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Items: 1 to 50 of 100

1.

Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes.

Lund J, Ouwens DM, Wettergreen M, Bakke SS, Thoresen GH, Aas V.

Cells. 2019 Sep 18;8(9). pii: E1101. doi: 10.3390/cells8091101.

2.

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.

Hörbelt T, Knebel B, Fahlbusch P, Barbosa D, de Wiza DH, Van de Velde F, Van Nieuwenhove Y, Lapauw B, Thoresen GH, Al-Hasani H, Müller-Wieland D, Ouwens DM, Kotzka J.

Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2671-2684. doi: 10.1016/j.bbadis.2019.07.008. Epub 2019 Jul 20.

PMID:
31336149
3.

Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells - A link between aortic heart valve degeneration and type 2 diabetes.

Selig JI, Ouwens DM, Raschke S, Thoresen GH, Fischer JW, Lichtenberg A, Akhyari P, Barth M.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2526-2537. doi: 10.1016/j.bbadis.2019.05.019. Epub 2019 May 30.

4.

Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E.

Carstensen-Kirberg M, Röhrig K, Niersmann C, Ouwens DM, Belgardt BF, Roden M, Herder C.

PLoS One. 2019 Mar 28;14(3):e0213650. doi: 10.1371/journal.pone.0213650. eCollection 2019.

5.

Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid.

Løvsletten NG, Bakke SS, Kase ET, Ouwens DM, Thoresen GH, Rustan AC.

PLoS One. 2018 Nov 29;13(11):e0208048. doi: 10.1371/journal.pone.0208048. eCollection 2018.

6.
7.

The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.

Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM.

Diabetologia. 2018 Sep;61(9):2054-2065. doi: 10.1007/s00125-018-4636-9. Epub 2018 May 12.

PMID:
29754289
8.

Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice.

Stermann T, Menzel F, Weidlich C, Jeruschke K, Weiss J, Altenhofen D, Benninghoff T, Pujol A, Bosch F, Rustenbeck I, Ouwens DM, Thoresen GH, de Wendt C, Lebek S, Schallschmidt T, Kragl M, Lammert E, Chadt A, Al-Hasani H.

Endocrinology. 2018 Apr 1;159(4):1748-1761. doi: 10.1210/en.2018-00087.

PMID:
29481597
9.

CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.

Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J.

Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21.

PMID:
29467502
10.

Assessment of circulating Wnt1 inducible signalling pathway protein 1 (WISP-1)/CCN4 as a novel biomarker of obesity.

Tacke C, Aleksandrova K, Rehfeldt M, Murahovschi V, Markova M, Kemper M, Hornemann S, Kaiser U, Honig C, Gerbracht C, Kabisch S, Hörbelt T, Ouwens DM, Weickert MO, Boeing H, Pfeiffer AFH, Pivovarova O, Rudovich N.

J Cell Commun Signal. 2018 Sep;12(3):539-548. doi: 10.1007/s12079-017-0427-1. Epub 2017 Nov 11.

11.

CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells.

Maciaczyk D, Picard D, Zhao L, Koch K, Herrera-Rios D, Li G, Marquardt V, Pauck D, Hoerbelt T, Zhang W, Ouwens DM, Remke M, Jiang T, Steiger HJ, Maciaczyk J, Kahlert UD.

Br J Cancer. 2017 Jun 27;117(1):102-112. doi: 10.1038/bjc.2017.157. Epub 2017 Jun 1.

12.

Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin-angiotensin system and induction of miR-208a.

Blumensatt M, Fahlbusch P, Hilgers R, Bekaert M, Herzfeld de Wiza D, Akhyari P, Ruige JB, Ouwens DM.

Basic Res Cardiol. 2017 Jan;112(1):2. Epub 2016 Nov 18.

PMID:
27864612
13.

Soluble CD14 inhibits contractile function and insulin action in primary adult rat cardiomyocytes.

Overhagen S, Blumensatt M, Fahlbusch P, Herzfeld de Wiza D, Müller H, Maxhera B, Akhyari P, Ouwens DM.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):365-374. doi: 10.1016/j.bbadis.2016.11.002. Epub 2016 Nov 3.

14.

Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity.

Bekaert M, Ouwens DM, Hörbelt T, Van de Velde F, Fahlbusch P, Herzfeld de Wiza D, Van Nieuwenhove Y, Calders P, Praet M, Hoorens A, Geerts A, Verhelst X, Kaufman JM, Lapauw B.

Obesity (Silver Spring). 2016 Dec;24(12):2544-2552. doi: 10.1002/oby.21674. Epub 2016 Oct 21.

