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New Technologies for Outcome Measures in Glaucoma: Review by the European Vision Institute Special Interest Focus Group.

Traber GL, Della Volpe-Waizel M, Maloca P, Schmidt-Erfurth U, Rubin G, Roska B, Cordeiro MF, Otto T, Weleber R, Lesmes LA, Arleo A, Scholl HPN.

Ophthalmic Res. 2020 Jan 14:1-9. doi: 10.1159/000504892. [Epub ahead of print] Review.


OH radicals reactivity towards phenol-related pollutants in water: temperature dependence of the rate constants and novel insights into the [OH-phenol]˙ adduct formation.

Kroflič A, Schaefer T, Huš M, Phuoc Le H, Otto T, Herrmann H.

Phys Chem Chem Phys. 2019 Dec 18. doi: 10.1039/c9cp05533a. [Epub ahead of print]


Late Glacial rapid climate change and human response in the Westernmost Mediterranean (Iberia and Morocco).

Weniger GC, de Andrés-Herrero M, Bolin V, Kehl M, Otto T, Potì A, Tafelmaier Y.

PLoS One. 2019 Dec 4;14(12):e0225049. doi: 10.1371/journal.pone.0225049. eCollection 2019.


Application of Dried Human Amnion Graft to Improve Post-Prostatectomy Incontinence and Potency: A Randomized Exploration Study Protocol.

Barski D, Gerullis H, Ecke T, Boros M, Brune J, Beutner U, Tsaur I, Ramon A, Otto T.

Adv Ther. 2020 Jan;37(1):592-602. doi: 10.1007/s12325-019-01158-3. Epub 2019 Nov 28.


Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania.

Sloan MA, Brooks K, Otto TD, Sanders MJ, Cotton JA, Ligoxygakis P.

PLoS Genet. 2019 Nov 11;15(11):e1008452. doi: 10.1371/journal.pgen.1008452. eCollection 2019 Nov.


Exploring Plasmodium falciparum Var Gene Expression to Assess Host Selection Pressure on Parasites During Infancy.

Kivisi CA, Muthui M, Hunt M, Fegan G, Otto TD, Githinji G, Warimwe GM, Rance R, Marsh K, Bull PC, Abdi AI.

Front Immunol. 2019 Oct 9;10:2328. doi: 10.3389/fimmu.2019.02328. eCollection 2019.


Aqueous-Phase Oxidation of cis-β-Isoprene Epoxydiol by Hydroxyl Radicals and Its Impact on Atmospheric Isoprene Processing.

Otto T, Schaefer T, Herrmann H.

J Phys Chem A. 2019 Dec 12;123(49):10599-10608. doi: 10.1021/acs.jpca.9b08836. Epub 2019 Dec 2.


Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.

Cerasoli DM, Armstrong SJ, Reeves TE, Hodgins SM, Kasten SA, Lee-Stubbs RB, Cadieux CL, Otto TC, Capacio BR, Lenz DE.

Biochem Pharmacol. 2020 Jan;171:113670. doi: 10.1016/j.bcp.2019.113670. Epub 2019 Oct 16.


The Search for a Signature of Life on Mars: A Biogeomorphological Approach.

Corenblit D, Darrozes J, Julien F, Otto T, Roussel E, Steiger J, Viles H.

Astrobiology. 2019 Oct;19(10):1279-1291. doi: 10.1089/ast.2018.1969.


Bulk Organic Aerosol Analysis by Proton-Transfer-Reaction Mass Spectrometry: An Improved Methodology for the Determination of Total Organic Mass, O:C and H:C Elemental Ratios, and the Average Molecular Formula.

Leglise J, Müller M, Piel F, Otto T, Wisthaler A.

Anal Chem. 2019 Oct 15;91(20):12619-12624. doi: 10.1021/acs.analchem.9b02949. Epub 2019 Sep 30.


Kinetic and Theoretical Study of the Atmospheric Aqueous-Phase Reactions of OH Radicals with Methoxyphenolic Compounds.

He L, Schaefer T, Otto T, Kroflič A, Herrmann H.

J Phys Chem A. 2019 Sep 12;123(36):7828-7838. doi: 10.1021/acs.jpca.9b05696. Epub 2019 Aug 28.


New Technologies for Outcome Measures in Retinal Disease: Review from the European Vision Institute Special Interest Focus Group.

Della Volpe-Waizel M, Traber GL, Maloca P, Zinkernagel M, Schmidt-Erfurth U, Rubin G, Roska B, Otto T, Weleber RG, Scholl HPN.

