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Items: 1 to 50 of 321

1.

Gain and loss of function screens coupled to next generation sequencing for antibiotic mode of action and resistance studies in Streptococcus pneumoniae.

Gingras H, Patron K, Bhattacharya A, Leprohon P, Ouellette M.

Antimicrob Agents Chemother. 2019 Feb 19. pii: AAC.02381-18. doi: 10.1128/AAC.02381-18. [Epub ahead of print]

PMID:
30783004
2.

A Gate-and-Switch Model for Head Orientation Behaviors in Caenorhabditis elegans.

Ouellette MH, Desrochers MJ, Gheta I, Ramos R, Hendricks M.

eNeuro. 2018 Dec 10;5(6). pii: ENEURO.0121-18.2018. doi: 10.1523/ENEURO.0121-18.2018. eCollection 2018 Nov-Dec.

3.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Convery MA, Votta BJ, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, LePage C, Ouellette MT, Totoritis RD, Donovan BT, Brown BS, Chaudhary KW, Gough PJ, Bertin J, Marquis RW.

ACS Med Chem Lett. 2018 Sep 26;9(10):1039-1044. doi: 10.1021/acsmedchemlett.8b00344. eCollection 2018 Oct 11.

PMID:
30344914
4.

New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates.

Bhattacharya A, Ouellette M.

EBioMedicine. 2018 Nov;37:13-14. doi: 10.1016/j.ebiom.2018.10.016. Epub 2018 Oct 9. No abstract available.

5.

Insights into gold nanoparticles as a mucoadhesive system.

Ouellette M, Masse F, Lefebvre-Demers M, Maestracci Q, Grenier P, Millar R, Bertrand N, Prieto M, Boisselier É.

Sci Rep. 2018 Sep 25;8(1):14357. doi: 10.1038/s41598-018-32699-2.

6.

Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.

Ding Y, Mullapudi B, Torres C, Mascariñas E, Mancinelli G, Diaz AM, McKinney R, Barron M, Schultz M, Heiferman M, Wojtanek M, Adrian K, DeCant B, Rao S, Ouellette M, Tsao MS, Bentrem DJ, Grippo PJ.

Nutrients. 2018 Sep 12;10(9). pii: E1289. doi: 10.3390/nu10091289.

7.

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.

Nimmakayala RK, Seshacharyulu P, Lakshmanan I, Rachagani S, Chugh S, Karmakar S, Rauth S, Vengoji R, Atri P, Talmon GA, Lele SM, Smith LM, Thapa I, Bastola D, Ouellette MM, Batra SK, Ponnusamy MP.

Gastroenterology. 2018 Sep;155(3):892-908.e6. doi: 10.1053/j.gastro.2018.05.041. Epub 2018 Jun 2.

PMID:
29864419
8.

Gold nanoparticles in ophthalmology.

Masse F, Ouellette M, Lamoureux G, Boisselier E.

Med Res Rev. 2019 Jan;39(1):302-327. doi: 10.1002/med.21509. Epub 2018 May 16. Review.

PMID:
29766541
9.

Clinical Characteristics, Sex Differences, and Outcomes in Patients With Normal or Near-Normal Coronary Arteries, Non-Obstructive or Obstructive Coronary Artery Disease.

Ouellette ML, Löffler AI, Beller GA, Workman VK, Holland E, Bourque JM.

J Am Heart Assoc. 2018 May 2;7(10). pii: e007965. doi: 10.1161/JAHA.117.007965.

10.

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.

Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):165-173. doi: 10.1016/j.ijpddr.2018.03.004. Epub 2018 Mar 16.

11.

Characterizing the DNA Methyltransferases of Haloferax volcanii via Bioinformatics, Gene Deletion, and SMRT Sequencing.

Ouellette M, Gogarten JP, Lajoie J, Makkay AM, Papke RT.

Genes (Basel). 2018 Feb 27;9(3). pii: E129. doi: 10.3390/genes9030129.

12.

Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli.

