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Carbon nitride photocatalyzes regioselective aminium radical addition to the carbonyl bond and yields N-fused pyrroles.

Kurpil B, Otte K, Mishchenko A, Lamagni P, Lipiński W, Lock N, Antonietti M, Savateev A.

Nat Commun. 2019 Feb 26;10(1):945. doi: 10.1038/s41467-019-08652-w.


CRISPR/Cas9-mediated knockout of microRNA-744 improves antibody titer of CHO production cell lines.

Raab N, Mathias S, Alt K, Handrick R, Fischer S, Schmieder V, Jadhav V, Borth N, Otte K.

Biotechnol J. 2019 Feb 25:e1800477. doi: 10.1002/biot.201800477. [Epub ahead of print]


Less Is More - Estimation of the Number of Strides Required to Assess Gait Variability in Spatially Confined Settings.

Kroneberg D, Elshehabi M, Meyer AC, Otte K, Doss S, Paul F, Nussbaum S, Berg D, Kühn AA, Maetzler W, Schmitz-Hübsch T.

Front Aging Neurosci. 2019 Jan 21;10:435. doi: 10.3389/fnagi.2018.00435. eCollection 2018.


Genetic redundancy fuels polygenic adaptation in Drosophila.

Barghi N, Tobler R, Nolte V, Jakšić AM, Mallard F, Otte KA, Dolezal M, Taus T, Kofler R, Schlötterer C.

PLoS Biol. 2019 Feb 4;17(2):e3000128. doi: 10.1371/journal.pbio.3000128. eCollection 2019 Feb.


A 24 h Age Difference Causes Twice as Much Gene Expression Divergence as 100 Generations of Adaptation to a Novel Environment.

Hsu SK, Jakšić AM, Nolte V, Barghi N, Mallard F, Otte KA, Schlötterer C.

Genes (Basel). 2019 Jan 28;10(2). pii: E89. doi: 10.3390/genes10020089.


Comparison of the novel ARCHITECT procalcitonin assay with established procalcitonin assay systems.

Soh A, Binder L, Clough M, Hernandez MH, Lefèvre G, Mostert K, Nguyen TB, Otte KM, Portakal O, Sandri MS, Yen JL, Huang J, Beshiri A.

Pract Lab Med. 2018 Nov 9;12:e00110. doi: 10.1016/j.plabm.2018.e00110. eCollection 2018 Nov.


Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5.

Kleemann M, Schneider H, Unger K, Bereuther J, Fischer S, Sander P, Marion Schneider E, Fischer-Posovszky P, Riedel CU, Handrick R, Otte K.

Cell Mol Life Sci. 2019 Feb;76(3):539-559. doi: 10.1007/s00018-018-2958-x. Epub 2018 Nov 3.


MRI Markers and Functional Performance in Patients With CIS and MS: A Cross-Sectional Study.

Rasche L, Scheel M, Otte K, Althoff P, van Vuuren AB, Gieß RM, Kuchling J, Bellmann-Strobl J, Ruprecht K, Paul F, Brandt AU, Schmitz-Hübsch T.

Front Neurol. 2018 Aug 29;9:718. doi: 10.3389/fneur.2018.00718. eCollection 2018.


The influence of ortho-methyl substitution in organometallic self-assembly - a comparative study on Cu(111) vs. Ag(111).

Fritton M, Otte K, Björk J, Biswas PK, Heckl WM, Schmittel M, Lackinger M.

Chem Commun (Camb). 2018 Aug 28;54(70):9745-9748. doi: 10.1039/c8cc04854a.


MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells.

Kleemann M, Schneider H, Unger K, Sander P, Schneider EM, Fischer-Posovszky P, Handrick R, Otte K.

Sci Rep. 2018 Jun 13;8(1):9020. doi: 10.1038/s41598-018-27438-6.


Synthesis and anticancer activity of the derivatives of marine compound rhizochalin in castration resistant prostate cancer.

Dyshlovoy SA, Otte K, Tabakmakher KM, Hauschild J, Makarieva TN, Shubina LK, Fedorov SN, Bokemeyer C, Stonik VA, von Amsberg G.

Oncotarget. 2018 Mar 30;9(24):16962-16973. doi: 10.18632/oncotarget.24764. eCollection 2018 Mar 30.


Stable miRNA overexpression in human CAP cells: Engineering alternative production systems for advanced manufacturing of biologics using miR-136 and miR-3074.

Weis BL, Guth N, Fischer S, Wissing S, Fradin S, Holzmann KH, Handrick R, Otte K.

