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Items: 1 to 50 of 245

1.

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Quancard J, Klein T, Fung SY, Renatus M, Hughes N, Israël L, Priatel JJ, Kang S, Blank MA, Viner RI, Blank J, Schlapbach A, Erbel P, Kizhakkedathu J, Villard F, Hersperger R, Turvey SE, Eder J, Bornancin F, Overall CM.

Nat Chem Biol. 2019 Jan 28. doi: 10.1038/s41589-018-0222-1. [Epub ahead of print]

PMID:
30692685
2.

Precision de novo peptide sequencing using mirror proteases of Ac-LysargiNase and trypsin for large-scale proteomics.

Yang H, Li Y, Zhao M, Wu F, Wang X, Xiao W, Wang Y, Zhang J, Wang F, Xu F, Zeng WF, Overall CM, He SM, Chi H, Xu P.

Mol Cell Proteomics. 2019 Jan 8. pii: mcp.TIR118.000918. doi: 10.1074/mcp.TIR118.000918. [Epub ahead of print]

3.

Hydroxamic acid inhibitors provide cross-species inhibition of Plasmodium M1 and M17 aminopeptidases.

Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S.

J Med Chem. 2018 Dec 11. doi: 10.1021/acs.jmedchem.8b01310. [Epub ahead of print]

PMID:
30537832
4.

Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma.

Hill LA, Vassiliadi DA, Dimopoulou I, Anderson AJ, Boyle LD, Kilgour AHM, Stimson RH, Machado Y, Overall CM, Walker BR, Lewis JG, Hammond GL.

J Endocrinol. 2019 Jan 1;240(1):27-39. doi: 10.1530/JOE-18-0479.

5.

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation.

Marshall NC, Klein T, Thejoe M, von Krosigk N, Kizhakkedathu J, Finlay BB, Overall CM.

J Proteome Res. 2018 Oct 29. doi: 10.1021/acs.jproteome.8b00675. [Epub ahead of print]

PMID:
30371095
6.

Highlight: Frontiers in Proteolysis.

Lemieux MJ, Denault JB, Overall CM.

Biol Chem. 2018 Nov 27;399(12):1351. doi: 10.1515/hsz-2018-0401. No abstract available.

PMID:
30352023
7.

TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations.

Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro S, Overall CM, Johnson SR.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L1003-L1014. doi: 10.1152/ajplung.00175.2018. Epub 2018 Oct 4.

PMID:
30284925
8.

Launching the C-HPP neXt-CP50 Pilot Project for Functional Characterization of Identified Proteins with No Known Function.

Paik YK, Lane L, Kawamura T, Chen YJ, Cho JY, LaBaer J, Yoo JS, Domont G, Corrales F, Omenn GS, Archakov A, Encarnación-Guevara S, Lui S, Salekdeh GH, Cho JY, Kim CY, Overall CM.

J Proteome Res. 2018 Nov 29. doi: 10.1021/acs.jproteome.8b00383. [Epub ahead of print]

PMID:
30269496
9.

Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.

Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Snyder M, Baker MS, Deutsch EW.

J Proteome Res. 2018 Aug 23. doi: 10.1021/acs.jproteome.8b00441. [Epub ahead of print]

PMID:
30099871
10.

Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.

Folgueras AR, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C.

J Biol Chem. 2018 Jul 27;293(30):11968-11969. doi: 10.1074/jbc.AAC118.004703. No abstract available.

11.

Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.

Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ.

Sci Rep. 2018 Jun 26;8(1):9690. doi: 10.1038/s41598-018-28070-0.

12.

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.

Dufour A, Bellac CL, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour SJ, Overall CM.

Nat Commun. 2018 Jun 20;9(1):2416. doi: 10.1038/s41467-018-04717-4.

13.

Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.

Tharmarajah G, Eckhard U, Jain F, Marino G, Prudova A, Urtatiz O, Fuchs H, de Angelis MH, Overall CM, Van Raamsdonk CD.

Pigment Cell Melanoma Res. 2018 Nov;31(6):693-707. doi: 10.1111/pcmr.12711. Epub 2018 Jun 5.

PMID:
29781574
14.

TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.

King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev SY, Schjoldager KT, Overall CM, Wandall HH.

J Biol Chem. 2018 May 18;293(20):7629-7644. doi: 10.1074/jbc.RA118.001978. Epub 2018 Mar 28.

PMID:
29593093
15.

N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection.

Jagdeo JM, Dufour A, Klein T, Solis N, Kleifeld O, Kizhakkedathu J, Luo H, Overall CM, Jan E.

J Virol. 2018 Mar 28;92(8). pii: e02211-17. doi: 10.1128/JVI.02211-17. Print 2018 Apr 15.

16.

Identification of Protease Cleavage Sites and Substrates in Cancer by Carboxy-TAILS (C-TAILS).

Solis N, Overall CM.

