR.

Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6329-39. doi: 10.1167/iovs.11-7836.


Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia.

VanderWyst SS, Perkumas KM, Read AT, Overby DR, Stamer WD.

Mol Vis. 2011 Jan 19;17:199-209.


Outflow physiology of the mouse eye: pressure dependence and washout.

Lei Y, Overby DR, Boussommier-Calleja A, Stamer WD, Ethier CR.

Invest Ophthalmol Vis Sci. 2011 Mar 29;52(3):1865-71. doi: 10.1167/iovs.10-6019. Print 2011 Mar.


A model of giant vacuole dynamics in human Schlemm's canal endothelial cells.

Pedrigi RM, Simon D, Reed A, Stamer WD, Overby DR.

Exp Eye Res. 2011 Jan;92(1):57-66. doi: 10.1016/j.exer.2010.11.003. Epub 2010 Nov 12.


Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins.

Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE.

Integr Biol (Camb). 2010 Sep;2(9):435-42. doi: 10.1039/c0ib00034e. Epub 2010 Aug 20.


A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium.

Lei Y, Overby DR, Read AT, Stamer WD, Ethier CR.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5744-50. doi: 10.1167/iovs.10-5703. Epub 2010 Jun 16.


The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium.

Overby DR, Stamer WD, Johnson M.

Exp Eye Res. 2009 Apr;88(4):656-70. doi: 10.1016/j.exer.2008.11.033. Epub 2008 Dec 11. Review.


Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes.

Battista SA, Lu Z, Hofmann S, Freddo T, Overby DR, Gong H.

Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5346-52. doi: 10.1167/iovs.08-1707. Epub 2008 May 30.


The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes.

Lu Z, Overby DR, Scott PA, Freddo TF, Gong H.

Exp Eye Res. 2008 Feb;86(2):271-81. Epub 2007 Nov 5.


Comparative studies between species that do and do not exhibit the washout effect.

Scott PA, Overby DR, Freddo TF, Gong H.

Exp Eye Res. 2007 Mar;84(3):435-43. Epub 2006 Dec 13.


Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry.

Overby DR, Matthews BD, Alsberg E, Ingber DE.

Acta Biomater. 2005 May;1(3):295-303. Epub 2005 Mar 31.


Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels.

Matthews BD, Overby DR, Mannix R, Ingber DE.

J Cell Sci. 2006 Feb 1;119(Pt 3):508-18.

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