15.

Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function.

Hartmann T, Overhagen S, Ouwens DM, Raschke S, Wohlfart P, Tennagels N, Wronkowitz N, Eckel J.

Cardiovasc Diabetol. 2016 Jul 15;15:96. doi: 10.1186/s12933-016-0410-9.

16.

Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy.

Herder C, Bongaerts BW, Ouwens DM, Rathmann W, Heier M, Carstensen-Kirberg M, Koenig W, Thorand B, Roden M, Meisinger C, Ziegler D; KORA Study Group.

Diabet Med. 2015 Nov;32(11):1479-83. doi: 10.1111/dme.12761. Epub 2015 Jun 11.

PMID:
26094489
17.

Determinants of testosterone levels in human male obesity.

Bekaert M, Van Nieuwenhove Y, Calders P, Cuvelier CA, Batens AH, Kaufman JM, Ouwens DM, Ruige JB.

Endocrine. 2015 Sep;50(1):202-11. doi: 10.1007/s12020-015-0563-4. Epub 2015 Mar 13.

18.

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study.

Herder C, Ouwens DM, Carstensen M, Kowall B, Huth C, Meisinger C, Rathmann W, Roden M, Thorand B.

Eur J Endocrinol. 2015 Apr;172(4):423-32. doi: 10.1530/EJE-14-0879.

PMID:
25733068
19.

Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6.

Hartwig S, Goeddeke S, Poschmann G, Dicken HD, Jacob S, Nitzgen U, Passlack W, Stühler K, Ouwens DM, Al-Hasani H, Knebel B, Kotzka J, Lehr S.

Arch Physiol Biochem. 2014 Dec;120(5):208-15. doi: 10.3109/13813455.2014.970197. Epub 2014 Oct 16.

PMID:
25319219
20.

Cerebrospinal fluid levels of Alzheimer's disease biomarkers in middle-aged patients with type 1 diabetes.

Ouwens DM, van Duinkerken E, Schoonenboom SN, Herzfeld de Wiza D, Klein M, van Golen L, Pouwels PJ, Barkhof F, Moll AC, Snoek FJ, Teunissen CE, Scheltens P, Diamant M.

Diabetologia. 2014 Oct;57(10):2208-14. doi: 10.1007/s00125-014-3333-6. Epub 2014 Jul 18.

PMID:
25034377
21.

Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes.

Jelenik T, Séquaris G, Kaul K, Ouwens DM, Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, Roden M.

Diabetes. 2014 Nov;63(11):3856-67. doi: 10.2337/db13-1794. Epub 2014 Jun 10.

22.

Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle.

Wiza C, Chadt A, Blumensatt M, Kanzleiter T, Herzfeld De Wiza D, Horrighs A, Mueller H, Nascimento EB, Schürmann A, Al-Hasani H, Ouwens DM.

Arch Physiol Biochem. 2014 May;120(2):64-72. doi: 10.3109/13813455.2014.894076. Epub 2014 Feb 27.

PMID:
24576065
23.

Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells.

Carstensen M, Wiza C, Röhrig K, Fahlbusch P, Roden M, Herder C, Ouwens DM.

PLoS One. 2014 Jan 21;9(1):e85906. doi: 10.1371/journal.pone.0085906. eCollection 2014.

24.

Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.

Blumensatt M, Wronkowitz N, Wiza C, Cramer A, Mueller H, Rabelink MJ, Hoeben RC, Eckel J, Sell H, Ouwens DM.

Biochim Biophys Acta. 2014 Feb;1842(2):275-83. doi: 10.1016/j.bbadis.2013.12.001. Epub 2013 Dec 9.

25.

Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.

van Genugten RE, van Raalte DH, Muskiet MH, Heymans MW, Pouwels PJ, Ouwens DM, Mari A, Diamant M.

Eur J Endocrinol. 2014 Feb 4;170(3):429-39. doi: 10.1530/EJE-13-0610. Print 2014 Mar.

PMID:
24297090
26.

Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes.

Chen WJ, Greulich S, van der Meer RW, Rijzewijk LJ, Lamb HJ, de Roos A, Smit JW, Romijn JA, Ruige JB, Lammertsma AA, Lubberink M, Diamant M, Ouwens DM.

Cardiovasc Diabetol. 2013 Oct 17;12:150. doi: 10.1186/1475-2840-12-150.

27.

Beneficial and adverse effects of testosterone on the cardiovascular system in men.

Ruige JB, Ouwens DM, Kaufman JM.

J Clin Endocrinol Metab. 2013 Nov;98(11):4300-10. doi: 10.1210/jc.2013-1970. Epub 2013 Sep 24.

