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Items: 1 to 50 of 668

1.

Communication and management of incidental pathology in 1,214 consecutive appendicectomies; a cohort study.

Kinnear N, Heijkoop B, Bramwell E, Frazzetto A, Noll A, Patel P, Hennessey D, Otto G, Dobbins C, Sammour T, Moore J.

Int J Surg. 2019 Nov 1. pii: S1743-9191(19)30292-4. doi: 10.1016/j.ijsu.2019.10.025. [Epub ahead of print]

PMID:
31683040
2.

StAMPing out antibiotic-resistant bacteria.

Otto G.

Nat Rev Drug Discov. 2019 Sep;18(10):746. doi: 10.1038/d41573-019-00152-2. No abstract available.

PMID:
31570846
3.

A novel approach to reverse proteinopathies.

Otto G.

Nat Rev Drug Discov. 2019 Sep;18(9):665. doi: 10.1038/d41573-019-00133-5. No abstract available.

PMID:
31477861
4.

Novel targets for itch treatment.

Otto G.

Nat Rev Drug Discov. 2019 Sep;18(9):666. doi: 10.1038/d41573-019-00126-4. No abstract available.

PMID:
31477857
5.

Neuropeptide regulation of motivation.

Otto G.

Nat Rev Neurosci. 2019 Oct;20(10):574-575. doi: 10.1038/s41583-019-0214-5. No abstract available.

PMID:
31391547
6.

Long-term observation of hepatocellular carcinoma recurrence after liver transplantation at a European transplantation centre.

Foerster F, Hoppe-Lotichius M, Vollmar J, Marquardt JU, Weinmann A, Wörns MA, Otto G, Zimmermann T, Galle PR.

United European Gastroenterol J. 2019 Jul;7(6):838-849. doi: 10.1177/2050640619840221. Epub 2019 Mar 25.

7.

Charting the Path Forward for Risk Prediction in Liver Transplant for Hepatocellular Carcinoma: International Validation of HALTHCC Among 4,089 Patients.

Firl DJ, Sasaki K, Agopian VG, Gorgen A, Kimura S, Dumronggittigule W, McVey JC, Iesari S, Mennini G, Vitale A, Finkenstedt A, Onali S, Hoppe-Lotichius M, Vennarecci G, Manzia TM, Nicolini D, Avolio AW, Agnes S, Vivarelli M, Tisone G, Ettorre GM, Otto G, Tsochatzis E, Rossi M, Viveiros A, Cillo U, Markmann JF, Ikegami T, Kaido T, Lai Q, Sapisochin G, Lerut J; European Hepatocellular Cancer Liver Transplant Study Group, Aucejo FN.

Hepatology. 2019 Jun 27. doi: 10.1002/hep.30838. [Epub ahead of print]

PMID:
31243778
8.

Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance.

Otto GW, Kaisaki PJ, Brial F, Le Lay A, Cazier JB, Mott R, Gauguier D.

Dis Model Mech. 2019 Jul 15;12(7). pii: dmm038539. doi: 10.1242/dmm.038539.

9.

Hepatocellular carcinoma recurrence after acute liver allograft rejection treatment: A multicenter European experience.

Lai Q, Iesari S, Finkenstedt A, Hoppe-Lotichius M, Foguenne M, Lehner K, Otto G, Lerut J.

Hepatobiliary Pancreat Dis Int. 2019 May 20. pii: S1499-3872(19)30092-X. doi: 10.1016/j.hbpd.2019.05.006. [Epub ahead of print]

PMID:
31151807
10.

The Intention-to-Treat Effect of Bridging Treatments in the Setting of Milan Criteria-In Patients Waiting for Liver Transplantation.

Lai Q, Vitale A, Iesari S, Finkenstedt A, Mennini G, Onali S, Hoppe-Lotichius M, Manzia TM, Nicolini D, Avolio AW, Mrzljak A, Kocman B, Agnes S, Vivarelli M, Tisone G, Otto G, Tsochatzis E, Rossi M, Viveiros A, Ciccarelli O, Cillo U, Lerut J; European Hepatocellular Cancer Liver Transplant Study Group.

