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Items: 1 to 50 of 107

1.

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.

Saline M, Badertscher L, Wolter M, Lau R, Gunnarsson A, Jacso T, Norris T, Ottmann C, Snijder A.

J Biol Chem. 2019 Aug 30;294(35):13106-13116. doi: 10.1074/jbc.RA119.008649. Epub 2019 Jul 15.

PMID:
31308176
2.

Multivalent Ligands with Tailor-Made Anion Binding Motif as Stabilizers of Protein-Protein Interactions.

Bartsch L, Bartel M, Gigante A, Iglesias-Fernández J, Ruiz-Blanco YB, Beuck C, Briels J, Toetsch N, Bayer P, Sanchez-Garcia E, Ottmann C, Schmuck C.

Chembiochem. 2019 Jun 6. doi: 10.1002/cbic.201900288. [Epub ahead of print]

PMID:
31168888
3.

Cooperativity basis for small-molecule stabilization of protein-protein interactions.

de Vink PJ, Andrei SA, Higuchi Y, Ottmann C, Milroy LG, Brunsveld L.

Chem Sci. 2019 Jan 25;10(10):2869-2874. doi: 10.1039/c8sc05242e. eCollection 2019 Mar 14.

4.

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins.

Maity D, Gigante A, Sánchez-Murcia PA, Sijbesma E, Li M, Bier D, Mosel S, Knauer S, Ottmann C, Schmuck C.

Org Biomol Chem. 2019 Apr 24;17(17):4359-4363. doi: 10.1039/c9ob00620f.

PMID:
30977756
5.

Modulating protein-protein interaction networks in protein homeostasis.

Zhong M, Lee GM, Sijbesma E, Ottmann C, Arkin MR.

Curr Opin Chem Biol. 2019 Jun;50:55-65. doi: 10.1016/j.cbpa.2019.02.012. Epub 2019 Mar 23. Review.

PMID:
30913483
6.

Clinical candidates modulating protein-protein interactions: The fragment-based experience.

Valenti D, Hristeva S, Tzalis D, Ottmann C.

Eur J Med Chem. 2019 Apr 1;167:76-95. doi: 10.1016/j.ejmech.2019.01.084. Epub 2019 Feb 5. Review.

PMID:
30769242
7.

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.

Sijbesma E, Hallenbeck KK, Leysen S, de Vink PJ, Skóra L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C.

J Am Chem Soc. 2019 Feb 27;141(8):3524-3531. doi: 10.1021/jacs.8b11658. Epub 2019 Feb 19.

PMID:
30707565
8.

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude.

Gigante A, Grad JN, Briels J, Bartel M, Hoffmann D, Ottmann C, Schmuck C.

Chem Commun (Camb). 2018 Dec 18;55(1):111-114. doi: 10.1039/c8cc07946c.

PMID:
30515494
9.

A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.

Stevers LM, de Vink PJ, Ottmann C, Huskens J, Brunsveld L.

J Am Chem Soc. 2018 Oct 31;140(43):14498-14510. doi: 10.1021/jacs.8b09618. Epub 2018 Oct 18.

10.

Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex.

Ballone A, Centorrino F, Wolter M, Ottmann C.

Data Brief. 2018 Jun 28;19:1683-1687. doi: 10.1016/j.dib.2018.06.060. eCollection 2018 Aug.

11.

Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks.

Aper SJA, den Hamer A, Wouters SFA, Lemmens LJM, Ottmann C, Brunsveld L, Merkx M.

ACS Synth Biol. 2018 Sep 21;7(9):2216-2225. doi: 10.1021/acssynbio.8b00217. Epub 2018 Aug 31.

12.

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions.

Andrei SA, de Vink P, Sijbesma E, Han L, Brunsveld L, Kato N, Ottmann C, Higuchi Y.

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13470-13474. doi: 10.1002/anie.201806584. Epub 2018 Sep 17.

PMID:
30025189
13.

Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins.

Yilmaz E, Bier D, Guillory X, Briels J, Ruiz-Blanco YB, Sanchez-Garcia E, Ottmann C, Kaiser M.

Chemistry. 2018 Sep 18;24(52):13807-13814. doi: 10.1002/chem.201801074. Epub 2018 Aug 22.

PMID:
29924885
14.

14-3-3: A Case Study in PPI Modulation.

Ballone A, Centorrino F, Ottmann C.

Molecules. 2018 Jun 8;23(6). pii: E1386. doi: 10.3390/molecules23061386. Review.

15.

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.

Andrei SA, Meijer FA, Neves JF, Brunsveld L, Landrieu I, Ottmann C, Milroy LG.

ACS Chem Neurosci. 2018 Nov 21;9(11):2639-2654. doi: 10.1021/acschemneuro.8b00118. Epub 2018 May 17.

16.

Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J.

J Am Soc Nephrol. 2018 May;29(5):1525-1535. doi: 10.1681/ASN.2017080856. Epub 2018 Feb 23.

