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Items: 1 to 50 of 219

1.

Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity.

Mohammad-Beigi H, Aliakbari F, Sahin C, Lomax C, Tawfike A, Schafer NP, Amiri-Nowdijeh A, Eskandari H, Møller IM, Hosseini-Mazinani M, Christiansen G, Ward JL, Morshedi D, Otzen DE.

J Biol Chem. 2019 Jan 17. pii: jbc.RA118.005723. doi: 10.1074/jbc.RA118.005723. [Epub ahead of print]

PMID:
30655291
2.

Physical Determinants of Amyloid Assembly in Biofilm Formation.

Andreasen M, Meisl G, Taylor JD, Michaels TCT, Levin A, Otzen DE, Chapman MR, Dobson CM, Matthews SJ, Knowles TPJ.

MBio. 2019 Jan 8;10(1). pii: e02279-18. doi: 10.1128/mBio.02279-18.

3.

In vitro and in silico assessment of the developability of a designed monoclonal antibody library.

Wolf Pérez AM, Sormanni P, Andersen JS, Sakhnini LI, Rodriguez-Leon I, Bjelke JR, Gajhede AJ, De Maria L, Otzen DE, Vendruscolo M, Lorenzen N.

MAbs. 2018 Dec 7. doi: 10.1080/19420862.2018.1556082. [Epub ahead of print]

PMID:
30523762
4.

The Sheaths of Methanospirillum Are Made of a New Type of Amyloid Protein.

Christensen LFB, Hansen LM, Finster K, Christiansen G, Nielsen PH, Otzen DE, Dueholm MS.

Front Microbiol. 2018 Nov 13;9:2729. doi: 10.3389/fmicb.2018.02729. eCollection 2018.

5.

Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures.

Pedersen JN, Jiang Z, Christiansen G, Lee JC, Pedersen JS, Otzen DE.

Biochim Biophys Acta Proteins Proteom. 2018 Nov 22. pii: S1570-9639(18)30205-X. doi: 10.1016/j.bbapap.2018.11.007. [Epub ahead of print]

PMID:
30471451
6.

Can a Charged Surfactant Unfold an Uncharged Protein?

Højgaard C, Sørensen HV, Pedersen JS, Winther JR, Otzen DE.

Biophys J. 2018 Dec 4;115(11):2081-2086. doi: 10.1016/j.bpj.2018.10.022. Epub 2018 Nov 15.

PMID:
30447995
7.

The Use of Surfactants to Solubilise a Glucagon Analogue.

Madsen JK, Giehm L, Otzen DE.

Pharm Res. 2018 Oct 15;35(12):235. doi: 10.1007/s11095-018-2494-2.

PMID:
30324334
8.

Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.

Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE.

Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6.

PMID:
30197194
9.

α-Synucleins from Animal Species Show Low Fibrillation Propensities and Weak Oligomer Membrane Disruption.

Sahin C, Kjær L, Christensen MS, N Pedersen J, Christiansen G, Pérez AW, Møller IM, Enghild JJ, Pedersen JS, Larsen K, Otzen DE.

Biochemistry. 2018 Aug 28;57(34):5145-5158. doi: 10.1021/acs.biochem.8b00627. Epub 2018 Aug 15.

PMID:
30067901
10.

Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms.

Bleem A, Christiansen G, Madsen DJ, Maric H, Strømgaard K, Bryers JD, Daggett V, Meyer RL, Otzen DE.

J Mol Biol. 2018 Oct 12;430(20):3751-3763. doi: 10.1016/j.jmb.2018.06.043. Epub 2018 Jun 30.

11.

The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.

Aliakbari F, Mohammad-Beigi H, Rezaei-Ghaleh N, Becker S, Dehghani Esmatabad F, Eslampanah Seyedi HA, Bardania H, Tayaranian Marvian A, Collingwood JF, Christiansen G, Zweckstetter M, Otzen DE, Morshedi D.

Nanoscale. 2018 May 17;10(19):9174-9185. doi: 10.1039/c8nr00632f.

PMID:
29725687
12.

Early events in copper-ion catalyzed oxidation of α-synuclein.

Tiwari MK, Leinisch F, Sahin C, Møller IM, Otzen DE, Davies MJ, Bjerrum MJ.

Free Radic Biol Med. 2018 Jun;121:38-50. doi: 10.1016/j.freeradbiomed.2018.04.559. Epub 2018 Apr 22.

PMID:
29689296
13.

Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation.

Andersen KK, Vad BS, Kjaer L, Tolker-Nielsen T, Christiansen G, Otzen DE.

