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Items: 1 to 50 of 186

1.

Small molecules that target the ubiquitin system.

Wu HQ, Baker D, Ovaa H.

Biochem Soc Trans. 2020 Mar 20. pii: BST20190535. doi: 10.1042/BST20190535. [Epub ahead of print]

PMID:
32196552
2.

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.

Poramba-Liyanage DW, Korthout T, Cucinotta CE, van Kruijsbergen I, van Welsem T, El Atmioui D, Ovaa H, Tsukiyama T, van Leeuwen F.

Genome Res. 2020 Mar 18. pii: gr.256255.119. doi: 10.1101/gr.256255.119. [Epub ahead of print]

3.

Strategy for Development of Site-Specific Ubiquitin Antibodies.

van Kruijsbergen I, Mulder MPC, Uckelmann M, van Welsem T, de Widt J, Spanjaard A, Jacobs H, El Oualid F, Ovaa H, van Leeuwen F.

Front Chem. 2020 Feb 21;8:111. doi: 10.3389/fchem.2020.00111. eCollection 2020.

4.

Development of a DUB-selective fluorogenic substrate.

Gjonaj L, Sapmaz A, Flierman D, Janssen GMC, van Veelen PA, Ovaa H.

Chem Sci. 2019 Sep 30;10(44):10290-10296. doi: 10.1039/c9sc02226k. eCollection 2019 Nov 28.

5.

Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code.

Pérez Berrocal DA, Witting KF, Ovaa H, Mulder MPC.

Front Chem. 2020 Jan 22;7:931. doi: 10.3389/fchem.2019.00931. eCollection 2019. Review.

6.

Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1.

Shahul Hameed D, van Tilburg GBA, Merkx R, Flierman D, Wienk H, El Oualid F, Hofmann K, Boelens R, Ovaa H.

Front Chem. 2020 Jan 22;7:921. doi: 10.3389/fchem.2019.00921. eCollection 2019.

7.

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis.

Liu S, González-Prieto R, Zhang M, Geurink PP, Kooij R, Iyengar PV, van Dinther M, Bos E, Zhang X, Le Dévédec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L, Martens JWM, Ten Dijke P.

Clin Cancer Res. 2020 Mar 15;26(6):1460-1473. doi: 10.1158/1078-0432.CCR-19-1373. Epub 2019 Dec 19.

8.

Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties.

Xin BT, Gan J, Fernandez DJ, Knobeloch KP, Geurink PP, Ovaa H.

Org Biomol Chem. 2019 Dec 28;17(48):10148-10152. doi: 10.1039/c9ob02127b. Epub 2019 Nov 11.

PMID:
31710063
9.

Cracking the Ubiquitin Code: The Ubiquitin Toolbox.

Mulder MPC, Witting KF, Ovaa H.

Curr Issues Mol Biol. 2020;37:1-20. doi: 10.21775/cimb.037.001. Epub 2019 Nov 1.

10.

Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.

Karpiyevich M, Adjalley S, Mol M, Ascher DB, Mason B, van der Heden van Noort GJ, Laman H, Ovaa H, Lee MCS, Artavanis-Tsakonas K.

PLoS Pathog. 2019 Oct 28;15(10):e1008086. doi: 10.1371/journal.ppat.1008086. eCollection 2019 Oct.

11.

Production and Thermal Exchange of Conditional Peptide-MHC I Multimers.

Luimstra JJ, Franken KLMC, Garstka MA, Drijfhout JW, Neefjes J, Ovaa H.

Curr Protoc Immunol. 2019 Sep;126(1):e85. doi: 10.1002/cpim.85.

12.

Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes.

Schipper-Krom S, Sanz AS, van Bodegraven EJ, Speijer D, Florea BI, Ovaa H, Reits EA.

Front Mol Biosci. 2019 Aug 20;6:56. doi: 10.3389/fmolb.2019.00056. eCollection 2019.

13.

Development of Ubiquitin-Based Probe for Metalloprotease Deubiquitinases.

Hameed DS, Sapmaz A, Burggraaff L, Amore A, Slingerland CJ, van Westen GJP, Ovaa H.

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14477-14482. doi: 10.1002/anie.201906790. Epub 2019 Aug 28.

PMID:
31381834
14.

Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs).

Jia Y, Claessens LA, Vertegaal ACO, Ovaa H.

ACS Chem Biol. 2019 Nov 15;14(11):2389-2395. doi: 10.1021/acschembio.9b00402. Epub 2019 Aug 5. Review.

15.

DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells.

Narasimhan S, Scherpe S, Lucini Paioni A, van der Zwan J, Folkers GE, Ovaa H, Baldus M.

Angew Chem Int Ed Engl. 2019 Sep 9;58(37):12969-12973. doi: 10.1002/anie.201903246. Epub 2019 Jul 19.

