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Targeted deletion of β1-syntrophin causes a loss of Kir 4.1 from Müller cell endfeet in mouse retina.

Rao SB, Katoozi S, Skauli N, Froehner SC, Ottersen OP, Adams ME, Amiry-Moghaddam M.

Glia. 2019 Jun;67(6):1138-1149. doi: 10.1002/glia.23600. Epub 2019 Feb 25.


Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.

Rosic B, Dukefoss DB, Åbjørsbråten KS, Tang W, Jensen V, Ottersen OP, Enger R, Nagelhus EA.

Glia. 2019 Jun;67(6):1113-1121. doi: 10.1002/glia.23604. Epub 2019 Feb 21.


Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study.

Ohene Y, Harrison IF, Nahavandi P, Ismail O, Bird EV, Ottersen OP, Nagelhus EA, Thomas DL, Lythgoe MF, Wells JA.

Neuroimage. 2019 Mar;188:515-523. doi: 10.1016/j.neuroimage.2018.12.026. Epub 2018 Dec 15.


Framing planetary health: arguing for resource-centred science.

Acunzo DJ, Escher G, Ottersen OP, Whittington JD, Gillet P, Stenseth NC, Negrutiu I.

Lancet Planet Health. 2018 Mar;2(3):e101-e102. doi: 10.1016/S2542-5196(18)30023-8. Epub 2018 Mar 2. No abstract available.


Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.

Stahl K, Rahmani S, Prydz A, Skauli N, MacAulay N, Mylonakou MN, Torp R, Skare Ø, Berg T, Leergaard TB, Paulsen RE, Ottersen OP, Amiry-Moghaddam M.

PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. eCollection 2018.


PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.

Dang DK, Shin EJ, Kim DJ, Tran HQ, Jeong JH, Jang CG, Ottersen OP, Nah SY, Hong JS, Nabeshima T, Kim HC.

Free Radic Biol Med. 2018 Feb 1;115:318-337. doi: 10.1016/j.freeradbiomed.2017.12.018. Epub 2017 Dec 18.


Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.

Holter KE, Kehlet B, Devor A, Sejnowski TJ, Dale AM, Omholt SW, Ottersen OP, Nagelhus EA, Mardal KA, Pettersen KH.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9894-9899. doi: 10.1073/pnas.1706942114. Epub 2017 Aug 28.


Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice.

Prydz A, Stahl K, Puchades M, Davarpaneh N, Nadeem M, Ottersen OP, Gundersen V, Amiry-Moghaddam M.

Neuroscience. 2017 Sep 17;359:258-266. doi: 10.1016/j.neuroscience.2017.07.029. Epub 2017 Jul 19.


Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions.

Katoozi S, Skauli N, Rahmani S, Camassa LMA, Boldt HB, Ottersen OP, Amiry-Moghaddam M.

Brain Struct Funct. 2017 Dec;222(9):3959-3972. doi: 10.1007/s00429-017-1448-5. Epub 2017 May 27.


Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice.

Enger R, Dukefoss DB, Tang W, Pettersen KH, Bjørnstad DM, Helm PJ, Jensen V, Sprengel R, Vervaeke K, Ottersen OP, Nagelhus EA.

Cereb Cortex. 2017 Jan 1;27(1):24-33. doi: 10.1093/cercor/bhw359.


The Sustainable Development Goals: ambiguities of accountability.

Engebretsen E, Heggen K, Ottersen OP.

Lancet. 2017 Jan 28;389(10067):365. doi: 10.1016/S0140-6736(17)30152-6. No abstract available.


Presynaptic PICK1 facilitates trafficking of AMPA-receptors between active zone and synaptic vesicle pool.

Haglerød C, Hussain S, Nakamura Y, Xia J, Haug FS, Ottersen OP, Henley JM, Davanger S.

Neuroscience. 2017 Mar 6;344:102-112. doi: 10.1016/j.neuroscience.2016.12.042. Epub 2017 Jan 3.


Loss or Mislocalization of Aquaporin-4 Affects Diffusion Properties and Intermediary Metabolism in Gray Matter of Mice.

