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Items: 1 to 50 of 181

1.

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein.

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MA, Villar-Piqué A, Szego É, Fonseca TL, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.

Hum Mol Genet. 2018 Sep 13. doi: 10.1093/hmg/ddy326. [Epub ahead of print]

PMID:
30219847
2.

Membrane binding, internalization, and sorting of alpha-synuclein in the cell.

Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF.

Acta Neuropathol Commun. 2018 Aug 14;6(1):79. doi: 10.1186/s40478-018-0578-1.

3.

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.

Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.

Neurobiol Dis. 2018 Nov;119:121-135. doi: 10.1016/j.nbd.2018.08.001. Epub 2018 Aug 6.

PMID:
30092270
4.

The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.

Magalhães RSS, Popova B, Braus GH, Outeiro TF, Eleutherio ECA.

FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy066.

PMID:
30007297
5.

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]

PMID:
29950682
6.

Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.

Vaz RL, Outeiro TF, Ferreira JJ.

Front Neurol. 2018 Jun 1;9:347. doi: 10.3389/fneur.2018.00347. eCollection 2018.

7.

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.

Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE, Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN.

Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z.

8.

The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.

Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.

Mol Neurobiol. 2018 Apr 19. doi: 10.1007/s12035-018-1084-y. [Epub ahead of print]

9.

Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View.

Biosa A, Outeiro TF, Bubacco L, Bisaglia M.

Mol Neurobiol. 2018 Mar 28. doi: 10.1007/s12035-018-1025-9. [Epub ahead of print] Review.

PMID:
29594935
10.

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.

Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.

Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003.

PMID:
29539391
11.

SIRT2 in age-related neurodegenerative disorders.

Fourcade S, Outeiro TF, Pujol A.

Aging (Albany NY). 2018 Mar 3;10(3):295-296. doi: 10.18632/aging/101397. No abstract available.

12.

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease.

König A, Vicente Miranda H, Outeiro TF.

J Parkinsons Dis. 2018;8(1):33-43. doi: 10.3233/JPD-171285.

13.

Guidelines and recommendations on yeast cell death nomenclature.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.

Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.

14.

Correction: Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF.

PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017.

15.

Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.

Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C, Meyer T.

World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print]

PMID:
29243550
16.

The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.

Bozek T, Blazekovic A, Perkovic MN, Jercic KG, Sustar A, Smircic-Duvnjak L, Outeiro TF, Pivac N, Borovecki F.

Diabetol Metab Syndr. 2017 Dec 4;9:97. doi: 10.1186/s13098-017-0295-0. eCollection 2017.

17.

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.

EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.

18.

Editorial: Molecular Chaperones and Neurodegeneration.

Roodveldt C, Outeiro TF, Braun JEA.

Front Neurosci. 2017 Oct 11;11:565. doi: 10.3389/fnins.2017.00565. eCollection 2017. No abstract available.

19.

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease.

Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.

Sci Rep. 2017 Oct 20;7(1):13713. doi: 10.1038/s41598-017-14175-5.

20.

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.

Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.

Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298.

PMID:
28973648
21.

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B.

Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.

Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25.

PMID:
28945221
22.

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.

Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.

Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260.

PMID:
28934390
23.

Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain.

López-León M, Outeiro TF, Goya RG.

Ageing Res Rev. 2017 Nov;40:168-181. doi: 10.1016/j.arr.2017.09.002. Epub 2017 Sep 10. Review.

PMID:
28903069
24.

Serum lipid alterations in GBA-associated Parkinson's disease.

Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G.

Parkinsonism Relat Disord. 2017 Nov;44:58-65. doi: 10.1016/j.parkreldis.2017.08.026. Epub 2017 Sep 1.

PMID:
28890071
25.

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.

Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.

Mol Neurobiol. 2018 Jun;55(6):5269-5281. doi: 10.1007/s12035-017-0755-4. Epub 2017 Sep 7.

26.

Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease.

Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ.

Mov Disord. 2017 Sep;32(9):1331-1333. doi: 10.1002/mds.27083. Epub 2017 Jul 7. No abstract available.

PMID:
28686310
27.

Tau deletion promotes brain insulin resistance.

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.

28.

IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function.

