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Items: 13


Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.

Ashley N, Ouaret D, Bodmer WF.

J Pathol. 2019 Mar;247(3):293-304. doi: 10.1002/path.5179. Epub 2019 Jan 16.


Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance.

Buzzelli JN, Ouaret D, Brown G, Allen PD, Muschel RJ.

Stem Cell Res. 2018 Mar;27:109-120. doi: 10.1016/j.scr.2018.01.016. Epub 2018 Jan 28.


ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.

Zinecker H, Ouaret D, Ebner D, Gaidt MM, Taylor S, Aulicino A, Jagielowicz M, Hornung V, Simmons A.

Oncotarget. 2017 Nov 1;8(63):106764-106777. doi: 10.18632/oncotarget.22264. eCollection 2017 Dec 5.


Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.

Hsia LT, Ashley N, Ouaret D, Wang LM, Wilding J, Bodmer WF.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2162-71. doi: 10.1073/pnas.1603534113. Epub 2016 Mar 28.


A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.

Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer W, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes C, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umaña P.

Clin Cancer Res. 2016 Jul 1;22(13):3286-97. doi: 10.1158/1078-0432.CCR-15-1696. Epub 2016 Feb 9.


Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.

Ayadi M, Bouygues A, Ouaret D, Ferrand N, Chouaib S, Thiery JP, Muchardt C, Sabbah M, Larsen AK.

Oncotarget. 2015 Jul 30;6(21):18518-33.


Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.

Gao S, Bajrami I, Verrill C, Kigozi A, Ouaret D, Aleksic T, Asher R, Han C, Allen P, Bailey D, Feller S, Kashima T, Athanasou N, Blay JY, Schmitz S, Machiels JP, Upile N, Jones TM, Thalmann G, Ashraf SQ, Wilding JL, Bodmer WF, Middleton MR, Ashworth A, Lord CJ, Macaulay VM.

Cancer Res. 2014 Oct 15;74(20):5866-77. doi: 10.1158/0008-5472.CAN-14-0806. Epub 2014 Aug 28.


Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays.

Ashley N, Jones M, Ouaret D, Wilding J, Bodmer WF.

J Pathol. 2014 Sep;234(1):34-45. doi: 10.1002/path.4371. Epub 2014 Jul 7.


Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.

Petitprez A, Poindessous V, Ouaret D, Regairaz M, Bastian G, Guérin E, Escargueil AE, Larsen AK.

Int J Oncol. 2013 May;42(5):1644-53. doi: 10.3892/ijo.2013.1868. Epub 2013 Mar 27.


EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies.

Poindessous V, Ouaret D, El Ouadrani K, Battistella A, Mégalophonos VF, Kamsu-Kom N, Petitprez A, Escargueil AE, Boudou P, Dumont S, Cervera P, Fléjou JF, André T, Tournigand C, Chibaudel B, de Gramont A, Larsen AK.

Clin Cancer Res. 2011 Oct 15;17(20):6522-30. doi: 10.1158/1078-0432.CCR-11-1607. Epub 2011 Aug 31.


Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells.

Soares DG, Machado MS, Rocca CJ, Poindessous V, Ouaret D, Sarasin A, Galmarini CM, Henriques JA, Escargueil AE, Larsen AK.

Mol Cancer Ther. 2011 Aug;10(8):1481-9. doi: 10.1158/1535-7163.MCT-11-0252. Epub 2011 May 27.


Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis.

Larsen AK, Ouaret D, El Ouadrani K, Petitprez A.

Pharmacol Ther. 2011 Jul;131(1):80-90. doi: 10.1016/j.pharmthera.2011.03.012. Epub 2011 Mar 23. Review.


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