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Plasma Branched-Chain Amino Acids and Risk of Incident Type 2 Diabetes: Results from the PREVEND Prospective Cohort Study.

Flores-Guerrero JL, Osté MCJ, Kieneker LM, Gruppen EG, Wolak-Dinsmore J, Otvos JD, Connelly MA, Bakker SJL, Dullaart RPF.

J Clin Med. 2018 Dec 4;7(12). pii: E513. doi: 10.3390/jcm7120513.


GlycA, a novel inflammatory marker, is associated with subclinical coronary disease in the multicenter AIDS cohort study.

Tibuakuu M, Fashanu OE, Zhao D, Otvos JD, Brown TT, Haberlen SA, Guallar E, Budoff MJ, Palella FJ Jr, Martinson JJ, Akinkuolie AO, Mora S, Post WS, Michos ED.

AIDS. 2018 Nov 19. doi: 10.1097/QAD.0000000000002079. [Epub ahead of print]


Associations of ideal cardiovascular health with GlycA, a novel inflammatory marker: The Multi-Ethnic Study of Atherosclerosis.

Benson EA, Tibuakuu M, Zhao D, Akinkuolie AO, Otvos JD, Duprez DA, Jacobs DR Jr, Mora S, Michos ED.

Clin Cardiol. 2018 Nov;41(11):1439-1445. doi: 10.1002/clc.23069. Epub 2018 Nov 19.


Comparability of Lipoprotein Particle Number Concentrations Across ES-DMA, NMR, LC-MS/MS, Immunonephelometry, and VAP: In Search of a Candidate Reference Measurement Procedure for apoB and non-HDL-P Standardization.

Delatour V, Clouet-Foraison N, Gaie-Levrel F, Marcovina SM, Hoofnagle AN, Kuklenyik Z, Caulfield MP, Otvos JD, Krauss RM, Kulkarni KR, Contois JH, Remaley AT, Vesper HW, Cobbaert CM, Gillery P.

Clin Chem. 2018 Oct;64(10):1485-1495. doi: 10.1373/clinchem.2018.288746. Epub 2018 Aug 7.


GlycA and hsCRP are independent and additive predictors of future cardiovascular events among patients undergoing angiography: The intermountain heart collaborative study.

Muhlestein JB, May HT, Galenko O, Knowlton KU, Otvos JD, Connelly MA, Lappe DL, Anderson JL.

Am Heart J. 2018 Aug;202:27-32. doi: 10.1016/j.ahj.2018.04.003. Epub 2018 Apr 6.


Lipid profile and effect of statin treatment in pooled phase II and phase III baricitinib studies.

Taylor PC, Kremer JM, Emery P, Zuckerman SH, Ruotolo G, Zhong J, Chen L, Witt S, Saifan C, Kurzawa M, Otvos JD, Connelly MA, Macias WL, Schlichting DE, Rooney TP, de Bono S, McInnes IB.

Ann Rheum Dis. 2018 Jul;77(7):988-995. doi: 10.1136/annrheumdis-2017-212461. Epub 2018 Feb 20.


A novel NMR-based assay to measure circulating concentrations of branched-chain amino acids: Elevation in subjects with type 2 diabetes mellitus and association with carotid intima media thickness.

Wolak-Dinsmore J, Gruppen EG, Shalaurova I, Matyus SP, Grant RP, Gegen R, Bakker SJL, Otvos JD, Connelly MA, Dullaart RPF.

Clin Biochem. 2018 Apr;54:92-99. doi: 10.1016/j.clinbiochem.2018.02.001. Epub 2018 Feb 9.


Relations of GlycA and lipoprotein particle subspecies with cardiovascular events and mortality: A post hoc analysis of the AIM-HIGH trial.

Otvos JD, Guyton JR, Connelly MA, Akapame S, Bittner V, Kopecky SL, Lacy M, Marcovina SM, Muhlestein JB, Boden WE.

J Clin Lipidol. 2018 Mar - Apr;12(2):348-355.e2. doi: 10.1016/j.jacl.2018.01.002. Epub 2018 Jan 12.


