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Items: 20

1.

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2.

Garibsingh RA, Otte NJ, Ndaru E, Colas C, Grewer C, Holst J, Schlessinger A.

Front Chem. 2018 Jul 24;6:279. doi: 10.3389/fchem.2018.00279. eCollection 2018.

2.

Extensive hyperpigmentation of the face in a Filipina.

Pirrone J, Broyer J, Otte N, Reich K, Boer-Auer A.

J Dtsch Dermatol Ges. 2017 Nov;15(11):1167-1168. doi: 10.1111/ddg.13329. Epub 2017 Oct 10. No abstract available.

PMID:
29024494
3.

ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma.

Marshall AD, van Geldermalsen M, Otte NJ, Lum T, Vellozzi M, Thoeng A, Pang A, Nagarajah R, Zhang B, Wang Q, Anderson L, Rasko JEJ, Holst J.

Oncogenesis. 2017 Jul 31;6(7):e367. doi: 10.1038/oncsis.2017.70.

4.

LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma.

Marshall AD, van Geldermalsen M, Otte NJ, Anderson LA, Lum T, Vellozzi MA, Zhang BK, Thoeng A, Wang Q, Rasko JE, Holst J.

Int J Cancer. 2016 Dec 1;139(11):2529-39. doi: 10.1002/ijc.30371. Epub 2016 Aug 16.

5.

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening.

Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K, Shere H, Bonomi M, Holst J, Schlessinger A.

PLoS Comput Biol. 2015 Oct 7;11(10):e1004477. doi: 10.1371/journal.pcbi.1004477. eCollection 2015 Oct.

6.

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.

Wang Q, Hardie RA, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, Sadowski MC, Balaban S, Schreuder M, Nagarajah R, Wong JJ, Metierre C, Pinello N, Otte NJ, Lehman ML, Gleave M, Nelson CC, Bailey CG, Ritchie W, Rasko JE, Holst J.

J Pathol. 2015 Jul;236(3):278-89. doi: 10.1002/path.4518. Epub 2015 Apr 7.

7.

Targeting glutamine transport to suppress melanoma cell growth.

Wang Q, Beaumont KA, Otte NJ, Font J, Bailey CG, van Geldermalsen M, Sharp DM, Tiffen JC, Ryan RM, Jormakka M, Haass NK, Rasko JE, Holst J.

Int J Cancer. 2014 Sep 1;135(5):1060-71. doi: 10.1002/ijc.28749. Epub 2014 Feb 17.

8.

BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy.

Koya RC, Mok S, Otte N, Blacketor KJ, Comin-Anduix B, Tumeh PC, Minasyan A, Graham NA, Graeber TG, Chodon T, Ribas A.

Cancer Res. 2012 Aug 15;72(16):3928-37. doi: 10.1158/0008-5472.CAN-11-2837. Epub 2012 Jun 12.

9.

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.

Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, Reis-Filho JS, Kong X, Koya RC, Flaherty KT, Chapman PB, Kim MJ, Hayward R, Martin M, Yang H, Wang Q, Hilton H, Hang JS, Noe J, Lambros M, Geyer F, Dhomen N, Niculescu-Duvaz I, Zambon A, Niculescu-Duvaz D, Preece N, Robert L, Otte NJ, Mok S, Kee D, Ma Y, Zhang C, Habets G, Burton EA, Wong B, Nguyen H, Kockx M, Andries L, Lestini B, Nolop KB, Lee RJ, Joe AK, Troy JL, Gonzalez R, Hutson TE, Puzanov I, Chmielowski B, Springer CJ, McArthur GA, Sosman JA, Lo RS, Ribas A, Marais R.

N Engl J Med. 2012 Jan 19;366(3):207-15. doi: 10.1056/NEJMoa1105358.

10.

Observation of pulsed gamma-rays above 25 GeV from the Crab pulsar with MAGIC.

