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Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv.

Mourik BC, de Steenwinkel JEM, de Knegt GJ, Huizinga R, Verbon A, Ottenhoff THM, van Soolingen D, Leenen PJM.

Sci Rep. 2019 Dec 27;9(1):19922. doi: 10.1038/s41598-019-56300-6.


Plasma metabolomics in tuberculosis patients with and without concurrent type 2 diabetes at diagnosis and during antibiotic treatment.

Vrieling F, Alisjahbana B, Sahiratmadja E, van Crevel R, Harms AC, Hankemeier T, Ottenhoff THM, Joosten SA.

Sci Rep. 2019 Dec 10;9(1):18669. doi: 10.1038/s41598-019-54983-5.


Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.

Tió-Coma M, van Hooij A, Bobosha K, van der Ploeg-van Schip JJ, Banu S, Khadge S, Thapa P, Kunwar CB, Goulart IM, Bekele Y, Hagge DA, Moraes MO, Teles RMB, Pinheiro RO, van Zwet EW, Goeman JJ, Aseffa A, Haks MC, Ottenhoff THM, Modlin RL, Geluk A.

Sci Rep. 2019 Nov 29;9(1):17931. doi: 10.1038/s41598-019-54213-y.


BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA- Indian adults.

Rakshit S, Ahmed A, Adiga V, Sundararaj BK, Sahoo PN, Kenneth J, D'Souza G, Bonam W, Johnson C, Franken KL, Ottenhoff TH, Finak G, Gottardo R, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A.

JCI Insight. 2019 Dec 19;4(24). pii: 130540. doi: 10.1172/jci.insight.130540.


Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity.

Dijkman K, Vervenne RAW, Sombroek CC, Boot C, Hofman SO, van Meijgaarden KE, Ottenhoff THM, Kocken CHM, Haanstra KG, Vierboom MPM, Verreck FAW.

Front Immunol. 2019 Nov 1;10:2479. doi: 10.3389/fimmu.2019.02479. eCollection 2019.


Abnormalities suggestive of latent tuberculosis infection on chest radiography; how specific are they?

Uzorka JW, Kroft LJM, Bakker JA, van Zwet EW, Huisman E, Prins C, van der Zwan CJ, Ottenhoff THM, Arend SM.

J Clin Tuberc Other Mycobact Dis. 2019 Jan 25;15:100089. doi: 10.1016/j.jctube.2019.01.004. eCollection 2019 May.


Mobilizing unconventional T cells.

Ottenhoff THM, Joosten SA.

Science. 2019 Oct 18;366(6463):302-303. doi: 10.1126/science.aay7079. No abstract available.


Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.

Teles RMB, Lu J, Tió-Coma M, Goulart IMB, Banu S, Hagge D, Bobosha K, Ottenhoff THM, Pellegrini M, Geluk A, Modlin RL.

PLoS Negl Trop Dis. 2019 Oct 10;13(10):e0007764. doi: 10.1371/journal.pntd.0007764. eCollection 2019 Oct.


Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests.

Nathavitharana RR, Yoon C, Macpherson P, Dowdy DW, Cattamanchi A, Somoskovi A, Broger T, Ottenhoff THM, Arinaminpathy N, Lonnroth K, Reither K, Cobelens F, Gilpin C, Denkinger CM, Schumacher SG.

J Infect Dis. 2019 Oct 8;220(Supplement_3):S116-S125. doi: 10.1093/infdis/jiz243.


Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review.

Schakel L, Veldhuijzen DS, Crompvoets PI, Bosch JA, Cohen S, van Middendorp H, Joosten SA, Ottenhoff THM, Visser LG, Evers AWM.

Psychother Psychosom. 2019;88(5):274-286. doi: 10.1159/000501645. Epub 2019 Aug 6. Review.


Radiological Signs of Latent Tuberculosis on Chest Radiography: A Systematic Review and Meta-Analysis.

Uzorka JW, Wallinga J, Kroft LJM, Ottenhoff THM, Arend SM.

Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz313. doi: 10.1093/ofid/ofz313.


Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana.

Adankwah E, Lundtoft C, Güler A, Franken KLMC, Ottenhoff THM, Mayatepek E, Owusu-Dabo E, Phillips RO, Nausch N, Jacobsen M.

Front Immunol. 2019 Jul 3;10:1518. doi: 10.3389/fimmu.2019.01518. eCollection 2019.


Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites.

