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Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice.

Mattson AM, Begun DL, Molstad DHH, Meyer MA, Oursler MJ, Westendorf JJ, Bradley EW.

J Biol Chem. 2019 Jun 12. pii: jbc.RA119.007660. doi: 10.1074/jbc.RA119.007660. [Epub ahead of print]


Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling.

Li Z, Liu T, Gilmore A, Gómez NM, Fu C, Lim J, Yang S, Mitchell CH, Li YP, Oursler MJ, Yang S.

J Bone Miner Res. 2019 Apr;34(4):752-764. doi: 10.1002/jbmr.3645. Epub 2019 Jan 28.


Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics.

Ng AY, Tu C, Shen S, Xu D, Oursler MJ, Qu J, Yang S.

JBMR Plus. 2018 Jul 7;2(6):328-340. doi: 10.1002/jbm4.10058. eCollection 2018 Nov.


Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384c.


Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.


Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned.

Drake MT, Clarke BL, Oursler MJ, Khosla S.

Endocr Rev. 2017 Aug 1;38(4):325-350. doi: 10.1210/er.2015-1114. Review.


Sclerostin expression and functions beyond the osteocyte.

Weivoda MM, Youssef SJ, Oursler MJ.

Bone. 2017 Mar;96:45-50. doi: 10.1016/j.bone.2016.11.024. Epub 2016 Nov 23. Review.


Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ.

Sci Signal. 2016 Aug 9;9(440):ra79. doi: 10.1126/scisignal.aaf3273.


Response to Wnt Signaling Pathways.

Oursler MJ, Westendorf JJ, Weivoda MM, Ruan M, Hachfeld CM, Howe A, Davey R, Zajac J, Williams BO, Khosla S.

J Bone Miner Res. 2015 Nov;30(11):2135-6. doi: 10.1002/jbmr.2694. Epub 2015 Sep 14. No abstract available.


Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.

McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ.

J Bone Miner Res. 2016 Jan;31(1):116-28. doi: 10.1002/jbmr.2602. Epub 2015 Aug 20.


Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways.

Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):65-75. doi: 10.1002/jbmr.2599. Epub 2015 Aug 19.


Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation.

Weivoda MM, Ruan M, Pederson L, Hachfeld C, Davey RA, Zajac JD, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):76-85. doi: 10.1002/jbmr.2586. Epub 2015 Aug 6.


Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss.

Yuan X, Cao J, Liu T, Li YP, Scannapieco F, He X, Oursler MJ, Zhang X, Vacher J, Li C, Olson D, Yang S.

Cell Death Differ. 2015 Dec;22(12):2046-57. doi: 10.1038/cdd.2015.45. Epub 2015 Apr 24.


The Roles of Small GTPases in Osteoclast Biology.

Weivoda MM, Oursler MJ.

Orthop Muscular Syst. 2014;3. pii: 1000161.


Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.

Weivoda MM, Oursler MJ.

Curr Osteoporos Rep. 2014 Mar;12(1):107-14. doi: 10.1007/s11914-014-0188-1. Review.


Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors.

Ota K, Quint P, Weivoda MM, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ.

Bone. 2013 Nov;57(1):68-75. doi: 10.1016/j.bone.2013.07.023. Epub 2013 Jul 25.


TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts.

Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ.

Endocrinology. 2013 Oct;154(10):3745-52. doi: 10.1210/en.2013-1272. Epub 2013 Jul 16.


MicroRNA functions in osteogenesis and dysfunctions in osteoporosis.

van Wijnen AJ, van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ, Oursler MJ, Im HJ, Taipaleenmäki H, Hesse E, Riester S, Kakar S.

Curr Osteoporos Rep. 2013 Jun;11(2):72-82. doi: 10.1007/s11914-013-0143-6. Review.


Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization.

Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ.

J Cell Biochem. 2013 Aug;114(8):1901-1907. doi: 10.1002/jcb.24537.


Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways.

Quint P, Ruan M, Pederson L, Kassem M, Westendorf JJ, Khosla S, Oursler MJ.

J Biol Chem. 2013 Feb 22;288(8):5398-406. doi: 10.1074/jbc.M112.413583. Epub 2013 Jan 7.


Estrogen and the skeleton.

Khosla S, Oursler MJ, Monroe DG.

Trends Endocrinol Metab. 2012 Nov;23(11):576-81. doi: 10.1016/j.tem.2012.03.008. Epub 2012 May 16. Review.


Update on Wnt signaling in bone cell biology and bone disease.

Monroe DG, McGee-Lawrence ME, Oursler MJ, Westendorf JJ.

Gene. 2012 Jan 15;492(1):1-18. doi: 10.1016/j.gene.2011.10.044. Epub 2011 Nov 3. Review.


TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction.

Kumar A, Ruan M, Clifton K, Syed F, Khosla S, Oursler MJ.

Endocrinology. 2012 Jan;153(1):254-63. doi: 10.1210/en.2011-1169. Epub 2011 Nov 8.


TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.

Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC.

PLoS One. 2011 Apr 29;6(4):e19429. doi: 10.1371/journal.pone.0019429.


Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women.

Mödder UI, Roforth MM, Hoey K, McCready LK, Peterson JM, Monroe DG, Oursler MJ, Khosla S.

Bone. 2011 Aug;49(2):202-7. doi: 10.1016/j.bone.2011.04.015. Epub 2011 Apr 29.


TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways.

Cicek M, Vrabel A, Sturchio C, Pederson L, Hawse JR, Subramaniam M, Spelsberg TC, Oursler MJ.