PMID:
24064693
28.

Anti-inflammatory cytokines and risk of type 2 diabetes.

Herder C, Carstensen M, Ouwens DM.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:39-50. doi: 10.1111/dom.12155. Review.

PMID:
24003920
29.

Secretome profiling of primary human skeletal muscle cells.

Hartwig S, Raschke S, Knebel B, Scheler M, Irmler M, Passlack W, Muller S, Hanisch FG, Franz T, Li X, Dicken HD, Eckardt K, Beckers J, de Angelis MH, Weigert C, Häring HU, Al-Hasani H, Ouwens DM, Eckel J, Kotzka J, Lehr S.

Biochim Biophys Acta. 2014 May;1844(5):1011-7. doi: 10.1016/j.bbapap.2013.08.004. Epub 2013 Aug 27.

PMID:
23994228
30.

The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system.

Coomans CP, Geerling JJ, van den Berg SA, van Diepen HC, Garcia-Tardón N, Thomas A, Schröder-van der Elst JP, Ouwens DM, Pijl H, Rensen PC, Havekes LM, Guigas B, Romijn JA.

Br J Pharmacol. 2013 Oct;170(4):908-18. doi: 10.1111/bph.12338.

31.

VEGF in the crosstalk between human adipocytes and smooth muscle cells: depot-specific release from visceral and perivascular adipose tissue.

Schlich R, Willems M, Greulich S, Ruppe F, Knoefel WT, Ouwens DM, Maxhera B, Lichtenberg A, Eckel J, Sell H.

Mediators Inflamm. 2013;2013:982458. doi: 10.1155/2013/982458. Epub 2013 Jul 9.

32.

Glucocorticoid treatment impairs microvascular function in healthy men in association with its adverse effects on glucose metabolism and blood pressure: a randomised controlled trial.

van Raalte DH, Diamant M, Ouwens DM, Ijzerman RG, Linssen MM, Guigas B, Eringa EC, Serné EH.

Diabetologia. 2013 Nov;56(11):2383-91. doi: 10.1007/s00125-013-3016-8. Epub 2013 Aug 11.

PMID:
23933953
33.

Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143.

Blumensatt M, Greulich S, Herzfeld de Wiza D, Mueller H, Maxhera B, Rabelink MJ, Hoeben RC, Akhyari P, Al-Hasani H, Ruige JB, Ouwens DM.

Cardiovasc Res. 2013 Nov 1;100(2):201-10. doi: 10.1093/cvr/cvt173. Epub 2013 Jun 28.

PMID:
23812417
34.

Proline-rich Akt substrate of 40-kDa contains a nuclear export signal.

Wiza C, Nascimento EB, Linssen MM, Carlotti F, Herzfeld de Wiza D, van der Zon GC, Maassen JA, Diamant M, Guigas B, Ouwens DM.

Cell Signal. 2013 Sep;25(9):1762-8. doi: 10.1016/j.cellsig.2013.05.022. Epub 2013 May 24.

PMID:
23712034
35.

Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies.

Greulich S, Chen WJ, Maxhera B, Rijzewijk LJ, van der Meer RW, Jonker JT, Mueller H, de Wiza DH, Floerke RR, Smiris K, Lamb HJ, de Roos A, Bax JJ, Romijn JA, Smit JW, Akhyari P, Lichtenberg A, Eckel J, Diamant M, Ouwens DM.

PLoS One. 2013;8(3):e59697. doi: 10.1371/journal.pone.0059697. Epub 2013 Mar 29.

36.

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.

Fleuren WW, Linssen MM, Toonen EJ, van der Zon GC, Guigas B, de Vlieg J, Dokter WH, Ouwens DM, Alkema W.

Arch Physiol Biochem. 2013 May;119(2):52-64. doi: 10.3109/13813455.2013.774022. Epub 2013 Mar 19.

37.

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.

Wiza C, Herzfeld de Wiza D, Nascimento EB, Lehr S, Al-Hasani H, Ouwens DM.

Diabetologia. 2013 May;56(5):1118-28. doi: 10.1007/s00125-013-2861-9. Epub 2013 Mar 5.

PMID:
23460019
38.

Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.

Steinbusch LK, Dirkx E, Hoebers NT, Roelants V, Foretz M, Viollet B, Diamant M, van Eys G, Ouwens DM, Bertrand L, Glatz JF, Luiken JJ.

J Mol Cell Cardiol. 2013 Feb;55:165-73. doi: 10.1016/j.yjmcc.2012.11.005. Epub 2012 Nov 15.

