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The Elimination of Neglected Tropical Diseases (NTDs): A Case Study Exemplifying How Foreign Assistance Funding Can Be Catalytic in Reducing the Burden of Major Global Health Conditions.

Wainwright E, Evans D, Rotondo L, Pou B, Yevstigneyeva V, Zoerhoff KL, Ottesen EA, Reithinger R.

Clin Infect Dis. 2019 Aug 12. pii: ciz742. doi: 10.1093/cid/ciz742. [Epub ahead of print]


The health and economic burden of lymphatic filariasis prior to mass drug administration programmes.

Mathew CG, Bettis AA, Chu BK, English M, Ottesen EA, Bradley MH, Turner HC.

Clin Infect Dis. 2019 Jul 25. pii: ciz671. doi: 10.1093/cid/ciz671. [Epub ahead of print]


Rapid and Stable Microbial Community Assembly in the Headwaters of a Third-Order Stream.

Teachey ME, McDonald JM, Ottesen EA.

Appl Environ Microbiol. 2019 May 16;85(11). pii: e00188-19. doi: 10.1128/AEM.00188-19. Print 2019 Jun 1.


The hindgut microbiota of praying mantids is highly variable and includes both prey-associated and host-specific microbes.

Tinker KA, Ottesen EA.

PLoS One. 2018 Dec 11;13(12):e0208917. doi: 10.1371/journal.pone.0208917. eCollection 2018.


Temporal and spatial dynamics in microbial community composition within a temperate stream network.

Hassell N, Tinker KA, Moore T, Ottesen EA.

Environ Microbiol. 2018 Oct;20(10):3560-3572. doi: 10.1111/1462-2920.14311. Epub 2018 Sep 13.


Onchocerciasis: shifting the target from control to elimination requires a new first-step-elimination mapping.

Rebollo MP, Zoure H, Ogoussan K, Sodahlon Y, Ottesen EA, Cantey PT.

Int Health. 2018 Mar 1;10(suppl_1):i14-i19. doi: 10.1093/inthealth/ihx052.


Transitioning from river blindness control to elimination: steps toward stopping treatment.

Cantey PT, Roy SL, Boakye D, Mwingira U, Ottesen EA, Hopkins AD, Sodahlon YK.

Int Health. 2018 Mar 1;10(suppl_1):i7-i13. doi: 10.1093/inthealth/ihx049.


Initiating NTD programs targeting schistosomiasis and soil-transmitted helminthiasis in two provinces of the Democratic Republic of the Congo: Establishment of baseline prevalence for mass drug administration.

Kabore A, Ibikounle M, Tougoue JJ, Mupoyi S, Ndombe M, Shannon S, Ottesen EA, Mukunda F, Awaca N.

Acta Trop. 2017 Feb;166:177-185. doi: 10.1016/j.actatropica.2016.11.023. Epub 2016 Nov 22.


The Core Gut Microbiome of the American Cockroach, Periplaneta americana, Is Stable and Resilient to Dietary Shifts.

Tinker KA, Ottesen EA.

Appl Environ Microbiol. 2016 Oct 27;82(22):6603-6610. Print 2016 Nov 15.


The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000-2014).

Turner HC, Bettis AA, Chu BK, McFarland DA, Hooper PJ, Ottesen EA, Bradley MH.

Infect Dis Poverty. 2016 May 24;5(1):54. doi: 10.1186/s40249-016-0147-4.


Probing the living ocean with ecogenomic sensors.

Ottesen EA.

Curr Opin Microbiol. 2016 Jun;31:132-139. doi: 10.1016/j.mib.2016.03.012. Epub 2016 Apr 6. Review.


Global programme to eliminate lymphatic filariasis: the processes underlying programme success.

Ichimori K, King JD, Engels D, Yajima A, Mikhailov A, Lammie P, Ottesen EA.

