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Items: 1 to 50 of 214

1.

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts.

Jana S, Zhang H, Lopaschuk GD, Freed DH, Sergi C, Kantor PF, Oudit GY, Kassiri Z.

J Am Heart Assoc. 2018 Oct 2;7(19):e010427. doi: 10.1161/JAHA.118.010427.

2.

Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass.

McLean BA, Hansen R, Paterson DI, White JA, Oudit GY.

J Am Coll Cardiol. 2018 Oct 9;72(15):1872-1873. doi: 10.1016/j.jacc.2018.07.057. No abstract available.

PMID:
30286931
3.

Comparison of Cardiac Magnetic Resonance Imaging and Echocardiography in Assessment of Left Ventricular Hypertrophy in Fabry Disease.

Hazari H, Belenkie I, Kryski A, White JA, Oudit GY, Thompson R, Fung T, Dehar N, Khan A.

Can J Cardiol. 2018 Aug;34(8):1041-1047. doi: 10.1016/j.cjca.2018.03.011. Epub 2018 Mar 29.

PMID:
29935990
4.

Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm.

Shen M, Hu M, Fedak PWM, Oudit GY, Kassiri Z.

Circ Res. 2018 Jul 20;123(3):372-388. doi: 10.1161/CIRCRESAHA.118.313181. Epub 2018 Jun 21.

PMID:
29930147
5.

Effects of age, gender, and risk-factors for heart failure on native myocardial T1 and extracellular volume fraction using the SASHA sequence at 1.5T.

Pagano JJ, Chow K, Paterson DI, Mikami Y, Schmidt A, Howarth A, White J, Friedrich MG, Oudit GY, Ezekowitz J, Dyck J, Thompson RB.

J Magn Reson Imaging. 2018 Nov;48(5):1307-1317. doi: 10.1002/jmri.26160. Epub 2018 Jun 13.

PMID:
29897656
6.

Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.

Duan Y, Beli E, Li Calzi S, Quigley JL, Miller RC, Moldovan L, Feng D, Salazar TE, Hazra S, Al-Sabah J, Chalam KV, Phuong Trinh TL, Meroueh M, Markel TA, Murray MC, Vyas RJ, Boulton ME, Parsons-Wingerter P, Oudit GY, Obukhov AG, Grant MB.

Stem Cells. 2018 Sep;36(9):1430-1440. doi: 10.1002/stem.2848. Epub 2018 Jul 15.

PMID:
29761600
7.

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease.

Lezutekong JN, Nikhanj A, Oudit GY.

Clin Sci (Lond). 2018 Apr 30;132(8):901-904. doi: 10.1042/CS20180172. Print 2018 Apr 30.

PMID:
29712884
8.

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB.

Diabetes. 2018 Sep;67(9):1867-1879. doi: 10.2337/db18-0158. Epub 2018 Apr 30.

PMID:
29712667
9.

Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device.

Miskew Nichols B, Nikhanj A, Wang F, Freed DH, Oudit GY.

Circ Heart Fail. 2018 Apr;11(4):e004960. doi: 10.1161/CIRCHEARTFAILURE.118.004960. No abstract available.

PMID:
29626101
10.

Chloroquine-induced cardiomyopathy: a reversible cause of heart failure.

Yogasundaram H, Hung W, Paterson ID, Sergi C, Oudit GY.

ESC Heart Fail. 2018 Jun;5(3):372-375. doi: 10.1002/ehf2.12276. Epub 2018 Feb 20.

11.

TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.

Zhabyeyev P, Das SK, Basu R, Shen M, Patel VB, Kassiri Z, Oudit GY.

Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H978-H990. doi: 10.1152/ajpheart.00597.2017. Epub 2018 Jan 26.

PMID:
29373036
12.

Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy.

Das SK, Zhabyeyev P, Basu R, Patel VB, Dyck JRB, Kassiri Z, Oudit GY.

Biosci Rep. 2018 Jan 10;38(1). pii: BSR20171302. doi: 10.1042/BSR20171302. Print 2018 Feb 28.

PMID:
29208771
13.

