Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 133

1.

Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.

Belcher JD, Gomperts E, Nguyen J, Chen C, Abdulla F, Kiser ZM, Gallo D, Levy H, Otterbein LE, Vercellotti GM.

PLoS One. 2018 Oct 11;13(10):e0205194. doi: 10.1371/journal.pone.0205194. eCollection 2018.

2.

HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease.

Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS.

J Autoimmun. 2018 Nov;94:122-133. doi: 10.1016/j.jaut.2018.07.022. Epub 2018 Aug 8.

PMID:
30098863
3.

Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?

Hopper CP, Meinel L, Steiger C, Otterbein LE.

Curr Pharm Des. 2018 Jul 23. doi: 10.2174/1381612824666180723161811. [Epub ahead of print]

PMID:
30039755
4.

Danger signals from mitochondrial DAMPS in trauma and post-injury sepsis.

Hauser CJ, Otterbein LE.

Eur J Trauma Emerg Surg. 2018 Jun;44(3):317-324. doi: 10.1007/s00068-018-0963-2. Epub 2018 May 24. Review.

PMID:
29797026
5.

A SUBSET OF FIVE HUMAN MITOCHONDRIAL FORMYL PEPTIDES MIMICS BACTERIAL PEPTIDES AND FUNCTIONALLY DEACTIVATES HUMAN NEUETROPHILS.

Kaczmarek E, Hauser CJ, Kwon WY, Rica I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich M, Itagaki K.

J Trauma Acute Care Surg. 2018 May 4. doi: 10.1097/TA.0000000000001971. [Epub ahead of print]

PMID:
29787548
6.

Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide.

Zheng Y, Ji X, Yu B, Ji K, Gallo D, Csizmadia E, Zhu M, Choudhury MR, De La Cruz LKC, Chittavong V, Pan Z, Yuan Z, Otterbein LE, Wang B.

Nat Chem. 2018 May 14. doi: 10.1038/s41557-018-0055-2. [Epub ahead of print]

PMID:
29760413
7.

Carbon monoxide protects the kidney through the central circadian clock and CD39.

Correa-Costa M, Gallo D, Csizmadia E, Gomperts E, Lieberum JL, Hauser CJ, Ji X, Wang B, Câmara NOS, Robson SC, Otterbein LE.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2302-E2310. doi: 10.1073/pnas.1716747115. Epub 2018 Feb 20.

8.

Intraoperative oxygen concentration and neurocognition after cardiac surgery: study protocol for a randomized controlled trial.

Shaefi S, Marcantonio ER, Mueller A, Banner-Goodspeed V, Robson SC, Spear K, Otterbein LE, O'Gara BP, Talmor DS, Subramaniam B.

Trials. 2017 Dec 19;18(1):600. doi: 10.1186/s13063-017-2337-1.

9.

Clinical Implications of Hyperoxia.

Shankar P, Robson SC, Otterbein LE, Shaefi S.

Int Anesthesiol Clin. 2018 Winter;56(1):68-79. doi: 10.1097/AIA.0000000000000176. No abstract available.

PMID:
29227312
10.

Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice.

Schallner N, Lieberum JL, Gallo D, LeBlanc RH 3rd, Fuller PM, Hanafy KA, Otterbein LE.

Stroke. 2017 Sep;48(9):2565-2573. doi: 10.1161/STROKEAHA.116.016165. Epub 2017 Jul 26.

11.

Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin β1 Recycling.

Lee H, Zhang D, Wu J, Otterbein LE, Jin Y.

J Immunol. 2017 Aug 15;199(4):1453-1464. doi: 10.4049/jimmunol.1700165. Epub 2017 Jul 3.

12.

Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns.

Itagaki K, Riça I, Zhang J, Gallo D, DePrato M, Otterbein LE, Hauser CJ.

J Trauma Acute Care Surg. 2017 May;82(5):853-860. doi: 10.1097/TA.0000000000001413.

13.

The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.

Gomperts E, Belcher JD, Otterbein LE, Coates TD, Wood J, Skolnick BE, Levy H, Vercellotti GM.

Am J Hematol. 2017 Jun;92(6):569-582. doi: 10.1002/ajh.24750. Epub 2017 Apr 29. Review.

14.

Heme oxygenase and carbon monoxide protect from muscle dystrophy.

Chan MC, Ziegler O, Liu L, Rowe GC, Das S, Otterbein LE, Arany Z.

Skelet Muscle. 2016 Nov 28;6(1):41.

15.

Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival.

Otterbein LE, Foresti R, Motterlini R.

Circ Res. 2016 Jun 10;118(12):1940-1959. doi: 10.1161/CIRCRESAHA.116.306588. Review.

16.

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.

Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B.

Oncotarget. 2016 Apr 26;7(17):23919-32. doi: 10.18632/oncotarget.8081.

17.

Update on Renal Replacement Therapy: Implantable Artificial Devices and Bioengineered Organs.

Attanasio C, Latancia MT, Otterbein LE, Netti PA.

