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Fostering improved human islet research: a European perspective.

Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M.

Diabetologia. 2019 Aug;62(8):1514-1516. doi: 10.1007/s00125-019-4911-4. Epub 2019 Jun 13. No abstract available.


Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.

Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, Overbergh L.

Cell Death Dis. 2019 Apr 5;10(4):309. doi: 10.1038/s41419-019-1518-0.


Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes.

Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L.

Diabetes. 2018 Nov;67(11):2337-2348. doi: 10.2337/db18-0295.


At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice.

Vangoitsenhoven R, van der Ende M, Corbeels K, Monteiro Carvalho Mori Cunha JP, Lannoo M, Bedossa P, van der Merwe S, Mertens A, Gesquiere I, Meulemans A, Matthys C, Mathieu C, Overbergh L, Van der Schueren B.

PLoS One. 2018 Jul 23;13(7):e0200779. doi: 10.1371/journal.pone.0200779. eCollection 2018.


Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Aug 4;23(8):1004. doi: 10.1038/nm0817-1004a. No abstract available.


Understanding type 1 diabetes through proteomics.

Crèvecoeur I, Vig S, Mathieu C, Overbergh L.

Expert Rev Proteomics. 2017 Jul;14(7):571-580. doi: 10.1080/14789450.2017.1345633. Epub 2017 Jun 28. Review.


Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Feb 7;23(2):264. doi: 10.1038/nm0217-264a. No abstract available.


Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis.

Crèvecoeur I, Gudmundsdottir V, Vig S, Marques Câmara Sodré F, D'Hertog W, Fierro AC, Van Lommel L, Gysemans C, Marchal K, Waelkens E, Schuit F, Brunak S, Overbergh L, Mathieu C.

Diabetologia. 2017 Mar;60(3):475-489. doi: 10.1007/s00125-016-4191-1. Epub 2017 Jan 12.


Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31. Erratum in: Nat Med. 2017 Feb 7;23 (2):264. Nat Med. 2017 Aug 4;23 (8):1004.


Human multipotent adult progenitor cells enhance islet function and revascularisation when co-transplanted as a composite pellet in a mouse model of diabetes.

Cunha JP, Leuckx G, Sterkendries P, Korf H, Bomfim-Ferreira G, Overbergh L, Vaes B, Heimberg H, Gysemans C, Mathieu C.

Diabetologia. 2017 Jan;60(1):134-142. Epub 2016 Oct 4.


Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, Di Marino D, Carr EJ, Oskolkov N, Lyssenko V, Franckaert D, Lagou V, Overbergh L, Vandenbussche J, Allemeersch J, Chabot-Roy G, Dahlstrom JE, Laybutt DR, Petrovsky N, Socha L, Gevaert K, Jetten AM, Lambrechts D, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM, Liston A.

Nat Genet. 2016 May;48(5):519-27. doi: 10.1038/ng.3531. Epub 2016 Mar 21.


Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice.

Vangoitsenhoven R, Wolden-Kirk H, Lemaire K, Verstuyf A, Verlinden L, Yamamoto Y, Kato S, Van Lommel L, Schuit F, Van der Schueren B, Mathieu C, Overbergh L.

J Steroid Biochem Mol Biol. 2016 Nov;164:309-317. doi: 10.1016/j.jsbmb.2016.02.011. Epub 2016 Feb 11.


Leptin-adiponectin ratio in pre-diabetic patients undergoing percutaneous coronary intervention.

Nguyen PA, Heggermont WA, Vanhaverbeke M, Dubois C, Vydt T, Vörös G, Van Der Schueren B, Overbergh L, Mathieu C, Desmet W, Sinnaeve PR.

Acta Cardiol. 2015 Dec;70(6):640-6. doi: 10.2143/AC.70.6.3120175.


Dendritic cell metabolism: immunity and tolerance.

Vanherwegen AS, Gysemans C, Overbergh L.

Oncotarget. 2015 Oct 27;6(33):34039-40. doi: 10.18632/oncotarget.5865. No abstract available.


The phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3.

Vanherwegen AS, Ferreira GB, Smeets E, Yamamoto Y, Kato S, Overbergh L, Gysemans C, Mathieu C.