Methods Mol Biol. 2018;1731:15-28. doi: 10.1007/978-1-4939-7595-2_2.

PMID:
29318539
17.

Proteolytic Cleavage-Mechanisms, Function, and "Omic" Approaches for a Near-Ubiquitous Posttranslational Modification.

Klein T, Eckhard U, Dufour A, Solis N, Overall CM.

Chem Rev. 2018 Feb 14;118(3):1137-1168. doi: 10.1021/acs.chemrev.7b00120. Epub 2017 Dec 21. Review.

PMID:
29265812
18.

Progress and Future Direction of Chromosome-Centric Human Proteome Project.

Paik YK, Overall CM, Deutsch EW, Van Eyk JE, Omenn GS.

J Proteome Res. 2017 Dec 1;16(12):4253-4258. doi: 10.1021/acs.jproteome.7b00734.

PMID:
29191025
19.

Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini.

Na CH, Barbhuiya MA, Kim MS, Verbruggen S, Eacker SM, Pletnikova O, Troncoso JC, Halushka MK, Menschaert G, Overall CM, Pandey A.

Genome Res. 2018 Jan;28(1):25-36. doi: 10.1101/gr.226050.117. Epub 2017 Nov 21.

20.

Advances in the Chromosome-Centric Human Proteome Project: looking to the future.

Paik YK, Omenn GS, Hancock WS, Lane L, Overall CM.

Expert Rev Proteomics. 2017 Dec;14(12):1059-1071. doi: 10.1080/14789450.2017.1394189. Epub 2017 Nov 10. Review.

21.

The Human Odontoblast Cell Layer and Dental Pulp Proteomes and N-Terminomes.

Abbey SR, Eckhard U, Solis N, Marino G, Matthew I, Overall CM.

J Dent Res. 2018 Mar;97(3):338-346. doi: 10.1177/0022034517736054. Epub 2017 Oct 16.

PMID:
29035686
22.

The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays.

Schwenk JM, Omenn GS, Sun Z, Campbell DS, Baker MS, Overall CM, Aebersold R, Moritz RL, Deutsch EW.

J Proteome Res. 2017 Dec 1;16(12):4299-4310. doi: 10.1021/acs.jproteome.7b00467. Epub 2017 Oct 10.

23.

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella.

Eckhard U, Bandukwala H, Mansfield MJ, Marino G, Cheng J, Wallace I, Holyoak T, Charles TC, Austin J, Overall CM, Doxey AC.

Nat Commun. 2017 Sep 12;8(1):521. doi: 10.1038/s41467-017-00599-0.

24.

Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.

Omenn GS, Lane L, Lundberg EK, Overall CM, Deutsch EW.

J Proteome Res. 2017 Dec 1;16(12):4281-4287. doi: 10.1021/acs.jproteome.7b00375. Epub 2017 Oct 9.

25.

Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray.

Kappelhoff R, Puente XS, Wilson CH, Seth A, López-Otín C, Overall CM.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2210-2219. doi: 10.1016/j.bbamcr.2017.08.004. Epub 2017 Aug 7. Review.

26.

Can we predict protein from mRNA levels?

Fortelny N, Overall CM, Pavlidis P, Freue GVC.

Nature. 2017 Jul 26;547(7664):E19-E20. doi: 10.1038/nature22293. No abstract available.

PMID:
28748932
27.

Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases.

Panwar P, Butler GS, Jamroz A, Azizi P, Overall CM, Brömme D.

Matrix Biol. 2018 Jan;65:30-44. doi: 10.1016/j.matbio.2017.06.004. Epub 2017 Jun 17.

PMID:
28634008
28.

New intracellular activities of matrix metalloproteinases shine in the moonlight.

Jobin PG, Butler GS, Overall CM.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):2043-2055. doi: 10.1016/j.bbamcr.2017.05.013. Epub 2017 May 16. Review.

29.

Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions.

Fortelny N, Butler GS, Overall CM, Pavlidis P.

Mol Cell Proteomics. 2017 Jun;16(6):1038-1051. doi: 10.1074/mcp.M116.065706. Epub 2017 Apr 6.

30.

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.

Sci Rep. 2017 Feb 23;7:43135. doi: 10.1038/srep43135.

31.

Protean proteases: at the cutting edge of lung diseases.

Taggart C, Mall MA, Lalmanach G, Cataldo D, Ludwig A, Janciauskiene S, Heath N, Meiners S, Overall CM, Schultz C, Turk B, Borensztajn KS.

Eur Respir J. 2017 Feb 8;49(2). pii: 1501200. doi: 10.1183/13993003.01200-2015. Print 2017 Feb. Review.

32.

Sharpening Host Defenses during Infection: Proteases Cut to the Chase.

Marshall NC, Finlay BB, Overall CM.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S161-S171. doi: 10.1074/mcp.O116.066456. Epub 2017 Feb 8. Review.