16.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N.

J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

17.

Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis.

Spits M, Janssen LJ, Voortman LM, Kooij R, Neefjes ACM, Ovaa H, Neefjes J.

J Cell Sci. 2019 May 15;132(10). pii: jcs225524. doi: 10.1242/jcs.225524.

18.

USP7: combining tools towards selectivity.

Gjonaj L, Sapmaz A, González-Prieto R, Vertegaal ACO, Flierman D, Ovaa H.

Chem Commun (Camb). 2019 Apr 25;55(35):5075-5078. doi: 10.1039/c9cc00969h.

PMID:
30972393
19.

Highlighting the Proteasome: Using Fluorescence to Visualize Proteasome Activity and Distribution.

Gan J, Leestemaker Y, Sapmaz A, Ovaa H.

Front Mol Biosci. 2019 Mar 22;6:14. doi: 10.3389/fmolb.2019.00014. eCollection 2019. Review.

20.

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.

Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H.

Nat Commun. 2019 Mar 29;10(1):1454. doi: 10.1038/s41467-019-09437-x.

21.

Synthetic ubiquitinated proteins meet the proteasome: Distinct roles of ubiquitin in a chain.

van der Heden van Noort GJ, Gan J, Ovaa H.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7614-7616. doi: 10.1073/pnas.1903405116. Epub 2019 Mar 29. No abstract available.

22.

Profiling DUBs and Ubl-specific proteases with activity-based probes.

Geurink PP, van der Heden van Noort GJ, Mulder MPC, Knaap RCM, Kikkert M, Ovaa H.

Methods Enzymol. 2019;618:357-387. doi: 10.1016/bs.mie.2018.12.037. Epub 2019 Feb 14.

23.

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K.

Mons E, Jansen IDC, Loboda J, van Doodewaerd BR, Hermans J, Verdoes M, van Boeckel CAA, van Veelen PA, Turk B, Turk D, Ovaa H.

J Am Chem Soc. 2019 Feb 27;141(8):3507-3514. doi: 10.1021/jacs.8b11027. Epub 2019 Feb 14.

24.

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.

van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB.

Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24.

25.

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

Kim RQ, Geurink PP, Mulder MPC, Fish A, Ekkebus R, El Oualid F, van Dijk WJ, van Dalen D, Ovaa H, van Ingen H, Sixma TK.

Nat Commun. 2019 Jan 16;10(1):231. doi: 10.1038/s41467-018-08231-5.

26.

SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock.

Liebelt F, Sebastian RM, Moore CL, Mulder MPC, Ovaa H, Shoulders MD, Vertegaal ACO.

Cell Rep. 2019 Jan 2;26(1):236-249.e4. doi: 10.1016/j.celrep.2018.12.027.

27.

Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms.

Heijkants R, Teunisse A, de Vries J, Ovaa H, Jochemsen A.

ACS Chem Biol. 2019 Jan 18;14(1):132-136. doi: 10.1021/acschembio.8b00292. Epub 2019 Jan 2.

PMID:
30525429
28.

Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates.

Hameed DS, Sapmaz A, Gjonaj L, Merkx R, Ovaa H.

Chembiochem. 2018 Dec 18;19(24):2553-2557. doi: 10.1002/cbic.201800649. Epub 2018 Nov 27.

PMID:
30351505
29.

One-Step Chemical Synthesis of Native Met1-Linked Poly-Ubiquitin Chains.

van der Heden van Noort GJ, Talavera Ormeño C, van Dalen D, Ovaa H.

Chembiochem. 2019 Jan 2;20(1):62-65. doi: 10.1002/cbic.201800520. Epub 2018 Nov 7.

PMID:
30264452
30.

A MALDI-TOF Approach to Ubiquitin Ligase Activity.

van Tol BDM, Geurink PP, Ovaa H.

Cell Chem Biol. 2018 Sep 20;25(9):1053-1055. doi: 10.1016/j.chembiol.2018.09.002.

31.

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.

van Welsem T, Korthout T, Ekkebus R, Morais D, Molenaar TM, van Harten K, Poramba-Liyanage DW, Sun SM, Lenstra TL, Srivas R, Ideker T, Holstege FCP, van Attikum H, El Oualid F, Ovaa H, Stulemeijer IJE, Vlaming H, van Leeuwen F.

Nucleic Acids Res. 2018 Nov 30;46(21):11251-11261. doi: 10.1093/nar/gky801.

32.

Generation of the UFM1 Toolkit for Profiling UFM1-Specific Proteases and Ligases.

Witting KF, van der Heden van Noort GJ, Kofoed C, Talavera Ormeño C, El Atmioui D, Mulder MPC, Ovaa H.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14164-14168. doi: 10.1002/anie.201809232. Epub 2018 Oct 1.

