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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.

Haffner CD, Charnley AK, Aquino CJ, Casillas L, Convery MA, Cox JA, Elban MA, Goodwin NC, Gough PJ, Haile PA, Hughes TV, Knapp-Reed B, Kreatsoulas C, Lakdawala AS, Li H, Lian Y, Lipshutz D, Mehlmann JF, Ouellette M, Romano J, Shewchuk L, Shu A, Votta BJ, Zhou H, Bertin J, Marquis RW.

ACS Med Chem Lett. 2019 Oct 11;10(11):1518-1523. doi: 10.1021/acsmedchemlett.9b00141. eCollection 2019 Nov 14.


Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

El Khoury JY, Maure A, Gingras H, Leprohon P, Ouellette M.

mSystems. 2019 Nov 19;4(6). pii: e00465-19. doi: 10.1128/mSystems.00465-19.


Balsacone C, a New Antibiotic Targeting Bacterial Cell Membranes, Inhibits Clinical Isolates of Methicillin-Resistant Staphylococcus aureus (MRSA) Without Inducing Resistance.

Côté H, Pichette A, Simard F, Ouellette ME, Ripoll L, Mihoub M, Grimard D, Legault J.

Front Microbiol. 2019 Oct 15;10:2341. doi: 10.3389/fmicb.2019.02341. eCollection 2019.


PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells.

Hein AL, Brandquist ND, Ouellette CY, Seshacharyulu P, Enke CA, Ouellette MM, Batra SK, Yan Y.

Oncogenesis. 2019 Oct 28;8(11):63. doi: 10.1038/s41389-019-0172-9.


Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue.

Ouellette MÈ, Bérubé JC, Bourget JM, Vallée M, Bossé Y, Fradette J.

PLoS One. 2019 Oct 22;14(10):e0224228. doi: 10.1371/journal.pone.0224228. eCollection 2019.


Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum.

Bhattacharya A, Sharma M, Pakkinathan C, Rosen BP, Leprohon P, Ouellette M.

mSystems. 2019 Oct 15;4(5). pii: e00416-19. doi: 10.1128/mSystems.00416-19.


Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.

Béliveau F, Tarkar A, Dion SP, Désilets A, Ghinet MG, Boudreault PL, St-Georges C, Marsault É, Paone D, Collins J, Macphee CH, Campobasso N, Groy A, Cottom J, Ouellette M, Pope AJ, Leduc R.

Cell Chem Biol. 2019 Nov 21;26(11):1559-1572.e9. doi: 10.1016/j.chembiol.2019.09.004. Epub 2019 Sep 19.


Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System.

Masse F, Desjardins P, Ouellette M, Couture C, Omar MM, Pernet V, Guérin S, Boisselier E.

Molecules. 2019 Aug 13;24(16). pii: E2929. doi: 10.3390/molecules24162929.


Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation.

Sosa Y, Deniskin R, Frame IJ, Steiginga MS, Bandyopadhyay D, Graybill TL, Kallal LA, Ouellette MT, Pope AJ, Widdowson KL, Young RJ, Akabas MH.

ACS Infect Dis. 2019 Oct 11;5(10):1738-1753. doi: 10.1021/acsinfecdis.9b00168. Epub 2019 Aug 14.


An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.

Lupien LE, Dunkley EM, Maloy MJ, Lehner IB, Foisey MG, Ouellette ME, Lewis LD, Pooler DB, Kinlaw WB, Baures PW.

J Pharmacol Exp Ther. 2019 Oct;371(1):171-185. doi: 10.1124/jpet.119.258947. Epub 2019 Jul 12.


Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ, Mehlmann JF, King BW, Erhard KF, Hanning CR, Lipshutz DB, Desai BM, Capriotti CA, Schaeffer MC, Berger SB, Mahajan MK, Reilly MA, Nagilla R, Rivera EJ, Sun HH, Kenna JK, Beal AM, Ouellette MT, Kelly M, Stemp G, Convery MA, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Marquis RW.

J Med Chem. 2019 Jul 25;62(14):6482-6494. doi: 10.1021/acs.jmedchem.9b00575. Epub 2019 Jul 2.


Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Harris PA, Marinis JM, Lich JD, Berger SB, Chirala A, Cox JA, Eidam PM, Finger JN, Gough PJ, Jeong JU, Kang J, Kasparcova V, Leister LK, Mahajan MK, Miller G, Nagilla R, Ouellette MT, Reilly MA, Rendina AR, Rivera EJ, Sun HH, Thorpe JH, Totoritis RD, Wang W, Wu D, Zhang D, Bertin J, Marquis RW.

ACS Med Chem Lett. 2019 May 9;10(6):857-862. doi: 10.1021/acsmedchemlett.9b00108. eCollection 2019 Jun 13.


Effect of UV-C light or hydrogen peroxide wipes on the inactivation of methicillin-resistant Staphylococcus aureus, Clostridium difficile spores and norovirus surrogate.

Wallace RL, Ouellette M, Jean J.

J Appl Microbiol. 2019 Aug;127(2):586-597. doi: 10.1111/jam.14308. Epub 2019 Jun 6.


Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW.

J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2.


Establishing an electronic health record-supported approach for outreach to and recruitment of persons at high risk of type 2 diabetes in clinical trials: The vitamin D and type 2 diabetes (D2d) study experience.

Aroda VR, Sheehan PR, Vickery EM, Staten MA, LeBlanc ES, Phillips LS, Brodsky IG, Chadha C, Chatterjee R, Ouellette MG, Desouza C, Pittas AG; D2d Research Group.

Clin Trials. 2019 Jun;16(3):306-315. doi: 10.1177/1740774519839062. Epub 2019 Apr 22.


Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania.

Potvin JE, Leprohon P, Gazanion E, Sharma M, Fernandez-Prada C, Ouellette M.

Methods Mol Biol. 2019;1971:141-167. doi: 10.1007/978-1-4939-9210-2_7.


Culture-enriched human gut microbiomes reveal core and accessory resistance genes.

Raymond F, Boissinot M, Ouameur AA, Déraspe M, Plante PL, Kpanou SR, Bérubé È, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J.

Microbiome. 2019 Apr 5;7(1):56. doi: 10.1186/s40168-019-0669-7.


Parent-Child Interaction Therapy as a Behavior and Spoken Language Intervention for Young Children With Hearing Loss.

Costa EA, Day L, Caverly C, Mellon N, Ouellette M, Wilson Ottley S.

Lang Speech Hear Serv Sch. 2019 Jan 28;50(1):34-52. doi: 10.1044/2018_LSHSS-18-0054.


Mutant p53R175H promotes cancer initiation in the pancreas by stabilizing HSP70.

Polireddy K, Singh K, Pruski M, Jones NC, Manisundaram NV, Ponnela P, Ouellette M, Van Buren G, Younes M, Bynon JS, Dar WA, Bailey JM.

Cancer Lett. 2019 Jul 1;453:122-130. doi: 10.1016/j.canlet.2019.03.047. Epub 2019 Apr 1.


The Patchy Distribution of Restriction⁻Modification System Genes and the Conservation of Orphan Methyltransferases in Halobacteria.

Fullmer MS, Ouellette M, Louyakis AS, Papke RT, Gogarten JP.

Genes (Basel). 2019 Mar 19;10(3). pii: E233. doi: 10.3390/genes10030233.


Gain- and Loss-of-Function Screens Coupled to Next-Generation Sequencing for Antibiotic Mode of Action and Resistance Studies in Streptococcus pneumoniae.

Gingras H, Patron K, Bhattacharya A, Leprohon P, Ouellette M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02381-18. doi: 10.1128/AAC.02381-18. Print 2019 May.


A Gate-and-Switch Model for Head Orientation Behaviors in Caenorhabditis elegans.

Ouellette MH, Desrochers MJ, Gheta I, Ramos R, Hendricks M.

eNeuro. 2018 Dec 10;5(6). pii: ENEURO.0121-18.2018. doi: 10.1523/ENEURO.0121-18.2018. eCollection 2018 Nov-Dec.


Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Convery MA, Votta BJ, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, LePage C, Ouellette MT, Totoritis RD, Donovan BT, Brown BS, Chaudhary KW, Gough PJ, Bertin J, Marquis RW.