MAGIC Collaboration, Aliu E, Anderhub H, Antonelli LA, Antoranz P, Backes M, Baixeras C, Barrio JA, Bartko H, Bastieri D, Becker JK, Bednarek W, Berger K, Bernardini E, Bigongiari C, Biland A, Bock RK, Bonnoli G, Bordas P, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Commichau S, Contreras JL, Cortina J, Costado MT, Covino S, Curtef V, Dazzi F, De Angelis A, De Cea Del Pozo E, de Los Reyes R, De Lotto B, De Maria M, De Sabata F, Delgado Mendez C, Dominguez A, Dorner D, Doro M, Elsässer D, Errando M, Fagiolini M, Ferenc D, Fernandez E, Firpo R, Fonseca MV, Font L, Galante N, Garcia Lopez RJ, Garczarczyk M, Gaug M, Goebel F, Hadasch D, Hayashida M, Herrero A, Höhne D, Hose J, Hsu CC, Huber S, Jogler T, Kranich D, La Barbera A, Laille A, Leonardo E, Lindfors E, Lombardi S, Longo F, Lopez M, Lorenz E, Majumdar P, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Mariotti M, Martinez M, Mazin D, Meucci M, Meyer M, Miranda JM, Mirzoyan R, Moles M, Moralejo A, Nieto D, Nilsson K, Ninkovic J, Otte N, Oya I, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pegna RG, Perez-Torres MA, Persic M, Peruzzo L, Piccioli A, Prada F, Prandini E, Puchades N, Raymers A, Rhode W, Ribó M, Rico J, Rissi M, Robert A, Rügamer S, Saggion A, Saito TY, Salvati M, Sanchez-Conde M, Sartori P, Satalecka K, Scalzotto V, Scapin V, Schweizer T, Shayduk M, Shinozaki K, Shore SN, Sidro N, Sierpowska-Bartosik A, Sillanpää A, Sobczynska D, Spanier F, Stamerra A, Stark LS, Takalo L, Tavecchio F, Temnikov P, Tescaro D, Teshima M, Tluczykont M, Torres DF, Turini N, Vankov H, Venturini A, Vitale V, Wagner RM, Wittek W, Zabalza V, Zandanel F, Zanin R, Zapatero J, de Jager OC, de Ona Wilhelmi E.

Science. 2008 Nov 21;322(5905):1221-4. doi: 10.1126/science.1164718. Epub 2008 Oct 16.

11.

Very-high-energy gamma rays from a distant quasar: how transparent is the universe?

MAGIC Collaboration, Albert J, Aliu E, Anderhub H, Antonelli LA, Antoranz P, Backes M, Baixeras C, Barrio JA, Bartko H, Bastieri D, Becker JK, Bednarek W, Berger K, Bernardini E, Bigongiari C, Biland A, Bock RK, Bonnoli G, Bordas P, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Commichau S, Contreras JL, Cortina J, Costado MT, Covino S, Curtef V, Dazzi F, De Angelis A, De Cea Del Pozo E, de Los Reyes R, De Lotto B, De Maria M, De Sabata F, Mendez CD, Dominguez A, Dorner D, Doro M, Errando M, Fagiolini M, Ferenc D, Fernández E, Firpo R, Fonseca MV, Font L, Galante N, López RJ, Garczarczyk M, Gaug M, Goebel F, Hayashida M, Herrero A, Höhne D, Hose J, Hsu CC, Huber S, Jogler T, Kneiske TM, Kranich D, La Barbera A, Laille A, Leonardo E, Lindfors E, Lombardi S, Longo F, López M, Lorenz E, Majumdar P, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Mariotti M, Martínez M, Mazin D, Meucci M, Meyer M, Miranda JM, Mirzoyan R, Mizobuchi S, Moles M, Moralejo A, Nieto D, Nilsson K, Ninkovic J, Otte N, Oya I, Panniello M, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pegna RG, Perez-Torres MA, Persic M, Peruzzo L, Piccioli A, Prada F, Prandini E, Puchades N, Raymers A, Rhode W, Ribó M, Rico J, Rissi M, Robert A, Rügamer S, Saggion A, Saito TY, Salvati M, Sanchez-Conde M, Sartori P, Satalecka K, Scalzotto V, Scapin V, Schmitt R, Schweizer T, Shayduk M, Shinozaki K, Shore SN, Sidro N, Sierpowska-Bartosik A, Sillanpää A, Sobczynska D, Spanier F, Stamerra A, Stark LS, Takalo L, Tavecchio F, Temnikov P, Tescaro D, Teshima M, Tluczykont M, Torres DF, Turini N, Vankov H, Venturini A, Vitale V, Wagner RM, Wittek W, Zabalza V, Zandanel F, Zanin R, Zapatero J.

Science. 2008 Jun 27;320(5884):1752-4. doi: 10.1126/science.1157087.

12.

Force-field parameters for the simulation of tetrahedral intermediates of serine hydrolases.

Otte N, Bocola M, Thiel W.

J Comput Chem. 2009 Jan 15;30(1):154-62. doi: 10.1002/jcc.21037.

PMID:
18566980
13.

Nicotinamide - biologic actions of an emerging cosmetic ingredient.