Gingras H, Dridi B, Leprohon P, Ouellette M.

Microb Genom. 2018 Jan 10. doi: 10.1099/mgen.0.000148. [Epub ahead of print]

13.

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.

Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, Houchens CR, Grayson ML, Hansen P, Singh N, Theuretzbacher U, Magrini N; WHO Pathogens Priority List Working Group.

Lancet Infect Dis. 2018 Mar;18(3):318-327. doi: 10.1016/S1473-3099(17)30753-3. Epub 2017 Dec 21.

PMID:
29276051
14.

Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells.

Burchett KM, Etekpo A, Batra SK, Yan Y, Ouellette MM.

Oncotarget. 2017 Jul 20;8(48):83754-83767. doi: 10.18632/oncotarget.19410. eCollection 2017 Oct 13.

15.

The use of Invos™ somatic oximetry to measure variations in placental tissue oxygenation in laboring healthy term parturients with epidural analgesia: an observational study.

Loubert C, Ouellette M, Zaphiratos V, Tanoubi I.

Med Devices (Auckl). 2017 Oct 25;10:253-256. doi: 10.2147/MDER.S150472. eCollection 2017.

16.

Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae.

El Khoury JY, Boucher N, Bergeron MG, Leprohon P, Ouellette M.

Sci Rep. 2017 Nov 6;7(1):14587. doi: 10.1038/s41598-017-15035-y.

17.

Complete Genome Sequence of Streptococcus pneumoniae Virulent Phage MS1.

Kot W, Sabri M, Gingras H, Ouellette M, Tremblay DM, Moineau S.

Genome Announc. 2017 Jul 13;5(28). pii: e00333-17. doi: 10.1128/genomeA.00333-17.

18.

Appropriate Referrals of Angiography Despite High Prevalence of Normal Coronary Arteries or Nonobstructive CAD.

Ouellette ML, Beller GA, Löffler AI, Workman VK, Bourque JM.

J Am Coll Cardiol. 2017 May 30;69(21):2673-2675. doi: 10.1016/j.jacc.2017.03.565. No abstract available.

19.

Discovery and characterization of small molecule Rac1 inhibitors.

Arnst JL, Hein AL, Taylor MA, Palermo NY, Contreras JI, Sonawane YA, Wahl AO, Ouellette MM, Natarajan A, Yan Y.

Oncotarget. 2017 May 23;8(21):34586-34600. doi: 10.18632/oncotarget.16656.

20.

Inhibition of MRSA and of Clostridium difficile by durancin 61A: synergy with bacteriocins and antibiotics.

Hanchi H, Hammami R, Gingras H, Kourda R, Bergeron MG, Ben Hamida J, Ouellette M, Fliss I.

Future Microbiol. 2017 Mar;12:205-212. doi: 10.2217/fmb-2016-0113. Epub 2017 Feb 20.

PMID:
28262046
21.

Biological determinants of radioresistance and their remediation in pancreatic cancer.

Seshacharyulu P, Baine MJ, Souchek JJ, Menning M, Kaur S, Yan Y, Ouellette MM, Jain M, Lin C, Batra SK.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):69-92. doi: 10.1016/j.bbcan.2017.02.003. Epub 2017 Feb 27. Review.

22.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

J Med Chem. 2017 Feb 23;60(4):1247-1261. doi: 10.1021/acs.jmedchem.6b01751. Epub 2017 Feb 10.

PMID:
28151659
23.

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

Fernandez-Prada C, Vincent IM, Brotherton MC, Roberts M, Roy G, Rivas L, Leprohon P, Smith TK, Ouellette M.

PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005171. doi: 10.1371/journal.pntd.0005171. eCollection 2016 Dec.

24.

Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes.

Martin E, Ouellette MH, Jenna S.

J Cell Biol. 2016 Nov 21;215(4):483-498. Epub 2016 Nov 7.

25.

Use of phylogenetical analysis to predict susceptibility of pathogenic Candida spp. to antifungal drugs.