Pavlin T, Nagelhus EA, Brekken C, Eyjolfsson EM, Thoren A, Haraldseth O, Sonnewald U, Ottersen OP, Håberg AK.

Neurochem Res. 2017 Jan;42(1):77-91. doi: 10.1007/s11064-016-2139-y. Epub 2016 Dec 30.


E-learning resources in Myanmar.

Bjertness E, Htay TT, Maung NS, Soe ZW, Aye SS, Ottersen OP, Liabsuetrakul T, Grøttum P, Hovland M, Amiry-Moghaddam M.

Lancet. 2016 Dec 17;388(10063):2990-2991. doi: 10.1016/S0140-6736(16)32520-X. No abstract available.


Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA.

Mol Cell Neurosci. 2016 Dec;77:47-52. doi: 10.1016/j.mcn.2016.10.004. Epub 2016 Oct 14.


Factors determining the density of AQP4 water channel molecules at the brain-blood interface.

Hoddevik EH, Khan FH, Rahmani S, Ottersen OP, Boldt HB, Amiry-Moghaddam M.

Brain Struct Funct. 2017 May;222(4):1753-1766. doi: 10.1007/s00429-016-1305-y. Epub 2016 Sep 15.


Osmotherapy With Hypertonic Saline Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4.

Nakayama S, Migliati E, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A.

Crit Care Med. 2016 Aug;44(8):e702-10. doi: 10.1097/CCM.0000000000001671.


Paradoxes of sustainability with consequences for health.

Engebretsen E, Heggen K, Das S, Farmer P, Ottersen OP.

Lancet Glob Health. 2016 Apr;4(4):e225-6. doi: 10.1016/S2214-109X(16)00038-3. No abstract available.


Conivaptan, a Selective Arginine Vasopressin V1a and V2 Receptor Antagonist Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4.

Nakayama S, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A.

Neurocrit Care. 2016 Apr;24(2):273-82. doi: 10.1007/s12028-015-0236-4.


Replacement of Asymmetric Synaptic Profiles in the Molecular Layer of Dentate Gyrus Following Cycloheximide in the Pilocarpine Model in Rats.

Bittencourt S, Covolan L, Hamani C, Longo BM, Faria FP, Freymuller E, Ottersen OP, Mello LE.

Front Psychiatry. 2015 Nov 17;6:157. doi: 10.3389/fpsyt.2015.00157. eCollection 2015.


Mechanisms underlying AQP4 accumulation in astrocyte endfeet.

Camassa LMA, Lunde LK, Hoddevik EH, Stensland M, Boldt HB, De Souza GA, Ottersen OP, Amiry-Moghaddam M.

Glia. 2015 Nov;63(11):2073-2091. doi: 10.1002/glia.22878. Epub 2015 Jun 29.


Global Governance for Health: how to motivate political change?

McNeill D, Ottersen OP.

Public Health. 2015 Jul;129(7):833-7. doi: 10.1016/j.puhe.2015.05.001. Epub 2015 Jun 23. Review.


Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.

Szokol K, Heuser K, Tang W, Jensen V, Enger R, Bedner P, Steinhäuser C, Taubøll E, Ottersen OP, Nagelhus EA.

Front Cell Neurosci. 2015 Feb 25;9:49. doi: 10.3389/fncel.2015.00049. eCollection 2015.


Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain.

Fujita A, Inanobe A, Hibino H, Nielsen S, Ottersen OP, Kurachi Y.

Cell Tissue Res. 2015 Feb;359(2):627-634. doi: 10.1007/s00441-014-2030-6. Epub 2014 Nov 8.


Postnatal development of the molecular complex underlying astrocyte polarization.

Lunde LK, Camassa LM, Hoddevik EH, Khan FH, Ottersen OP, Boldt HB, Amiry-Moghaddam M.

Brain Struct Funct. 2015 Jul;220(4):2087-101. doi: 10.1007/s00429-014-0775-z. Epub 2014 Apr 29.


Commission on Global Governance for Health: just another report?--authors' reply.

Ottersen OP, McNeill D, Dasgupta J, Scheel I, Roalkvam S.