PLoS Negl Trop Dis. 2014 Dec 11;8(12):e3328. doi: 10.1371/journal.pntd.0003328. eCollection 2014 Dec. No abstract available.


Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease.

Ramaiah KD, Ottesen EA.

PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3319. doi: 10.1371/journal.pntd.0003319. eCollection 2014 Nov.


Assessing progress in reducing the at-risk population after 13 years of the global programme to eliminate lymphatic filariasis.

Hooper PJ, Chu BK, Mikhailov A, Ottesen EA, Bradley M.

PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3333. doi: 10.1371/journal.pntd.0003333. eCollection 2014 Nov.


Ocean microbes. Multispecies diel transcriptional oscillations in open ocean heterotrophic bacterial assemblages.

Ottesen EA, Young CR, Gifford SM, Eppley JM, Marin R 3rd, Schuster SC, Scholin CA, DeLong EF.

Science. 2014 Jul 11;345(6193):207-12. doi: 10.1126/science.1252476.


Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.

Chu BK, Deming M, Biritwum NK, Bougma WR, Dorkenoo AM, El-Setouhy M, Fischer PU, Gass K, Gonzalez de Peña M, Mercado-Hernandez L, Kyelem D, Lammie PJ, Flueckiger RM, Mwingira UJ, Noordin R, Offei Owusu I, Ottesen EA, Pavluck A, Pilotte N, Rao RU, Samarasekera D, Schmaedick MA, Settinayake S, Simonsen PE, Supali T, Taleo F, Torres M, Weil GJ, Won KY.

PLoS Negl Trop Dis. 2013 Dec 5;7(12):e2584. doi: 10.1371/journal.pntd.0002584. eCollection 2013.


Distinct dissolved organic matter sources induce rapid transcriptional responses in coexisting populations of Prochlorococcus, Pelagibacter and the OM60 clade.

Sharma AK, Becker JW, Ottesen EA, Bryant JA, Duhamel S, Karl DM, Cordero OX, Repeta DJ, DeLong EF.

Environ Microbiol. 2014 Sep;16(9):2815-30. doi: 10.1111/1462-2920.12254. Epub 2013 Sep 30.


Localizing transcripts to single cells suggests an important role of uncultured deltaproteobacteria in the termite gut hydrogen economy.

Rosenthal AZ, Zhang X, Lucey KS, Ottesen EA, Trivedi V, Choi HM, Pierce NA, Leadbetter JR.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16163-8. doi: 10.1073/pnas.1307876110. Epub 2013 Sep 16.


Predictive vs. empiric assessment of schistosomiasis: implications for treatment projections in Ghana.

Kabore A, Biritwum NK, Downs PW, Soares Magalhaes RJ, Zhang Y, Ottesen EA.

PLoS Negl Trop Dis. 2013;7(3):e2051. doi: 10.1371/journal.pntd.0002051. Epub 2013 Mar 7.


Pattern and synchrony of gene expression among sympatric marine microbial populations.

Ottesen EA, Young CR, Eppley JM, Ryan JP, Chavez FP, Scholin CA, DeLong EF.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E488-97. doi: 10.1073/pnas.1222099110. Epub 2013 Jan 23.


Antibody to the filarial antigen Wb123 reflects reduced transmission and decreased exposure in children born following single mass drug administration (MDA).

Steel C, Kubofcik J, Ottesen EA, Nutman TB.

PLoS Negl Trop Dis. 2012;6(12):e1940. doi: 10.1371/journal.pntd.0001940. Epub 2012 Dec 6.


Integrated implementation of programs targeting neglected tropical diseases through preventive chemotherapy: identifying best practices to roll out programs at national scale.

Hanson C, Weaver A, Zoerhoff KL, Kabore A, Linehan M, Doherty A, Engels D, Savioli L, Ottesen EA.

Am J Trop Med Hyg. 2012 Mar;86(3):508-513. doi: 10.4269/ajtmh.2012.11-1589.