Angiotensin 1-7 stimulates brown adipose tissue and reduces diet-induced obesity.

Morimoto H, Mori J, Nakajima H, Kawabe Y, Tsuma Y, Fukuhara S, Kodo K, Ikoma K, Matoba S, Oudit GY, Hosoi H.

Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E131-E138. doi: 10.1152/ajpendo.00192.2017. Epub 2017 Oct 24.

PMID:
29066463
14.

Apelin Is a Negative Regulator of Angiotensin II-Mediated Adverse Myocardial Remodeling and Dysfunction.

Zhang ZZ, Wang W, Jin HY, Chen X, Cheng YW, Xu YL, Song B, Penninger JM, Oudit GY, Zhong JC.

Hypertension. 2017 Dec;70(6):1165-1175. doi: 10.1161/HYPERTENSIONAHA.117.10156. Epub 2017 Oct 3.

PMID:
28974565
15.

Is β-Arrestin 2 a Magic Bullet for Heart Failure Treatment?

Zhabyeyev P, Zhang H, Oudit GY.

Hypertension. 2017 Nov;70(5):887-889. doi: 10.1161/HYPERTENSIONAHA.117.09943. Epub 2017 Sep 5. No abstract available.

PMID:
28874463
16.

Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels.

Toma M, Mak GJ, Chen V, Hollander Z, Shannon CP, Lam KKY, Ng RT, Tebbutt SJ, Wilson-McManus JE, Ignaszewski A, Anderson T, Dyck JRB, Howlett J, Ezekowitz J, McManus BM, Oudit GY.

ESC Heart Fail. 2017 Aug;4(3):301-311. doi: 10.1002/ehf2.12136. Epub 2017 Mar 4.

17.

Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure.

Hall DD, Ponce JM, Chen B, Spitler KM, Alexia A, Oudit GY, Song LS, Grueter CE.

JCI Insight. 2017 Aug 3;2(15). pii: 92476. doi: 10.1172/jci.insight.92476. [Epub ahead of print]

18.

Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease.

Patel VB, Shah S, Verma S, Oudit GY.

Heart Fail Rev. 2017 Nov;22(6):889-902. doi: 10.1007/s10741-017-9644-1. Review.

PMID:
28762019
19.

A prospective evaluation of the established criteria for heart failure with preserved ejection fraction using the Alberta HEART cohort.

Ezekowitz JA, McAlister FA, Howlett J, Alemayehu W, Paterson I, Belenkie I, Oudit GY, Kaul P, Dyck JR, Anderson T; Alberta HEART Investigators.

ESC Heart Fail. 2018 Feb;5(1):19-26. doi: 10.1002/ehf2.12200. Epub 2017 Jul 25.

20.

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

J Med Chem. 2017 Jul 27;60(14):6408-6427. doi: 10.1021/acs.jmedchem.7b00723. Epub 2017 Jul 7.

PMID:
28685579
21.

Clinical Features, Diagnosis, and Management of Patients With Anderson-Fabry Cardiomyopathy.

Yogasundaram H, Kim D, Oudit O, Thompson RB, Weidemann F, Oudit GY.

Can J Cardiol. 2017 Jul;33(7):883-897. doi: 10.1016/j.cjca.2017.04.015. Epub 2017 May 4. Review.

PMID:
28668140
22.

Reply: RAS Fingerprint.

Poglitsch M, Basu R, Oudit GY.

J Am Coll Cardiol. 2017 Jun 20;69(24):3011-3013. doi: 10.1016/j.jacc.2017.03.603. No abstract available.

23.

Hemochromatosis Protein (HFE) Knockout Mice As a Novel Model of Hemochromatosis: Implications for Study and Management of Iron-Overload Cardiomyopathy.

Zhabyeyev P, Oudit GY.

Can J Cardiol. 2017 Jul;33(7):835-837. doi: 10.1016/j.cjca.2017.04.013. Epub 2017 May 3. No abstract available.

PMID:
28558947
24.

Recombinant Human ACE2 and the Angiotensin 1-7 Axis as Potential New Therapies for Heart Failure.

