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Items: 1 to 50 of 145


A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice.

Mattiske D, Behringer RR, Overbeek PA, Pask AJ.

Differentiation. 2019 Dec 4;112:1-6. doi: 10.1016/j.diff.2019.10.007. [Epub ahead of print]


Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy.

Galvan DL, Badal SS, Long J, Chang BH, Schumacker PT, Overbeek PA, Danesh FR.

Kidney Int. 2017 Nov;92(5):1282-1287. doi: 10.1016/j.kint.2017.05.015. Epub 2017 Jul 26.


Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling.

Li J, Lu D, Liu H, Williams BO, Overbeek PA, Lee B, Zheng L, Yang T.

Hum Mol Genet. 2017 Aug 1;26(15):2949-2960. doi: 10.1093/hmg/ddx183.


Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography.

Wang S, Garcia MD, Lopez AL 3rd, Overbeek PA, Larin KV, Larina IV.

Biomed Opt Express. 2016 Dec 21;8(1):407-419. doi: 10.1364/BOE.8.000407. eCollection 2017 Jan 1.


Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy.

Long J, Badal SS, Ye Z, Wang Y, Ayanga BA, Galvan DL, Green NH, Chang BH, Overbeek PA, Danesh FR.

J Clin Invest. 2016 Nov 1;126(11):4205-4218. doi: 10.1172/JCI87927. Epub 2016 Oct 17.


Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice.

Fu C, Begum K, Jordan PW, He Y, Overbeek PA.

PLoS One. 2016 Aug 3;11(8):e0159800. doi: 10.1371/journal.pone.0159800. eCollection 2016.


miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.

Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR.

Nat Commun. 2016 Jun 28;7:12076. doi: 10.1038/ncomms12076.


Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model.

Fu C, Begum K, Overbeek PA.

PLoS One. 2016 Mar 3;11(3):e0144285. doi: 10.1371/journal.pone.0144285. eCollection 2016.


Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant.

Lopez AL 3rd, Wang S, Larin KV, Overbeek PA, Larina IV.

J Biomed Opt. 2015;20(9):090501. doi: 10.1117/1.JBO.20.9.090501.


Human adipose tissue as a reservoir for memory CD4+ T cells and HIV.

Couturier J, Suliburk JW, Brown JM, Luke DJ, Agarwal N, Yu X, Nguyen C, Iyer D, Kozinetz CA, Overbeek PA, Metzker ML, Balasubramanyam A, Lewis DE.

AIDS. 2015 Mar 27;29(6):667-74. doi: 10.1097/QAD.0000000000000599.


Mutant cohesin in premature ovarian failure.

Caburet S, Arboleda VA, Llano E, Overbeek PA, Barbero JL, Oka K, Harrison W, Vaiman D, Ben-Neriah Z, García-Tuñón I, Fellous M, Pendás AM, Veitia RA, Vilain E.

N Engl J Med. 2014 Mar 6;370(10):943-949. doi: 10.1056/NEJMoa1309635.


The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.

Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK.

PLoS Genet. 2014 Jan;10(1):e1004055. doi: 10.1371/journal.pgen.1004055. Epub 2014 Jan 2.


A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion.

Lorenzetti D, Poirier C, Zhao M, Overbeek PA, Harrison W, Bishop CE.

Mamm Genome. 2014 Apr;25(3-4):141-8. doi: 10.1007/s00335-013-9491-x. Epub 2013 Nov 26.


Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A.

Nucleic Acids Res. 2013 Dec;41(22):10199-214. doi: 10.1093/nar/gkt824. Epub 2013 Sep 12.


Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

Beck TF, Shchelochkov OA, Yu Z, Kim BJ, Hernández-García A, Zaveri HP, Bishop C, Overbeek PA, Stockton DW, Justice MJ, Scott DA.

PLoS One. 2013;8(3):e58830. doi: 10.1371/journal.pone.0058830. Epub 2013 Mar 11.


A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.

Tao J, Koster MI, Harrison W, Moran JL, Beier DR, Roop DR, Overbeek PA.