17.

Biophysical and structural insight into the USP8/14-3-3 interaction.

Centorrino F, Ballone A, Wolter M, Ottmann C.

FEBS Lett. 2018 Apr;592(7):1211-1220. doi: 10.1002/1873-3468.13017. Epub 2018 Mar 2.

18.

Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1).

Ballone A, Centorrino F, Wolter M, Ottmann C.

J Struct Biol. 2018 Jun;202(3):210-215. doi: 10.1016/j.jsb.2018.01.011. Epub 2018 Feb 1.

PMID:
29408703
19.

Rational Design, Binding Studies, and Crystal-Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14-3-3ζ Adapter Protein.

Ehlers M, Grad JN, Mittal S, Bier D, Mertel M, Ohl L, Bartel M, Briels J, Heimann M, Ottmann C, Sanchez-Garcia E, Hoffmann D, Schmuck C.

Chembiochem. 2018 Mar 16;19(6):591-595. doi: 10.1002/cbic.201700588. Epub 2018 Feb 15.

PMID:
29282826
20.

Locating Large, Flexible Ligands on Proteins.

Grad JN, Gigante A, Wilms C, Dybowski JN, Ohl L, Ottmann C, Schmuck C, Hoffmann D.

J Chem Inf Model. 2018 Feb 26;58(2):315-327. doi: 10.1021/acs.jcim.7b00413. Epub 2018 Jan 11.

PMID:
29266929
21.

Protein-Protein Interactions.

Ottmann C.

Drug Discov Today Technol. 2017 Jun;24:1-2. doi: 10.1016/j.ddtec.2017.11.008. No abstract available.

PMID:
29233293
22.

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.

Bier D, Mittal S, Bravo-Rodriguez K, Sowislok A, Guillory X, Briels J, Heid C, Bartel M, Wettig B, Brunsveld L, Sanchez-Garcia E, Schrader T, Ottmann C.

J Am Chem Soc. 2017 Nov 15;139(45):16256-16263. doi: 10.1021/jacs.7b07939. Epub 2017 Nov 2.

23.

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.

Krüger DM, Glas A, Bier D, Pospiech N, Wallraven K, Dietrich L, Ottmann C, Koch O, Hennig S, Grossmann TN.

J Med Chem. 2017 Nov 9;60(21):8982-8988. doi: 10.1021/acs.jmedchem.7b01221. Epub 2017 Oct 27.

24.

Modulators of 14-3-3 Protein-Protein Interactions.

Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C.

J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19. Review.

25.

A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments.

Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR.

SLAS Discov. 2018 Feb;23(2):183-192. doi: 10.1177/2472555217732072. Epub 2017 Sep 25.

26.

Supramolecular Chemistry Targeting Proteins.

van Dun S, Ottmann C, Milroy LG, Brunsveld L.

J Am Chem Soc. 2017 Oct 11;139(40):13960-13968. doi: 10.1021/jacs.7b01979. Epub 2017 Sep 28.

27.

14-3-3 adaptor protein-protein interactions as therapeutic targets for CNS diseases.

Kaplan A, Ottmann C, Fournier AE.

Pharmacol Res. 2017 Nov;125(Pt B):114-121. doi: 10.1016/j.phrs.2017.09.007. Epub 2017 Sep 14. Review.

PMID:
28918174
28.

Stabilization of protein-protein interactions in drug discovery.

Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C.

Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Review.

PMID:
28695752
29.

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.

Scheepstra M, Andrei SA, de Vries RMJM, Meijer FA, Ma JN, Burstein ES, Olsson R, Ottmann C, Milroy LG, Brunsveld L.

ACS Chem Neurosci. 2017 Sep 20;8(9):2065-2077. doi: 10.1021/acschemneuro.7b00216. Epub 2017 Jul 24.

30.

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.

Sijbesma E, Skora L, Leysen S, Brunsveld L, Koch U, Nussbaumer P, Jahnke W, Ottmann C.

Biochemistry. 2017 Aug 1;56(30):3972-3982. doi: 10.1021/acs.biochem.7b00153. Epub 2017 Jul 21.

31.

Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.

Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C.

FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017 Aug 6.

32.

Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum.

Plowright AT, Ottmann C, Arkin M, Auberson YP, Timmerman H, Waldmann H.

Cell Chem Biol. 2017 Sep 21;24(9):1058-1065. doi: 10.1016/j.chembiol.2017.05.019. Epub 2017 Jun 8. Review.

33.

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

de Vink PJ, Briels JM, Schrader T, Milroy LG, Brunsveld L, Ottmann C.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):8998-9002. doi: 10.1002/anie.201701807. Epub 2017 Jun 29.

34.

Designed Spiroketal Protein Modulation.

Scheepstra M, Andrei SA, Unver MY, Hirsch AKH, Leysen S, Ottmann C, Brunsveld L, Milroy LG.

Angew Chem Int Ed Engl. 2017 May 8;56(20):5480-5484. doi: 10.1002/anie.201612504. Epub 2017 Apr 13.