Liver Transpl. 2019 Jul;25(7):1023-1033. doi: 10.1002/lt.25492.

PMID:
31087772
11.

Acute surgical unit improves outcomes in appendicectomy.

Kinnear N, Bramwell E, Frazzetto A, Noll A, Patel P, Hennessey D, Otto G, Dobbins C, Sammour T, Moore J.

ANZ J Surg. 2019 Sep;89(9):1108-1113. doi: 10.1111/ans.15141. Epub 2019 Apr 15.

PMID:
30989789
12.

Selective intra-operative parathyroid hormone in re-do neck exploration in parathyroidectomy: A case report.

To H, Otto G.

Int J Surg Case Rep. 2019;57:1-4. doi: 10.1016/j.ijscr.2019.02.031. Epub 2019 Feb 28.

13.

Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment.

Brial F, Le Lay A, Hedjazi L, Tsang T, Fearnside JF, Otto GW, Alzaid F, Wilder SP, Venteclef N, Cazier JB, Nicholson JK, Day C, Burt AD, Gut IG, Lathrop M, Dumas ME, Gauguier D.

Sci Rep. 2019 Mar 6;9(1):3656. doi: 10.1038/s41598-019-40153-0.

14.

Safety analysis of proposed pegfilgrastim biosimilar in Phase I and Phase III studies.

Harbeck N, Wang J, Otto GP, Gattu S, Krendyukov A.

Future Oncol. 2019 Apr;15(12):1313-1322. doi: 10.2217/fon-2018-0878. Epub 2019 Mar 5.

15.

Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function.

Sharma D, Otto G, Warren EC, Beesley P, King JS, Williams RSB.

Autophagy. 2019 Aug;15(8):1407-1418. doi: 10.1080/15548627.2019.1586245. Epub 2019 Mar 21.

16.

May the force be with your lipids.

Otto G.

Nat Rev Mol Cell Biol. 2019 Apr;20(4):196-197. doi: 10.1038/s41580-019-0109-3. No abstract available.

PMID:
30760883
17.

Expression and prognostic significance of insulin‑like growth factor-2 receptor in human hepatocellular carcinoma and the influence of transarterial chemoembolization.

Lautem A, Simon F, Hoppe-Lotichius M, Mittler J, Vollmar J, Schad A, Düber C, Galle PR, Otto G, Zimmermann T, Lang H.

Oncol Rep. 2019 Apr;41(4):2299-2310. doi: 10.3892/or.2019.6995. Epub 2019 Feb 1.

PMID:
30720132
18.

Donor Shortage in Germany: Impact on Short- and Long-Term Results in Liver Transplantation.

Otto G.

Visc Med. 2018 Dec;34(6):449-452. doi: 10.1159/000493891. Epub 2018 Nov 27. Review.

PMID:
30675492
19.

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.

Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA.

Cancer Res. 2019 Mar 1;79(5):905-917. doi: 10.1158/0008-5472.CAN-18-1261. Epub 2019 Jan 23.

PMID:
30674530
20.

Enhancers and promoters regulate burst kinetics.

Otto G.

Nat Rev Mol Cell Biol. 2019 Mar;20(3):134-135. doi: 10.1038/s41580-019-0100-z. No abstract available.

PMID:
30647472
21.

Lipid give and take.

Otto G.

Nat Rev Mol Cell Biol. 2019 Mar;20(3):134-135. doi: 10.1038/s41580-018-0098-7. No abstract available.

PMID:
30610206
22.

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.

Chagraoui H, Kristiansen MS, Ruiz JP, Serra-Barros A, Richter J, Hall-Ponselé E, Gray N, Waithe D, Clark K, Hublitz P, Repapi E, Otto G, Sopp P, Taylor S, Thongjuea S, Vyas P, Porcher C.

Nat Commun. 2018 Dec 18;9(1):5375. doi: 10.1038/s41467-018-07787-6.

23.

6mA in stress tolerance across generations.

Otto G.

Nat Rev Mol Cell Biol. 2019 Feb;20(2):66-67. doi: 10.1038/s41580-018-0091-1. No abstract available.

PMID:
30523331
24.

Effects of CT FOV displacement and acquisition parameters variation on texture analysis features.