Biotechnol Bioeng. 2018 Aug;115(8):2027-2038. doi: 10.1002/bit.26715. Epub 2018 May 3.


Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy.

Mathias S, Fischer S, Handrick R, Fieder J, Schulz P, Bradl H, Gorr I, Gamer M, Otte K.

J Biotechnol. 2018 Apr 10;271:47-55. doi: 10.1016/j.jbiotec.2018.02.009. Epub 2018 Mar 2.


Antibody-Mediated Neutralization of uPA Proteolytic Function Reduces Disease Progression in Mouse Arthritis Models.

Almholt K, Hebsgaard JB, Nansen A, Andersson C, Pass J, Rønø B, Thygesen P, Pelzer H, Loftager M, Lund IK, Høyer-Hansen G, Frisch T, Jensen CH, Otte KS, Søe NH, Bartels EM, Andersen M, Bliddal H, Usher PA.

J Immunol. 2018 Feb 1;200(3):957-965. doi: 10.4049/jimmunol.1701317. Epub 2017 Dec 27.


Maximum walking speed in multiple sclerosis assessed with visual perceptive computing.

Grobelny A, Behrens JR, Mertens S, Otte K, Mansow-Model S, Krüger T, Gusho E, Bellmann-Strobl J, Paul F, Brandt AU, Schmitz-Hübsch T.

PLoS One. 2017 Dec 15;12(12):e0189281. doi: 10.1371/journal.pone.0189281. eCollection 2017.


Cementless One-Stage Revision in Chronic Periprosthetic Hip Joint Infection. Ninety-One Percent Infection Free Survival in 56 Patients at Minimum 2-Year Follow-Up.

Lange J, Troelsen A, Solgaard S, Otte KS, Jensen NK, Søballe K; CORIHA Research Group.

J Arthroplasty. 2018 Apr;33(4):1160-1165.e1. doi: 10.1016/j.arth.2017.11.024. Epub 2017 Nov 22.


miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.

Flum M, Kleemann M, Schneider H, Weis B, Fischer S, Handrick R, Otte K.

J Cell Commun Signal. 2018 Jun;12(2):451-466. doi: 10.1007/s12079-017-0410-x. Epub 2017 Sep 14.


Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells.

Dyshlovoy SA, Rast S, Hauschild J, Otte K, Alsdorf WH, Madanchi R, Kalinin VI, Silchenko AS, Avilov SA, Dierlamm J, Honecker F, Stonik VA, Bokemeyer C, von Amsberg G.

Leuk Lymphoma. 2017 Dec;58(12):2905-2915. doi: 10.1080/10428194.2017.1317091. Epub 2017 May 16.


Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):857-862. doi: 10.1007/s00210-017-1376-1. Epub 2017 Apr 27.


Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin.

Dyshlovoy SA, Otte K, Venz S, Hauschild J, Junker H, Makarieva TN, Balabanov S, Alsdorf WH, Madanchi R, Honecker F, Bokemeyer C, Stonik VA, von Amsberg G.

Proteomics. 2017 Jun;17(11). doi: 10.1002/pmic.201700048.


miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.

Schoellhorn M, Fischer S, Wagner A, Handrick R, Otte K.

Biotechnol Prog. 2017 Jul;33(4):1046-1058. doi: 10.1002/btpr.2475. Epub 2017 Apr 21.


Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial.

Nangia J, Wang T, Osborne C, Niravath P, Otte K, Papish S, Holmes F, Abraham J, Lacouture M, Courtright J, Paxman R, Rude M, Hilsenbeck S, Osborne CK, Rimawi M.

JAMA. 2017 Feb 14;317(6):596-605. doi: 10.1001/jama.2016.20939.


The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells.

Dyshlovoy SA, Madanchi R, Hauschild J, Otte K, Alsdorf WH, Schumacher U, Kalinin VI, Silchenko AS, Avilov SA, Honecker F, Stonik VA, Bokemeyer C, von Amsberg G.

BMC Cancer. 2017 Feb 1;17(1):93. doi: 10.1186/s12885-017-3085-z.


Polymorphism-aware protein databases - a prerequisite for an unbiased proteomic analysis of natural populations.

Otte KA, Schlötterer C.

Mol Ecol Resour. 2017 Nov;17(6):1148-1155. doi: 10.1111/1755-0998.12656. Epub 2017 Mar 30.


Subjective and objective assessment of physical activity in multiple sclerosis and their relation to health-related quality of life.