ACS Med Chem Lett. 2018 Sep 26;9(10):1039-1044. doi: 10.1021/acsmedchemlett.8b00344. eCollection 2018 Oct 11.


New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates.

Bhattacharya A, Ouellette M.

EBioMedicine. 2018 Nov;37:13-14. doi: 10.1016/j.ebiom.2018.10.016. Epub 2018 Oct 9. No abstract available.


Insights into gold nanoparticles as a mucoadhesive system.

Ouellette M, Masse F, Lefebvre-Demers M, Maestracci Q, Grenier P, Millar R, Bertrand N, Prieto M, Boisselier É.

Sci Rep. 2018 Sep 25;8(1):14357. doi: 10.1038/s41598-018-32699-2.


Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.

Ding Y, Mullapudi B, Torres C, Mascariñas E, Mancinelli G, Diaz AM, McKinney R, Barron M, Schultz M, Heiferman M, Wojtanek M, Adrian K, DeCant B, Rao S, Ouellette M, Tsao MS, Bentrem DJ, Grippo PJ.

Nutrients. 2018 Sep 12;10(9). pii: E1289. doi: 10.3390/nu10091289.


Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.

Nimmakayala RK, Seshacharyulu P, Lakshmanan I, Rachagani S, Chugh S, Karmakar S, Rauth S, Vengoji R, Atri P, Talmon GA, Lele SM, Smith LM, Thapa I, Bastola D, Ouellette MM, Batra SK, Ponnusamy MP.

Gastroenterology. 2018 Sep;155(3):892-908.e6. doi: 10.1053/j.gastro.2018.05.041. Epub 2018 Jun 2.


Gold nanoparticles in ophthalmology.

Masse F, Ouellette M, Lamoureux G, Boisselier E.

Med Res Rev. 2019 Jan;39(1):302-327. doi: 10.1002/med.21509. Epub 2018 May 16. Review.


Clinical Characteristics, Sex Differences, and Outcomes in Patients With Normal or Near-Normal Coronary Arteries, Non-Obstructive or Obstructive Coronary Artery Disease.

Ouellette ML, Löffler AI, Beller GA, Workman VK, Holland E, Bourque JM.

J Am Heart Assoc. 2018 May 2;7(10). pii: e007965. doi: 10.1161/JAHA.117.007965.


High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.

Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):165-173. doi: 10.1016/j.ijpddr.2018.03.004. Epub 2018 Mar 16.


Characterizing the DNA Methyltransferases of Haloferax volcanii via Bioinformatics, Gene Deletion, and SMRT Sequencing.

Ouellette M, Gogarten JP, Lajoie J, Makkay AM, Papke RT.

Genes (Basel). 2018 Feb 27;9(3). pii: E129. doi: 10.3390/genes9030129.


Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli.

Gingras H, Dridi B, Leprohon P, Ouellette M.

Microb Genom. 2018 Feb;4(2). doi: 10.1099/mgen.0.000148. Epub 2018 Jan 10.


Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.

Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, Houchens CR, Grayson ML, Hansen P, Singh N, Theuretzbacher U, Magrini N; WHO Pathogens Priority List Working Group.

Lancet Infect Dis. 2018 Mar;18(3):318-327. doi: 10.1016/S1473-3099(17)30753-3. Epub 2017 Dec 21.


Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells.

Burchett KM, Etekpo A, Batra SK, Yan Y, Ouellette MM.

Oncotarget. 2017 Jul 20;8(48):83754-83767. doi: 10.18632/oncotarget.19410. eCollection 2017 Oct 13.


The use of Invos™ somatic oximetry to measure variations in placental tissue oxygenation in laboring healthy term parturients with epidural analgesia: an observational study.

Loubert C, Ouellette M, Zaphiratos V, Tanoubi I.

Med Devices (Auckl). 2017 Oct 25;10:253-256. doi: 10.2147/MDER.S150472. eCollection 2017.


Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae.

El Khoury JY, Boucher N, Bergeron MG, Leprohon P, Ouellette M.

Sci Rep. 2017 Nov 6;7(1):14587. doi: 10.1038/s41598-017-15035-y.


