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Items: 42


Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.

Nimmakayala RK, Seshacharyulu P, Lakshmanan I, Rachagani S, Chugh S, Karmakar S, Rauth S, Vengoji R, Atri P, Talmon GA, Lele SM, Smith LM, Thapa I, Bastola D, Ouellette MM, Batra SK, Ponnusamy MP.

Gastroenterology. 2018 Sep;155(3):892-908.e6. doi: 10.1053/j.gastro.2018.05.041. Epub 2018 Jun 2.


Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells.

Burchett KM, Etekpo A, Batra SK, Yan Y, Ouellette MM.

Oncotarget. 2017 Jul 20;8(48):83754-83767. doi: 10.18632/oncotarget.19410. eCollection 2017 Oct 13.


Discovery and characterization of small molecule Rac1 inhibitors.

Arnst JL, Hein AL, Taylor MA, Palermo NY, Contreras JI, Sonawane YA, Wahl AO, Ouellette MM, Natarajan A, Yan Y.

Oncotarget. 2017 May 23;8(21):34586-34600. doi: 10.18632/oncotarget.16656.


Biological determinants of radioresistance and their remediation in pancreatic cancer.

Seshacharyulu P, Baine MJ, Souchek JJ, Menning M, Kaur S, Yan Y, Ouellette MM, Jain M, Lin C, Batra SK.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):69-92. doi: 10.1016/j.bbcan.2017.02.003. Epub 2017 Feb 27. Review.


RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.

Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y.

Oncogene. 2016 Dec 8;35(49):6319-6329. doi: 10.1038/onc.2016.163. Epub 2016 May 16.


PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.

Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK, Yan Y.

Cancer Res. 2016 Apr 15;76(8):2243-2253. doi: 10.1158/0008-5472.CAN-15-2119. Epub 2016 Feb 18.


CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer.

Purohit A, Varney M, Rachagani S, Ouellette MM, Batra SK, Singh RK.

Oncotarget. 2016 Feb 9;7(6):7280-96. doi: 10.18632/oncotarget.6906.


Rac1 GTPase in pancreatic cancer.

Yan Y, Ouellette MM.

Aging (Albany NY). 2015 Sep;7(9):609-10. No abstract available.


The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs.

Choi KH, Lakamp-Hawley AS, Kolar C, Yan Y, Borgstahl GEO, Ouellette MM.

Biochimie. 2015 Aug;115:17-27. doi: 10.1016/j.biochi.2015.04.015. Epub 2015 Apr 28.


Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.

Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM.

Oncotarget. 2014 Nov 15;5(21):10251-70.


Radiation-induced signaling pathways that promote cancer cell survival (review).

Hein AL, Ouellette MM, Yan Y.

Int J Oncol. 2014 Nov;45(5):1813-9. doi: 10.3892/ijo.2014.2614. Epub 2014 Aug 20. Review.


Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.

Cox JL, Wilder PJ, Wuebben EL, Ouellette MM, Hollingsworth MA, Rizzino A.

Cancer Biol Ther. 2014 Aug;15(8):1042-52. doi: 10.4161/cbt.29182. Epub 2014 May 19. Erratum in: Cancer Biol Ther. 2016;17(3):336.


Telomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cells.

Burchett KM, Yan Y, Ouellette MM.

PLoS One. 2014 Jan 7;9(1):e85155. doi: 10.1371/journal.pone.0085155. eCollection 2014.


Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.

Peters HL, Tuli A, Wang X, Liu C, Pan Z, Ouellette MM, Hollingsworth MA, Macdonald RG, Solheim JC.

Int J Oncol. 2012 Oct;41(4):1464-74. doi: 10.3892/ijo.2012.1553. Epub 2012 Jul 13.


Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation.

Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, Ouellette MM, Batra SK.

Oncogene. 2013 Mar 14;32(11):1384-95. doi: 10.1038/onc.2012.163. Epub 2012 May 21.


A ssDNA Aptamer That Blocks the Function of the Anti-FLAG M2 Antibody.

Lakamp AS, Ouellette MM.

J Nucleic Acids. 2011;2011:720798. doi: 10.4061/2011/720798. Epub 2011 Oct 16.


Characterization of the DNA binding specificity of Shelterin complexes.

Choi KH, Farrell AS, Lakamp AS, Ouellette MM.

Nucleic Acids Res. 2011 Nov;39(21):9206-23. doi: 10.1093/nar/gkr665. Epub 2011 Aug 18.


Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA.

Prakash A, Natarajan A, Marky LA, Ouellette MM, Borgstahl GE.

J Nucleic Acids. 2011;2011:896947. doi: 10.4061/2011/896947. Epub 2011 May 21.


Targeting telomerase-expressing cancer cells.

Ouellette MM, Wright WE, Shay JW.

