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Essential role of IFN-γ in T cell-associated intestinal inflammation.

Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ.

JCI Insight. 2018 Sep 20;3(18). pii: 121886. doi: 10.1172/jci.insight.121886. eCollection 2018 Sep 20.


Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species.

Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00111-18. doi: 10.1128/AAC.00111-18. Print 2018 Jun.


Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme.

Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME.

J Biol Chem. 2018 Feb 23;293(8):2725-2734. doi: 10.1074/jbc.RA117.000793. Epub 2018 Jan 9.


Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide.

Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME.

PLoS One. 2017 Nov 16;12(11):e0187868. doi: 10.1371/journal.pone.0187868. eCollection 2017.


A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of Chemokine XCL1.

Nevins AM, Subramanian A, Tapia JL, Delgado DP, Tyler RC, Jensen DR, Ouellette AJ, Volkman BF.

Biochemistry. 2016 Jul 12;55(27):3784-93. doi: 10.1021/acs.biochem.6b00353. Epub 2016 Jun 28.


Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.

Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M.

Cell Host Microbe. 2016 Jun 8;19(6):814-25. doi: 10.1016/j.chom.2016.05.005.


Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection.

Gounder AP, Myers ND, Treuting PM, Bromme BA, Wilson SS, Wiens ME, Lu W, Ouellette AJ, Spindler KR, Parks WC, Smith JG.

PLoS Pathog. 2016 Mar 2;12(3):e1005474. doi: 10.1371/journal.ppat.1005474. eCollection 2016 Mar.


Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways.

Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME.

J Leukoc Biol. 2015 Dec;98(6):1061-70. doi: 10.1189/jlb.3A0315-102R. Epub 2015 Aug 12.


Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes.

Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG.

Antibiotics (Basel). 2014;3(4):617-31. doi: 10.3390/antibiotics3040617.


Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions.

Mastroianni JR, Lu W, Selsted ME, Ouellette AJ.

Antibiotics (Basel). 2014;3(4):493-508.


Hydrophobic determinants of α-defensin bactericidal activity.

Tai KP, Le VV, Selsted ME, Ouellette AJ.

Infect Immun. 2014 Jun;82(6):2195-202. doi: 10.1128/IAI.01414-13. Epub 2014 Mar 10.


Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa.

Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted ME, Ouellette AJ, Wong-Beringer A.

Innate Immun. 2015 Jan;21(1):17-29. doi: 10.1177/1753425913514784. Epub 2013 Dec 17.


Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities.

Patil AA, Ouellette AJ, Lu W, Zhang G.

Antimicrob Agents Chemother. 2013 Apr;57(4):1823-31. doi: 10.1128/AAC.02237-12. Epub 2013 Feb 4.


Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis.

Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME.

PLoS One. 2012;7(12):e51337. doi: 10.1371/journal.pone.0051337. Epub 2012 Dec 6.


A novel role for lipid droplets in the organismal antibacterial response.

Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP.

Elife. 2012 Nov 13;1:e00003. doi: 10.7554/eLife.00003.


Paneth cell-mediated multiorgan dysfunction after acute kidney injury.

Park SW, Kim M, Kim JY, Ham A, Brown KM, Mori-Akiyama Y, Ouellette AJ, D'Agati VD, Lee HT.

J Immunol. 2012 Dec 1;189(11):5421-33. doi: 10.4049/jimmunol.1200581. Epub 2012 Oct 29.


Immunology. HD6 defensin nanonets.

Ouellette AJ, Selsted ME.

Science. 2012 Jul 27;337(6093):420-1. doi: 10.1126/science.1225906. No abstract available.


CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity.

Burkhardt AM, Tai KP, Flores-Guiterrez JP, Vilches-Cisneros N, Kamdar K, Barbosa-Quintana O, Valle-Rios R, Hevezi PA, Zuñiga J, Selman M, Ouellette AJ, Zlotnik A.

J Immunol. 2012 Jun 15;188(12):6399-406. doi: 10.4049/jimmunol.1102903. Epub 2012 May 18.


Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior.

Schmidt NW, Tai KP, Kamdar K, Mishra A, Lai GH, Zhao K, Ouellette AJ, Wong GC.

J Biol Chem. 2012 Jun 22;287(26):21866-72. doi: 10.1074/jbc.M112.358721. Epub 2012 May 7.


High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3.

Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME.

PLoS One. 2012;7(3):e32469. doi: 10.1371/journal.pone.0032469. Epub 2012 Mar 20.


Alternative luminal activation mechanisms for paneth cell α-defensins.

Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ.

J Biol Chem. 2012 Mar 30;287(14):11205-12. doi: 10.1074/jbc.M111.333559. Epub 2012 Feb 13.


The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.

Andersson HS, Figueredo SM, Haugaard-Kedström LM, Bengtsson E, Daly NL, Qu X, Craik DJ, Ouellette AJ, Rosengren KJ.

Amino Acids. 2012 Oct;43(4):1471-83.


Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins.

Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA.

Biochemistry. 2011 Dec 6;50(48):10508-19. doi: 10.1021/bi201430f. Epub 2011 Nov 9.


Paneth cell α-defensins in enteric innate immunity.

Ouellette AJ.