A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.

Gass K, Beau de Rochars MV, Boakye D, Bradley M, Fischer PU, Gyapong J, Itoh M, Ituaso-Conway N, Joseph H, Kyelem D, Laney SJ, Legrand AM, Liyanage TS, Melrose W, Mohammed K, Pilotte N, Ottesen EA, Plichart C, Ramaiah K, Rao RU, Talbot J, Weil GJ, Williams SA, Won KY, Lammie P.

PLoS Negl Trop Dis. 2012 Jan;6(1):e1479. doi: 10.1371/journal.pntd.0001479. Epub 2012 Jan 17.


Probing individual environmental bacteria for viruses by using microfluidic digital PCR.

Tadmor AD, Ottesen EA, Leadbetter JR, Phillips R.

Science. 2011 Jul 1;333(6038):58-62. doi: 10.1126/science.1200758.


Metatranscriptomic analysis of autonomously collected and preserved marine bacterioplankton.

Ottesen EA, Marin R 3rd, Preston CM, Young CR, Ryan JP, Scholin CA, DeLong EF.

ISME J. 2011 Dec;5(12):1881-95. doi: 10.1038/ismej.2011.70. Epub 2011 Jun 30.


Formyltetrahydrofolate synthetase gene diversity in the guts of higher termites with different diets and lifestyles.

Ottesen EA, Leadbetter JR.

Appl Environ Microbiol. 2011 May;77(10):3461-7. doi: 10.1128/AEM.02657-10. Epub 2011 Mar 25.


Integrated implementation of programs targeting neglected tropical diseases through preventive chemotherapy: proving the feasibility at national scale.

Linehan M, Hanson C, Weaver A, Baker M, Kabore A, Zoerhoff KL, Sankara D, Torres S, Ottesen EA.

Am J Trop Med Hyg. 2011 Jan;84(1):5-14. doi: 10.4269/ajtmh.2011.10-0411.


The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000-2007).

Chu BK, Hooper PJ, Bradley MH, McFarland DA, Ottesen EA.

PLoS Negl Trop Dis. 2010 Jun 1;4(6):e708. doi: 10.1371/journal.pntd.0000708.


Diversity of formyltetrahydrofolate synthetases in the guts of the wood-feeding cockroach Cryptocercus punctulatus and the omnivorous cockroach Periplaneta americana.

Ottesen EA, Leadbetter JR.

Appl Environ Microbiol. 2010 Jul;76(14):4909-13. doi: 10.1128/AEM.00299-10. Epub 2010 May 21.


Development and quantitative analyses of a universal rRNA-subtraction protocol for microbial metatranscriptomics.

Stewart FJ, Ottesen EA, DeLong EF.

ISME J. 2010 Jul;4(7):896-907. doi: 10.1038/ismej.2010.18. Epub 2010 Mar 11.


The Global Programme to Eliminate Lymphatic Filariasis: health impact during its first 8 years (2000-2007).

Hooper PJ, Bradley MH, Biswas G, Ottesen EA.

Ann Trop Med Parasitol. 2009 Oct;103 Suppl 1:S17-21. doi: 10.1179/000349809X12502035776513.


Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population.

Cuenco KT, Ottesen EA, Williams SA, Nutman TB, Steel C.

J Infect Dis. 2009 Oct 15;200(8):1271-8. doi: 10.1086/605844.


The global programme to eliminate lymphatic filariasis: health impact after 8 years.

Ottesen EA, Hooper PJ, Bradley M, Biswas G.

PLoS Negl Trop Dis. 2008 Oct 8;2(10):e317. doi: 10.1371/journal.pntd.0000317.


Determinants of success in national programs to eliminate lymphatic filariasis: a perspective identifying essential elements and research needs.

Kyelem D, Biswas G, Bockarie MJ, Bradley MH, El-Setouhy M, Fischer PU, Henderson RH, Kazura JW, Lammie PJ, Njenga SM, Ottesen EA, Ramaiah KD, Richards FO, Weil GJ, Williams SA.