Patel VB, Lezutekong JN, Chen X, Oudit GY.

Can J Cardiol. 2017 Jul;33(7):943-946. doi: 10.1016/j.cjca.2016.12.012. Epub 2016 Dec 23. Review.

PMID:
28279521
25.

Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome.

Bae EH, Fang F, Williams VR, Konvalinka A, Zhou X, Patel VB, Song X, John R, Oudit GY, Pei Y, Scholey JW.

Kidney Int. 2017 Jun;91(6):1347-1361. doi: 10.1016/j.kint.2016.12.022. Epub 2017 Feb 27.

PMID:
28249676
26.

Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease.

Alibhai FJ, LaMarre J, Reitz CJ, Tsimakouridze EV, Kroetsch JT, Bolz SS, Shulman A, Steinberg S, Burris TP, Oudit GY, Martino TA.

J Mol Cell Cardiol. 2017 Apr;105:24-37. doi: 10.1016/j.yjmcc.2017.01.008. Epub 2017 Feb 20.

27.

Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.

Basu R, Poglitsch M, Yogasundaram H, Thomas J, Rowe BH, Oudit GY.

J Am Coll Cardiol. 2017 Feb 21;69(7):805-819. doi: 10.1016/j.jacc.2016.11.064.

28.

Novel Dominant-Negative Mutation in Cardiac Troponin I Causes Severe Restrictive Cardiomyopathy.

Shah S, Yogasundaram H, Basu R, Wang F, Paterson DI, Alastalo TP, Oudit GY.

Circ Heart Fail. 2017 Feb;10(2). pii: e003820. doi: 10.1161/CIRCHEARTFAILURE.116.003820. No abstract available.

PMID:
28174160
29.

Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.

Spitler KM, Ponce JM, Oudit GY, Hall DD, Grueter CE.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H768-H780. doi: 10.1152/ajpheart.00728.2016. Epub 2017 Feb 3.

30.

Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress.

Das SK, Patel VB, Basu R, Wang W, DesAulniers J, Kassiri Z, Oudit GY.

J Am Heart Assoc. 2017 Jan 23;6(1). pii: e003456. doi: 10.1161/JAHA.116.003456.

31.

Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101-Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity.

Pituskin E, Mackey JR, Koshman S, Jassal D, Pitz M, Haykowsky MJ, Pagano JJ, Chow K, Thompson RB, Vos LJ, Ghosh S, Oudit GY, Ezekowitz JA, Paterson DI.

J Clin Oncol. 2017 Mar 10;35(8):870-877. doi: 10.1200/JCO.2016.68.7830. Epub 2016 Nov 28.

PMID:
27893331
32.

Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.

Zhong JC, Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY.

Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1942-1950. doi: 10.1016/j.bbadis.2016.11.007. Epub 2016 Nov 4.

33.

Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling.

Xu R, Zhang ZZ, Chen LJ, Yu HM, Guo SJ, Xu YL, Oudit GY, Zhang Y, Chang Q, Song B, Chen DR, Zhu DL, Zhong JC.

Peptides. 2016 Dec;86:85-94. doi: 10.1016/j.peptides.2016.10.005. Epub 2016 Oct 20.

PMID:
27773659
34.

Unravelling the molecular basis for cardiac iron metabolism and deficiency in heart failure.

Zhabyeyev P, Oudit GY.

Eur Heart J. 2017 Feb 1;38(5):373-375. doi: 10.1093/eurheartj/ehw386. No abstract available.

35.

ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity.

Patel VB, Basu R, Oudit GY.

Adipocyte. 2016 Jan 6;5(3):306-11. doi: 10.1080/21623945.2015.1131881. eCollection 2016 Jul-Sep.

36.

A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1.

Fan D, Takawale A, Shen M, Samokhvalov V, Basu R, Patel V, Wang X, Fernandez-Patron C, Seubert JM, Oudit GY, Kassiri Z.

Hypertension. 2016 Oct;68(4):937-48. doi: 10.1161/HYPERTENSIONAHA.116.07566. Epub 2016 Aug 22.