Effects of hepato-preferential basal insulin peglispro on nuclear magnetic resonance biomarkers lipoprotein insulin resistance index and GlycA in patients with diabetes.

Connelly MA, Otvos JD, Zhang Q, Zhang S, Antalis CJ, Chang AM, Hoogwerf BJ.

Biomark Med. 2017 Nov;11(11):991-1001. doi: 10.2217/bmm-2017-0112.


GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk.

Connelly MA, Otvos JD, Shalaurova I, Playford MP, Mehta NN.

J Transl Med. 2017 Oct 27;15(1):219. doi: 10.1186/s12967-017-1321-6. Review.


TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function.

Gruppen EG, Garcia E, Connelly MA, Jeyarajah EJ, Otvos JD, Bakker SJL, Dullaart RPF.

Sci Rep. 2017 Oct 23;7(1):13781. doi: 10.1038/s41598-017-13739-9.


Association Between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Kianoush S, Bittencourt MS, Lotufo PA, Bensenor IM, Jones SR, DeFilippis AP, Toth PP, Otvos JD, Tibuakuu M, Hall ME, Harada PHN, Blaha MJ.

J Am Heart Assoc. 2017 Aug 23;6(8). pii: e006545. doi: 10.1161/JAHA.117.006545. Erratum in: J Am Heart Assoc. 2017 Dec 2;6(12 ):.


Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease.

Davidson WS, Heink A, Sexmith H, Dolan LM, Gordon SM, Otvos JD, Melchior JT, Elder DA, Khoury J, Geh E, Shah AS.

J Lipid Res. 2017 Sep;58(9):1916-1923. doi: 10.1194/jlr.M078667. Epub 2017 Jul 25.


NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting.

Garcia E, Wolak-Dinsmore J, Wang Z, Li XS, Bennett DW, Connelly MA, Otvos JD, Hazen SL, Jeyarajah EJ.

Clin Biochem. 2017 Nov;50(16-17):947-955. doi: 10.1016/j.clinbiochem.2017.06.003. Epub 2017 Jun 15.


The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes.

Orchard TJ, Cariou B, Connelly MA, Otvos JD, Zhang S, Antalis CJ, Ivanyi T, Hoogwerf BJ.

Cardiovasc Diabetol. 2017 Jun 6;16(1):73. doi: 10.1186/s12933-017-0555-1.


Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

AbouAssi H, Connelly MA, Bateman LA, Tune KN, Huebner JL, Kraus VB, Winegar DA, Otvos JD, Kraus WE, Huffman KM.

Lipids Health Dis. 2017 Feb 10;16(1):39. doi: 10.1186/s12944-017-0427-4.


Utility of high density lipoprotein particle concentration in predicting future major adverse cardiovascular events among patients undergoing angiography.

May HT, Anderson JL, Winegar DA, Rollo J, Connelly MA, Otvos JD, Muhlestein JB.

Clin Biochem. 2016 Oct;49(15):1122-1126. doi: 10.1016/j.clinbiochem.2016.09.004. Epub 2016 Sep 9.


Differences in GlycA and lipoprotein particle parameters may help distinguish acute kawasaki disease from other febrile illnesses in children.

Connelly MA, Shimizu C, Winegar DA, Shalaurova I, Pourfarzib R, Otvos JD, Kanegaye JT, Tremoulet AH, Burns JC.

BMC Pediatr. 2016 Sep 5;16(1):151. doi: 10.1186/s12887-016-0688-5.


Inflammatory glycoproteins in cardiometabolic disorders, autoimmune diseases and cancer.

Connelly MA, Gruppen EG, Otvos JD, Dullaart RPF.

Clin Chim Acta. 2016 Aug 1;459:177-186. doi: 10.1016/j.cca.2016.06.012. Epub 2016 Jun 13. Review.


GlycA, a novel proinflammatory glycoprotein biomarker, and high-sensitivity C-reactive protein are inversely associated with sodium intake after controlling for adiposity: the Prevention of Renal and Vascular End-Stage Disease study.