Complete Genome Sequence of Streptococcus pneumoniae Virulent Phage MS1.

Kot W, Sabri M, Gingras H, Ouellette M, Tremblay DM, Moineau S.

Genome Announc. 2017 Jul 13;5(28). pii: e00333-17. doi: 10.1128/genomeA.00333-17.


Appropriate Referrals of Angiography Despite High Prevalence of Normal Coronary Arteries or Nonobstructive CAD.

Ouellette ML, Beller GA, Löffler AI, Workman VK, Bourque JM.

J Am Coll Cardiol. 2017 May 30;69(21):2673-2675. doi: 10.1016/j.jacc.2017.03.565. No abstract available.


Discovery and characterization of small molecule Rac1 inhibitors.

Arnst JL, Hein AL, Taylor MA, Palermo NY, Contreras JI, Sonawane YA, Wahl AO, Ouellette MM, Natarajan A, Yan Y.

Oncotarget. 2017 May 23;8(21):34586-34600. doi: 10.18632/oncotarget.16656.


Inhibition of MRSA and of Clostridium difficile by durancin 61A: synergy with bacteriocins and antibiotics.

Hanchi H, Hammami R, Gingras H, Kourda R, Bergeron MG, Ben Hamida J, Ouellette M, Fliss I.

Future Microbiol. 2017 Mar;12:205-212. doi: 10.2217/fmb-2016-0113. Epub 2017 Feb 20.


Biological determinants of radioresistance and their remediation in pancreatic cancer.

Seshacharyulu P, Baine MJ, Souchek JJ, Menning M, Kaur S, Yan Y, Ouellette MM, Jain M, Lin C, Batra SK.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):69-92. doi: 10.1016/j.bbcan.2017.02.003. Epub 2017 Feb 27. Review.


Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

J Med Chem. 2017 Feb 23;60(4):1247-1261. doi: 10.1021/acs.jmedchem.6b01751. Epub 2017 Feb 10.


Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

Fernandez-Prada C, Vincent IM, Brotherton MC, Roberts M, Roy G, Rivas L, Leprohon P, Smith TK, Ouellette M.

PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005171. doi: 10.1371/journal.pntd.0005171. eCollection 2016 Dec.


Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes.

Martin E, Ouellette MH, Jenna S.

J Cell Biol. 2016 Nov 21;215(4):483-498. Epub 2016 Nov 7.


Use of phylogenetical analysis to predict susceptibility of pathogenic Candida spp. to antifungal drugs.

Maheux AF, Sellam A, Piché Y, Boissinot M, Pelletier R, Boudreau DK, Picard FJ, Trépanier H, Boily MJ, Ouellette M, Roy PH, Bergeron MG.

J Microbiol Methods. 2016 Dec;131:51-60. doi: 10.1016/j.mimet.2016.09.020. Epub 2016 Oct 3.


Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance.

Laffitte MN, Leprohon P, Papadopoulou B, Ouellette M.

F1000Res. 2016 Sep 20;5:2350. doi: 10.12688/f1000research.9218.1. eCollection 2016. Review.


Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance.

Laffitte MC, Leprohon P, Légaré D, Ouellette M.

Parasitol Res. 2016 Oct;115(10):3699-703. doi: 10.1007/s00436-016-5195-y. Epub 2016 Jul 26.


A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators.

Xie W, Silvers R, Ouellette M, Wu Z, Lu Q, Li H, Gallagher K, Johnson K, Montoute M.

Methods Mol Biol. 2016;1439:207-26. doi: 10.1007/978-1-4939-3673-1_14.


Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism.

Laffitte MC, Leprohon P, Hainse M, Légaré D, Masson JY, Ouellette M.

PLoS Genet. 2016 Jun 17;12(6):e1006117. doi: 10.1371/journal.pgen.1006117. eCollection 2016 Jun.


Coordinating funding in public health emergencies.

Matthiessen L, Colli W, Delfraissy JF, Hwang ES, Mphahlele J, Ouellette M; GloPID-R members.

Lancet. 2016 May 28;387(10034):2197-8. doi: 10.1016/S0140-6736(16)30604-3. No abstract available.


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