Tissue Eng Part B Rev. 2016 Aug;22(4):330-40. doi: 10.1089/ten.TEB.2015.0467. Epub 2016 Apr 12. Review.

PMID:
26905099
18.

Toward Carbon Monoxide-Based Therapeutics: Critical Drug Delivery and Developability Issues.

Ji X, Damera K, Zheng Y, Yu B, Otterbein LE, Wang B.

J Pharm Sci. 2016 Feb;105(2):406-416. doi: 10.1016/j.xphs.2015.10.018. Epub 2016 Jan 6. Review.

19.

Heme as a danger molecule in pathogen recognition.

Wegiel B, Hauser CJ, Otterbein LE.

Free Radic Biol Med. 2015 Dec;89:651-61. doi: 10.1016/j.freeradbiomed.2015.08.020. Epub 2015 Oct 9. Review.

PMID:
26456060
20.

Escherichia coli heme oxygenase modulates host innate immune responses.

Maharshak N, Ryu HS, Fan TJ, Onyiah JC, Schulz S, Otterbein SL, Wong R, Hansen JJ, Otterbein LE, Carroll IM, Plevy SE.

Microbiol Immunol. 2015 Aug;59(8):452-65. doi: 10.1111/1348-0421.12282.

21.

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1.

Schallner N, Pandit R, LeBlanc R 3rd, Thomas AJ, Ogilvy CS, Zuckerbraun BS, Gallo D, Otterbein LE, Hanafy KA.

J Clin Invest. 2015 Jul 1;125(7):2609-25. doi: 10.1172/JCI78443. Epub 2015 May 26.

22.

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.

Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ.

Nat Med. 2015 Jun;21(6):638-46. doi: 10.1038/nm.3868. Epub 2015 May 25.

23.

Mitochondrial DNA released by trauma induces neutrophil extracellular traps.

Itagaki K, Kaczmarek E, Lee YT, Tang IT, Isal B, Adibnia Y, Sandler N, Grimm MJ, Segal BH, Otterbein LE, Hauser CJ.

PLoS One. 2015 Mar 16;10(3):e0120549. doi: 10.1371/journal.pone.0120549. eCollection 2015.

24.

Friend or foe? Carbon monoxide and the mitochondria.

Schallner N, Otterbein LE.

Front Physiol. 2015 Feb 3;6:17. doi: 10.3389/fphys.2015.00017. eCollection 2015. No abstract available.

25.

Innate immunity for better or worse govern the allograft response.

Otterbein LE, Fan Z, Koulmanda M, Thronley T, Strom TB.

Curr Opin Organ Transplant. 2015 Feb;20(1):8-12. doi: 10.1097/MOT.0000000000000152. Review.

26.

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation.

Ahmad S, Hewett PW, Fujisawa T, Sissaoui S, Cai M, Gueron G, Al-Ani B, Cudmore M, Ahmed SF, Wong MK, Wegiel B, Otterbein LE, Vítek L, Ramma W, Wang K, Ahmed A.

Thromb Haemost. 2015 Feb;113(2):329-37. doi: 10.1160/TH14-01-0002. Epub 2014 Oct 30.

PMID:
25354586
27.

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.

Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE.

J Clin Invest. 2014 Nov;124(11):4926-40. doi: 10.1172/JCI72853. Epub 2014 Oct 8.

28.

Carbon monoxide protects against hemorrhagic shock and resuscitation-induced microcirculatory injury and tissue injury.

Nassour I, Kautza B, Rubin M, Escobar D, Luciano J, Loughran P, Gomez H, Scott J, Gallo D, Brumfield J, Otterbein LE, Zuckerbraun BS.

Shock. 2015 Feb;43(2):166-71. doi: 10.1097/SHK.0000000000000264.

29.

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling.

Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC.

Biochem Biophys Res Commun. 2014 Jun 20;449(1):94-9. doi: 10.1016/j.bbrc.2014.04.150. Epub 2014 May 9.

30.

Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells.

Wegiel B, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun BS, Soares M, Persson JL, Otterbein LE.

Cell Death Dis. 2014 Mar 20;5:e1139. doi: 10.1038/cddis.2014.97.

31.

Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota.

Onyiah JC, Sheikh SZ, Maharshak N, Otterbein LE, Plevy SE.

Gut Microbes. 2014 Mar-Apr;5(2):220-4. doi: 10.4161/gmic.27290. Epub 2013 Dec 20. Review.

32.

Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration.

Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B.

Thromb Haemost. 2014 May 5;111(5):951-9. doi: 10.1160/TH13-09-0748. Epub 2014 Jan 30.

PMID:
24477332
33.

Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation.

Dong H, Huang H, Yun X, Kim DS, Yue Y, Wu H, Sutter A, Chavin KD, Otterbein LE, Adams DB, Kim YB, Wang H.

Endocrinology. 2014 Mar;155(3):818-28. doi: 10.1210/en.2013-1667. Epub 2014 Jan 1.

34.

Heme oxygenase-1: a metabolic nike.