Cell Mol Life Sci. 2011 Jul;68(13):2215-29. doi: 10.1007/s00018-011-0714-6. Epub 2011 May 11. Review.


Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.

Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC.

J Am Chem Soc. 2011 May 4;133(17):6720-7. doi: 10.1021/ja200079a. Epub 2011 Apr 7.


Small-angle X-ray scattering studies of peptide-lipid interactions using the mouse paneth cell α-defensin cryptdin-4.

Mishra A, Tai KP, Schmidt NW, Ouellette AJ, Wong GC.

Methods Enzymol. 2011;492:127-49. doi: 10.1016/B978-0-12-381268-1.00016-1.


Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS.

Zaragoza MM, Sankaran-Walters S, Canfield DR, Hung JK, Martinez E, Ouellette AJ, Dandekar S.

J Immunol. 2011 Feb 1;186(3):1589-97. doi: 10.4049/jimmunol.1002021. Epub 2010 Dec 22.


Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities.

Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME.

J Leukoc Biol. 2011 Feb;89(2):283-90. doi: 10.1189/jlb.0910535. Epub 2010 Nov 17.


Strain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenes.

Shanahan MT, Tanabe H, Ouellette AJ.

Infect Immun. 2011 Jan;79(1):459-73. doi: 10.1128/IAI.00996-10. Epub 2010 Nov 1.


Paneth cells and innate mucosal immunity.

Ouellette AJ.

Curr Opin Gastroenterol. 2010 Nov;26(6):547-53. doi: 10.1097/MOG.0b013e32833dccde. Review.


Expression and purification of recombinant alpha-defensins and alpha-defensin precursors in Escherichia coli.

Figueredo S, Mastroianni JR, Tai KP, Ouellette AJ.

Methods Mol Biol. 2010;618:47-60. doi: 10.1007/978-1-60761-594-1_4.


Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action.

Shanahan MT, Vidrich A, Shirafuji Y, Dubois CL, Henschen-Edman A, Hagen SJ, Cohn SM, Ouellette AJ.

J Biol Chem. 2010 Mar 5;285(10):7493-504. doi: 10.1074/jbc.M109.083220. Epub 2010 Jan 7.


Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.

Zhao F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, Ouellette AJ, Andersen B, Lipkin SM.

Dev Biol. 2010 Feb 15;338(2):270-9. doi: 10.1016/j.ydbio.2009.12.008. Epub 2009 Dec 16.


Inhibition of bactericidal activity is maintained in a mouse alpha-defensin precursor with proregion truncations.

Figueredo SM, Ouellette AJ.

Peptides. 2010 Jan;31(1):9-15. doi: 10.1016/j.peptides.2009.10.004. Epub 2009 Oct 29.


Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure.

Llenado RA, Weeks CS, Cocco MJ, Ouellette AJ.

Infect Immun. 2009 Nov;77(11):5035-43. doi: 10.1128/IAI.00695-09. Epub 2009 Sep 8.


Alpha-defensins in enteric innate immunity: functional Paneth cell alpha-defensins in mouse colonic lumen.

Mastroianni JR, Ouellette AJ.

J Biol Chem. 2009 Oct 9;284(41):27848-56. doi: 10.1074/jbc.M109.050773. Epub 2009 Aug 17.


Anionic amino acids near the pro-alpha-defensin N terminus mediate inhibition of bactericidal activity in mouse pro-cryptdin-4.

Figueredo SM, Weeks CS, Young SK, Ouellette AJ.

J Biol Chem. 2009 Mar 13;284(11):6826-31. doi: 10.1074/jbc.M807024200. Epub 2008 Dec 23.


Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue.

Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E.

Biochemistry. 2008 Nov 25;47(47):12626-34. doi: 10.1021/bi800335e.


In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases.

Kamdar K, Maemoto A, Qu X, Young SK, Ouellette AJ.

J Biol Chem. 2008 Nov 21;283(47):32361-8. doi: 10.1074/jbc.M805296200. Epub 2008 Sep 5.


A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion.

Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO.

J Immunol. 2007 Jul 15;179(2):1245-53.


Paneth cell alpha-defensin synthesis and function.

Ouellette AJ.

Curr Top Microbiol Immunol. 2006;306:1-25. Review.


Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4.

Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ.

J Biol Chem. 2006 Sep 22;281(38):28068-78. Epub 2006 Jul 20.


Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity.

Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ.

J Biol Chem. 2006 Sep 29;281(39):28932-42. Epub 2006 Jul 5.


Quantification of toxic Microcystis spp. during the 2003 and 2004 blooms in western Lake Erie using quantitative real-time PCR.

Rinta-Kanto JM, Ouellette AJ, Boyer GL, Twiss MR, Bridgeman TB, Wilhelm SW.

Environ Sci Technol. 2005 Jun 1;39(11):4198-205.


Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine.

Ouellette AJ.

Springer Semin Immunopathol. 2005 Sep;27(2):133-46. Epub 2005 Jun 2. Review.


Mammalian defensins in the antimicrobial immune response.

Selsted ME, Ouellette AJ.

Nat Immunol. 2005 Jun;6(6):551-7. Review.


The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides.

Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC.

Mol Microbiol. 2005 May;56(3):789-99.

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