J Steroid Biochem Mol Biol. 2016 Nov;164:239-245. doi: 10.1016/j.jsbmb.2015.08.010. Epub 2015 Sep 4.


Cereulide food toxin, beta cell function and diabetes: Facts and hypotheses.

Vangoitsenhoven R, Maris M, Overbergh L, Van Loco J, Mathieu C, Van der Schueren B.

Diabetes Res Clin Pract. 2015 Jul;109(1):1-5. doi: 10.1016/j.diabres.2015.04.029. Epub 2015 May 6. Review.


A proteomic study of the regulatory role for STAT-1 in cytokine-induced beta-cell death.

Rondas D, Gudmundsdottir V, D'Hertog W, Crèvecoeur I, Waelkens E, Brunak S, Mathieu C, Overbergh L.

Proteomics Clin Appl. 2015 Oct;9(9-10):938-52. doi: 10.1002/prca.201400124. Epub 2015 Apr 11.


Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.

Ferreira GB, Vanherwegen AS, Eelen G, Gutiérrez ACF, Van Lommel L, Marchal K, Verlinden L, Verstuyf A, Nogueira T, Georgiadou M, Schuit F, Eizirik DL, Gysemans C, Carmeliet P, Overbergh L, Mathieu C.

Cell Rep. 2015 Feb 10;10(5):711-725. doi: 10.1016/j.celrep.2015.01.013. Epub 2015 Feb 7.


The beta-cell in type 1 diabetes: What have we learned from proteomic studies?

Crèvecoeur I, Rondas D, Mathieu C, Overbergh L.

Proteomics Clin Appl. 2015 Aug;9(7-8):755-66. doi: 10.1002/prca.201400135. Epub 2015 Mar 26. Review.


Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.

Rondas D, Crèvecoeur I, D'Hertog W, Ferreira GB, Staes A, Garg AD, Eizirik DL, Agostinis P, Gevaert K, Overbergh L, Mathieu C.

Diabetes. 2015 Feb;64(2):573-86. doi: 10.2337/db14-0621. Epub 2014 Sep 9.


Foodborne cereulide causes beta-cell dysfunction and apoptosis.

Vangoitsenhoven R, Rondas D, Crèvecoeur I, D'Hertog W, Baatsen P, Masini M, Andjelkovic M, Van Loco J, Matthys C, Mathieu C, Overbergh L, Van der Schueren B.

PLoS One. 2014 Aug 13;9(8):e104866. doi: 10.1371/journal.pone.0104866. eCollection 2014.


1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.

Ferreira GB, Gysemans CA, Demengeot J, da Cunha JP, Vanherwegen AS, Overbergh L, Van Belle TL, Pauwels F, Verstuyf A, Korf H, Mathieu C.

J Immunol. 2014 May 1;192(9):4210-20. doi: 10.4049/jimmunol.1302350. Epub 2014 Mar 24.


PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B.

Science. 2014 Apr 11;344(6180):203-7. doi: 10.1126/science.1249161. Epub 2014 Mar 20.


The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.

Wali JA, Rondas D, McKenzie MD, Zhao Y, Elkerbout L, Fynch S, Gurzov EN, Akira S, Mathieu C, Kay TW, Overbergh L, Strasser A, Thomas HE.

Cell Death Dis. 2014 Mar 13;5:e1124. doi: 10.1038/cddis.2014.88.


Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans.

Wolden-Kirk H, Rondas D, Bugliani M, Korf H, Van Lommel L, Brusgaard K, Christesen HT, Schuit F, Proost P, Masini M, Marchetti P, Eizirik DL, Overbergh L, Mathieu C.

Endocrinology. 2014 Mar;155(3):736-47. doi: 10.1210/en.2013-1409. Epub 2014 Jan 1.


IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.

Grieco FA, Moore F, Vigneron F, Santin I, Villate O, Marselli L, Rondas D, Korf H, Overbergh L, Dotta F, Marchetti P, Mathieu C, Eizirik DL.