Otte N, Borelli C, Korting HC.

Int J Cosmet Sci. 2005 Oct;27(5):255-61. doi: 10.1111/j.1467-2494.2005.00266.x.

PMID:
18492206
14.

Looking at self-consistent-charge density functional tight binding from a semiempirical perspective.

Otte N, Scholten M, Thiel W.

J Phys Chem A. 2007 Jul 5;111(26):5751-5. Epub 2007 Mar 27.

PMID:
17385847
15.

Learning from directed evolution: Further lessons from theoretical investigations into cooperative mutations in lipase enantioselectivity.

Reetz MT, Puls M, Carballeira JD, Vogel A, Jaeger KE, Eggert T, Thiel W, Bocola M, Otte N.

Chembiochem. 2007 Jan 2;8(1):106-12.

PMID:
17133645
16.

Variable very-high-energy gamma-ray emission from the microquasar LS I +61 303.

Albert J, Aliu E, Anderhub H, Antoranz P, Armada A, Asensio M, Baixeras C, Barrio JA, Bartelt M, Bartko H, Bastieri D, Bavikadi SR, Bednarek W, Berger K, Bigongiari C, Biland A, Bisesi E, Bock RK, Bordas P, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Ciprini S, Coarasa JA, Commichau S, Contreras JL, Cortina J, Curtef V, Danielyan V, Dazzi F, De Angelis A, de Los Reyes R, De Lotto B, Domingo-Santamaría E, Dorner D, Doro M, Errando M, Fagiolini M, Ferenc D, Fernández E, Firpo R, Flix J, Fonseca MV, Font L, Fuchs M, Galante N, Garczarczyk M, Gaug M, Giller M, Goebel F, Hakobyan D, Hayashida M, Hengstebeck T, Höhne D, Hose J, Hsu CC, Isar PG, Jacon P, Kalekin O, Kosyra R, Kranich D, Laatiaoui M, Laille A, Lenisa T, Liebing P, Lindfors E, Lombardi S, Longo F, López J, López M, Lorenz E, Lucarelli F, Majumdar P, Maneva G, Mannheim K, Mansutti O, Mariotti M, Martínez M, Mase K, Mazin D, Merck C, Meucci M, Meyer M, Miranda JM, Mirzoyan R, Mizobuchi S, Moralejo A, Nilsson K, Oña-Wilhelmi E, Orduña R, Otte N, Oya I, Paneque D, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pavel N, Pegna R, Persic M, Peruzzo L, Piccioli A, Poller M, Pooley G, Prandini E, Raymers A, Rhode W, Ribó M, Rico J, Riegel B, Rissi M, Robert A, Romero GE, Rügamer S, Saggion A, Sánchez A, Sartori P, Scalzotto V, Scapin V, Schmitt R, Schweizer T, Shayduk M, Shinozaki K, Shore SN, Sidro N, Sillanpää A, Sobczynska D, Stamerra A, Stark LS, Takalo L, Temnikov P, Tescaro D, Teshima M, Tonello N, Torres A, Torres DF, Turini N, Vankov H, Vitale V, Wagner RM, Wibig T, Wittek W, Zanin R, Zapatero J.

Science. 2006 Jun 23;312(5781):1771-3. Epub 2006 May 18.

17.

QM/MM Free-Energy Perturbation Compared to Thermodynamic Integration and Umbrella Sampling:  Application to an Enzymatic Reaction.

Kästner J, Senn HM, Thiel S, Otte N, Thiel W.

J Chem Theory Comput. 2006 Mar;2(2):452-61. doi: 10.1021/ct050252w.

PMID:
26626532
18.

Combination of computational prescreening and experimental library construction can accelerate enzyme optimization by directed evolution.

Funke SA, Otte N, Eggert T, Bocola M, Jaeger KE, Thiel W.

Protein Eng Des Sel. 2005 Nov;18(11):509-14. Epub 2005 Oct 3.

PMID:
16203748
19.

Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics.

Schreiner E, Nicolini C, Ludolph B, Ravindra R, Otte N, Kohlmeyer A, Rousseau R, Winter R, Marx D.

Phys Rev Lett. 2004 Apr 9;92(14):148101. Epub 2004 Apr 7.

PMID:
15089575
20.

Learning from directed evolution: theoretical investigations into cooperative mutations in lipase enantioselectivity.

Bocola M, Otte N, Jaeger KE, Reetz MT, Thiel W.

Chembiochem. 2004 Feb 6;5(2):214-23.

PMID:
14760743

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