Tran TM, Bijker EM, Haks MC, Ottenhoff THM, Visser L, Schats R, Venepally P, Lorenzi H, Crompton PD, Sauerwein RW.

Sci Rep. 2019 Jun 10;9(1):8386. doi: 10.1038/s41598-019-44924-7.


Harnessing donor unrestricted T-cells for new vaccines against tuberculosis.

Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, Seshadri C; Collaboration for Tuberculosis Vaccine Discovery - Donor-Unrestricted T-cells Working Group, Bill and Melinda Gates Foundation.

Vaccine. 2019 May 21;37(23):3022-3030. doi: 10.1016/j.vaccine.2019.04.050. Epub 2019 Apr 27. Review.


Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction.

Vrieling F, Wilson L, Rensen PCN, Walzl G, Ottenhoff THM, Joosten SA.

PLoS Pathog. 2019 Apr 18;15(4):e1007724. doi: 10.1371/journal.ppat.1007724. eCollection 2019 Apr.


Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome.

Duffy FJ, Weiner J 3rd, Hansen S, Tabb DL, Suliman S, Thompson E, Maertzdorf J, Shankar S, Tromp G, Parida S, Dover D, Axthelm MK, Sutherland JS, Dockrell HM, Ottenhoff THM, Scriba TJ, Picker LJ, Walzl G, Kaufmann SHE, Zak DE; GC6-74 Consortium.

Front Immunol. 2019 Mar 22;10:527. doi: 10.3389/fimmu.2019.00527. eCollection 2019.


Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains.

Ramaiah A, Nayak S, Rakshit S, Manson AL, Abeel T, Shanmugam S, Sahoo PN, John AJUK, Sundaramurthi JC, Narayanan S, D'Souza G, von Hoegen P, Ottenhoff THM, Swaminathan S, Earl AM, Vyakarnam A.

Front Immunol. 2019 Feb 13;10:195. doi: 10.3389/fimmu.2019.00195. eCollection 2019.


Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells.

Tanner R, Smith SG, van Meijgaarden KE, Giannoni F, Wilkie M, Gabriele L, Palma C, Dockrell HM, Ottenhoff THM, McShane H.

J Immunol Methods. 2019 Jun;469:1-10. doi: 10.1016/j.jim.2019.01.006. Epub 2019 Jan 31.


Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques.

Dijkman K, Sombroek CC, Vervenne RAW, Hofman SO, Boot C, Remarque EJ, Kocken CHM, Ottenhoff THM, Kondova I, Khayum MA, Haanstra KG, Vierboom MPM, Verreck FAW.

Nat Med. 2019 Feb;25(2):255-262. doi: 10.1038/s41591-018-0319-9. Epub 2019 Jan 21.


Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype.

Caccamo N, Joosten SA, Ottenhoff THM, Dieli F.

Front Immunol. 2018 Dec 3;9:2832. doi: 10.3389/fimmu.2018.02832. eCollection 2018. Review.


Metabolite changes in blood predict the onset of tuberculosis.

Weiner J 3rd, Maertzdorf J, Sutherland JS, Duffy FJ, Thompson E, Suliman S, McEwen G, Thiel B, Parida SK, Zyla J, Hanekom WA, Mohney RP, Boom WH, Mayanja-Kizza H, Howe R, Dockrell HM, Ottenhoff THM, Scriba TJ, Zak DE, Walzl G, Kaufmann SHE; GC6-74 consortium.

Nat Commun. 2018 Dec 6;9(1):5208. doi: 10.1038/s41467-018-07635-7.


A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis.

Meier NR, Jacobsen M, Ottenhoff THM, Ritz N.

Front Immunol. 2018 Nov 9;9:2476. doi: 10.3389/fimmu.2018.02476. eCollection 2018.


NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC.

JCI Insight. 2018 Nov 15;3(22). pii: 122958. doi: 10.1172/jci.insight.122958.


Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis.

Lubbers R, Sutherland JS, Goletti D, de Paus RA, van Moorsel CHM, Veltkamp M, Vestjens SMT, Bos WJW, Petrone L, Del Nonno F, Bajema IM, Dijkman K, Verreck FAW, Walzl G, Gelderman KA, Groeneveld GH, Geluk A, Ottenhoff THM, Joosten SA, Trouw LA.

Front Immunol. 2018 Oct 23;9:2427. doi: 10.3389/fimmu.2018.02427. eCollection 2018.


Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination.

Coppola M, Ottenhoff TH.