PMID:
23159540
39.

Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction.

Greulich S, Maxhera B, Vandenplas G, de Wiza DH, Smiris K, Mueller H, Heinrichs J, Blumensatt M, Cuvelier C, Akhyari P, Ruige JB, Ouwens DM, Eckel J.

Circulation. 2012 Nov 6;126(19):2324-34. doi: 10.1161/CIRCULATIONAHA.111.039586. Epub 2012 Oct 12.

PMID:
23065384
40.

Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females.

Berings M, Wehlou C, Verrijken A, Deschepper E, Mertens I, Kaufman JM, Van Gaal LF, Ouwens DM, Ruige JB.

PLoS One. 2012;7(9):e45145. doi: 10.1371/journal.pone.0045145. Epub 2012 Sep 28.

41.

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Phielix E, Meex R, Ouwens DM, Sparks L, Hoeks J, Schaart G, Moonen-Kornips E, Hesselink MK, Schrauwen P.

Diabetes. 2012 Oct;61(10):2472-8. Epub 2012 Jul 10.

42.

Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice.

Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual-Cladera E, Jörgensen JA, van Beurden D, den Hartog GJM, Ouwens DM, Briedé JJ, Schrauwen P, Hoeks J.

Diabetologia. 2012 Oct;55(10):2759-2768. doi: 10.1007/s00125-012-2626-x. Epub 2012 Jul 12.

PMID:
22782287
43.

CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes.

Angin Y, Steinbusch LK, Simons PJ, Greulich S, Hoebers NT, Douma K, van Zandvoort MA, Coumans WA, Wijnen W, Diamant M, Ouwens DM, Glatz JF, Luiken JJ.

Biochem J. 2012 Nov 15;448(1):43-53. doi: 10.1042/BJ20120060.

PMID:
22780108
44.

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies.

Vandenplas G, De Bacquer D, Calders P, Fiers T, Kaufman JM, Ouwens DM, Ruige JB.

Heart. 2012 Oct;98(20):1478-82. Epub 2012 Jun 26. Review.

PMID:
22735686
45.

Effects of adding exercise to a 16-week very low-calorie diet in obese, insulin-dependent type 2 diabetes mellitus patients.

Snel M, Gastaldelli A, Ouwens DM, Hesselink MK, Schaart G, Buzzigoli E, Frölich M, Romijn JA, Pijl H, Meinders AE, Jazet IM.

J Clin Endocrinol Metab. 2012 Jul;97(7):2512-20. doi: 10.1210/jc.2011-3178. Epub 2012 May 8.

PMID:
22569236
46.

Sex steroid-induced changes in circulating monocyte chemoattractant protein-1 levels may contribute to metabolic dysfunction in obese men.

Ruige JB, Bekaert M, Lapauw B, Fiers T, Lehr S, Hartwig S, Herzfeld de Wiza D, Schiller M, Passlack W, Van Nieuwenhove Y, Pattyn P, Cuvelier C, Taes YE, Sell H, Eckel J, Kaufman JM, Ouwens DM.

J Clin Endocrinol Metab. 2012 Jul;97(7):E1187-91. doi: 10.1210/jc.2011-3069. Epub 2012 Apr 20.

PMID:
22523336
47.

Role of PRAS40 in Akt and mTOR signaling in health and disease.

Wiza C, Nascimento EB, Ouwens DM.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1453-60. doi: 10.1152/ajpendo.00660.2011. Epub 2012 Feb 21.

48.

Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome.

Ouwens DM, Bekaert M, Lapauw B, Van Nieuwenhove Y, Lehr S, Hartwig S, Calders P, Kaufman JM, Sell H, Eckel J, Ruige JB.

Arch Physiol Biochem. 2012 Jul;118(3):135-8. doi: 10.3109/13813455.2012.654800. Epub 2012 Feb 15.

PMID:
22335466
49.

Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance.

Märker T, Sell H, Zillessen P, Glöde A, Kriebel J, Ouwens DM, Pattyn P, Ruige J, Famulla S, Roden M, Eckel J, Habich C.

Diabetes. 2012 Mar;61(3):615-25. doi: 10.2337/db10-1574. Epub 2012 Feb 7.

50.

Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men.

De Naeyer H, Ouwens DM, Van Nieuwenhove Y, Pattyn P, 't Hart LM, Kaufman JM, Sell H, Eckel J, Cuvelier C, Taes YE, Ruige JB.

Obes Facts. 2011;4(5):407-16. doi: 10.1159/000333445. Epub 2011 Oct 14.

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