Ophthalmic Res. 2019 Jul 26:1-11. doi: 10.1159/000501887. [Epub ahead of print] Review.


Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact.

Schober ME, Requena DF, Casper TC, Velhorst AK, Lolofie A, McFarlane KE, Otto TE, Terry C, Gensel JC.

Exp Neurol. 2019 Oct;320:112971. doi: 10.1016/j.expneurol.2019.112971. Epub 2019 Jun 24. Review.


Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions.

Georgiadou A, Lee HJ, Walther M, van Beek AE, Fitriani F, Wouters D, Kuijpers TW, Nwakanma D, D'Alessandro U, Riley EM, Otto TD, Ghani A, Levin M, Coin LJ, Conway DJ, Bretscher MT, Cunnington AJ.

Nat Microbiol. 2019 Sep;4(9):1592-1602. doi: 10.1038/s41564-019-0474-x. Epub 2019 Jun 17.


Progression of the canonical reference malaria parasite genome from 2002-2019.

Böhme U, Otto TD, Sanders M, Newbold CI, Berriman M.

Version 2. Wellcome Open Res. 2019 May 28 [revised 2019 Jan 1];4:58. doi: 10.12688/wellcomeopenres.15194.2. eCollection 2019.


Cortisol modulates the engagement of multiple memory systems: Exploration of a common NR3C2 polymorphism.

Langer K, Moser D, Otto T, Wolf OT, Kumsta R.

Psychoneuroendocrinology. 2019 Sep;107:133-140. doi: 10.1016/j.psyneuen.2019.05.006. Epub 2019 May 15.


Hippocampal Arc protein expression and conditioned fear.

Hudgins C, Otto T.

Neurobiol Learn Mem. 2019 May;161:175-191. doi: 10.1016/j.nlm.2019.04.004. Epub 2019 Apr 13.


Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer.

Sobhani N, D'Angelo A, Pittacolo M, Roviello G, Miccoli A, Corona SP, Bernocchi O, Generali D, Otto T.

Cells. 2019 Apr 6;8(4). pii: E321. doi: 10.3390/cells8040321. Review.


An experimental human blood stage model for studying Plasmodium malariae infection.

Woodford J, Collins KA, Odedra A, Wang C, Kyung JI, Domingo GJ, Watts R, Marquart L, Berriman M, Otto TD, McCarthy JS.

J Infect Dis. 2019 Mar 10. pii: jiz102. doi: 10.1093/infdis/jiz102. [Epub ahead of print]


A comparative analysis of response times shows that multisensory benefits and interactions are not equivalent.

Innes BR, Otto TU.

Sci Rep. 2019 Feb 27;9(1):2921. doi: 10.1038/s41598-019-39924-6.


MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.

Mohs A, Kuttkat N, Otto T, Youssef SA, De Bruin A, Trautwein C.

Carcinogenesis. 2019 Feb 13. pii: bgy173. doi: 10.1093/carcin/bgy173. [Epub ahead of print]


Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis.

Sackett SD, Otto T, Mohs A, Sander LE, Strauch S, Streetz KL, Kroy DC, Trautwein C.

FASEB J. 2019 May;33(5):6035-6044. doi: 10.1096/fj.201802118R. Epub 2019 Feb 6.


Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

Abdallah AM, Weerdenburg EM, Guan Q, Ummels R, Borggreve S, Adroub SA, Malas TB, Naeem R, Zhang H, Otto TD, Bitter W, Pain A.

PLoS One. 2019 Jan 23;14(1):e0211003. doi: 10.1371/journal.pone.0211003. eCollection 2019.


Advance care planning for the severely ill in the hospital: a randomized trial.

Krones T, Budilivschi A, Karzig I, Otto T, Valeri F, Biller-Andorno N, Mitchell C, Loupatatzis B.

BMJ Support Palliat Care. 2019 Jan 21. pii: bmjspcare-2017-001489. doi: 10.1136/bmjspcare-2017-001489. [Epub ahead of print]


Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents.

Zhang P, Liu EJ, Tsao C, Kasten SA, Boeri MV, Dao TL, DeBus SJ, Cadieux CL, Baker CA, Otto TC, Cerasoli DM, Chen Y, Jain P, Sun F, Li W, Hung HC, Yuan Z, Ma J, Bigley AN, Raushel FM, Jiang S.

Sci Transl Med. 2019 Jan 2;11(473). pii: eaau7091. doi: 10.1126/scitranslmed.aau7091.


Low sulfated heparins target multiple proteins for central nervous system repair.

