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Items: 1 to 50 of 94

1.

Aberrant differential expression of EZH1 and EZH2 in Polycomb repressive complex 2 among B- and T/NK-cell neoplasms.

Abdalkader L, Oka T, Takata K, Sato H, Murakami I, Otte AP, Yoshino T.

Pathology. 2016 Aug;48(5):467-82. doi: 10.1016/j.pathol.2016.05.002. Epub 2016 Jun 14.

PMID:
27311868
2.

Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy.

Cerase A, Smeets D, Tang YA, Gdula M, Kraus F, Spivakov M, Moindrot B, Leleu M, Tattermusch A, Demmerle J, Nesterova TB, Green C, Otte AP, Schermelleh L, Brockdorff N.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2235-40. doi: 10.1073/pnas.1312951111. Epub 2014 Jan 27.

3.

Role of transcriptional corepressor CtBP1 in prostate cancer progression.

Wang R, Asangani IA, Chakravarthi BV, Ateeq B, Lonigro RJ, Cao Q, Mani RS, Camacho DF, McGregor N, Schumann TE, Jing X, Menawat R, Tomlins SA, Zheng H, Otte AP, Mehra R, Siddiqui J, Dhanasekaran SM, Nyati MK, Pienta KJ, Palanisamy N, Kunju LP, Rubin MA, Chinnaiyan AM, Varambally S.

Neoplasia. 2012 Oct;14(10):905-14.

4.

Methods to create a stringent selection system for mammalian cell lines.

Van Blokland HJ, Hoeksema F, Siep M, Otte AP, Verhees JA.

Cytotechnology. 2011 Aug;63(4):371-84. doi: 10.1007/s10616-011-9354-9. Epub 2011 Apr 21.

5.

Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels.

Hoeksema F, Hamer K, Siep M, Verhees JA, Otte AP.

Biotechnol Res Int. 2011;2011:492875. doi: 10.4061/2011/492875. Epub 2010 Dec 19.

6.

Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.

Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H.

Mol Cell Biol. 2011 Jan;31(2):351-64. doi: 10.1128/MCB.00259-10. Epub 2010 Nov 8. Erratum in: Mol Cell Biol. 2014 Jul;34(14):2773.

7.

The use of a stringent selection system allows the identification of DNA elements that augment gene expression.

Hoeksema F, van Blokland R, Siep M, Hamer K, Siersma T, den Blaauwen J, Verhees J, Otte AP.

Mol Biotechnol. 2011 May;48(1):19-29. doi: 10.1007/s12033-010-9344-8.

8.

Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.

Inoue K, Kohda T, Sugimoto M, Sado T, Ogonuki N, Matoba S, Shiura H, Ikeda R, Mochida K, Fujii T, Sawai K, Otte AP, Tian XC, Yang X, Ishino F, Abe K, Ogura A.

Science. 2010 Oct 22;330(6003):496-9. doi: 10.1126/science.1194174. Epub 2010 Sep 16.

9.

Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis.

Fluge Ø, Gravdal K, Carlsen E, Vonen B, Kjellevold K, Refsum S, Lilleng R, Eide TJ, Halvorsen TB, Tveit KM, Otte AP, Akslen LA, Dahl O; Norwegian Gastrointestinal Cancer Group.

Br J Cancer. 2009 Oct 20;101(8):1282-9. doi: 10.1038/sj.bjc.6605333. Epub 2009 Sep 22.

10.

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.

Boukarabila H, Saurin AJ, Batsché E, Mossadegh N, van Lohuizen M, Otte AP, Pradel J, Muchardt C, Sieweke M, Duprez E.

Genes Dev. 2009 May 15;23(10):1195-206. doi: 10.1101/gad.512009.

11.

Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.

Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH.

Dev Cell. 2008 Nov;15(5):668-79. doi: 10.1016/j.devcel.2008.08.015. Epub 2008 Oct 9.

12.

Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.

Hoffmann MJ, Engers R, Florl AR, Otte AP, Muller M, Schulz WA.

Cancer Biol Ther. 2007 Sep;6(9):1403-12.

PMID:
18637271
13.

Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma.

Engelsen IB, Mannelqvist M, Stefansson IM, Carter SL, Beroukhim R, Øyan AM, Otte AP, Kalland KH, Akslen LA, Salvesen HB.