Lancet. 2014 Apr 19;383(9926):1380-1. doi: 10.1016/S0140-6736(14)60676-0. No abstract available.


Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus.

Haj-Yasein NN, Bugge CE, Jensen V, Østby I, Ottersen OP, Hvalby Ø, Nagelhus EA.

Brain Struct Funct. 2015 Jul;220(4):2469-74. doi: 10.1007/s00429-014-0767-z. Epub 2014 Apr 18.


The political origins of health inequity: prospects for change.

Ottersen OP, Dasgupta J, Blouin C, Buss P, Chongsuvivatwong V, Frenk J, Fukuda-Parr S, Gawanas BP, Giacaman R, Gyapong J, Leaning J, Marmot M, McNeill D, Mongella GI, Moyo N, Møgedal S, Ntsaluba A, Ooms G, Bjertness E, Lie AL, Moon S, Roalkvam S, Sandberg KI, Scheel IB.

Lancet. 2014 Feb 15;383(9917):630-67. doi: 10.1016/S0140-6736(13)62407-1. Epub 2014 Feb 11. No abstract available.


The nuclear calcium signaling target, activating transcription factor 3 (ATF3), protects against dendrotoxicity and facilitates the recovery of synaptic transmission after an excitotoxic insult.

Ahlgren H, Bas-Orth C, Freitag HE, Hellwig A, Ottersen OP, Bading H.

J Biol Chem. 2014 Apr 4;289(14):9970-82. doi: 10.1074/jbc.M113.502914. Epub 2014 Feb 10.


Physiological roles of aquaporin-4 in brain.

Nagelhus EA, Ottersen OP.

Physiol Rev. 2013 Oct;93(4):1543-62. doi: 10.1152/physrev.00011.2013. Review.


The impact of alpha-syntrophin deletion on the changes in tissue structure and extracellular diffusion associated with cell swelling under physiological and pathological conditions.

Dmytrenko L, Cicanic M, Anderova M, Vorisek I, Ottersen OP, Sykova E, Vargova L.

PLoS One. 2013 Jul 5;8(7):e68044. doi: 10.1371/journal.pone.0068044. Print 2013.


Immunogold cytochemistry in neuroscience.

Amiry-Moghaddam M, Ottersen OP.

Nat Neurosci. 2013 Jul;16(7):798-804. doi: 10.1038/nn.3418. Epub 2013 Jun 25.


In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.

Thrane AS, Takano T, Rangroo Thrane V, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA.

J Cereb Blood Flow Metab. 2013 Jul;33(7):996-9. doi: 10.1038/jcbfm.2013.63. Epub 2013 Apr 24.


[The largest, the smallest and most complex].

Ottersen OP.

Tidsskr Nor Laegeforen. 2013 Mar 19;133(6):607. doi: 10.4045/tidsskr.13.0159. Norwegian. No abstract available.


Regulation of AQP4 surface expression via vesicle mobility in astrocytes.

Potokar M, Stenovec M, Jorgačevski J, Holen T, Kreft M, Ottersen OP, Zorec R.

Glia. 2013 Jun;61(6):917-28. doi: 10.1002/glia.22485. Epub 2013 Mar 18.


Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy.

Alvestad S, Hammer J, Hoddevik EH, Skare Ø, Sonnewald U, Amiry-Moghaddam M, Ottersen OP.

Epilepsy Res. 2013 Jul;105(1-2):30-41. doi: 10.1016/j.eplepsyres.2013.01.006. Epub 2013 Jan 26.


Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse.

Enger R, Gundersen GA, Haj-Yasein NN, Eilert-Olsen M, Thoren AE, Vindedal GF, Petersen PH, Skare Ø, Nedergaard M, Ottersen OP, Nagelhus EA.

Glia. 2012 Dec;60(12):2018-26. doi: 10.1002/glia.22416. Epub 2012 Sep 17.


Small-scale purification and mass spectrometry analysis reveal a third aquaporin-4 protein isoform of 36 kDa in rat brain.

Sørbø JG, Fleckenstein B, Ottersen OP, Holen T.