Gruppen EG, Connelly MA, Vart P, Otvos JD, Bakker SJ, Dullaart RP.

Am J Clin Nutr. 2016 Aug;104(2):415-22. doi: 10.3945/ajcn.116.133744. Epub 2016 Jun 15.


Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA).

Kim DS, Li YK, Bell GA, Burt AA, Vaisar T, Hutchins PM, Furlong CE, Otvos JD, Polak JF, Arnan MK, Kaufman JD, McClelland RL, Longstreth WT Jr, Jarvik GP.

J Am Heart Assoc. 2016 May 20;5(5). pii: e002977. doi: 10.1161/JAHA.115.002977.


Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial.

Siebel AL, Trinh SK, Formosa MF, Mundra PA, Natoli AK, Reddy-Luthmoodoo M, Huynh K, Khan AA, Carey AL, van Hall G, Cobelli C, Dalla-Man C, Otvos JD, Rye KA, Johansson J, Gordon A, Wong NC, Sviridov D, Barter P, Duffy SJ, Meikle PJ, Kingwell BA.

Metabolism. 2016 Jun;65(6):904-14. doi: 10.1016/j.metabol.2016.03.002. Epub 2016 Mar 8.


Discordance of Low-Density Lipoprotein and High-Density Lipoprotein Cholesterol Particle Versus Cholesterol Concentration for the Prediction of Cardiovascular Disease in Patients With Metabolic Syndrome and Diabetes Mellitus (from the Multi-Ethnic Study of Atherosclerosis [MESA]).

Tehrani DM, Zhao Y, Blaha MJ, Mora S, Mackey RH, Michos ED, Budoff MJ, Cromwell W, Otvos JD, Rosenblit PD, Wong ND.

Am J Cardiol. 2016 Jun 15;117(12):1921-7. doi: 10.1016/j.amjcard.2016.03.040. Epub 2016 Apr 6.


Novel measures of inflammation and insulin resistance are related to obesity and fitness in a diverse sample of 11-14 year olds: The HEALTHY Study.

Jago R, Drews KL, Otvos JD, Willi SM, Buse JB.

Int J Obes (Lond). 2016 Jul;40(7):1157-63. doi: 10.1038/ijo.2016.84. Epub 2016 May 4.


High-density lipoprotein and inflammation in cardiovascular disease.

Connelly MA, Shalaurova I, Otvos JD.

Transl Res. 2016 Jul;173:7-18. doi: 10.1016/j.trsl.2016.01.006. Epub 2016 Jan 20. Review.


Longitudinal Evaluation of Lipoprotein Variables in Systemic Lupus Erythematosus Reveals Adverse Changes with Disease Activity and Prednisone and More Favorable Profiles with Hydroxychloroquine Therapy.

Durcan L, Winegar DA, Connelly MA, Otvos JD, Magder LS, Petri M.

J Rheumatol. 2016 Apr;43(4):745-50. doi: 10.3899/jrheum.150437. Epub 2016 Feb 1.


Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease.

Jiang ZG, Tapper EB, Connelly MA, Pimentel CF, Feldbrügge L, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Otvos JD, Mukamal KJ, Lai M.

Liver Int. 2016 Aug;36(8):1213-20. doi: 10.1111/liv.13076. Epub 2016 Feb 24.


GlycA, a novel marker of inflammation, is elevated in systemic lupus erythematosus.

Chung CP, Ormseth MJ, Connelly MA, Oeser A, Solus JF, Otvos JD, Raggi P, Stein CM.

Lupus. 2016 Mar;25(3):296-300. doi: 10.1177/0961203315617842. Epub 2015 Dec 3.


GlycA, a marker of acute phase glycoproteins, and the risk of incident type 2 diabetes mellitus: PREVEND study.

Connelly MA, Gruppen EG, Wolak-Dinsmore J, Matyus SP, Riphagen IJ, Shalaurova I, Bakker SJ, Otvos JD, Dullaart RP.