Wegiel B, Nemeth Z, Correa-Costa M, Bulmer AC, Otterbein LE.

Antioxid Redox Signal. 2014 Apr 10;20(11):1709-22. doi: 10.1089/ars.2013.5667. Epub 2014 Feb 27. Review.

35.

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth.

Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE.

Cancer Res. 2013 Dec 1;73(23):7009-21. doi: 10.1158/0008-5472.CAN-13-1075. Epub 2013 Oct 11.

36.

Biliverdin protects against liver ischemia reperfusion injury in swine.

Andria B, Bracco A, Attanasio C, Castaldo S, Cerrito MG, Cozzolino S, Di Napoli D, Giovannoni R, Mancini A, Musumeci A, Mezza E, Nasti M, Scuderi V, Staibano S, Lavitrano M, Otterbein LE, Calise F.

PLoS One. 2013 Jul 29;8(7):e69972. doi: 10.1371/journal.pone.0069972. Print 2013.

37.

Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation.

Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y.

Am J Pathol. 2013 Jul;183(1):182-94. doi: 10.1016/j.ajpath.2013.03.018. Epub 2013 May 14.

38.

Carbon monoxide abrogates ischemic insult to neuronal cells via the soluble guanylate cyclase-cGMP pathway.

Schallner N, Romão CC, Biermann J, Lagrèze WA, Otterbein LE, Buerkle H, Loop T, Goebel U.

PLoS One. 2013 Apr 8;8(4):e60672. doi: 10.1371/journal.pone.0060672. Print 2013.

39.

Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways.

Sun S, Sursal T, Adibnia Y, Zhao C, Zheng Y, Li H, Otterbein LE, Hauser CJ, Itagaki K.

PLoS One. 2013;8(3):e59989. doi: 10.1371/journal.pone.0059989. Epub 2013 Mar 20.

40.

Quoth the Raven: carbon monoxide and nothing more.

Otterbein LE.

Med Gas Res. 2013 Mar 6;3(1):7. doi: 10.1186/2045-9912-3-7.

41.

Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance.

Onyiah JC, Sheikh SZ, Maharshak N, Steinbach EC, Russo SM, Kobayashi T, Mackey LC, Hansen JJ, Moeser AJ, Rawls JF, Borst LB, Otterbein LE, Plevy SE.

Gastroenterology. 2013 Apr;144(4):789-98. doi: 10.1053/j.gastro.2012.12.025. Epub 2012 Dec 22.

42.

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics.

Seixas JD, Mukhopadhyay A, Santos-Silva T, Otterbein LE, Gallo DJ, Rodrigues SS, Guerreiro BH, Gonçalves AM, Penacho N, Marques AR, Coelho AC, Reis PM, Romão MJ, Romão CC.

Dalton Trans. 2013 May 7;42(17):5985-98. doi: 10.1039/c2dt32174b.

43.

The social network of carbon monoxide in medicine.

Wegiel B, Hanto DW, Otterbein LE.

Trends Mol Med. 2013 Jan;19(1):3-11. doi: 10.1016/j.molmed.2012.10.001. Epub 2012 Nov 8. Review.

44.

Carbon Monoxide and the brain: time to rethink the dogma.

Hanafy KA, Oh J, Otterbein LE.

Curr Pharm Des. 2013;19(15):2771-5. Review.

45.

Inhaled carbon monoxide provides cerebral cytoprotection in pigs.

Mahan VL, Zurakowski D, Otterbein LE, Pigula FA.

PLoS One. 2012;7(8):e41982. doi: 10.1371/journal.pone.0041982. Epub 2012 Aug 7.

46.

Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules.

Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM, Pal S.

J Biol Chem. 2012 Sep 14;287(38):32113-23. doi: 10.1074/jbc.M112.393140. Epub 2012 Jul 26.

47.

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.

Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, Knapp B, Haas R, Schmid JA, Jandl C, Amir S, Lubec G, Park J, Esterbauer H, Bilban M, Brizuela L, Pospisilik JA, Otterbein LE, Wagner O.

Cell Metab. 2012 Jun 6;15(6):813-26. doi: 10.1016/j.cmet.2012.04.023.

48.

Activation of peroxisome proliferator-activated receptor γ prolongs islet allograft survival.

Wang H, Wu H, Rocuts F, Gu Z, Bach FH, Otterbein LE.

Cell Transplant. 2012;21(10):2111-8. doi: 10.3727/096368911X637399. Epub 2012 Mar 28.

PMID:
22469179
49.

Go green: the anti-inflammatory effects of biliverdin reductase.

Wegiel B, Otterbein LE.

Front Pharmacol. 2012 Mar 16;3:47. doi: 10.3389/fphar.2012.00047. eCollection 2012.

50.

Induction of protective genes leads to islet survival and function.

Wang H, Ferran C, Attanasio C, Calise F, Otterbein LE.

J Transplant. 2011;2011:141898. doi: 10.1155/2011/141898. Epub 2011 Dec 14.

Supplemental Content

Loading ...
Support Center