33.

Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage.

Goth CK, Tuhkanen HE, Khan H, Lackman JJ, Wang S, Narimatsu Y, Hansen LH, Overall CM, Clausen H, Schjoldager KT, Petäjä-Repo UE.

J Biol Chem. 2017 Mar 17;292(11):4714-4726. doi: 10.1074/jbc.M116.730614. Epub 2017 Feb 6.

34.

Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics.

Tsiatsiani L, Giansanti P, Scheltema RA, van den Toorn H, Overall CM, Altelaar AF, Heck AJ.

J Proteome Res. 2017 Feb 3;16(2):852-861. doi: 10.1021/acs.jproteome.6b00825. Epub 2016 Dec 2.

PMID:
28111955
35.

Interactome disassembly during apoptosis occurs independent of caspase cleavage.

Scott NE, Rogers LD, Prudova A, Brown NF, Fortelny N, Overall CM, Foster LJ.

Mol Syst Biol. 2017 Jan 12;13(1):906. doi: 10.15252/msb.20167067.

36.

Progress in the Chromosome-Centric Human Proteome Project as Highlighted in the Annual Special Issue IV.

Paik YK, Overall CM, Deutsch EW, Hancock WS, Omenn GS.

J Proteome Res. 2016 Nov 4;15(11):3945-3950. No abstract available.

37.

Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 2.1.

Deutsch EW, Overall CM, Van Eyk JE, Baker MS, Paik YK, Weintraub ST, Lane L, Martens L, Vandenbrouck Y, Kusebauch U, Hancock WS, Hermjakob H, Aebersold R, Moritz RL, Omenn GS.

J Proteome Res. 2016 Nov 4;15(11):3961-3970. Epub 2016 Aug 24.

38.

Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications.

Omenn GS, Lane L, Lundberg EK, Beavis RC, Overall CM, Deutsch EW.

J Proteome Res. 2016 Nov 4;15(11):3951-3960. Epub 2016 Sep 20.

39.

Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity.

Klein T, Viner RI, Overall CM.

Philos Trans A Math Phys Eng Sci. 2016 Oct 28;374(2079). pii: 20150372. doi: 10.1098/rsta.2015.0372. Review.

40.

Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration.

Abdul-Muneer PM, Conte AA, Haldar D, Long M, Patel RK, Santhakumar V, Overall CM, Pfister BJ.

Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.

PMID:
27614125
41.

iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice.

Qing X, Rogers L, Mortha A, Lavin Y, Redecha P, Issuree PD, Maretzky T, Merad M, McIlwain D, Mak TW, Overall CM, Blobel CP, Salmon JE.

Eur J Immunol. 2016 Dec;46(12):2737-2748. doi: 10.1002/eji.201646482. Epub 2016 Sep 28.

42.

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.

43.

Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).

Butler GS, Connor AR, Sounni NE, Eckhard U, Morrison CJ, Noël A, Overall CM.

Matrix Biol. 2017 May;59:23-38. doi: 10.1016/j.matbio.2016.07.006. Epub 2016 Jul 26.

44.

Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death.

Anania VG, Yu K, Gnad F, Pferdehirt RR, Li H, Ma TP, Jeon D, Fortelny N, Forrest W, Ashkenazi A, Overall CM, Lill JR.

Mol Cell Proteomics. 2016 Jul;15(7):2293-307. doi: 10.1074/mcp.M115.055376. Epub 2016 Apr 28.

45.

Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion.

Moon H, Cremmel CV, Kulpa A, Jaeger NA, Kappelhoff R, Overall CM, Waterfield JD, Brunette DM.

J Biomed Mater Res A. 2016 Sep;104(9):2243-54. doi: 10.1002/jbm.a.35757. Epub 2016 May 10.

PMID:
27102570
46.

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.

47.

TAILS N-terminomic and proteomic datasets of healthy human dental pulp.

Eckhard U, Marino G, Abbey SR, Matthew I, Overall CM.

Data Brief. 2015 Oct 16;5:542-8. doi: 10.1016/j.dib.2015.10.003. eCollection 2015 Dec.

48.

Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.

Hamey JJ, Winter DL, Yagoub D, Overall CM, Hart-Smith G, Wilkins MR.

Mol Cell Proteomics. 2016 Jan;15(1):164-76. doi: 10.1074/mcp.M115.052449. Epub 2015 Nov 6.

49.

Positional proteomics in the era of the human proteome project on the doorstep of precision medicine.

Eckhard U, Marino G, Butler GS, Overall CM.

Biochimie. 2016 Mar;122:110-8. doi: 10.1016/j.biochi.2015.10.018. Epub 2015 Nov 14. Review.

50.

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.

Klein T, Fung SY, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE, Overall CM.

Nat Commun. 2015 Nov 3;6:8777. doi: 10.1038/ncomms9777.

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