35.

Structural interface between LRRK2 and 14-3-3 protein.

Stevers LM, de Vries RM, Doveston RG, Milroy LG, Brunsveld L, Ottmann C.

Biochem J. 2017 Mar 23;474(7):1273-1287. doi: 10.1042/BCJ20161078.

PMID:
28202711
36.

Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold.

den Hamer A, Lemmens LJ, Nijenhuis MA, Ottmann C, Merkx M, de Greef TF, Brunsveld L.

Chembiochem. 2017 Feb 1;18(3):331-335. doi: 10.1002/cbic.201600631. Epub 2016 Dec 27.

37.

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis.

Cromm PM, Wallraven K, Glas A, Bier D, Fürstner A, Ottmann C, Grossmann TN.

Chembiochem. 2016 Oct 17;17(20):1915-1919. doi: 10.1002/cbic.201600362. Epub 2016 Sep 6.

38.

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Stevers LM, Lam CV, Leysen SF, Meijer FA, van Scheppingen DS, de Vries RM, Carlile GW, Milroy LG, Thomas DY, Brunsveld L, Ottmann C.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61. doi: 10.1073/pnas.1516631113. Epub 2016 Feb 17.

39.

Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.

Sundén H, Schäfer A, Scheepstra M, Leysen S, Malo M, Ma JN, Burstein ES, Ottmann C, Brunsveld L, Olsson R.

J Med Chem. 2016 Feb 11;59(3):1232-8. doi: 10.1021/acs.jmedchem.5b01702. Epub 2016 Jan 28.

PMID:
26820900
40.

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.

Bier D, Bartel M, Sies K, Halbach S, Higuchi Y, Haranosono Y, Brummer T, Kato N, Ottmann C.

ChemMedChem. 2016 Apr 19;11(8):911-8. doi: 10.1002/cmdc.201500484. Epub 2015 Dec 8.

PMID:
26644359
41.

Identification of an allosteric binding site for RORγt inhibition.

Scheepstra M, Leysen S, van Almen GC, Miller JR, Piesvaux J, Kutilek V, van Eenennaam H, Zhang H, Barr K, Nagpal S, Soisson SM, Kornienko M, Wiley K, Elsen N, Sharma S, Correll CC, Trotter BW, van der Stelt M, Oubrie A, Ottmann C, Parthasarathy G, Brunsveld L.

Nat Commun. 2015 Dec 7;6:8833. doi: 10.1038/ncomms9833.

42.

Stabilizer-Guided Inhibition of Protein-Protein Interactions.

Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15720-4. doi: 10.1002/anie.201507976. Epub 2015 Nov 5.

PMID:
26537010
43.

Protein-protein interactions as drug targets.

Skwarczynska M, Ottmann C.

Future Med Chem. 2015;7(16):2195-219. doi: 10.4155/fmc.15.138. Epub 2015 Oct 29. Review.

PMID:
26510391
44.

New Compound Classes: Protein-Protein Interactions.

Ottmann C.

Handb Exp Pharmacol. 2016;232:125-38. Review.

PMID:
26489828
45.

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode.

Nieto L, Tharun IM, Balk M, Wienk H, Boelens R, Ottmann C, Milroy LG, Brunsveld L.

ACS Chem Biol. 2015 Nov 20;10(11):2624-32. doi: 10.1021/acschembio.5b00568. Epub 2015 Sep 18.

PMID:
26352092
46.

Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.

Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, Choi HS, Jeon NL, Chang KA, Kim HS, Ottmann C, Suh YH.

FASEB J. 2015 Oct;29(10):4133-44. doi: 10.1096/fj.14-265009. Epub 2015 Jun 23.

PMID:
26103986
47.

Stabilization of Protein-Protein Interactions in chemical biology and drug discovery.

Bier D, Thiel P, Briels J, Ottmann C.

Prog Biophys Mol Biol. 2015 Oct;119(1):10-9. doi: 10.1016/j.pbiomolbio.2015.05.002. Epub 2015 Jun 18. Review.

PMID:
26093250
48.

Stabilization of protein-protein interactions by small molecules.

Giordanetto F, Schäfer A, Ottmann C.

Drug Discov Today. 2014 Nov;19(11):1812-1821. doi: 10.1016/j.drudis.2014.08.005. Epub 2014 Aug 28. Review.

PMID:
25173701
49.

The renaissance of Ras.

Milroy LG, Ottmann C.

ACS Chem Biol. 2014 Nov 21;9(11):2447-58. doi: 10.1021/cb500555h. Epub 2014 Sep 23. Review.

PMID:
25148694
50.

Blocked inverted indices for exact clustering of large chemical spaces.

Thiel P, Sach-Peltason L, Ottmann C, Kohlbacher O.

J Chem Inf Model. 2014 Sep 22;54(9):2395-401. doi: 10.1021/ci500150t. Epub 2014 Sep 2.

PMID:
25136755

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