J Neurosci Methods. 2012 Oct 15;211(1):31-9. doi: 10.1016/j.jneumeth.2012.07.021. Epub 2012 Aug 7.


Loss of perivascular Kir4.1 potassium channels in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy.

Heuser K, Eid T, Lauritzen F, Thoren AE, Vindedal GF, Taubøll E, Gjerstad L, Spencer DD, Ottersen OP, Nagelhus EA, de Lanerolle NC.

J Neuropathol Exp Neurol. 2012 Sep;71(9):814-25. doi: 10.1097/NEN.0b013e318267b5af.


Inner hair cells of mice express the glutamine transporter SAT1.

Oguchi T, Suzuki N, Hashimoto S, Chaudhry GA, Chaudhry FA, Usami S, Ottersen OP.

Hear Res. 2012 Oct;292(1-2):59-63. doi: 10.1016/j.heares.2012.07.005. Epub 2012 Jul 25.


Aquaporin-4 in the heart: expression, regulation and functional role in ischemia.

Rutkovskiy A, Stensløkken KO, Mariero LH, Skrbic B, Amiry-Moghaddam M, Hillestad V, Valen G, Perreault MC, Ottersen OP, Gullestad L, Dahl CP, Vaage J.

Basic Res Cardiol. 2012 Sep;107(5):280. doi: 10.1007/s00395-012-0280-6. Epub 2012 Jul 10.


Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy.

Perez EL, Lauritzen F, Wang Y, Lee TS, Kang D, Zaveri HP, Chaudhry FA, Ottersen OP, Bergersen LH, Eid T.

Neurobiol Dis. 2012 Sep;47(3):331-7. doi: 10.1016/j.nbd.2012.05.010. Epub 2012 May 31.


Mixed Electrical-Chemical Synapses in Adult Rat Hippocampus are Primarily Glutamatergic and Coupled by Connexin-36.

Hamzei-Sichani F, Davidson KG, Yasumura T, Janssen WG, Wearne SL, Hof PR, Traub RD, Gutiérrez R, Ottersen OP, Rash JE.

Front Neuroanat. 2012 May 15;6:13. doi: 10.3389/fnana.2012.00013. eCollection 2012.


Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus.

Haj-Yasein NN, Jensen V, Østby I, Omholt SW, Voipio J, Kaila K, Ottersen OP, Hvalby Ø, Nagelhus EA.

Glia. 2012 May;60(6):867-74. doi: 10.1002/glia.22319. Epub 2012 Mar 14.


Aquaporin-4 and epilepsy.

Binder DK, Nagelhus EA, Ottersen OP.

Glia. 2012 Aug;60(8):1203-14. doi: 10.1002/glia.22317. Epub 2012 Feb 29. Review.


The Lancet-University of Oslo Commission on Global Governance for Health, in collaboration with the Harvard Global Health Institute.

Ottersen OP, Frenk J, Horton R.

Lancet. 2011 Nov 5;378(9803):1612-3. doi: 10.1016/S0140-6736(11)61617-6. No abstract available.


Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.

Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17815-20. doi: 10.1073/pnas.1110655108. Epub 2011 Oct 11.


Development of γ-aminobutyric acid-, glycine-, and glutamate-immunopositive boutons on rat jaw-opening motoneurons.

Paik SK, Kwak WK, Bae JY, Na YK, Park SY, Yi HW, Ahn DK, Ottersen OP, Yoshida A, Bae YC.

J Comp Neurol. 2012 Apr 15;520(6):1212-26. doi: 10.1002/cne.22771.


Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes.

Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JF, Røe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V.

Cereb Cortex. 2012 Jul;22(7):1690-7. doi: 10.1093/cercor/bhr254. Epub 2011 Sep 12.


Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort.

Kerty E, Heuser K, Indahl UG, Berg PR, Nakken S, Lien S, Omholt SW, Ottersen OP, Nagelhus EA.

Acta Ophthalmol. 2013 Feb;91(1):88-91. doi: 10.1111/j.1755-3768.2011.02231.x. Epub 2011 Sep 13.

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