McCanney GA, McGrath MA, Otto TD, Burchmore R, Yates EA, Bavington CD, Willison HJ, Turnbull JE, Barnett SC.

Glia. 2019 Apr;67(4):668-687. doi: 10.1002/glia.23562. Epub 2018 Dec 26.


Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum.

Tarr SJ, Díaz-Ingelmo O, Stewart LB, Hocking SE, Murray L, Duffy CW, Otto TD, Chappell L, Rayner JC, Awandare GA, Conway DJ.

BMC Genomics. 2018 Dec 10;19(1):894. doi: 10.1186/s12864-018-5257-x.


UBC® Rapid Test-A Urinary Point-of-Care (POC) Assay for Diagnosis of Bladder Cancer with a focus on Non-Muscle Invasive High-Grade Tumors: Results of a Multicenter-Study.

Ecke TH, Weiß S, Stephan C, Hallmann S, Arndt C, Barski D, Otto T, Gerullis H.

Int J Mol Sci. 2018 Dec 2;19(12). pii: E3841. doi: 10.3390/ijms19123841.


Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate.

Mendes AM, Reuling IJ, Andrade CM, Otto TD, Machado M, Teixeira F, Pissarra J, Gonçalves-Rosa N, Bonaparte D, Sinfrónio J, Sanders M, Janse CJ, Khan SM, Newbold CI, Berriman M, Lee CK, Wu Y, Ockenhouse CF, Sauerwein RW, Prudêncio M.

NPJ Vaccines. 2018 Nov 27;3:54. doi: 10.1038/s41541-018-0091-3. eCollection 2018.


A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways.

Campino S, Marin-Menendez A, Kemp A, Cross N, Drought L, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A, Rayner JC.

PLoS Pathog. 2018 Nov 29;14(11):e1007436. doi: 10.1371/journal.ppat.1007436. eCollection 2018 Nov.


Aluminum Patterned Electroplating from AlCl₃⁻[EMIm]Cl Ionic Liquid towards Microsystems Application.

Al Farisi MS, Hertel S, Wiemer M, Otto T.

Micromachines (Basel). 2018 Nov 12;9(11). pii: E589. doi: 10.3390/mi9110589.


Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development.

Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray L, Stewart LB, D'Alessandro U, Otto TD, Kwiatkowski DP, Conway DJ.

Sci Rep. 2018 Oct 25;8(1):15763. doi: 10.1038/s41598-018-34078-3.


Aqueous-Phase Oxidation of Terpene-Derived Acids by Atmospherically Relevant Radicals.

Otto T, Schaefer T, Herrmann H.

J Phys Chem A. 2018 Nov 29;122(47):9233-9241. doi: 10.1021/acs.jpca.8b08922. Epub 2018 Nov 15.


Genome organization and DNA accessibility control antigenic variation in trypanosomes.

Müller LSM, Cosentino RO, Förstner KU, Guizetti J, Wedel C, Kaplan N, Janzen CJ, Arampatzi P, Vogel J, Steinbiss S, Otto TD, Saliba AE, Sebra RP, Siegel TN.

Nature. 2018 Nov;563(7729):121-125. doi: 10.1038/s41586-018-0619-8. Epub 2018 Oct 17.


Utilization patterns of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus in Germany: a retrospective cohort study.

Otto T, Myland M, Jung H, Lebrec J, Richter H, Norrbacka K.

Curr Med Res Opin. 2019 May;35(5):893-901. doi: 10.1080/03007995.2018.1538011. Epub 2018 Nov 14.


[Advance Care Planning in Swiss Nursing Homes: Results of a Focus Group Study].

Hecht K, Krones T, Otto T, Karzig-Roduner I, Loupatatzis B.

Praxis (Bern 1994). 2018;107(20):1085-1092. doi: 10.1024/1661-8157/a003101. German.


Good to be stressed? Improved response inhibition and error processing after acute stress in young and older men.

Dierolf AM, Schoofs D, Hessas EM, Falkenstein M, Otto T, Paul M, Suchan B, Wolf OT.

Neuropsychologia. 2018 Oct;119:434-447. doi: 10.1016/j.neuropsychologia.2018.08.020. Epub 2018 Aug 29.


Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution.

Gilabert A, Otto TD, Rutledge GG, Franzon B, Ollomo B, Arnathau C, Durand P, Moukodoum ND, Okouga AP, Ngoubangoye B, Makanga B, Boundenga L, Paupy C, Renaud F, Prugnolle F, Rougeron V.

PLoS Biol. 2018 Aug 24;16(8):e2006035. doi: 10.1371/journal.pbio.2006035. eCollection 2018 Aug.