FEBS Lett. 2018 May;592(9):1484-1496. doi: 10.1002/1873-3468.13038. Epub 2018 Apr 10.

PMID:
29572816
14.

Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.

Stenvang M, Schafer NP, Malmos KG, Pérez AW, Niembro O, Sormanni P, Basaiawmoit RV, Christiansen G, Andreasen M, Otzen DE.

J Mol Biol. 2018 Apr 13;430(8):1116-1140. doi: 10.1016/j.jmb.2018.03.001. Epub 2018 Mar 7.

PMID:
29524512
15.

Stabilizing vitamin D3 using the molten globule state of α-lactalbumin.

Pedersen JN, Sørensen HV, Otzen DE.

J Dairy Sci. 2018 Mar;101(3):1817-1826. doi: 10.3168/jds.2017-13818. Epub 2018 Jan 10.

PMID:
29331461
16.

Myoglobin and α-Lactalbumin Form Smaller Complexes with the Biosurfactant Rhamnolipid Than with SDS.

Mortensen HG, Madsen JK, Andersen KK, Vosegaard T, Deen GR, Otzen DE, Pedersen JS.

Biophys J. 2017 Dec 19;113(12):2621-2633. doi: 10.1016/j.bpj.2017.10.024.

17.

Dynamic content exchange between liprotides.

Frislev HS, Jakobsen SCL, Frank SA, Otzen DE.

Biophys Chem. 2018 Feb;233:13-18. doi: 10.1016/j.bpc.2017.11.006. Epub 2017 Dec 5.

PMID:
29227791
18.

Role of Charge and Hydrophobicity in Liprotide Formation: A Molecular Dynamics Study with Experimental Constraints.

Nedergaard Pedersen J, Frederix PWJM, Skov Pedersen J, Marrink SJ, Otzen DE.

Chembiochem. 2018 Feb 2;19(3):263-271. doi: 10.1002/cbic.201700496. Epub 2018 Jan 9.

PMID:
29156084
19.

Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome.

Aliakbari F, Shabani AA, Bardania H, Mohammad-Beigi H, Tayaranian Marvian A, Dehghani Esmatabad F, Vafaei AA, Shojaosadati SA, Saboury AA, Christiansen G, Otzen DE, Morshedi D.

Colloids Surf B Biointerfaces. 2018 Jan 1;161:578-587. doi: 10.1016/j.colsurfb.2017.11.023. Epub 2017 Nov 11.

PMID:
29149763
20.

Liprotides assist in folding of outer membrane proteins.

Nedergaard Pedersen J, Skov Pedersen J, Otzen DE.

Protein Sci. 2018 Feb;27(2):451-462. doi: 10.1002/pro.3337. Epub 2017 Nov 17.

PMID:
29094406
21.

How glycosaminoglycans promote fibrillation of salmon calcitonin.

Malmos KG, Bjerring M, Jessen CM, Nielsen EHT, Poulsen ET, Christiansen G, Vosegaard T, Skrydstrup T, Enghild JJ, Pedersen JS, Otzen DE.

J Biol Chem. 2017 Sep 22;292(38):15992. doi: 10.1074/jbc.A116.715466. No abstract available.

22.

Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils.

Risør MW, Juhl DW, Bjerring M, Mathiesen J, Enghild JJ, Nielsen NC, Otzen DE.

Biophys J. 2017 Aug 8;113(3):580-596. doi: 10.1016/j.bpj.2017.06.030.

23.

The Changing Face of Aging: Highly Sulfated Glycosaminoglycans Induce Amyloid Formation in a Lattice Corneal Dystrophy Model Protein.

Malmos KG, Stenvang M, Sahin C, Christiansen G, Otzen DE.

J Mol Biol. 2017 Sep 1;429(18):2755-2764. doi: 10.1016/j.jmb.2017.07.014. Epub 2017 Jul 21.

PMID:
28739480
24.

Glycolipid Biosurfactants Activate, Dimerize, and Stabilize Thermomyces lanuginosus Lipase in a pH-Dependent Fashion.

Madsen JK, Kaspersen JD, Andersen CB, Nedergaard Pedersen J, Andersen KK, Pedersen JS, Otzen DE.

Biochemistry. 2017 Aug 15;56(32):4256-4268. doi: 10.1021/acs.biochem.7b00420. Epub 2017 Aug 7.

PMID:
28726390
25.

Refolding of SDS-Unfolded Proteins by Nonionic Surfactants.

Kaspersen JD, Søndergaard A, Madsen DJ, Otzen DE, Pedersen JS.