Krüger T, Behrens JR, Grobelny A, Otte K, Mansow-Model S, Kayser B, Bellmann-Strobl J, Brandt AU, Paul F, Schmitz-Hübsch T.

BMC Neurol. 2017 Jan 13;17(1):10. doi: 10.1186/s12883-016-0783-0.


Accuracy and Reliability of the Kinect Version 2 for Clinical Measurement of Motor Function.

Otte K, Kayser B, Mansow-Model S, Verrel J, Paul F, Brandt AU, Schmitz-Hübsch T.

PLoS One. 2016 Nov 18;11(11):e0166532. doi: 10.1371/journal.pone.0166532. eCollection 2016.


Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis.

Kleemann M, Bereuther J, Fischer S, Marquart K, Hänle S, Unger K, Jendrossek V, Riedel CU, Handrick R, Otte K.

Oncotarget. 2017 Mar 21;8(12):18773-18791. doi: 10.18632/oncotarget.13095.


Improved cryotolerance and developmental potential of in vitro and in vivo matured mouse oocytes by supplementing with a glutathione donor prior to vitrification.

Trapphoff T, Heiligentag M, Simon J, Staubach N, Seidel T, Otte K, Fröhlich T, Arnold GJ, Eichenlaub-Ritter U.

Mol Hum Reprod. 2016 Dec;22(12):867-881. Epub 2016 Sep 7.


miR-483 is a self-regulating microRNA and can activate its own expression via USF1 in HeLa cells.

Emmerling VV, Fischer S, Kleemann M, Handrick R, Kochanek S, Otte K.

Int J Biochem Cell Biol. 2016 Nov;80:81-86. doi: 10.1016/j.biocel.2016.09.022. Epub 2016 Sep 28.


Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.

Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ.

Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362.


Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer.

Dyshlovoy SA, Otte K, Alsdorf WH, Hauschild J, Lange T, Venz S, Bauer CK, Bähring R, Amann K, Mandanchi R, Schumacher U, Schröder-Schwarz J, Makarieva TN, Guzii AG, Tabakmakher KM, Fedorov SN, Shubina LK, Kasheverov IE, Ehmke H, Steuber T, Stonik VA, Bokemeyer C, Honecker F, von Amsberg G.

Oncotarget. 2016 Oct 25;7(43):69703-69717. doi: 10.18632/oncotarget.11941.


Suitability of Different Mapping Algorithms for Genome-Wide Polymorphism Scans with Pool-Seq Data.

Kofler R, Langmüller AM, Nouhaud P, Otte KA, Schlötterer C.

G3 (Bethesda). 2016 Nov 8;6(11):3507-3515. doi: 10.1534/g3.116.034488.


Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro.

Dyshlovoy SA, Tabakmakher KM, Hauschild J, Shchekaleva RK, Otte K, Guzii AG, Makarieva TN, Kudryashova EK, Fedorov SN, Shubina LK, Bokemeyer C, Honecker F, Stonik VA, von Amsberg G.

Mar Drugs. 2016 Jul 15;14(7). pii: E133. doi: 10.3390/md14070133.


Production of ω-hydroxy octanoic acid with Escherichia coli.

Kirtz M, Klebensberger J, Otte KB, Richter SM, Hauer B.

J Biotechnol. 2016 Jul 20;230:30-3. doi: 10.1016/j.jbiotec.2016.05.017. Epub 2016 May 13.


Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s.

Weissenborn MJ, Notonier S, Lang SL, Otte KB, Herter S, Turner NJ, Flitsch SL, Hauer B.

Chem Commun (Camb). 2016 May 4;52(36):6158-61. doi: 10.1039/c6cc01749e. Epub 2016 Apr 14.


miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering.

Stiefel F, Fischer S, Sczyrba A, Otte K, Hesse F.

J Biotechnol. 2016 May 10;225:31-43. doi: 10.1016/j.jbiotec.2016.03.028. Epub 2016 Mar 19.


Anti-migratory activity of marine alkaloid monanchocidin A - proteomics-based discovery and confirmation.

Dyshlovoy SA, Venz S, Hauschild J, Tabakmakher KM, Otte K, Madanchi R, Walther R, Guzii AG, Makarieva TN, Shubina LK, Fedorov SN, Stonik VA, Bokemeyer C, Balabanov S, Honecker F, V Amsberg G.

Proteomics. 2016 May;16(10):1590-603. doi: 10.1002/pmic.201500334. Epub 2016 Apr 27.