Holocene evolution of Portus Pisanus, the lost harbour of Pisa.

Kaniewski D, Marriner N, Morhange C, Vacchi M, Sarti G, Rossi V, Bini M, Pasquinucci M, Allinne C, Otto T, Luce F, Van Campo E.

Sci Rep. 2018 Aug 23;8(1):11625. doi: 10.1038/s41598-018-29890-w.


Human amniotic membrane dressing for the treatment of an infected wound due to an entero-cutaneous fistula: Case report.

Barski D, Gerullis H, Ecke T, Varga G, Boros M, Pintelon I, Timmermans JP, Otto T.

Int J Surg Case Rep. 2018;51:11-13. doi: 10.1016/j.ijscr.2018.08.015. Epub 2018 Aug 13.


Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.

Wyllie S, Thomas M, Patterson S, Crouch S, De Rycker M, Lowe R, Gresham S, Urbaniak MD, Otto TD, Stojanovski L, Simeons FRC, Manthri S, MacLean LM, Zuccotto F, Homeyer N, Pflaumer H, Boesche M, Sastry L, Connolly P, Albrecht S, Berriman M, Drewes G, Gray DW, Ghidelli-Disse S, Dixon S, Fiandor JM, Wyatt PG, Ferguson MAJ, Fairlamb AH, Miles TJ, Read KD, Gilbert IH.

Nature. 2018 Aug;560(7717):192-197. doi: 10.1038/s41586-018-0356-z. Epub 2018 Jul 25.


Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.

Lee HJ, Georgiadou A, Walther M, Nwakanma D, Stewart LB, Levin M, Otto TD, Conway DJ, Coin LJ, Cunnington AJ.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaar3619. doi: 10.1126/scitranslmed.aar3619.


Feeling the force: Changes in a left-lateralized network of brain areas under simulated workday conditions are reflected in subjective mental effort investment.

Otto T, Zijlstra FRH, Goebel R.

PLoS One. 2018 Jun 18;13(6):e0198204. doi: 10.1371/journal.pone.0198204. eCollection 2018.


Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres.

Otto TD, Böhme U, Sanders M, Reid A, Bruske EI, Duffy CW, Bull PC, Pearson RD, Abdi A, Dimonte S, Stewart LB, Campino S, Kekre M, Hamilton WL, Claessens A, Volkman SK, Ndiaye D, Amambua-Ngwa A, Diakite M, Fairhurst RM, Conway DJ, Franck M, Newbold CI, Berriman M.

Wellcome Open Res. 2018 May 3;3:52. doi: 10.12688/wellcomeopenres.14571.1. eCollection 2018.


Epidemiology of Adult Soft-Tissue Sarcomas in Germany.

Saltus CW, Calingaert B, Candrilli S, Lorenzo M, D'yachkova Y, Otto T, Wagner U, Kaye JA.

Sarcoma. 2018 Apr 4;2018:5671926. doi: 10.1155/2018/5671926. eCollection 2018.


Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria.

Otto TD, Gilabert A, Crellen T, Böhme U, Arnathau C, Sanders M, Oyola SO, Okouga AP, Boundenga L, Willaume E, Ngoubangoye B, Moukodoum ND, Paupy C, Durand P, Rougeron V, Ollomo B, Renaud F, Newbold C, Berriman M, Prugnolle F.

Nat Microbiol. 2018 Jun;3(6):687-697. doi: 10.1038/s41564-018-0162-2. Epub 2018 May 21.


Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis.

Zhang M, Wang C, Otto TD, Oberstaller J, Liao X, Adapa SR, Udenze K, Bronner IF, Casandra D, Mayho M, Brown J, Li S, Swanson J, Rayner JC, Jiang RHY, Adams JH.

Science. 2018 May 4;360(6388). pii: eaap7847. doi: 10.1126/science.aap7847.


Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.

Lee HJ, Georgiadou A, Otto TD, Levin M, Coin LJ, Conway DJ, Cunnington AJ.

Microbiol Mol Biol Rev. 2018 Apr 25;82(2). pii: e00071-17. doi: 10.1128/MMBR.00071-17. Print 2018 Jun. Review.


Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals.

Böhme U, Otto TD, Cotton JA, Steinbiss S, Sanders M, Oyola SO, Nicot A, Gandon S, Patra KP, Herd C, Bushell E, Modrzynska KK, Billker O, Vinetz JM, Rivero A, Newbold CI, Berriman M.

Genome Res. 2018 Apr;28(4):547-560. doi: 10.1101/gr.218123.116. Epub 2018 Mar 2.

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