Diabetologia. 2014 Mar;57(3):502-11. doi: 10.1007/s00125-013-3135-2. Epub 2013 Dec 19.


A proteomic approach on the effects of TX527, a 1α,25-dihydroxyvitamin D3 analog, in human T lymphocytes.

Ferreira GB, Baeke F, Verstuyf A, De Clercq P, Waelkens E, Mathieu C, Overbergh L.

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:96-101. doi: 10.1016/j.jsbmb.2013.10.013. Epub 2013 Oct 28.


Glucagon-like peptide-1: modulator of β-cell dysfunction and death.

Rondas D, D'Hertog W, Overbergh L, Mathieu C.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:185-92. doi: 10.1111/dom.12165. Review.


Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: a proteomic study of the pathways involved.

Rondas D, Bugliani M, D'Hertog W, Lage K, Masini M, Waelkens E, Marchetti P, Mathieu C, Overbergh L.

J Proteome Res. 2013 Sep 6;12(9):4193-206. doi: 10.1021/pr400527q. Epub 2013 Aug 26.


Functional studies and proteomics in platelets and fibroblasts reveal a lysosomal defect with increased cathepsin-dependent apoptosis in ATP1A3 defective alternating hemiplegia of childhood.

Di Michele M, Goubau C, Waelkens E, Thys C, De Vos R, Overbergh L, Schyns T, Buyse G, Casaer P, Van Geet C, Freson K.

J Proteomics. 2013 Jun 28;86:53-69. doi: 10.1016/j.jprot.2013.05.005. Epub 2013 May 13.


Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes.

Viaene L, Evenepoel P, Meijers B, Vanderschueren D, Overbergh L, Mathieu C.

Am J Nephrol. 2012;36(6):497-508. doi: 10.1159/000345146. Epub 2012 Nov 16.


Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction.

Maris M, Robert S, Waelkens E, Derua R, Hernangomez MH, D'Hertog W, Cnop M, Mathieu C, Overbergh L.

J Proteome Res. 2013 Jan 4;12(1):347-62. doi: 10.1021/pr300596g. Epub 2012 Dec 4.


Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets.

Wolden-Kirk H, Overbergh L, Gysemans C, Brusgaard K, Naamane N, Van Lommel L, Schuit F, Eizirik DL, Christesen H, Mathieu C.

J Steroid Biochem Mol Biol. 2013 Jul;136:68-79. doi: 10.1016/j.jsbmb.2012.10.017. Epub 2012 Nov 5.


1α,25-Dihydroxyvitamin D3 and its analogs as modulators of human dendritic cells: a comparison dose-titration study.

Ferreira GB, Overbergh L, Verstuyf A, Mathieu C.

J Steroid Biochem Mol Biol. 2013 Jul;136:160-5. doi: 10.1016/j.jsbmb.2012.10.009. Epub 2012 Oct 23. Review.


Posttranslational modifications of proteins in type 1 diabetes: the next step in finding the cure?

Dunne JL, Overbergh L, Purcell AW, Mathieu C.

Diabetes. 2012 Aug;61(8):1907-14. doi: 10.2337/db11-1675.


Expression of the growth hormone/insulin-like growth factor axis during Balb/c thymus ontogeny and effects of growth hormone upon ex vivo T cell differentiation.

Kermani H, Goffinet L, Mottet M, Bodart G, Morrhaye G, Dardenne O, Renard C, Overbergh L, Baron F, Beguin Y, Geenen V, Martens HJ.

Neuroimmunomodulation. 2012;19(3):137-47. doi: 10.1159/000328844. Epub 2012 Jan 18.


Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance.

Maris M, Overbergh L, Gysemans C, Waget A, Cardozo AK, Verdrengh E, Cunha JP, Gotoh T, Cnop M, Eizirik DL, Burcelin R, Mathieu C.

Diabetologia. 2012 Apr;55(4):1167-78. doi: 10.1007/s00125-011-2427-7. Epub 2012 Jan 12.


Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.

Ferreira GB, Kleijwegt FS, Waelkens E, Lage K, Nikolic T, Hansen DA, Workman CT, Roep BO, Overbergh L, Mathieu C.