Br J Cancer. 2008 May 20;98(10):1662-9. doi: 10.1038/sj.bjc.6604360. Epub 2008 May 13.

14.

Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.

Endoh M, Endo TA, Endoh T, Fujimura Y, Ohara O, Toyoda T, Otte AP, Okano M, Brockdorff N, Vidal M, Koseki H.

Development. 2008 Apr;135(8):1513-24. doi: 10.1242/dev.014340. Epub 2008 Mar 13.

15.

High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma.

Vékony H, Raaphorst FM, Otte AP, van Lohuizen M, Leemans CR, van der Waal I, Bloemena E.

J Clin Pathol. 2008 Jun;61(6):744-9. doi: 10.1136/jcp.2007.054262. Epub 2008 Mar 6.

PMID:
18326020
16.

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.

Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH.

Nat Genet. 2008 Apr;40(4):411-20. doi: 10.1038/ng.99. Epub 2008 Mar 2.

PMID:
18311137
17.

Loss of BMI-1 expression is associated with clinical progress of malignant melanoma.

Bachmann IM, Puntervoll HE, Otte AP, Akslen LA.

Mod Pathol. 2008 May;21(5):583-90. doi: 10.1038/modpathol.2008.17. Epub 2008 Feb 8.

18.

Various expression-augmenting DNA elements benefit from STAR-Select, a novel high stringency selection system for protein expression.

Otte AP, Kwaks TH, van Blokland RJ, Sewalt RG, Verhees J, Klaren VN, Siersma TK, Korse HW, Teunissen NC, Botschuijver S, van Mer C, Man SY.

Biotechnol Prog. 2007 Jul-Aug;23(4):801-7. Epub 2007 Jun 22.

PMID:
17585780
19.

Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.

van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA, Otte AP, Meijer CJ, Raaphorst FM.

Eur Urol. 2007 Aug;52(2):455-63. Epub 2006 Nov 17.

PMID:
17134822
20.

A novel, high stringency selection system allows screening of few clones for high protein expression.

van Blokland HJ, Kwaks TH, Sewalt RG, Verhees JA, Klaren VN, Siersma TK, Korse JW, Teunissen NC, Botschuijver S, van Mer C, Man SY, Otte AP.

J Biotechnol. 2007 Feb 1;128(2):237-45. Epub 2006 Oct 10.

PMID:
17092592
21.

Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL.

van Galen JC, Muris JJ, Oudejans JJ, Vos W, Giroth CP, Ossenkoppele GJ, Otte AP, Raaphorst FM, Meijer CJ.

J Clin Pathol. 2007 Feb;60(2):167-72. Epub 2006 Jul 12.

22.

Control of developmental regulators by Polycomb in human embryonic stem cells.

Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA.

Cell. 2006 Apr 21;125(2):301-13.

23.

Polycomb complexes repress developmental regulators in murine embryonic stem cells.

Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R.

Nature. 2006 May 18;441(7091):349-53. Epub 2006 Apr 19.

PMID:
16625203
24.

Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer.

Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A, Aas T, Otte AP, Akslen LA.

Clin Cancer Res. 2006 Feb 15;12(4):1168-74.

25.

Employing epigenetics to augment the expression of therapeutic proteins in mammalian cells.

Kwaks TH, Otte AP.

Trends Biotechnol. 2006 Mar;24(3):137-42. Epub 2006 Feb 7. Review.

PMID:
16460822
26.

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.

Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T.

Nat Cell Biol. 2006 Feb;8(2):195-202. Epub 2006 Jan 15.

27.

EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast.

Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, Salvesen HB, Otte AP, Akslen LA.

J Clin Oncol. 2006 Jan 10;24(2):268-73. Epub 2005 Dec 5.

PMID:
16330673
28.

Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice.

Okamoto I, Arnaud D, Le Baccon P, Otte AP, Disteche CM, Avner P, Heard E.

Nature. 2005 Nov 17;438(7066):369-73. Epub 2005 Oct 16.

PMID:
16227973
29.

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.

Science. 2005 Oct 14;310(5746):306-10.

30.

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.

Montgomery ND, Yee D, Chen A, Kalantry S, Chamberlain SJ, Otte AP, Magnuson T.

Curr Biol. 2005 May 24;15(10):942-7.