J Cell Mol Med. 2011 Jul;15(7):1433-42. doi: 10.1111/j.1582-4934.2011.01279.x. Review.


Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.

Zhao S, Wang Y, Cao L, Ouellette MM, Freeman JW.

Int J Cancer. 2010 Nov 1;127(9):2076-87. doi: 10.1002/ijc.25412.


K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.

Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S.

Mol Cancer Res. 2009 Jun;7(6):799-808. doi: 10.1158/1541-7786.MCR-08-0577. Epub 2009 Jun 9.


Use of exogenous hTERT to immortalize primary human cells.

Lee KM, Choi KH, Ouellette MM.

Cytotechnology. 2004 Jun;45(1-2):33-8. doi: 10.1007/10.1007/s10616-004-5123-3.



Ouellette MM.

Cytotechnology. 2004 Jun;45(1-2):1-2. doi: 10.1007/s10616-004-5119-z. No abstract available.


Sonic hedgehog promotes desmoplasia in pancreatic cancer.

Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T, Ouellette MM, Hollingsworth MA.

Clin Cancer Res. 2008 Oct 1;14(19):5995-6004. doi: 10.1158/1078-0432.CCR-08-0291.


Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.

Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C, Bardeesy N, Ouellette MM, Yu W, Maitra A.

Gut. 2008 Oct;57(10):1420-30. doi: 10.1136/gut.2007.148189. Epub 2008 May 30.


Ras-driven transformation of human nestin-positive pancreatic epithelial cells.

Campbell PM, Lee KM, Ouellette MM, Kim HJ, Groehler AL, Khazak V, Der CJ.

Methods Enzymol. 2008;439:451-65. doi: 10.1016/S0076-6879(07)00431-4.


Gene targeting in adult rhesus macaque fibroblasts.

Meehan DT, Zink MA, Mahlen M, Nelson M, Sanger WG, Mitalipov SM, Wolf DP, Ouellette MM, Norgren RB Jr.

BMC Biotechnol. 2008 Mar 26;8:31. doi: 10.1186/1472-6750-8-31.


Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia.

Lee KM, Cao D, Itami A, Pour PM, Hruban RH, Maitra A, Ouellette MM.

Histopathology. 2007 Oct;51(4):539-46. Epub 2007 Aug 21.


Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells.

Salaria SN, Illei P, Sharma R, Walter KM, Klein AP, Eshleman JR, Maitra A, Schulick R, Winter J, Ouellette MM, Goggins M, Hruban R.

Cancer Biol Ther. 2007 Mar;6(3):324-8. Epub 2007 Mar 24.


K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.

Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ.

Cancer Res. 2007 Mar 1;67(5):2098-106.


Muscle impairments and behavioral factors mediate functional limitations and disability following stroke.

LeBrasseur NK, Sayers SP, Ouellette MM, Fielding RA.

Phys Ther. 2006 Oct;86(10):1342-50.


Notch 2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells.

Lee KM, Yasuda H, Hollingsworth MA, Ouellette MM.

Lab Invest. 2005 Aug;85(8):1003-12.


High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivors.

Ouellette MM, LeBrasseur NK, Bean JF, Phillips E, Stein J, Frontera WR, Fielding RA.

Stroke. 2004 Jun;35(6):1404-9. Epub 2004 Apr 22.


Immortalization with telomerase of the Nestin-positive cells of the human pancreas.

Lee KM, Nguyen C, Ulrich AB, Pour PM, Ouellette MM.

Biochem Biophys Res Commun. 2003 Feb 21;301(4):1038-44.


Telomerase: diagnostics, cancer therapeutics and tissue engineering.

Ouellette MM, Lee K.

Drug Discov Today. 2001 Dec 1;6(23):1231-1237.


Transplantation of normal and DMD myoblasts expressing the telomerase gene in SCID mice.

Seigneurin-Venin S, Bernard V, Moisset PA, Ouellette MM, Mouly V, Di Donna S, Wright WE, Tremblay JP.

Biochem Biophys Res Commun. 2000 Jun 7;272(2):362-9.


Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase.

Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS, Shay JW, Wright WE.

J Biol Chem. 2000 Apr 7;275(14):10072-6.


The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes.

Ouellette MM, McDaniel LD, Wright WE, Shay JW, Schultz RA.

Hum Mol Genet. 2000 Feb 12;9(3):403-11.


Telomerase activity does not always imply telomere maintenance.

Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW.

Biochem Biophys Res Commun. 1999 Jan 27;254(3):795-803.


Use of reiterative selection for defining protein-nucleic acid interactions.

Ouellette MM, Wright WE.

Curr Opin Biotechnol. 1995 Feb;6(1):65-72. Review.


Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site.

Ouellette MM, Chen J, Wright WE, Shay JW.

Oncogene. 1992 Jun;7(6):1075-81.


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