Semin Immunol. 2018 Oct;39:88-101. doi: 10.1016/j.smim.2018.07.001. Epub 2018 Jul 7. Review.


Correlates of vaccine adjuvanticity, vaccine activity, protective immunity and disease in human infectious disease and cancer.

Ottenhoff THM.

Semin Immunol. 2018 Oct;39:1-3. doi: 10.1016/j.smim.2018.10.002. Epub 2018 Oct 11. No abstract available.


Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies.

van Meijgaarden KE, Khatri B, Smith SG, Drittij AMFH, de Paus RA, Goeman JJ, Ho MM, Dockrell HM, McShane H, Joosten SA, Ottenhoff THM.

PLoS One. 2018 Sep 4;13(9):e0201205. doi: 10.1371/journal.pone.0201205. eCollection 2018.


Borderline QuantiFERON results and the distinction between specific responses and test variability.

Uzorka JW, Bossink AWJ, Franken WPJ, Thijsen SFT, Leyten EMS, van Haeften AC, Doornenbal G, Boonstra P, Ottenhoff THM, Arend SM.

Tuberculosis (Edinb). 2018 Jul;111:102-108. doi: 10.1016/ Epub 2018 Jun 7.


Host Gene Expression Kinetics During Treatment of Tuberculosis in HIV-Coinfected Individuals Is Independent of Highly Active Antiretroviral Therapy.

Gebremicael G, Kassa D, Quinten E, Alemayehu Y, Gebreegziaxier A, Belay Y, van Baarle D, Ottenhoff THM, Cliff JM, Haks MC.

J Infect Dis. 2018 Oct 20;218(11):1833-1846. doi: 10.1093/infdis/jiy404.


Antibody glycosylation in inflammation, disease and vaccination.

Alter G, Ottenhoff THM, Joosten SA.

Semin Immunol. 2018 Oct;39:102-110. doi: 10.1016/j.smim.2018.05.003. Epub 2018 Jun 11. Review.


Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease.

Orlando V, La Manna MP, Goletti D, Palmieri F, Lo Presti E, Joosten SA, La Mendola C, Buccheri S, Ottenhoff THM, Dieli F, Caccamo N.

Front Immunol. 2018 May 23;9:1119. doi: 10.3389/fimmu.2018.01119. eCollection 2018.


Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults.

Weinberger B, Haks MC, de Paus RA, Ottenhoff THM, Bauer T, Grubeck-Loebenstein B.

Front Immunol. 2018 May 15;9:1035. doi: 10.3389/fimmu.2018.01035. eCollection 2018.


Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile.

Vrieling F, Ronacher K, Kleynhans L, van den Akker E, Walzl G, Ottenhoff THM, Joosten SA.

EBioMedicine. 2018 Jun;32:192-200. doi: 10.1016/j.ebiom.2018.05.011. Epub 2018 May 17.


A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer.

Bilsen MP, van Meijgaarden KE, de Jong HK, Joosten SA, Prins C, Kroft LJM, Jonker JT, Crobach S, Pelger RC, Ottenhoff THM, Arend SM.

Int J Infect Dis. 2018 Jul;72:63-68. doi: 10.1016/j.ijid.2018.05.006. Epub 2018 May 17.


A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts.

Duffy FJ, Thompson E, Downing K, Suliman S, Mayanja-Kizza H, Boom WH, Thiel B, Weiner Iii J, Kaufmann SHE, Dover D, Tabb DL, Dockrell HM, Ottenhoff THM, Tromp G, Scriba TJ, Zak DE, Walzl G; GC6-74 Consortium.

Front Immunol. 2018 Apr 13;9:661. doi: 10.3389/fimmu.2018.00661. eCollection 2018.


Retinal Pigment Epithelial Cells Control Early Mycobacterium tuberculosis Infection via Interferon Signaling.

La Distia Nora R, Walburg KV, van Hagen PM, Swagemakers SMA, van der Spek PJ, Quinten E, van Velthoven M, Ottenhoff THM, Dik WA, Haks MC.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1384-1395. doi: 10.1167/iovs.17-23246.


Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis.

Suliman S, Thompson E, Sutherland J, Weiner Rd J, Ota MOC, Shankar S, Penn-Nicholson A, Thiel B, Erasmus M, Maertzdorf J, Duffy FJ, Hill PC, Hughes EJ, Stanley K, Downing K, Fisher ML, Valvo J, Parida SK, van der Spuy G, Tromp G, Adetifa IMO, Donkor S, Howe R, Mayanja-Kizza H, Boom WH, Dockrell H, Ottenhoff THM, Hatherill M, Aderem A, Hanekom WA, Scriba TJ, Kaufmann SH, Zak DE, Walzl G; GC6-74 and ACS cohort study groups.

Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201711-2340OC. [Epub ahead of print]


Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application.

Coppola M, van den Eeden SJF, Robbins N, Wilson L, Franken KLMC, Adams LB, Gillis TP, Ottenhoff THM, Geluk A.

Front Immunol. 2018 Feb 26;9:308. doi: 10.3389/fimmu.2018.00308. eCollection 2018. Review.


Mycobacterial growth inhibition is associated with trained innate immunity.

Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH.

J Clin Invest. 2018 May 1;128(5):1837-1851. doi: 10.1172/JCI97508. Epub 2018 Apr 3.


Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease.

Goletti D, Lee MR, Wang JY, Walter N, Ottenhoff THM.

Respirology. 2018 May;23(5):455-466. doi: 10.1111/resp.13272. Epub 2018 Feb 18. Review.


Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

Chegou NN, Sutherland JS, Namuganga AR, Corstjens PL, Geluk A, Gebremichael G, Mendy J, Malherbe S, Stanley K, van der Spuy GD, Kriel M, Loxton AG, Kriel B, Simukonda F, Bekele Y, Sheehama JA, Nelongo J, van der Vyver M, Gebrexabher A, Hailu H, Esterhuyse MM, Rosenkrands I, Aagard C, Kidd M, Kassa D, Mihret A, Howe R, Cliff JM, Crampin AC, Mayanja-Kizza H, Kaufmann SHE, Dockrell HM, Ottenhoff THM, Walzl G; AE-TBC consortium.

Sci Rep. 2018 Feb 8;8(1):2675. doi: 10.1038/s41598-018-20855-7.


IgA and IgG against Mycobacterium tuberculosis Rv2031 discriminate between pulmonary tuberculosis patients, Mycobacterium tuberculosis-infected and non-infected individuals.

Abebe F, Belay M, Legesse M, K L M C F, Ottenhoff THM.

PLoS One. 2018 Jan 26;13(1):e0190989. doi: 10.1371/journal.pone.0190989. eCollection 2018.


Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials.

Korbee CJ, Heemskerk MT, Kocev D, van Strijen E, Rabiee O, Franken KLMC, Wilson L, Savage NDL, Džeroski S, Haks MC, Ottenhoff THM.

Nat Commun. 2018 Jan 24;9(1):358. doi: 10.1038/s41467-017-02777-6.


Tuberculosis vaccines: Opportunities and challenges.

Zhu B, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y.

Respirology. 2018 Apr;23(4):359-368. doi: 10.1111/resp.13245. Epub 2018 Jan 17. Review.


Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia.

Arroyo L, Marín D, Franken KLMC, Ottenhoff THM, Barrera LF.

BMC Infect Dis. 2018 Jan 8;18(1):26. doi: 10.1186/s12879-017-2929-0.


Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination.

Haks MC, Bottazzi B, Cecchinato V, De Gregorio C, Del Giudice G, Kaufmann SHE, Lanzavecchia A, Lewis DJM, Maertzdorf J, Mantovani A, Sallusto F, Sironi M, Uguccioni M, Ottenhoff THM.

Front Immunol. 2017 Nov 15;8:1563. doi: 10.3389/fimmu.2017.01563. eCollection 2017. Review.


Proof of concept that most borderline Quantiferon results are true antigen-specific responses.

Uzorka JW, Kroft LJM, Bakker JA, van Zwet EW, Huisman E, Knetsch-Prins C, van der Zwan CJ, Ottenhoff THM, Arend SM.

Eur Respir J. 2017 Nov 16;50(5). pii: 1701630. doi: 10.1183/13993003.01630-2017. Print 2017 Nov. No abstract available.


Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+ T cells.

Prezzemolo T, van Meijgaarden KE, Franken KLMC, Caccamo N, Dieli F, Ottenhoff THM, Joosten SA.

Eur J Immunol. 2018 Feb;48(2):293-305. doi: 10.1002/eji.201747184. Epub 2017 Dec 15.


TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.

Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams A; TBVAC2020 Consortium.

Front Immunol. 2017 Oct 4;8:1203. doi: 10.3389/fimmu.2017.01203. eCollection 2017. Review.


The SysteMHC Atlas project.

Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron E.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1237-D1247. doi: 10.1093/nar/gkx664.

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