Pardo J, Abba MC, Lacunza E, Ogundele OM, Paiva I, Morel GR, Outeiro TF, Goya RG.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):459-467. doi: 10.1093/gerona/glx125.

PMID:
28645186
29.

Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.

Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5.

30.

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease.

Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, Carvalho AN, Outeiro TF, Rodrigues CMP, Gama MJ, Castro-Caldas M.

Exp Neurol. 2017 Sep;295:77-87. doi: 10.1016/j.expneurol.2017.05.009. Epub 2017 May 25.

PMID:
28552716
31.

Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.

Lázaro DF, Pavlou MAS, Outeiro TF.

Exp Neurol. 2017 Dec;298(Pt B):162-171. doi: 10.1016/j.expneurol.2017.05.007. Epub 2017 May 16. Review.

PMID:
28526239
32.

Epigenetics in Parkinson's Disease.

Pavlou MAS, Outeiro TF.

Adv Exp Med Biol. 2017;978:363-390. doi: 10.1007/978-3-319-53889-1_19. Review.

PMID:
28523556
33.

Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway.

Szegő ÉM, Gerhardt E, Outeiro TF.

Neurobiol Aging. 2017 Aug;56:7-16. doi: 10.1016/j.neurobiolaging.2017.04.001. Epub 2017 Apr 10.

PMID:
28478325
34.

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.

Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.

Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.

PMID:
28398476
35.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.

36.

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.

Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego ÉM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF.

Hum Mol Genet. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114.

PMID:
28369321
37.

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics.

Villar-Piqué A, Rossetti G, Ventura S, Carloni P, Fernández CO, Outeiro TF.

Commun Integr Biol. 2017 Feb 6;10(1):e1270484. doi: 10.1080/19420889.2016.1270484. eCollection 2017.

38.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

39.

A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies.

Cukierman DS, Pinheiro AB, Castiñeiras-Filho SL, da Silva AS, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha AL, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, Rey NA.

J Inorg Biochem. 2017 May;170:160-168. doi: 10.1016/j.jinorgbio.2017.02.020. Epub 2017 Feb 22.

PMID:
28249224
40.

Yeast models of Parkinson's disease-associated molecular pathologies.

Tenreiro S, Franssens V, Winderickx J, Outeiro TF.

Curr Opin Genet Dev. 2017 Jun;44:74-83. doi: 10.1016/j.gde.2017.01.013. Review.

PMID:
28232272
41.

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress.

Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken J.

Sci Rep. 2017 Feb 22;7:42942. doi: 10.1038/srep42942.

42.

Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats.

Pardo J, Abba MC, Lacunza E, Francelle L, Morel GR, Outeiro TF, Goya RG.

Hippocampus. 2017 Apr;27(4):435-449. doi: 10.1002/hipo.22703. Epub 2017 Jan 23.

PMID:
28085212
43.

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.

Lázaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF.

Acta Neuropathol Commun. 2016 Dec 9;4(1):128.

44.

A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies.

Fernandes JT, Chutna O, Chu V, Conde JP, Outeiro TF.

Front Neurosci. 2016 Nov 15;10:511. eCollection 2016.

45.

Glycation potentiates neurodegeneration in models of Huntington's disease.

Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF.

Sci Rep. 2016 Nov 18;6:36798. doi: 10.1038/srep36798.

46.

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. Epub 2016 Oct 5.

47.

Analysis of Protein Oligomeric Species by Sucrose Gradients.

Tenreiro S, Macedo D, Marijanovic Z, Outeiro TF.

Methods Mol Biol. 2016;1449:331-9. doi: 10.1007/978-1-4939-3756-1_21.

PMID:
27613047
48.

The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.

Pavlou MAS, Pinho R, Paiva I, Outeiro TF.

Brain. 2017 Apr 1;140(4):878-886. doi: 10.1093/brain/aww227.

PMID:
27585855
49.

Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.

Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF.

Neuromolecular Med. 2017 Mar;19(1):113-121. doi: 10.1007/s12017-016-8435-5. Epub 2016 Aug 17.

PMID:
27535567
50.

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV.

Sci Rep. 2016 Aug 11;6:31493. doi: 10.1038/srep31493.

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