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Items: 1 to 50 of 92

1.

CD4+ CCR6+ T cells, but not γδ T cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice.

Razawy W, Asmawidjaja PS, Mus AM, Salioska N, Davelaar N, Kops N, Oukka M, Alves CH, Lubberts E.

Eur J Immunol. 2019 Nov 12. doi: 10.1002/eji.201948112. [Epub ahead of print]

PMID:
31778214
2.

ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients.

Eken A, Cansever M, Okus FZ, Erdem S, Nain E, Azizoglu ZB, Haliloglu Y, Karakukcu M, Ozcan A, Devecioglu O, Aksu G, Arikan Ayyildiz Z, Topal E, Karakoc Aydiner E, Kiykim A, Metin A, Cipe F, Kaya A, Artac H, Reisli I, Guner SN, Uygun V, Karasu G, Dönmez Altuntas H, Canatan H, Oukka M, Ozen A, Chatila TA, Keles S, Baris S, Unal E, Patiroglu T.

Allergy. 2019 Oct 9. doi: 10.1111/all.14081. [Epub ahead of print]

PMID:
31596517
3.

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.

Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, Waisman A, Opitz L, Oukka M, Schreiner B, Pelczar P, Becher B.

Immunity. 2019 May 21;50(5):1289-1304.e6. doi: 10.1016/j.immuni.2019.04.006. Epub 2019 May 9.

PMID:
31079916
4.

Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells.

Eken A, Yetkin MF, Vural A, Okus FZ, Erdem S, Azizoglu ZB, Haliloglu Y, Cakir M, Turkoglu EM, Kilic O, Kara I, Dönmez Altuntaş H, Oukka M, Kutuk MS, Mirza M, Canatan H.

Front Immunol. 2019 Feb 13;10:217. doi: 10.3389/fimmu.2019.00217. eCollection 2019.

5.

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.

Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ.

Front Immunol. 2019 Jan 25;10:44. doi: 10.3389/fimmu.2019.00044. eCollection 2019.

6.

Regulation of lymphocyte trafficking in central nervous system autoimmunity.

Oukka M, Bettelli E.

Curr Opin Immunol. 2018 Dec;55:38-43. doi: 10.1016/j.coi.2018.09.008. Epub 2018 Sep 27. Review.

7.

Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses.

Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ.

J Exp Med. 2018 Oct 1;215(10):2485-2496. doi: 10.1084/jem.20180617. Epub 2018 Sep 7.

8.

S1P1 deletion differentially affects TH17 and Regulatory T cells.

Eken A, Duhen R, Singh AK, Fry M, Buckner JH, Kita M, Bettelli E, Oukka M.

Sci Rep. 2017 Oct 10;7(1):12905. doi: 10.1038/s41598-017-13376-2.

9.

DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling.

Singh AK, Eken A, Hagin D, Komal K, Bhise G, Shaji A, Arkatkar T, Jackson SW, Bettelli E, Torgerson TR, Oukka M.

JCI Insight. 2017 Oct 5;2(19). pii: 94275. doi: 10.1172/jci.insight.94275.

10.

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.

11.

A BAFFling Association between Malaria Resistance and the Risk of Multiple Sclerosis.

Korn T, Oukka M.

N Engl J Med. 2017 Apr 27;376(17):1680-1681. doi: 10.1056/NEJMe1700720. No abstract available.

12.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Mar 22;18(4):474. doi: 10.1038/ni0417-474b. No abstract available.

PMID:
28323263
13.

Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.

Allenspach EJ, Finn LS, Rendi MH, Eken A, Singh AK, Oukka M, Taylor SD, Altman MC, Fligner CL, Ochs HD, Rawlings DJ, Torgerson TR.

J Allergy Clin Immunol. 2017 Aug;140(2):616-619.e7. doi: 10.1016/j.jaci.2017.02.017. Epub 2017 Mar 16. No abstract available.

PMID:
28322850
14.

The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program.

Wu C, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, Han T, Oukka M, Kuchroo V.

Nat Immunol. 2017 Mar;18(3):344-353. doi: 10.1038/ni.3667. Epub 2017 Jan 23.

15.