PLoS One. 2011 Mar 14;6(3):e17522. doi: 10.1371/journal.pone.0017522.


Wnt10b activates the Wnt, notch, and NFκB pathways in U2OS osteosarcoma cells.

Mödder UI, Oursler MJ, Khosla S, Monroe DG.

J Cell Biochem. 2011 May;112(5):1392-402. doi: 10.1002/jcb.23048.


Recent advances in understanding the mechanisms of osteoclast precursor fusion.

Oursler MJ.

J Cell Biochem. 2010 Aug 1;110(5):1058-62. doi: 10.1002/jcb.22640.


Regulation of circulating sclerostin levels by sex steroids in women and in men.

Mödder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, Riggs BL, Khosla S.

J Bone Miner Res. 2011 Jan;26(1):27-34. doi: 10.1002/jbmr.128.


Effects of chronic estrogen treatment on modulating age-related bone loss in female mice.

Syed FA, Mödder UI, Roforth M, Hensen I, Fraser DG, Peterson JM, Oursler MJ, Khosla S.

J Bone Miner Res. 2010 Nov;25(11):2438-46. doi: 10.1002/jbmr.129.


Transforming growth factor-{beta} coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis.

Ruan M, Pederson L, Bradley EW, Bamberger AM, Oursler MJ.

Endocrinology. 2010 Apr;151(4):1713-22. doi: 10.1210/en.2009-0813. Epub 2010 Feb 24.


TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts.

Subramaniam M, Hawse JR, Bruinsma ES, Grygo SB, Cicek M, Oursler MJ, Spelsberg TC.

Biochem Biophys Res Commun. 2010 Jan 29;392(1):72-6. doi: 10.1016/j.bbrc.2009.12.171. Epub 2010 Jan 6.


Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.

Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20764-9. doi: 10.1073/pnas.0805133106. Epub 2008 Dec 15.


Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo.

Clowes JA, Eghbali-Fatourechi GZ, McCready L, Oursler MJ, Khosla S, Riggs BL.

Osteoporos Int. 2009 May;20(5):761-9. doi: 10.1007/s00198-008-0731-y. Epub 2008 Sep 4.


PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival.

Bradley EW, Ruan MM, Oursler MJ.

J Cell Physiol. 2008 Dec;217(3):752-8. doi: 10.1002/jcp.21550.


TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

Gingery A, Bradley EW, Pederson L, Ruan M, Horwood NJ, Oursler MJ.

Exp Cell Res. 2008 Sep 10;314(15):2725-38. doi: 10.1016/j.yexcr.2008.06.006. Epub 2008 Jun 13.


Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain.

Hawse JR, Subramaniam M, Monroe DG, Hemmingsen AH, Ingle JN, Khosla S, Oursler MJ, Spelsberg TC.

Mol Endocrinol. 2008 Jul;22(7):1579-95. doi: 10.1210/me.2007-0253. Epub 2008 May 15.


Osteoclast culture and resorption assays.

Bradley EW, Oursler MJ.

Methods Mol Biol. 2008;455:19-35. doi: 10.1007/978-1-59745-104-8_2.


TIEG-null mice display an osteopenic gender-specific phenotype.

Hawse JR, Iwaniec UT, Bensamoun SF, Monroe DG, Peters KD, Ilharreborde B, Rajamannan NM, Oursler MJ, Turner RT, Spelsberg TC, Subramaniam M.

Bone. 2008 Jun;42(6):1025-31. doi: 10.1016/j.bone.2008.02.004. Epub 2008 Mar 4.


Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival.

Bradley EW, Ruan MM, Vrable A, Oursler MJ.

J Cell Biochem. 2008 Jul 1;104(4):1439-51. doi: 10.1002/jcb.21719.


Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women.

Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S.

Osteoporos Int. 2008 Sep;19(9):1323-30. doi: 10.1007/s00198-008-0574-6. Epub 2008 Feb 15.


Building bone to reverse osteoporosis and repair fractures.

Khosla S, Westendorf JJ, Oursler MJ.

J Clin Invest. 2008 Feb;118(2):421-8. doi: 10.1172/JCI33612. Review.


Regulation of bone turnover by sex steroids in men.

Sanyal A, Hoey KA, Mödder UI, Lamsam JL, McCready LK, Peterson JM, Achenbach SJ, Oursler MJ, Khosla S.

J Bone Miner Res. 2008 May;23(5):705-14.


2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo.

Cicek M, Iwaniec UT, Goblirsch MJ, Vrabel A, Ruan M, Clohisy DR, Turner RR, Oursler MJ.

Cancer Res. 2007 Nov 1;67(21):10106-11.


Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells.

Rudnik V, Sanyal A, Syed FA, Monroe DG, Spelsberg TC, Oursler MJ, Khosla S.

J Cell Biochem. 2008 Feb 15;103(3):896-907.


Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors.

Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC.

J Cell Biochem. 2008 Feb 1;103(2):383-92. Review.


Breast cancer bone metastasis and current small therapeutics.

Cicek M, Oursler MJ.

Cancer Metastasis Rev. 2006 Dec;25(4):635-44. Review.


TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture.

Bensamoun SF, Hawse JR, Subramaniam M, Ilharreborde B, Bassillais A, Benhamou CL, Fraser DG, Oursler MJ, Amadio PC, An KN, Spelsberg TC.

Bone. 2006 Dec;39(6):1244-51. Epub 2006 Jul 28.


2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts.

Maran A, Gorny G, Oursler MJ, Zhang M, Shogren KL, Yaszemski MJ, Turner RT.

J Cell Biochem. 2006 Oct 1;99(2):425-34.


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