Am J Trop Med Hyg. 2008 Oct;79(4):480-4.


Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite.

Warnecke F, Luginbühl P, Ivanova N, Ghassemian M, Richardson TH, Stege JT, Cayouette M, McHardy AC, Djordjevic G, Aboushadi N, Sorek R, Tringe SG, Podar M, Martin HG, Kunin V, Dalevi D, Madejska J, Kirton E, Platt D, Szeto E, Salamov A, Barry K, Mikhailova N, Kyrpides NC, Matson EG, Ottesen EA, Zhang X, Hernández M, Murillo C, Acosta LG, Rigoutsos I, Tamayo G, Green BD, Chang C, Rubin EM, Mathur EJ, Robertson DE, Hugenholtz P, Leadbetter JR.

Nature. 2007 Nov 22;450(7169):560-5.


National mass drug administration costs for lymphatic filariasis elimination.

Goldman AS, Guisinger VH, Aikins M, Amarillo ML, Belizario VY, Garshong B, Gyapong J, Kabali C, Kamal HA, Kanjilal S, Kyelem D, Lizardo J, Malecela M, Mubyazi G, Nitièma PA, Ramzy RM, Streit TG, Wallace A, Brady MA, Rheingans R, Ottesen EA, Haddix AC.

PLoS Negl Trop Dis. 2007 Oct 31;1(1):e67.


Microfluidic digital PCR enables multigene analysis of individual environmental bacteria.

Ottesen EA, Hong JW, Quake SR, Leadbetter JR.

Science. 2006 Dec 1;314(5804):1464-7.


Lymphatic filariasis: Treatment, control and elimination.

Ottesen EA.

Adv Parasitol. 2006;61:395-441. Review.


Projected benefits from integrating NTD programs in sub-Saharan Africa.

Brady MA, Hooper PJ, Ottesen EA.

Trends Parasitol. 2006 Jul;22(7):285-91. Epub 2006 May 26. Review.


Treatment strategies underpinning the global programme to eliminate lymphatic filariasis.

Gyapong JO, Kumaraswami V, Biswas G, Ottesen EA.

Expert Opin Pharmacother. 2005 Feb;6(2):179-200. Review.


Development and standardization of a rapid, PCR-based method for the detection of Wuchereria bancrofti in mosquitoes, for xenomonitoring the human prevalence of bancroftian filariasis.

Williams SA, Laney SJ, Bierwert LA, Saunders LJ, Boakye DA, Fischer P, Goodman D, Helmy H, Hoti SL, Vasuki V, Lammie PJ, Plichart C, Ramzy RM, Ottesen EA.

Ann Trop Med Parasitol. 2002 Dec;96 Suppl 2:S41-6.


Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia.

O'Bryan L, Pinkston P, Kumaraswami V, Vijayan V, Yenokida G, Rosenberg HF, Crystal R, Ottesen EA, Nutman TB.

Infect Immun. 2003 Mar;71(3):1337-42.


Major progress toward eliminating lymphatic filariasis.

Ottesen EA.

N Engl J Med. 2002 Dec 5;347(23):1885-6. No abstract available.


Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions.

Keiser PB, Reynolds SM, Awadzi K, Ottesen EA, Taylor MJ, Nutman TB.

J Infect Dis. 2002 Mar 15;185(6):805-11. Epub 2002 Feb 19.


Towards a vaccine for onchocerciasis.

Cook JA, Steel C, Ottesen EA.

Trends Parasitol. 2001 Dec;17(12):555-8. No abstract available.


Lymphatic filariasis in children: adenopathy and its evolution in two young girls.

Dreyer G, Figueredo-Silva J, Carvalho K, Amaral F, Ottesen EA.

Am J Trop Med Hyg. 2001 Sep;65(3):204-7.


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