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Erratum in: Nat Immunol. 2017 Mar 22;18(4):474.

16.

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

Krausgruber T, Schiering C, Adelmann K, Harrison OJ, Chomka A, Pearson C, Ahern PP, Shale M, Oukka M, Powrie F.

Nat Commun. 2016 May 19;7:11627. doi: 10.1038/ncomms11627.

17.

IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis.

Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E.

J Immunol. 2015 Sep 1;195(5):1974-83. doi: 10.4049/jimmunol.1403135. Epub 2015 Jul 29.

18.

IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology.

Chen L, He Z, Slinger E, Bongers G, Lapenda TLS, Pacer ME, Jiao J, Beltrao MF, Soto AJ, Harpaz N, Gordon RE, Ochando JC, Oukka M, Iuga AC, Chensue SW, Blander JM, Furtado GC, Lira SA.

Mucosal Immunol. 2015 Mar;8(2):390-402. doi: 10.1038/mi.2014.77. Epub 2014 Aug 27.

19.

DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs.

Singh AK, Eken A, Fry M, Bettelli E, Oukka M.

Nat Commun. 2014 Aug 5;5:4603. doi: 10.1038/ncomms5603.

20.

IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.

Li H, Hsu HC, Wu Q, Yang P, Li J, Luo B, Oukka M, Steele CH 3rd, Cua DJ, Grizzle WE, Mountz JD.

Nat Commun. 2014 Jul 8;5:4259. doi: 10.1038/ncomms5259.

21.

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1.

Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T.

Nat Commun. 2014 May 6;5:3770. doi: 10.1038/ncomms4770.

PMID:
24796719
22.

Interleukin 23 in Crohn's disease.

Eken A, Singh AK, Oukka M.

Inflamm Bowel Dis. 2014 Mar;20(3):587-95. doi: 10.1097/01.MIB.0000442014.52661.20. Review.

23.

Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.

Do JS, Visperas A, Freeman ML, Iwakura Y, Oukka M, Min B.

Immunol Cell Biol. 2014 Jan;92(1):90-8. doi: 10.1038/icb.2013.70. Epub 2013 Nov 5.

24.

IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism.

Eken A, Singh AK, Treuting PM, Oukka M.

Mucosal Immunol. 2014 Jan;7(1):143-54. doi: 10.1038/mi.2013.33. Epub 2013 May 29.

25.

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.

Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ.

Nat Immunol. 2013 May;14(5):514-22. doi: 10.1038/ni.2569. Epub 2013 Apr 7.

26.

Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet.

Duhen R, Glatigny S, Arbelaez CA, Blair TC, Oukka M, Bettelli E.

J Immunol. 2013 May 1;190(9):4478-82. doi: 10.4049/jimmunol.1203172. Epub 2013 Mar 29.

27.

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.

Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M.

Nature. 2012 Nov 8;491(7423):254-8. doi: 10.1038/nature11465.

28.

Vaccination with a UV-irradiated genetically attenuated mutant of Staphylococcus aureus provides protection against subsequent systemic infection.

Burnside K, Lembo A, Harrell MI, Klein JA, Lopez-Guisa J, Siegesmund AM, Torgerson TR, Oukka M, Molina DM, Rajagopal L.

J Infect Dis. 2012 Dec 1;206(11):1734-44. doi: 10.1093/infdis/jis579. Epub 2012 Sep 10.

29.

Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.

Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK.

J Immunol. 2012 Jan 1;188(1):155-62. doi: 10.4049/jimmunol.1102042. Epub 2011 Nov 28.

30.

Cutting edge: loss of α4 integrin expression differentially affects the homing of Th1 and Th17 cells.

Glatigny S, Duhen R, Oukka M, Bettelli E.

J Immunol. 2011 Dec 15;187(12):6176-9. doi: 10.4049/jimmunol.1102515. Epub 2011 Nov 14.

31.

GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.

Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y.

J Clin Invest. 2011 Nov;121(11):4503-15. doi: 10.1172/JCI57456. Epub 2011 Oct 3.

32.

Alterations in regulatory T-cells: rediscovered pathways in immunotoxicology.