PLoS One. 2012;7(11):e50634. doi: 10.1371/journal.pone.0050634. Epub 2012 Nov 30. Erratum in: PLoS One. 2014;9(2):e91624.


Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models.

Larina IV, Syed SH, Sudheendran N, Overbeek PA, Dickinson ME, Larin KV.

J Biomed Opt. 2012 Aug;17(8):081410-1. doi: 10.1117/1.JBO.17.8.081410.


Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo.

Hicks AN, Lorenzetti D, Gilley J, Lu B, Andersson KE, Miligan C, Overbeek PA, Oppenheim R, Bishop CE.

PLoS One. 2012;7(10):e47869. doi: 10.1371/journal.pone.0047869. Epub 2012 Oct 17.


Insertional mutagenesis by a hybrid piggyBac and sleeping beauty transposon in the rat.

Furushima K, Jang CW, Chen DW, Xiao N, Overbeek PA, Behringer RR.

Genetics. 2012 Dec;192(4):1235-48. doi: 10.1534/genetics.112.140855. Epub 2012 Sep 28. Erratum in: Genetics. 2014 Nov;198(3):1345.


Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells.

Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Chévez-Barrios P, Hurwitz RL.

Invest Ophthalmol Vis Sci. 2012 Jun 8;53(7):3454-62. doi: 10.1167/iovs.12-9549.


Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.

Somma G, Alger HM, McGuire RM, Kretlow JD, Ruiz FR, Yatsenko SA, Stankiewicz P, Harrison W, Funk E, Bergamaschi A, Oghalai JS, Mikos AG, Overbeek PA, Pereira FA.

J Assoc Res Otolaryngol. 2012 Jun;13(3):335-49. doi: 10.1007/s10162-012-0316-5. Epub 2012 Mar 2.


Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.

Wang B, Harrison W, Overbeek PA, Zheng H.

Development. 2011 Oct;138(20):4487-97. doi: 10.1242/dev.067264.


Activation of unfolded protein response in transgenic mouse lenses.

Reneker LW, Chen H, Overbeek PA.

Invest Ophthalmol Vis Sci. 2011 Apr 4;52(5):2100-8. doi: 10.1167/iovs.10-5650. Print 2011 Apr.


Multiple autism-like behaviors in a novel transgenic mouse model.

Hamilton SM, Spencer CM, Harrison WR, Yuva-Paylor LA, Graham DF, Daza RA, Hevner RF, Overbeek PA, Paylor R.

Behav Brain Res. 2011 Mar 17;218(1):29-41. doi: 10.1016/j.bbr.2010.11.026. Epub 2010 Nov 17.


Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome.

Sales KU, Masedunskas A, Bey AL, Rasmussen AL, Weigert R, List K, Szabo R, Overbeek PA, Bugge TH.

Nat Genet. 2010 Aug;42(8):676-83. doi: 10.1038/ng.629. Epub 2010 Jul 25.


Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.

Li W, Puertollano R, Bonifacino JS, Overbeek PA, Everett ET.

Cleft Palate Craniofac J. 2010 Nov;47(6):566-73. doi: 10.1597/09-145. Epub 2010 Mar 2.


Activated Ras alters lens and corneal development through induction of distinct downstream targets.

Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V.

BMC Dev Biol. 2010 Jan 27;10:13. doi: 10.1186/1471-213X-10-13.


Induction of corneal myofibroblasts by lens-derived transforming growth factor beta1 (TGFbeta1): a transgenic mouse model.

Reneker LW, Bloch A, Xie L, Overbeek PA, Ash JD.

Brain Res Bull. 2010 Feb 15;81(2-3):287-96. doi: 10.1016/j.brainresbull.2009.10.019. Epub 2009 Nov 6.


Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.

Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R.

Dev Cell. 2009 Jul;17(1):49-61. doi: 10.1016/j.devcel.2009.05.011.


Pax6 dosage requirements in iris and ciliary body differentiation.