Biophys J. 2017 Apr 25;112(8):1609-1620. doi: 10.1016/j.bpj.2017.03.013.

26.

Tailoring thermal treatment to form liprotide complexes between oleic acid and different proteins.

Sørensen HV, Pedersen JN, Pedersen JS, Otzen DE.

Biochim Biophys Acta Proteins Proteom. 2017 Jun;1865(6):682-693. doi: 10.1016/j.bbapap.2017.03.011. Epub 2017 Mar 27.

PMID:
28351690
27.

The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.

Christiansen SH, Zhang X, Juul-Madsen K, Hvam ML, Vad BS, Behrens MA, Thygesen IL, Jalilian B, Pedersen JS, Howard KA, Otzen DE, Vorup-Jensen T.

Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):425-437. doi: 10.1016/j.bbamem.2017.01.001. Epub 2017 Jan 5.

28.

Concatemers of Outer Membrane Protein A Take Detours in the Folding Landscape.

Andersen KK, Vad B, Omer S, Otzen DE.

Biochemistry. 2016 Dec 27;55(51):7123-7140. doi: 10.1021/acs.biochem.6b01153. Epub 2016 Dec 14.

PMID:
27973779
29.

Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.

Andersen KK, Vad BS, Scavenius C, Enghild JJ, Otzen DE.

Biochemistry. 2017 Jan 10;56(1):260-270. doi: 10.1021/acs.biochem.6b01009. Epub 2016 Dec 20.

PMID:
27931094
30.

Weak and Saturable Protein-Surfactant Interactions in the Denaturation of Apo-α-Lactalbumin by Acidic and Lactonic Sophorolipid.

Andersen KK, Vad BS, Roelants S, van Bogaert IN, Otzen DE.

Front Microbiol. 2016 Nov 8;7:1711. eCollection 2016.

31.

Antibodies against the C-terminus of α-synuclein modulate its fibrillation.

Sahin C, Lorenzen N, Lemminger L, Christiansen G, Møller IM, Vesterager LB, Pedersen LØ, Fog K, Kallunki P, Otzen DE.

Biophys Chem. 2017 Jan;220:34-41. doi: 10.1016/j.bpc.2016.11.002. Epub 2016 Nov 10.

PMID:
27863716
32.

Epigallocatechin Gallate Remodels Overexpressed Functional Amyloids in Pseudomonas aeruginosa and Increases Biofilm Susceptibility to Antibiotic Treatment.

Stenvang M, Dueholm MS, Vad BS, Seviour T, Zeng G, Geifman-Shochat S, Søndergaard MT, Christiansen G, Meyer RL, Kjelleberg S, Nielsen PH, Otzen DE.

J Biol Chem. 2016 Dec 16;291(51):26540-26553. Epub 2016 Oct 26.

33.

Biosurfactants and surfactants interacting with membranes and proteins: Same but different?

Otzen DE.

Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):639-649. doi: 10.1016/j.bbamem.2016.09.024. Epub 2016 Sep 30. Review.

34.

Using protein-fatty acid complexes to improve vitamin D stability.

Pedersen JN, Frislev HS, Pedersen JS, Otzen DE.

J Dairy Sci. 2016 Oct;99(10):7755-7767. doi: 10.3168/jds.2016-11343. Epub 2016 Jul 27.

PMID:
27474981
35.

The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.

Jarvela TS, Lam HA, Helwig M, Lorenzen N, Otzen DE, McLean PJ, Maidment NT, Lindberg I.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4708-15. doi: 10.1073/pnas.1601091113. Epub 2016 Jul 25.

36.

A Complex Dance: The Importance of Glycosaminoglycans and Zinc in the Aggregation of Human Prolactin.

Christensen LF, Malmos KG, Christiansen G, Otzen DE.

Biochemistry. 2016 Jul 5;55(26):3674-84. doi: 10.1021/acs.biochem.6b00153. Epub 2016 Jun 22.

PMID:
27305175
37.

How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin.

Malmos KG, Bjerring M, Jessen CM, Nielsen EH, Poulsen ET, Christiansen G, Vosegaard T, Skrydstrup T, Enghild JJ, Pedersen JS, Otzen DE.

J Biol Chem. 2016 Aug 5;291(32):16849-62. doi: 10.1074/jbc.M116.715466. Epub 2016 Jun 8. Erratum in: J Biol Chem. 2017 Sep 22;292(38):15992.

38.

The transcriptional regulator GalR self-assembles to form highly regular tubular structures.