Maheux AF, Sellam A, Piché Y, Boissinot M, Pelletier R, Boudreau DK, Picard FJ, Trépanier H, Boily MJ, Ouellette M, Roy PH, Bergeron MG.

J Microbiol Methods. 2016 Dec;131:51-60. doi: 10.1016/j.mimet.2016.09.020. Epub 2016 Oct 3.

PMID:
27713018
26.

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance.

Laffitte MN, Leprohon P, Papadopoulou B, Ouellette M.

F1000Res. 2016 Sep 20;5:2350. doi: 10.12688/f1000research.9218.1. eCollection 2016. Review.

27.

Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance.

Laffitte MC, Leprohon P, Légaré D, Ouellette M.

Parasitol Res. 2016 Oct;115(10):3699-703. doi: 10.1007/s00436-016-5195-y. Epub 2016 Jul 26.

PMID:
27457482
28.

A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators.

Xie W, Silvers R, Ouellette M, Wu Z, Lu Q, Li H, Gallagher K, Johnson K, Montoute M.

Methods Mol Biol. 2016;1439:207-26. doi: 10.1007/978-1-4939-3673-1_14.

PMID:
27316998
29.

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism.

Laffitte MC, Leprohon P, Hainse M, Légaré D, Masson JY, Ouellette M.

PLoS Genet. 2016 Jun 17;12(6):e1006117. doi: 10.1371/journal.pgen.1006117. eCollection 2016 Jun.

30.

Coordinating funding in public health emergencies.

Matthiessen L, Colli W, Delfraissy JF, Hwang ES, Mphahlele J, Ouellette M; GloPID-R members.

Lancet. 2016 May 28;387(10034):2197-8. doi: 10.1016/S0140-6736(16)30604-3. No abstract available.

PMID:
27302027
31.

A French adaptation of the Overt Behaviour Scale (OBS) measuring challenging behaviours following acquired brain injury: The Échelle des comportements observables (ÉCO).

Gagnon J, Simpson GK, Kelly G, Godbout D, Ouellette M, Drolet J.

Brain Inj. 2016;30(8):1019-25. doi: 10.3109/02699052.2016.1148197. Epub 2016 May 16.

PMID:
27185308
32.

RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.

Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y.

Oncogene. 2016 Dec 8;35(49):6319-6329. doi: 10.1038/onc.2016.163. Epub 2016 May 16.

33.

Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.

Gazanion É, Fernández-Prada C, Papadopoulou B, Leprohon P, Ouellette M.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3012-21. doi: 10.1073/pnas.1520693113. Epub 2016 May 9.

34.

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, Beal AM, Finger JN, Cook MN, King BW, Ouellette MT, Totoritis RD, Pierdomenico M, Negroni A, Stronati L, Cucchiara S, Ziółkowski B, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Casillas LN.

J Med Chem. 2016 May 26;59(10):4867-80. doi: 10.1021/acs.jmedchem.6b00211. Epub 2016 May 4.

PMID:
27109867
35.

PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.

Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK, Yan Y.

Cancer Res. 2016 Apr 15;76(8):2243-2253. doi: 10.1158/0008-5472.CAN-15-2119. Epub 2016 Feb 18.

36.

Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major.

Roy G, Ouellette M.

Mol Biochem Parasitol. 2015 Dec;204(2):106-110. doi: 10.1016/j.molbiopara.2016.02.003. Epub 2016 Feb 8.

PMID:
26868981
37.

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, Lakdawala AS, Lehr R, McNulty DE, Nagilla R, Ouellette MT, Pao CS, Rendina AR, Schaeffer MC, Summerfield JD, Swift BA, Totoritis RD, Ward P, Zhang A, Zhang D, Marquis RW, Bertin J, Gough PJ.

J Med Chem. 2016 Mar 10;59(5):2163-78. doi: 10.1021/acs.jmedchem.5b01898. Epub 2016 Feb 23.

PMID:
26854747
38.

CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer.