Davis N, Yoffe C, Raviv S, Antes R, Berger J, Holzmann S, Stoykova A, Overbeek PA, Tamm ER, Ashery-Padan R.

Dev Biol. 2009 Sep 1;333(1):132-42. doi: 10.1016/j.ydbio.2009.06.023. Epub 2009 Jun 27.


Hair follicles are required for optimal growth during lateral skin expansion.

Heath J, Langton AK, Hammond NL, Overbeek PA, Dixon MJ, Headon DJ.

J Invest Dermatol. 2009 Oct;129(10):2358-64. doi: 10.1038/jid.2009.102. Epub 2009 Apr 23.


Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations.

Lavail MM, Nishikawa S, Duncan JL, Yang H, Matthes MT, Yasumura D, Vollrath D, Overbeek PA, Ash JD, Robinson ML.

J Comp Neurol. 2008 Dec 20;511(6):724-35. doi: 10.1002/cne.21858.


Essential role of BMPs in FGF-induced secondary lens fiber differentiation.

Boswell BA, Overbeek PA, Musil LS.

Dev Biol. 2008 Dec 15;324(2):202-12. doi: 10.1016/j.ydbio.2008.09.003. Epub 2008 Sep 18.


Dominant inhibition of lens placode formation in mice.

Zhang Y, Burgess D, Overbeek PA, Govindarajan V.

Dev Biol. 2008 Nov 1;323(1):53-63. doi: 10.1016/j.ydbio.2008.08.016. Epub 2008 Aug 26.


Perinatal ablation of the mouse lens causes multiple anterior chamber defects.

Zhang Y, Overbeek PA, Govindarajan V.

Mol Vis. 2007 Dec 18;13:2289-300.


A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice.

Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matzuk MM, Andersson KE, Overbeek PA, Bishop CE.

Biol Reprod. 2008 Apr;78(4):601-10. Epub 2007 Dec 19.


Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.

Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE.

Mamm Genome. 2007 May;18(5):338-46. Epub 2007 Jun 8.


Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.

Xie L, Chen H, Overbeek PA, Reneker LW.

Mol Vis. 2007 Mar 26;13:397-407.


Gene expression profiling in embryonic mouse lenses.

Xiao W, Liu W, Li Z, Liang D, Li L, White LD, Fox DA, Overbeek PA, Chen Q.

Mol Vis. 2006 Dec 26;12:1692-8.


Ras signaling is essential for lens cell proliferation and lens growth during development.

Xie L, Overbeek PA, Reneker LW.

Dev Biol. 2006 Oct 15;298(2):403-14. Epub 2006 Jul 4.


Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3.

Banh A, Deschamps PA, Gauldie J, Overbeek PA, Sivak JG, West-Mays JA.

Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3450-60.


Generation of the primary hair follicle pattern.

Mou C, Jackson B, Schneider P, Overbeek PA, Headon DJ.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9075-80. Epub 2006 Jun 12.


FGF9 can induce endochondral ossification in cranial mesenchyme.

Govindarajan V, Overbeek PA.

BMC Dev Biol. 2006 Feb 20;6:7.


Intracorneal positioning of the lens in Pax6-GAL4/VP16 transgenic mice.

Govindarajan V, Harrison WR, Xiao N, Liang D, Overbeek PA.

Mol Vis. 2005 Oct 26;11:876-86.


Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation.

Graham DR, Overbeek PA, Ash JD.

Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2601-10.


Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice.

Chen Q, Liang D, Yang T, Leone G, Overbeek PA.

Dev Neurosci. 2004;26(5-6):435-45.


Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.

Reneker LW, Xie L, Xu L, Govindarajan V, Overbeek PA.

Int J Dev Biol. 2004;48(8-9):879-88.


Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice.

Reneker LW, Chen Q, Bloch A, Xie L, Schuster G, Overbeek PA.

Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4083-90.


Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice.

Yang T, Liang D, Koch PJ, Hohl D, Kheradmand F, Overbeek PA.

Genes Dev. 2004 Oct 1;18(19):2354-8.

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