Agerschou ED, Christiansen G, Schafer NP, Madsen DJ, Brodersen DE, Semsey S, Otzen DE.

Sci Rep. 2016 Jun 9;6:27672. doi: 10.1038/srep27672.

39.

Liprotides made of α-lactalbumin and cis fatty acids form core-shell and multi-layer structures with a common membrane-targeting mechanism.

Frislev HS, Jessen CM, Oliveira CL, Pedersen JS, Otzen DE.

Biochim Biophys Acta. 2016 Jul;1864(7):847-59. doi: 10.1016/j.bbapap.2016.04.003. Epub 2016 Apr 9.

PMID:
27068540
40.

α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.

Christiansen JR, Olesen MN, Otzen DE, Romero-Ramos M, Sanchez-Guajardo V.

J Neuroinflammation. 2016 Apr 7;13(1):74. doi: 10.1186/s12974-016-0532-8.

41.

Epigallocatechin Gallate Remodels Fibrils of Lattice Corneal Dystrophy Protein, Facilitating Proteolytic Degradation and Preventing Formation of Membrane-Permeabilizing Species.

Stenvang M, Christiansen G, Otzen DE.

Biochemistry. 2016 Apr 26;55(16):2344-57. doi: 10.1021/acs.biochem.6b00063. Epub 2016 Apr 14.

PMID:
27042751
42.

Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease.

Schafer NP, Truong HH, Otzen DE, Lindorff-Larsen K, Wolynes PG.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2098-103. doi: 10.1073/pnas.1524027113. Epub 2016 Feb 8.

43.

A Monte Carlo Study of the Early Steps of Functional Amyloid Formation.

Tian P, Lindorff-Larsen K, Boomsma W, Jensen MH, Otzen DE.

PLoS One. 2016 Jan 8;11(1):e0146096. doi: 10.1371/journal.pone.0146096. eCollection 2016.

44.

The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.

Scavenius C, Nikolajsen CL, Stenvang M, Thøgersen IB, Wyrożemski Ł, Wisniewski HG, Otzen DE, Sanggaard KW, Enghild JJ.

J Biol Chem. 2016 Feb 26;291(9):4658-70. doi: 10.1074/jbc.M115.678748. Epub 2016 Jan 4.

45.

Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11.

Kim JY, Sahu S, Yau YH, Wang X, Shochat SG, Nielsen PH, Dueholm MS, Otzen DE, Lee J, Delos Santos MM, Yam JK, Kang NY, Park SJ, Kwon H, Seviour T, Yang L, Givskov M, Chang YT.

J Am Chem Soc. 2016 Jan 13;138(1):402-7. doi: 10.1021/jacs.5b11357. Epub 2016 Jan 4.

PMID:
26684612
46.

Strong interactions with polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA NPs) alter α-synuclein conformation and aggregation kinetics.

Mohammad-Beigi H, Shojaosadati SA, Marvian AT, Pedersen JN, Klausen LH, Christiansen G, Pedersen JS, Dong M, Morshedi D, Otzen DE.

Nanoscale. 2015 Dec 14;7(46):19627-40. doi: 10.1039/c5nr05663b.

PMID:
26549058
47.

Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness.

Zeng G, Vad BS, Dueholm MS, Christiansen G, Nilsson M, Tolker-Nielsen T, Nielsen PH, Meyer RL, Otzen DE.

Front Microbiol. 2015 Oct 7;6:1099. doi: 10.3389/fmicb.2015.01099. eCollection 2015.

48.

Formation and Characterization of α-Synuclein Oligomers.

Paslawski W, Lorenzen N, Otzen DE.

Methods Mol Biol. 2016;1345:133-50. doi: 10.1007/978-1-4939-2978-8_9.

PMID:
26453210
49.

Promoting protein self-association in non-glycosylated Thermomyces lanuginosus lipase based on crystal lattice contacts.

Madsen JK, Sørensen TR, Kaspersen JD, Silow MB, Vind J, Pedersen JS, Svendsen A, Otzen DE.

Biochim Biophys Acta. 2015 Dec;1854(12):1914-1921. doi: 10.1016/j.bbapap.2015.09.007. Epub 2015 Oct 1.

PMID:
26431886
50.

Sucrose prevents protein fibrillation through compaction of the tertiary structure but hardly affects the secondary structure.

Estrela N, Franquelim HG, Lopes C, Tavares E, Macedo JA, Christiansen G, Otzen DE, Melo EP.

Proteins. 2015 Nov;83(11):2039-51. doi: 10.1002/prot.24921. Epub 2015 Sep 22.

PMID:
26344410

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