Ranking of Dystonia Severity by Pairwise Video Comparison.

Ellermeyer T, Otte K, Heinrich F, Mansow-Model S, Kayser B, Lipp A, Seidel A, Krause P, Lauritsch K, Gusho E, Paul F, Kühn AA, Brandt AU, Schmitz-Hübsch T.

Mov Disord Clin Pract. 2016 Mar 24;3(6):587-595. doi: 10.1002/mdc3.12340. eCollection 2016 Nov-Dec.


GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M.

Endocrinology. 2016 Jun;157(6):2416-31. doi: 10.1210/en.2015-1927. Epub 2016 Mar 14.


Validity of visual perceptive computing for static posturography in patients with multiple sclerosis.

Behrens JR, Mertens S, Krüger T, Grobelny A, Otte K, Mansow-Model S, Gusho E, Paul F, Brandt AU, Schmitz-Hübsch T.

Mult Scler. 2016 Oct;22(12):1596-1606. Epub 2016 Jan 26.


The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.

Dyshlovoy SA, Menchinskaya ES, Venz S, Rast S, Amann K, Hauschild J, Otte K, Kalinin VI, Silchenko AS, Avilov SA, Alsdorf W, Madanchi R, Bokemeyer C, Schumacher U, Walther R, Aminin DL, Fedorov SN, Shubina LK, Stonik VA, Balabanov S, Honecker F, von Amsberg G.

Int J Cancer. 2016 May 15;138(10):2450-65. doi: 10.1002/ijc.29977. Epub 2016 Jan 23.


Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy.

Osswald A, Sun Z, Grimm V, Ampem G, Riegel K, Westendorf AM, Sommergruber W, Otte K, Dürre P, Riedel CU.

Microb Cell Fact. 2015 Dec 12;14:199. doi: 10.1186/s12934-015-0383-5.


The art of CHO cell engineering: A comprehensive retrospect and future perspectives.

Fischer S, Handrick R, Otte K.

Biotechnol Adv. 2015 Dec;33(8):1878-96. doi: 10.1016/j.biotechadv.2015.10.015. Epub 2015 Oct 31. Review.


Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells.

Emmerling VV, Fischer S, Stiefel F, Holzmann K, Handrick R, Hesse F, Hörer M, Kochanek S, Otte K.

Biotechnol Bioeng. 2016 Apr;113(4):830-41. doi: 10.1002/bit.25853. Epub 2015 Oct 20.


Reflexivity in Teams: A Review and New Perspectives.

Konradt U, Otte KP, Schippers MC, Steenfatt C.

J Psychol. 2016;150(2):153-74. doi: 10.1080/00223980.2015.1050977. Epub 2015 Oct 12. Review.


Removal of restrictions following primary THA with posterolateral approach does not increase the risk of early dislocation--reply.

Gromov K, Troelsen A, Otte KS, Ørsnes T, Ladelund S, Husted H.

Acta Orthop. 2015;86(4):518-9. No abstract available.


The influence of simulated microgravity on the proteome of Daphnia magna.

Trotter B, Otte KA, Schoppmann K, Hemmersbach R, Fröhlich T, Arnold GJ, Laforsch C.

NPJ Microgravity. 2015 Sep 24;1:15016. doi: 10.1038/npjmgrav.2015.16. eCollection 2015.


Enhanced protein production by microRNA-30 family in CHO cells is mediated by the modulation of the ubiquitin pathway.

Fischer S, Mathias S, Schaz S, Emmerling VV, Buck T, Kleemann M, Hackl M, Grillari J, Aschrafi A, Handrick R, Otte K.

J Biotechnol. 2015 Oct 20;212:32-43. doi: 10.1016/j.jbiotec.2015.08.002. Epub 2015 Aug 6.


Proteomic analysis of extracellular medium of cryopreserved carp (Cyprinus carpio L.) semen.

Dietrich MA, Arnold GJ, Fröhlich T, Otte KA, Dietrich GJ, Ciereszko A.

Comp Biochem Physiol Part D Genomics Proteomics. 2015 Sep;15:49-57. doi: 10.1016/j.cbd.2015.05.003. Epub 2015 Jun 6.


Interclonal proteomic responses to predator exposure in Daphnia magna may depend on predator composition of habitats.

Otte KA, Schrank I, Fröhlich T, Arnold GJ, Laforsch C.

Mol Ecol. 2015 Aug;24(15):3901-17. doi: 10.1111/mec.13287. Epub 2015 Jul 20.


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