J Proteome Res. 2012 Feb 3;11(2):941-71. doi: 10.1021/pr200724e. Epub 2011 Dec 15.


1,25-Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo.

Ferreira GB, van Etten E, Verstuyf A, Waer M, Overbergh L, Gysemans C, Mathieu C.

Diabetes Metab Res Rev. 2011 Nov;27(8):933-41. doi: 10.1002/dmrr.1275.


Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-κB: a proteomic study.

Di Michele M, Peeters K, Loyen S, Thys C, Waelkens E, Overbergh L, Hoylaerts M, Van Geet C, Freson K.

Mol Cell Proteomics. 2012 Jan;11(1):M111.007625. doi: 10.1074/mcp.M111.007625. Epub 2011 Oct 4.


Vitamin D and diabetes: its importance for beta cell and immune function.

Wolden-Kirk H, Overbergh L, Christesen HT, Brusgaard K, Mathieu C.

Mol Cell Endocrinol. 2011 Dec 5;347(1-2):106-20. doi: 10.1016/j.mce.2011.08.016. Epub 2011 Aug 26. Review.


How can macroscopically normal peritoneum contribute to the pathogenesis of endometriosis?

Fassbender A, Overbergh L, Verdrengh E, Kyama CM, Vodolazakaia A, Bokor A, Meuleman C, Peeraer K, Tomassetti C, Waelkens E, Mathieu C, D'Hooghe T.

Fertil Steril. 2011 Sep;96(3):697-9. doi: 10.1016/j.fertnstert.2011.06.034. Epub 2011 Jul 16.


Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid.

Maris M, Waelkens E, Cnop M, D'Hertog W, Cunha DA, Korf H, Koike T, Overbergh L, Mathieu C.

J Proteome Res. 2011 Aug 5;10(8):3372-85. doi: 10.1021/pr101290n. Epub 2011 Jul 13.


An integrated proteomics and genomics analysis to unravel a heterogeneous platelet secretion defect.

Di Michele M, Thys C, Waelkens E, Overbergh L, D'Hertog W, Mathieu C, De Vos R, Peerlinck K, Van Geet C, Freson K.

J Proteomics. 2011 May 16;74(6):902-13. doi: 10.1016/j.jprot.2011.03.007. Epub 2011 Mar 23.


Two-dimensional gel proteome reference map of INS-1E cells.

D'Hertog W, Maris M, Thorrez L, Waelkens E, Overbergh L, Mathieu C.

Proteomics. 2011 Apr;11(7):1365-9. doi: 10.1002/pmic.201000006. Epub 2011 Feb 17.


1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer.

Clinckspoor I, Verlinden L, Overbergh L, Korch C, Bouillon R, Mathieu C, Verstuyf A, Decallonne B.

J Steroid Biochem Mol Biol. 2011 Mar;124(1-2):1-9. doi: 10.1016/j.jsbmb.2010.12.008. Epub 2010 Dec 21.


Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling.

Ferreira GB, Mathieu C, Overbergh L.

Proteomics Clin Appl. 2010 Feb;4(2):190-203. doi: 10.1002/prca.200900162. Epub 2009 Nov 19. Review.


The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.

Baeke F, Korf H, Overbergh L, Verstuyf A, Thorrez L, Van Lommel L, Waer M, Schuit F, Gysemans C, Mathieu C.

J Immunol. 2011 Jan 1;186(1):132-42. doi: 10.4049/jimmunol.1000695. Epub 2010 Dec 3.


High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach.

Maris M, Ferreira GB, D'Hertog W, Cnop M, Waelkens E, Overbergh L, Mathieu C.

J Proteome Res. 2010 Dec 3;9(12):6274-87. doi: 10.1021/pr100557w. Epub 2010 Nov 4.


Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress.

D'Hertog W, Maris M, Ferreira GB, Verdrengh E, Lage K, Hansen DA, Cardozo AK, Workman CT, Moreau Y, Eizirik DL, Waelkens E, Overbergh L, Mathieu C.

J Proteome Res. 2010 Oct 1;9(10):5142-52. doi: 10.1021/pr1004086.


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