31.

Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions.

Breuer RH, Snijders PJ, Sutedja GT, Sewalt RG, Otte AP, Postmus PE, Meijer CJ, Raaphorst FM, Smit EF.

Lung Cancer. 2005 Jun;48(3):299-306.

PMID:
15892997
32.

Dynamic chromatin modifications characterise the first cell cycle in mouse embryos.

Santos F, Peters AH, Otte AP, Reik W, Dean W.

Dev Biol. 2005 Apr 1;280(1):225-36.

33.

X chromosome reactivation and regulation in cloned embryos.

Nolen LD, Gao S, Han Z, Mann MR, Gie Chung Y, Otte AP, Bartolomei MS, Latham KE.

Dev Biol. 2005 Mar 15;279(2):525-40.

34.

Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis.

Breuer RH, Snijders PJ, Smit EF, Sutedja TG, Sewalt RG, Otte AP, van Kemenade FJ, Postmus PE, Meijer CJ, Raaphorst FM.

Neoplasia. 2004 Nov-Dec;6(6):736-43.

35.

Targeting of a histone acetyltransferase domain to a promoter enhances protein expression levels in mammalian cells.

Kwaks TH, Sewalt RG, van Blokland R, Siersma TJ, Kasiem M, Kelder A, Otte AP.

J Biotechnol. 2005 Jan 12;115(1):35-46.

PMID:
15607223
36.

Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.

Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B.

J Cell Biol. 2004 Dec 20;167(6):1025-35. Epub 2004 Dec 13.

37.

Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N.

Dev Cell. 2004 Nov;7(5):663-76.

38.

Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction.

van Galen JC, Dukers DF, Giroth C, Sewalt RG, Otte AP, Meijer CJ, Raaphorst FM.

Eur J Immunol. 2004 Jul;34(7):1870-81.

39.

Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines.

Dukers DF, van Galen JC, Giroth C, Jansen P, Sewalt RG, Otte AP, Kluin-Nelemans HC, Meijer CJ, Raaphorst FM.

Am J Pathol. 2004 Mar;164(3):873-81.

40.
41.

Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene.

Raaphorst FM, Meijer CJ, Fieret E, Blokzijl T, Mommers E, Buerger H, Packeisen J, Sewalt RA, Otte AP, van Diest PJ.

Neoplasia. 2003 Nov-Dec;5(6):481-8.

42.

Reactivation of the paternal X chromosome in early mouse embryos.

Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N.

Science. 2004 Jan 30;303(5658):666-9.

43.

Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas.

Raaphorst FM, Vermeer M, Fieret E, Blokzijl T, Dukers D, Sewalt RG, Otte AP, Willemze R, Meijer CJ.

Am J Pathol. 2004 Feb;164(2):533-42.

44.

Epigenetic dynamics of imprinted X inactivation during early mouse development.

Okamoto I, Otte AP, Allis CD, Reinberg D, Heard E.

Science. 2004 Jan 30;303(5658):644-9. Epub 2003 Dec 11.

45.

Gene repression by Polycomb group protein complexes: a distinct complex for every occasion?

Otte AP, Kwaks TH.

Curr Opin Genet Dev. 2003 Oct;13(5):448-54. Review.

PMID:
14550408
46.

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.

Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11606-11. Epub 2003 Sep 19.

47.

Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer.

Rhodes DR, Sanda MG, Otte AP, Chinnaiyan AM, Rubin MA.

J Natl Cancer Inst. 2003 May 7;95(9):661-8.

PMID:
12734317
48.

Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.

Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N.

Dev Cell. 2003 Apr;4(4):481-95.

49.

Identification of anti-repressor elements that confer high and stable protein production in mammalian cells.

Kwaks TH, Barnett P, Hemrika W, Siersma T, Sewalt RG, Satijn DP, Brons JF, van Blokland R, Kwakman P, Kruckeberg AL, Kelder A, Otte AP.

Nat Biotechnol. 2003 May;21(5):553-8. Epub 2003 Apr 7. Erratum in: Nat Biotechnol. 2003 Jul;21(7):822.

PMID:
12679786
50.

Role of histone H3 lysine 27 methylation in X inactivation.

Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y.

Science. 2003 Apr 4;300(5616):131-5. Epub 2003 Mar 20.

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