Biondi M, Vanzi E, De Otto G, Carbone SF, Nardone V, Banci Buonamici F.

Phys Med Biol. 2018 Dec 4;63(23):235021. doi: 10.1088/1361-6560/aaefac.

PMID:
30511662
25.

Protein trafficking through TIGER domains.

Otto G.

Nat Rev Mol Cell Biol. 2019 Jan;20(1):3. doi: 10.1038/s41580-018-0088-9. No abstract available.

PMID:
30479375
26.

Inhibition by nuclear cGAS.

Otto G.

Nat Rev Mol Cell Biol. 2018 Dec;19(12):752-753. doi: 10.1038/s41580-018-0082-2. No abstract available.

PMID:
30382173
27.

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.

Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.

Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.

PMID:
30355676
28.

Impact of an acute surgical unit on outcomes in acute cholecystitis.

Bazzi ZT, Kinnear N, Bazzi CS, Hennessey D, Henneberg M, Otto G.

ANZ J Surg. 2018 Dec;88(12):E835-E839. doi: 10.1111/ans.14802. Epub 2018 Sep 11.

PMID:
30207047
29.

Regenerative medicine: Stem cell-derived cardiomyocytes heal a broken heart.

Otto G.

Nat Rev Drug Discov. 2018 Sep;17(9):622. doi: 10.1038/nrd.2018.139. Epub 2018 Aug 17. No abstract available.

PMID:
30116050
30.

Mregs kick-start transplant tolerance.

Otto G.

Nat Rev Nephrol. 2018 Oct;14(10):599. doi: 10.1038/s41581-018-0049-8. No abstract available.

PMID:
30093695
31.

Progression of transthyretin (TTR) amyloidosis in donors and recipients after domino liver transplantation-a prospective single-center cohort study.

Vollmar J, Schmid JC, Hoppe-Lotichius M, Barreiros AP, Azizi M, Emrich T, Geber C, Schad A, Weyer V, Otto G, Heise M, Mittler J, Birklein F, Lang H, Galle PR, Zimmermann T.

Transpl Int. 2018 Nov;31(11):1207-1215. doi: 10.1111/tri.13326. Epub 2018 Aug 28.

32.

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab.

Gandara DR, Paul SM, Kowanetz M, Schleifman E, Zou W, Li Y, Rittmeyer A, Fehrenbacher L, Otto G, Malboeuf C, Lieber DS, Lipson D, Silterra J, Amler L, Riehl T, Cummings CA, Hegde PS, Sandler A, Ballinger M, Fabrizio D, Mok T, Shames DS.

Nat Med. 2018 Sep;24(9):1441-1448. doi: 10.1038/s41591-018-0134-3. Epub 2018 Aug 6.

PMID:
30082870
33.

Autoimmune disease: A human antibody selectively targets regulatory T cells.

Otto G.

Nat Rev Drug Discov. 2018 Aug;17(8):546. doi: 10.1038/nrd.2018.122. Epub 2018 Jul 20. No abstract available.

PMID:
30026526
34.

Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms.

Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA.

Dev Cell. 2018 Jul 16;46(2):219-235.e8. doi: 10.1016/j.devcel.2018.06.016.

35.

Hedgehog-TGFβ signalling controls nephrogenesis.

Otto G.

Nat Rev Nephrol. 2018 Oct;14(10):598. doi: 10.1038/s41581-018-0043-1. No abstract available.

PMID:
29995834
36.

CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α.

Piper CJM, Wilkinson MGL, Deakin CT, Otto GW, Dowle S, Duurland CL, Adams S, Marasco E, Rosser EC, Radziszewska A, Carsetti R, Ioannou Y, Beales PL, Kelberman D, Isenberg DA, Mauri C, Nistala K, Wedderburn LR.

Front Immunol. 2018 Jun 22;9:1372. doi: 10.3389/fimmu.2018.01372. eCollection 2018.

37.

Tumour decides immune cell ins and outs.

Otto G.

Nat Rev Immunol. 2018 Aug;18(8):481. doi: 10.1038/s41577-018-0038-y. No abstract available.

PMID:
29985485
38.

Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.