33.

How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling.

van der Heden van Noort GJ, Ovaa H.

Curr Top Microbiol Immunol. 2019;420:111-130. doi: 10.1007/82_2018_134. Review.

PMID:
30178261
34.

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation.

Xin BT, van Tol BDM, Ovaa H, Geurink PP.

Org Biomol Chem. 2018 Aug 29;16(34):6306-6315. doi: 10.1039/c8ob01627e.

PMID:
30117511
35.

Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases.

Mulder MPC, Merkx R, Witting KF, Hameed DS, El Atmioui D, Lelieveld L, Liebelt F, Neefjes J, Berlin I, Vertegaal ACO, Ovaa H.

Angew Chem Int Ed Engl. 2018 Jul 16;57(29):8958-8962. doi: 10.1002/anie.201803483. Epub 2018 Jun 14.

36.

Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

Liepe J, Ovaa H, Mishto M.

Curr Opin Immunol. 2018 Jun;52:81-86. doi: 10.1016/j.coi.2018.04.016. Epub 2018 Jun 1. Review.

37.

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells.

Luimstra JJ, Garstka MA, Roex MCJ, Redeker A, Janssen GMC, van Veelen PA, Arens R, Falkenburg JHF, Neefjes J, Ovaa H.

J Exp Med. 2018 May 7;215(5):1493-1504. doi: 10.1084/jem.20180156. Epub 2018 Apr 17.

38.

Probing ubiquitin and SUMO conjugation and deconjugation.

Ovaa H, Vertegaal ACO.

Biochem Soc Trans. 2018 Apr 17;46(2):423-436. doi: 10.1042/BST20170086. Epub 2018 Mar 27. Review.

PMID:
29588386
39.

SUMO targets the APC/C to regulate transition from metaphase to anaphase.

Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO.

Nat Commun. 2018 Mar 16;9(1):1119. doi: 10.1038/s41467-018-03486-4.

40.

A family of unconventional deubiquitinases with modular chain specificity determinants.

Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K.

Nat Commun. 2018 Feb 23;9(1):799. doi: 10.1038/s41467-018-03148-5.

41.

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.

Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2371-2376. doi: 10.1073/pnas.1710617115. Epub 2018 Feb 20.

42.

Proteome-wide identification of ubiquitin interactions using UbIA-MS.

Zhang X, Smits AH, van Tilburg GB, Ovaa H, Huber W, Vermeulen M.

Nat Protoc. 2018 Mar;13(3):530-550. doi: 10.1038/nprot.2017.147. Epub 2018 Feb 15.

PMID:
29446774
43.

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.

Oerlemans R, Berkers CR, Assaraf YG, Scheffer GL, Peters GJ, Verbrugge SE, Cloos J, Slootstra J, Meloen RH, Shoemaker RH, Dijkmans BAC, Scheper RJ, Ovaa H, Jansen G.

Invest New Drugs. 2018 Oct;36(5):797-809. doi: 10.1007/s10637-018-0569-x. Epub 2018 Feb 14.

44.

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.

Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA.

Sci Rep. 2018 Jan 23;8(1):1405. doi: 10.1038/s41598-018-19538-0.

45.

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation.

Palmer AL, de Jong A, Leestemaker Y, Geurink PP, Wijdeven RH, Ovaa H, Dolan BP.

J Immunol. 2018 Feb 1;200(3):928-936. doi: 10.4049/jimmunol.1700273. Epub 2017 Dec 27.

46.

Tools to investigate the ubiquitin proteasome system.

Leestemaker Y, Ovaa H.

Drug Discov Today Technol. 2017 Dec;26:25-31. doi: 10.1016/j.ddtec.2017.11.006. Epub 2017 Nov 26. Review.

47.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1659-1662. doi: 10.1002/anie.201710527. Epub 2018 Jan 8.

PMID:
29215186
48.

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams.

Janssen GV, van den Heuvel JAC, Megens RP, Benningshof JCJ, Ovaa H.

Bioorg Med Chem. 2018 Jan 1;26(1):41-49. doi: 10.1016/j.bmc.2017.11.014. Epub 2017 Nov 16.

49.

Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.

van der Heden van Noort GJ, Kooij R, Elliott PR, Komander D, Ovaa H.

Org Lett. 2017 Dec 15;19(24):6490-6493. doi: 10.1021/acs.orglett.7b03085. Epub 2017 Nov 27.

50.

Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity.

Dohmen AJC, Qiao X, Duursma A, Wijdeven RH, Lieftink C, Hageman F, Morris B, Halonen P, Vens C, van den Brekel MWM, Ovaa H, Neefjes J, Zuur CL.

Oncotarget. 2017 May 19;8(43):73925-73937. doi: 10.18632/oncotarget.18034. eCollection 2017 Sep 26.

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