Clin Chim Acta. 2016 Jan 15;452:10-7. doi: 10.1016/j.cca.2015.11.001. Epub 2015 Nov 5.


Increase in the Inflammatory Marker GlycA over 13 Years in Young Adults Is Associated with Poorer Cognitive Function in Midlife.

Cohen-Manheim I, Doniger GM, Sinnreich R, Simon ES, Pinchas-Mizrachi R, Otvos JD, Kark JD.

PLoS One. 2015 Sep 25;10(9):e0138036. doi: 10.1371/journal.pone.0138036. eCollection 2015.


GlycA, a Pro-Inflammatory Glycoprotein Biomarker, and Incident Cardiovascular Disease: Relationship with C-Reactive Protein and Renal Function.

Gruppen EG, Riphagen IJ, Connelly MA, Otvos JD, Bakker SJ, Dullaart RP.

PLoS One. 2015 Sep 23;10(9):e0139057. doi: 10.1371/journal.pone.0139057. eCollection 2015.


A novel protein glycan biomarker and LCAT activity in metabolic syndrome.

Gruppen EG, Connelly MA, Otvos JD, Bakker SJ, Dullaart RP.

Eur J Clin Invest. 2015 Aug;45(8):850-9. doi: 10.1111/eci.12481.


Effects of icosapent ethyl on lipoprotein particle concentration and size in statin-treated patients with persistent high triglycerides (the ANCHOR Study).

Ballantyne CM, Braeckman RA, Bays HE, Kastelein JJ, Otvos JD, Stirtan WG, Doyle RT Jr, Soni PN, Juliano RA.

J Clin Lipidol. 2015 May-Jun;9(3):377-83. doi: 10.1016/j.jacl.2014.11.009. Epub 2014 Nov 29.


GlycA, a biomarker of inflammatory glycoproteins, is more closely related to the leptin/adiponectin ratio than to glucose tolerance status.

Dullaart RP, Gruppen EG, Connelly MA, Otvos JD, Lefrandt JD.

Clin Biochem. 2015 Aug;48(12):811-4. doi: 10.1016/j.clinbiochem.2015.05.001. Epub 2015 May 11.


Utility of a novel inflammatory marker, GlycA, for assessment of rheumatoid arthritis disease activity and coronary atherosclerosis.

Ormseth MJ, Chung CP, Oeser AM, Connelly MA, Sokka T, Raggi P, Solus JF, Otvos JD, Stein CM.

Arthritis Res Ther. 2015 May 9;17:117. doi: 10.1186/s13075-015-0646-x.


The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis.

Sanchez OA, Duprez DA, Daniels LB, Maisel AS, Otvos JD, Peralta CA, Lima JA, Bahrami H, Jacobs DR Jr.

Metabolism. 2015 Aug;64(8):857-61. doi: 10.1016/j.metabol.2015.04.001. Epub 2015 Apr 15.


GlycA: A Composite Nuclear Magnetic Resonance Biomarker of Systemic Inflammation.

Otvos JD, Shalaurova I, Wolak-Dinsmore J, Connelly MA, Mackey RH, Stein JH, Tracy RP.

Clin Chem. 2015 May;61(5):714-23. doi: 10.1373/clinchem.2014.232918. Epub 2015 Mar 16.


A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.

Bartlett DB, Connelly MA, AbouAssi H, Bateman LA, Tune KN, Huebner JL, Kraus VB, Winegar DA, Otvos JD, Kraus WE, Huffman KM.

Arthritis Res Ther. 2016 Apr 12;18:86. doi: 10.1186/s13075-016-0982-5.


Lipoprotein insulin resistance index: a lipoprotein particle-derived measure of insulin resistance.

Shalaurova I, Connelly MA, Garvey WT, Otvos JD.

Metab Syndr Relat Disord. 2014 Oct;12(8):422-9. doi: 10.1089/met.2014.0050. Epub 2014 Jun 24.


Serum paraoxonase-1 activity is more closely related to HDL particle concentration and large HDL particles than to HDL cholesterol in Type 2 diabetic and non-diabetic subjects.