Corsini E, Oukka M, Pieters R, Kerkvliet NI, Ponce R, Germolec DR.

J Immunotoxicol. 2011 Oct-Dec;8(4):251-7. doi: 10.3109/1547691X.2011.598885. Epub 2011 Aug 17. Review.

33.

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt.

Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH.

Nat Immunol. 2011 Jan;12(1):96-104. doi: 10.1038/ni.1969. Epub 2010 Dec 12.

34.

γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.

Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T.

Immunity. 2010 Sep 24;33(3):351-63. doi: 10.1016/j.immuni.2010.08.013. Epub 2010 Sep 9.

35.

Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.

Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC.

J Immunol. 2010 May 1;184(9):4605-9. doi: 10.4049/jimmunol.0903595. Epub 2010 Mar 22.

36.

Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish.

Quintana FJ, Iglesias AH, Farez MF, Caccamo M, Burns EJ, Kassam N, Oukka M, Weiner HL.

PLoS One. 2010 Mar 5;5(3):e9478. doi: 10.1371/journal.pone.0009478.

37.

FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.

Tartar DM, VanMorlan AM, Wan X, Guloglu FB, Jain R, Haymaker CL, Ellis JS, Hoeman CM, Cascio JA, Dhakal M, Oukka M, Zaghouani H.

J Immunol. 2010 Apr 1;184(7):3377-85. doi: 10.4049/jimmunol.0903324. Epub 2010 Feb 24.

38.

IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.

Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M.

J Immunol. 2010 Feb 15;184(4):1710-20. doi: 10.4049/jimmunol.0902796. Epub 2010 Jan 18.

39.

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS.

J Immunol. 2009 Oct 15;183(8):5146-57. doi: 10.4049/jimmunol.0802610. Epub 2009 Sep 25.

40.

Regulatory T cells in mouse periapical lesions.

AlShwaimi E, Purcell P, Kawai T, Sasaki H, Oukka M, Campos-Neto A, Stashenko P.

J Endod. 2009 Sep;35(9):1229-33. doi: 10.1016/j.joen.2009.06.006.

41.

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.

Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12885-90. doi: 10.1073/pnas.0812530106. Epub 2009 May 11.

42.

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells.

Awasthi A, Riol-Blanco L, Jäger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M.

J Immunol. 2009 May 15;182(10):5904-8. doi: 10.4049/jimmunol.0900732.

43.

TH17 cells and regulatory T cells in primary immunodeficiency diseases.

Ochs HD, Oukka M, Torgerson TR.

J Allergy Clin Immunol. 2009 May;123(5):977-83; quiz 984-5. doi: 10.1016/j.jaci.2009.03.030. Review.

44.

IL-17 and Th17 Cells.

Korn T, Bettelli E, Oukka M, Kuchroo VK.

Annu Rev Immunol. 2009;27:485-517. doi: 10.1146/annurev.immunol.021908.132710. Review.

PMID:
19132915
45.

Th17 cells in immunity and autoimmunity.

Oukka M.

Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii26-9. doi: 10.1136/ard.2008.098004. Review.

PMID:
19022809
46.

IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice.

Edgerton C, Crispín JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen J, Dalle Lucca JJ, Juang YT, Tsokos GC.

Clin Immunol. 2009 Mar;130(3):313-21. doi: 10.1016/j.clim.2008.09.019. Epub 2008 Dec 5.

47.

Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys.

Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC.

J Immunol. 2008 Dec 15;181(12):8761-6.

48.

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.

Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, Vollmar P, Stritesky GL, Kaplan MH, Waisman A, Kuchroo VK, Oukka M.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18460-5. doi: 10.1073/pnas.0809850105. Epub 2008 Nov 17.

49.

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.

Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK.

Nat Immunol. 2008 Dec;9(12):1347-55. doi: 10.1038/ni.1677. Epub 2008 Nov 9. Erratum in: Nat Immunol. 2009 May;10(5):551.

50.

Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.

Feng G, Gao W, Strom TB, Oukka M, Francis RS, Wood KJ, Bushell A.

Eur J Immunol. 2008 Sep;38(9):2512-27. doi: 10.1002/eji.200838411.

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