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Items: 25

1.

Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.

Fagundez C, Sellanes D, Peña S, Scarone L, Aguiar ACC, de Souza JO, Guido RVC, Stewart L, Yardley V, Ottilie S, Winzeler EA, Gamo FJ, Sanz LM, Serra GL.

ACS Med Chem Lett. 2018 Dec 26;10(1):137-141. doi: 10.1021/acsmedchemlett.8b00543. eCollection 2019 Jan 10.

PMID:
30655961
2.

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA.

Science. 2018 Dec 7;362(6419). pii: eaat9446. doi: 10.1126/science.aat9446.

PMID:
30523084
3.

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.

Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould AE, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, Hutton CA, Burrows JN, Winzeler EA, Avery VM, Dick LR, Tilley L.

J Med Chem. 2018 Nov 21;61(22):10053-10066. doi: 10.1021/acs.jmedchem.8b01161. Epub 2018 Nov 7.

4.

Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies.

Ottilie S, Goldgof GM, Cheung AL, Walker JL, Vigil E, Allen KE, Antonova-Koch Y, Slayman CW, Suzuki Y, Durrant JD.

J Cheminform. 2018 Feb 20;10(1):6. doi: 10.1186/s13321-018-0261-3.

5.

Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.

Luth MR, Gupta P, Ottilie S, Winzeler EA.

ACS Infect Dis. 2018 Mar 9;4(3):301-314. doi: 10.1021/acsinfecdis.7b00276. Epub 2018 Feb 21.

6.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.

Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Science. 2018 Jan 12;359(6372):191-199. doi: 10.1126/science.aan4472.

7.

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.

LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S.

J Med Chem. 2017 Aug 10;60(15):6721-6732. doi: 10.1021/acs.jmedchem.7b00671. Epub 2017 Jul 25.

8.

Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.

Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA.

ACS Chem Biol. 2017 Feb 17;12(2):422-434. doi: 10.1021/acschembio.6b01037. Epub 2016 Dec 23.

9.

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.

Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Stanhope R, Prescott M, McNamara CW, Slayman CW, Amaro RE, Suzuki Y, Winzeler EA.

Sci Rep. 2016 Jun 13;6:27806. doi: 10.1038/srep27806.

10.

Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A.

Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore BS, Gerwick WH.

FEBS J. 2012 Apr;279(7):1243-51. doi: 10.1111/j.1742-4658.2012.08517.x. Epub 2012 Mar 1.

11.

Mutational analysis of the interacting cell death regulators CED-9 and CED-4.

Ottilie S, Wang Y, Banks S, Chang J, Vigna NJ, Weeks S, Armstrong RC, Fritz LC, Oltersdorf T.

Cell Death Differ. 1997 Oct;4(7):526-33.

12.

Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.

Sells MA, Barratt JT, Caviston J, Ottilie S, Leberer E, Chernoff J.

J Biol Chem. 1998 Jul 17;273(29):18490-8.

13.

Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.

Forsburg SL, Sherman DA, Ottilie S, Yasuda JR, Hodson JA.

Genetics. 1997 Nov;147(3):1025-41.

14.

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T.

J Biol Chem. 1997 Dec 5;272(49):30866-72.

15.

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.

Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES.

J Biol Chem. 1997 Jul 25;272(30):18542-5.

16.

Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation.

Ottilie S, Diaz JL, Chang J, Wilson G, Tuffo KM, Weeks S, McConnell M, Wang Y, Oltersdorf T, Fritz LC.

J Biol Chem. 1997 Jul 4;272(27):16955-61.

17.

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.

Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI.

Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1172-6.

18.

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

Jürgensmeier JM, Krajewski S, Armstrong RC, Wilson GM, Oltersdorf T, Fritz LC, Reed JC, Ottilie S.

Mol Biol Cell. 1997 Feb;8(2):325-39.

19.

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.

Ottilie S, Miller PJ, Johnson DI, Creasy CL, Sells MA, Bagrodia S, Forsburg SL, Chernoff J.

EMBO J. 1995 Dec 1;14(23):5908-19.

20.

Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants.

Hannig G, Ottilie S, Erikson RL.

Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10084-8.

21.
22.

The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL.

Mol Cell Biol. 1992 Dec;12(12):5571-80.

23.

Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris.

Ottilie S, Raulf F, Barnekow A, Hannig G, Schartl M.

Oncogene. 1992 Aug;7(8):1625-30.

PMID:
1378585
24.

A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases.

Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL.

Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3455-9.

25.

Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates.

Hannig G, Ottilie S, Schartl M.

Oncogene. 1991 Mar;6(3):361-9.

PMID:
1707152

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