Purohit A, Varney M, Rachagani S, Ouellette MM, Batra SK, Singh RK.

Oncotarget. 2016 Feb 9;7(6):7280-96. doi: 10.18632/oncotarget.6906.

39.

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.

Vaz AP, Deb S, Rachagani S, Dey P, Muniyan S, Lakshmanan I, Karmakar S, Smith L, Johansson S, Lele S, Ouellette M, Ponnusamy MP, Batra SK.

Oncotarget. 2016 Jan 19;7(3):3317-31. doi: 10.18632/oncotarget.6580.

40.

A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages.

Leprohon P, Gingras H, Ouennane S, Moineau S, Ouellette M.

BMC Genomics. 2015 Nov 18;16:972. doi: 10.1186/s12864-015-2134-8.

41.

Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans.

Ouellette MH, Martin E, Lacoste-Caron G, Hamiche K, Jenna S.

J Mol Cell Biol. 2016 Aug;8(4):313-27. doi: 10.1093/jmcb/mjv062. Epub 2015 Nov 16.

42.

The Canadian Institutes of Health Research response to antimicrobial resistance.

Pagé EL, Desnoyers S, Létourneau IJ, Keown K, Jackson A, Ouellette M.

Can Commun Dis Rep. 2015 Nov 19;41(Suppl 5):11-15. eCollection 2015 Nov 19.

43.

Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination.

Le Lay C, Dridi L, Bergeron MG, Ouellette M, Fliss IL.

J Med Microbiol. 2016 Feb;65(2):169-75. doi: 10.1099/jmm.0.000202. Epub 2015 Nov 9.

PMID:
26555543
44.

Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum.

Vincent IM, Racine G, Légaré D, Ouellette M.

Proteomes. 2015 Oct 21;3(4):328-346. doi: 10.3390/proteomes3040328.

45.

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.

Charnley AK, Convery MA, Lakdawala Shah A, Jones E, Hardwicke P, Bridges A, Ouellette M, Totoritis R, Schwartz B, King BW, Wisnoski DD, Kang J, Eidam PM, Votta BJ, Gough PJ, Marquis RW, Bertin J, Casillas L.

Bioorg Med Chem. 2015 Nov 1;23(21):7000-6. doi: 10.1016/j.bmc.2015.09.038. Epub 2015 Sep 25.

PMID:
26455654
46.

On Lactococcus lactis UL719 competitivity and nisin (Nisaplin(®)) capacity to inhibit Clostridium difficile in a model of human colon.

Le Lay C, Fernandez B, Hammami R, Ouellette M, Fliss I.

Front Microbiol. 2015 Sep 25;6:1020. doi: 10.3389/fmicb.2015.01020. eCollection 2015.

47.

Rac1 GTPase in pancreatic cancer.

Yan Y, Ouellette MM.

Aging (Albany NY). 2015 Sep;7(9):609-10. No abstract available.

48.

Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis-Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling.

Memari B, Bouttier M, Dimitrov V, Ouellette M, Behr MA, Fritz JH, White JH.

J Immunol. 2015 Nov 1;195(9):4479-91. doi: 10.4049/jimmunol.1501141. Epub 2015 Sep 28.

49.

Next Generation Vaccine Biomarkers workshop October 30-31, 2014--Ottawa, Canada.

Twine SM, Fulton KM, Spika J, Ouellette M, Raven JF, Conlan JW, Krishnan L, Barreto L, Richards JC.

Hum Vaccin Immunother. 2015;11(12):2923-30. doi: 10.1080/21645515.2015.1083663.

50.

The initial state of the human gut microbiome determines its reshaping by antibiotics.

Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B, Leprohon P, Plante PL, Giroux R, Bérubé È, Frenette J, Boudreau DK, Simard JL, Chabot I, Domingo MC, Trottier S, Boissinot M, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J.

ISME J. 2016 Mar;10(3):707-20. doi: 10.1038/ismej.2015.148. Epub 2015 Sep 11.

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