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Items: 13

1.

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies.

Kratochwil NA, Dueker SR, Muri D, Senn C, Yoon H, Yu BY, Lee GH, Dong F, Otteneder MB.

PLoS One. 2018 Oct 17;13(10):e0205435. doi: 10.1371/journal.pone.0205435. eCollection 2018.

2.

Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches.

Eigenmann MJ, Karlsen TV, Krippendorff BF, Tenstad O, Fronton L, Otteneder MB, Wiig H.

J Physiol. 2017 Dec 15;595(24):7311-7330. doi: 10.1113/JP274819. Epub 2017 Oct 29.

PMID:
28960303
3.

Quantification of IgG monoclonal antibody clearance in tissues.

Eigenmann MJ, Fronton L, Grimm HP, Otteneder MB, Krippendorff BF.

MAbs. 2017 Aug/Sep;9(6):1007-1015. doi: 10.1080/19420862.2017.1337619. Epub 2017 Jun 14.

4.

Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro-In Vivo Comparisons.

Wilkinson DJ, Southall RL, Li M, Wright LM, Corfield LJ, Heeley TA, Bratby B, Mannu R, Johnson SL, Shaw V, Friett HL, Blakeburn LA, Kendrick JS, Otteneder MB.

AAPS J. 2017 Jul;19(4):1163-1174. doi: 10.1208/s12248-017-0087-3. Epub 2017 May 4.

PMID:
28474310
5.

Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.

Jaramillo CAC, Belli S, Cascais AC, Dudal S, Edelmann MR, Haak M, Brun ME, Otteneder MB, Ullah M, Funk C, Schuler F, Simon S.

MAbs. 2017 Jul;9(5):781-791. doi: 10.1080/19420862.2017.1320008. Epub 2017 Apr 25.

6.

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.

Jadhav SB, Khaowroongrueng V, Fueth M, Otteneder MB, Richter W, Derendorf H.

J Pharm Sci. 2017 Sep;106(9):2853-2859. doi: 10.1016/j.xphs.2017.03.033. Epub 2017 Apr 13.

PMID:
28414146
7.

Distribution of FcRn Across Species and Tissues.

Latvala S, Jacobsen B, Otteneder MB, Herrmann A, Kronenberg S.

J Histochem Cytochem. 2017 Jun;65(6):321-333. doi: 10.1369/0022155417705095. Epub 2017 Apr 12.

8.

Erratum to: Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.

Lignet F, Sherbetjian E, Kratochwil N, Jones R, Suenderhauf C, Otteneder MB, Singer T, Parrott N.

Pharm Res. 2016 Nov;33(11):2844. No abstract available.

PMID:
27549317
9.

Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.

Lignet F, Sherbetjian E, Kratochwil N, Jones R, Suenderhauf C, Otteneder MB, Singer T, Parrott N.

Pharm Res. 2016 Oct;33(10):2565-79. doi: 10.1007/s11095-016-1982-5. Epub 2016 Jul 28. Erratum in: Pharm Res. 2016 Nov;33(11):2844.

PMID:
27469324
10.

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.

Poirier A, Belli S, Funk C, Otteneder MB, Portmann R, Heinig K, Prinssen E, Lazic SE, Rayner CR, Hoffmann G, Singer T, Smith DE, Schuler F.

Drug Metab Dispos. 2012 Aug;40(8):1556-65. doi: 10.1124/dmd.112.044990. Epub 2012 May 14.

11.

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.

Anselm L, Banner DW, Benz J, Zbinden KG, Himber J, Hilpert H, Huber W, Kuhn B, Mary JL, Otteneder MB, Panday N, Ricklin F, Stahl M, Thomi S, Haap W.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5313-9. doi: 10.1016/j.bmcl.2010.06.126. Epub 2010 Jul 1.

PMID:
20650636
12.

Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.

Hoffmann G, Funk C, Fowler S, Otteneder MB, Breidenbach A, Rayner CR, Chu T, Prinssen EP.

Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. doi: 10.1128/AAC.01541-08. Epub 2009 Aug 31.

13.

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

Otteneder MB, Knutson CG, Daniels JS, Hashim M, Crews BC, Remmel RP, Wang H, Rizzo C, Marnett LJ.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6665-9. Epub 2006 Apr 13.

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