Clark TA, Chung JH, Kennedy M, Hughes JD, Chennagiri N, Lieber DS, Fendler B, Young L, Zhao M, Coyne M, Breese V, Young G, Donahue A, Pavlick D, Tsiros A, Brennan T, Zhong S, Mughal T, Bailey M, He J, Roels S, Frampton GM, Spoerke JM, Gendreau S, Lackner M, Schleifman E, Peters E, Ross JS, Ali SM, Miller VA, Gregg JP, Stephens PJ, Welsh A, Otto GA, Lipson D.

J Mol Diagn. 2018 Sep;20(5):686-702. doi: 10.1016/j.jmoldx.2018.05.004. Epub 2018 Jun 22.

39.

Distinct age-associated molecular profiles in acute myeloid leukemia defined by comprehensive clinical genomic profiling.

Tarlock K, Zhong S, He Y, Ries R, Severson E, Bailey M, Morley S, Balasubramanian S, Erlich R, Lipson D, Otto GA, Vergillo JA, Kolb EA, Ross JS, Mughal T, Stephens PJ, Miller V, Meshinchi S, He J.

Oncotarget. 2018 May 29;9(41):26417-26430. doi: 10.18632/oncotarget.25443. eCollection 2018 May 29.

40.

Recipient liver function before liver transplantation influences post-transplantation survival in patients with HCC.

Foerster F, Mittler J, Darstein F, Heise M, Marquardt JU, Wörns MA, Weinmann A, Sälter L, Hoppe-Lotichius M, Heinrich S, Kloeckner R, Pitton MB, Schattenberg JM, Sprinzl MF, Düber C, Otto G, Lang H, Galle PR, Zimmermann T.

Eur J Intern Med. 2018 Sep;55:57-65. doi: 10.1016/j.ejim.2018.05.024. Epub 2018 May 30.

PMID:
29859798
41.

RHO-like GTPases in nephrotic syndrome.

Otto G.

Nat Rev Nephrol. 2018 Sep;14(9):536. doi: 10.1038/s41581-018-0030-6. No abstract available.

PMID:
29855604
42.

T cell balancing act in TB.

Otto G.

Nat Rev Immunol. 2018 Jul;18(7):420-421. doi: 10.1038/s41577-018-0023-5. No abstract available.

PMID:
29799012
43.

IL-1β switches on kidney fibrosis.

Otto G.

Nat Rev Nephrol. 2018 Aug;14(8):475. doi: 10.1038/s41581-018-0026-2. No abstract available.

PMID:
29799011
44.

FGF21 ACEs hypertension.

Otto G.

Nat Rev Nephrol. 2018 Jul;14(7):413. doi: 10.1038/s41581-018-0020-8. No abstract available.

PMID:
29795243
45.

γδ T cells turn up the heat.

Otto G.

Nat Rev Immunol. 2018 Jun;18(6):359. doi: 10.1038/s41577-018-0017-3. No abstract available.

PMID:
29725118
46.

EpiTOFing ageing.

Otto G.

Nat Rev Mol Cell Biol. 2018 Jul;19(7):416-417. doi: 10.1038/s41580-018-0026-x. No abstract available.

PMID:
29717231
47.

Synaptic nibbling.

Otto G.

Nat Rev Neurosci. 2018 Jun;19(6):322. doi: 10.1038/s41583-018-0008-1. No abstract available.

PMID:
29717204
48.

Seq-ing answers: uncovering the unexpected in global gene regulation.

Otto GM, Brar GA.

Curr Genet. 2018 Dec;64(6):1183-1188. doi: 10.1007/s00294-018-0839-3. Epub 2018 Apr 19. Review.

49.

Immunometabolism: Itaconate helps KEAP1's cool.

Otto G.

Nat Rev Immunol. 2018 May;18(5):294-295. doi: 10.1038/nri.2018.27. Epub 2018 Apr 9. No abstract available.

PMID:
29629713
50.

Human evolution: Archaic admixture with Denisovans.

Otto G.

Nat Rev Genet. 2018 May;19(5):251. doi: 10.1038/nrg.2018.18. Epub 2018 Apr 4. No abstract available.

PMID:
29615820

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