Dullaart RP, Otvos JD, James RW.

Clin Biochem. 2014 Aug;47(12):1022-7. doi: 10.1016/j.clinbiochem.2014.04.013. Epub 2014 Apr 21.


Elevated cholesteryl ester transfer protein (CETP) activity, a major determinant of the atherogenic dyslipidemia, and atherosclerotic cardiovascular disease in South Asians.

Rashid S, Sniderman A, Melone M, Brown PE, Otvos JD, Mente A, Schulze K, McQueen MJ, Anand SS, Yusuf S.

Eur J Prev Cardiol. 2015 Apr;22(4):468-77. doi: 10.1177/2047487314528461. Epub 2014 Mar 21.


Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease.

Williams PT, Zhao XQ, Marcovina SM, Otvos JD, Brown BG, Krauss RM.

Atherosclerosis. 2014 Apr;233(2):713-20. doi: 10.1016/j.atherosclerosis.2014.01.034. Epub 2014 Jan 30.


Effect of relative weight group change on nuclear magnetic resonance spectroscopy derived lipoprotein particle size and concentrations among adolescents.

Jago R, Drews KL, Otvos JD, Foster GD, Marcus MD, Buse JB, Mietus-Snyder M, Willi SM; HEALTHY Study Group.

J Pediatr. 2014 May;164(5):1091-1098.e3. doi: 10.1016/j.jpeds.2013.12.029. Epub 2014 Feb 5.


Low-density lipoprotein cholesterol versus particle number in middle school children.

Mietus-Snyder M, Drews KL, Otvos JD, Willi SM, Foster GD, Jago R, Buse JB; HEALTHY Study Group.

J Pediatr. 2013 Aug;163(2):355-62. doi: 10.1016/j.jpeds.2013.01.012. Epub 2013 Feb 14.


Interrelationships between the concentration and size of the largest high-density lipoprotein subfraction and apolipoprotein C-I in infants at birth and follow-up at 2-3 months of age and their parents.

Kwiterovich PO, Virgil DG, Chu AY, Khouzami VA, Alaupovic P, Otvos JD.

J Clin Lipidol. 2013 Jan-Feb;7(1):29-37. doi: 10.1016/j.jacl.2012.09.002. Epub 2012 Sep 19.


Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study).

Bays HE, Braeckman RA, Ballantyne CM, Kastelein JJ, Otvos JD, Stirtan WG, Soni PN.

J Clin Lipidol. 2012 Nov-Dec;6(6):565-72. doi: 10.1016/j.jacl.2012.07.001. Epub 2012 Jul 24.


Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study.

Parish S, Offer A, Clarke R, Hopewell JC, Hill MR, Otvos JD, Armitage J, Collins R; Heart Protection Study Collaborative Group.

Circulation. 2012 May 22;125(20):2469-78. doi: 10.1161/CIRCULATIONAHA.111.073684. Epub 2012 Apr 26.


The surprising AIM-HIGH results are not surprising when viewed through a particle lens.

Otvos JD.

J Clin Lipidol. 2011 Sep-Oct;5(5):368-70. doi: 10.1016/j.jacl.2011.06.012. Epub 2011 Jun 28. No abstract available.


Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans.

Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Divers J, Hicks PJ, Bowden DW, Rocco MV, Parks JS.

Nephrol Dial Transplant. 2011 Nov;26(11):3805-10. doi: 10.1093/ndt/gfr542. Epub 2011 Sep 19.


Relation of cholesterol and lipoprotein parameters with carotid artery plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) carotid MRI study.

Virani SS, Catellier DJ, Pompeii LA, Nambi V, Hoogeveen RC, Wasserman BA, Coresh J, Mosley TH, Otvos JD, Sharrett AR, Boerwinkle E, Ballantyne CM.

Atherosclerosis. 2011 Dec;219(2):596-602. doi: 10.1016/j.atherosclerosis.2011.08.001. Epub 2011 Aug 7.

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