PMID:
27550917
37.

Glycogen Storage Disease Because of a PRKAG2 Mutation Causing Severe Biventricular Hypertrophy and High-Grade Atrio-Ventricular Block.

Yogasundaram H, Paterson ID, Graham M, Sergi C, Oudit GY.

Circ Heart Fail. 2016 Aug;9(8). pii: e003367. doi: 10.1161/CIRCHEARTFAILURE.116.003367. No abstract available.

PMID:
27496753
38.

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides.

McKinnie SM, Fischer C, Tran KM, Wang W, Mosquera F, Oudit GY, Vederas JC.

Chembiochem. 2016 Aug 17;17(16):1495-8. doi: 10.1002/cbic.201600244. Epub 2016 Jul 5.

PMID:
27377680
39.

Reduced Right Ventricular Native Myocardial T1 in Anderson-Fabry Disease: Comparison to Pulmonary Hypertension and Healthy Controls.

Pagano JJ, Chow K, Khan A, Michelakis E, Paterson I, Oudit GY, Thompson RB.

PLoS One. 2016 Jun 15;11(6):e0157565. doi: 10.1371/journal.pone.0157565. eCollection 2016.

40.

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.

Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY.

Hypertension. 2016 Aug;68(2):365-77. doi: 10.1161/HYPERTENSIONAHA.115.06892. Epub 2016 May 23.

PMID:
27217402
41.

Ces3/TGH Deficiency Attenuates Steatohepatitis.

Lian J, Wei E, Groenendyk J, Das SK, Hermansson M, Li L, Watts R, Thiesen A, Oudit GY, Michalak M, Lehner R.

Sci Rep. 2016 May 16;6:25747. doi: 10.1038/srep25747.

42.

Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice.

Dominguez JM 2nd, Hu P, Caballero S, Moldovan L, Verma A, Oudit GY, Li Q, Grant MB.

Am J Pathol. 2016 Jun;186(6):1688-700. doi: 10.1016/j.ajpath.2016.01.023. Epub 2016 May 10.

43.

Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.

Patel VB, Zhong JC, Grant MB, Oudit GY.

Circ Res. 2016 Apr 15;118(8):1313-26. doi: 10.1161/CIRCRESAHA.116.307708. Review.

44.

Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research.

Oudit GY, Backx PH.

Can J Cardiol. 2016 Aug;32(8):938-40. doi: 10.1016/j.cjca.2015.11.017. Epub 2015 Nov 26. No abstract available.

PMID:
27062235
45.

Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient mice.

Chen LJ, Xu YL, Song B, Yu HM, Oudit GY, Xu R, Zhang ZZ, Jin HY, Chang Q, Zhu DL, Zhong JC.

Peptides. 2016 May;79:49-57. doi: 10.1016/j.peptides.2016.03.008. Epub 2016 Mar 24.

PMID:
27018342
46.

Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.

Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z.

Transl Res. 2016 Jun;172:30-44. doi: 10.1016/j.trsl.2016.02.006. Epub 2016 Feb 23.

PMID:
26963743
47.

Reply to Letter From Floras et al.--Central Sleep Apnea: Risk Factor or Pathogenic Process in Patients With Heart Failure.

Yogasundaram H, Oudit GY.

Can J Cardiol. 2016 Mar;32(3):396.e5. doi: 10.1016/j.cjca.2015.11.009. Epub 2015 Nov 19. No abstract available.

PMID:
26831512
49.

MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis.

Hsu YH, Yogasundaram H, Parajuli N, Valtuille L, Sergi C, Oudit GY.

Heart Fail Rev. 2016 Jan;21(1):103-16. doi: 10.1007/s10741-015-9524-5. Review.

PMID:
26712328
50.

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy.

Das SK, Wang W, Zhabyeyev P, Basu R, McLean B, Fan D, Parajuli N, DesAulniers J, Patel VB, Hajjar RJ, Dyck JR, Kassiri Z, Oudit GY.

Sci Rep. 2015 Dec 7;5:18132. doi: 10.1038/srep18132.

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