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Items: 36

1.

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.

Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ.

Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19.

PMID:
31543463
2.

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.

Viny AD, Bowman RL, Liu Y, Lavallée VP, Eisman SE, Xiao W, Durham BH, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe'er D, Dekker J, Koche R, Levine RL.

Cell Stem Cell. 2019 Nov 7;25(5):682-696.e8. doi: 10.1016/j.stem.2019.08.003. Epub 2019 Sep 5.

PMID:
31495782
3.

Small-molecule targeting of brachyury transcription factor addiction in chordoma.

Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL.

Nat Med. 2019 Feb;25(2):292-300. doi: 10.1038/s41591-018-0312-3. Epub 2019 Jan 21.

4.

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.

Fulciniti M, Lin CY, Samur MK, Lopez MA, Singh I, Lawlor MA, Szalat RE, Ott CJ, Avet-Loiseau H, Anderson KC, Young RA, Bradner JE, Munshi NC.

Cell Rep. 2018 Dec 26;25(13):3693-3705.e6. doi: 10.1016/j.celrep.2018.12.016.

5.

Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.

Ott CJ, Federation AJ, Schwartz LS, Kasar S, Klitgaard JL, Lenci R, Li Q, Lawlor M, Fernandes SM, Souza A, Polaski D, Gadi D, Freedman ML, Brown JR, Bradner JE.

Cancer Cell. 2018 Dec 10;34(6):982-995.e7. doi: 10.1016/j.ccell.2018.11.001. Epub 2018 Nov 29.

PMID:
30503705
6.

Opportunities for targeting gene regulatory factors in B-cell acute lymphoblastic leukemia.

Ott CJ.

Int J Hematol Oncol. 2017 Nov;6(3):57-59. doi: 10.2217/ijh-2017-0018. Epub 2017 Nov 20. No abstract available.

7.

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.

Peeken JC, Jutzi JS, Wehrle J, Koellerer C, Staehle HF, Becker H, Schoenwandt E, Seeger TS, Schanne DH, Gothwal M, Ott CJ, Gründer A, Pahl HL.

Blood. 2018 May 3;131(18):2065-2073. doi: 10.1182/blood-2017-10-810622. Epub 2018 Mar 8.

8.

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.

Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE.

Nat Chem Biol. 2018 Apr;14(4):405-412. doi: 10.1038/s41589-018-0010-y. Epub 2018 Mar 5.

9.

HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.

Ott CJ, Wu CJ.

Cancer Cell. 2017 Jul 10;32(1):1-3. doi: 10.1016/j.ccell.2017.06.008.

10.

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.

Winter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS, Bradner JE.

Mol Cell. 2017 Jul 6;67(1):5-18.e19. doi: 10.1016/j.molcel.2017.06.004. Epub 2017 Jun 29.

11.

A chemical probe toolbox for dissecting the cancer epigenome.

Shortt J, Ott CJ, Johnstone RW, Bradner JE.

Nat Rev Cancer. 2017 Mar 23;17(4):268. doi: 10.1038/nrc.2017.26. No abstract available.

PMID:
28332503
12.

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.

Hogg SJ, Vervoort SJ, Deswal S, Ott CJ, Li J, Cluse LA, Beavis PA, Darcy PK, Martin BP, Spencer A, Traunbauer AK, Sadovnik I, Bauer K, Valent P, Bradner JE, Zuber J, Shortt J, Johnstone RW.

Cell Rep. 2017 Feb 28;18(9):2162-2174. doi: 10.1016/j.celrep.2017.02.011.

13.

A chemical probe toolbox for dissecting the cancer epigenome.

Shortt J, Ott CJ, Johnstone RW, Bradner JE.

Nat Rev Cancer. 2017 Feb 23;17(3):160-183. doi: 10.1038/nrc.2016.148. Review. Erratum in: Nat Rev Cancer. 2017 Mar 23;17 (4):268.

PMID:
28228643
14.

Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.

Koblan LW, Buckley DL, Ott CJ, Fitzgerald ME, Ember SW, Zhu JY, Liu S, Roberts JM, Remillard D, Vittori S, Zhang W, Schonbrunn E, Bradner JE.

ChemMedChem. 2016 Dec 6;11(23):2575-2581. doi: 10.1002/cmdc.201600502. Epub 2016 Nov 15.

PMID:
27862999
15.

ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication.

Koo SJ, Fernández-Montalván AE, Badock V, Ott CJ, Holton SJ, von Ahsen O, Toedling J, Vittori S, Bradner JE, Gorjánácz M.

Oncotarget. 2016 Oct 25;7(43):70323-70335. doi: 10.18632/oncotarget.11855.

16.

Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes.

Yang S, Ott CJ, Rossmann MP, Superdock M, Zon LI, Zhou Y.

Methods Cell Biol. 2016;135:387-412. doi: 10.1016/bs.mcb.2016.04.019. Epub 2016 Jun 20.

17.

Spiclypeus shipporum gen. et sp. nov., a Boldly Audacious New Chasmosaurine Ceratopsid (Dinosauria: Ornithischia) from the Judith River Formation (Upper Cretaceous: Campanian) of Montana, USA.

Mallon JC, Ott CJ, Larson PL, Iuliano EM, Evans DC.

PLoS One. 2016 May 18;11(5):e0154218. doi: 10.1371/journal.pone.0154218. eCollection 2016.

18.

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.

Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL.

J Exp Med. 2015 Oct 19;212(11):1819-32. doi: 10.1084/jem.20151317. Epub 2015 Oct 5.

19.

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE.

Nat Genet. 2014 Apr;46(4):364-70. doi: 10.1038/ng.2913. Epub 2014 Mar 2.

20.

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr.

Science. 2014 Jan 17;343(6168):305-9. doi: 10.1126/science.1244917. Epub 2013 Nov 29.

21.

Nucleosome mapping across the CFTR locus identifies novel regulatory factors.

Yigit E, Bischof JM, Zhang Z, Ott CJ, Kerschner JL, Leir SH, Buitrago-Delgado E, Zhang Q, Wang JP, Widom J, Harris A.

Nucleic Acids Res. 2013 Mar 1;41(5):2857-68. doi: 10.1093/nar/gks1462. Epub 2013 Jan 15.

22.

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.

Ott CJ, Kopp N, Bird L, Paranal RM, Qi J, Bowman T, Rodig SJ, Kung AL, Bradner JE, Weinstock DM.

Blood. 2012 Oct 4;120(14):2843-52. doi: 10.1182/blood-2012-02-413021. Epub 2012 Aug 17.

23.

A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function.

Bischof JM, Ott CJ, Leir SH, Gosalia N, Song L, London D, Furey TS, Cotton CU, Crawford GE, Harris A.

Thorax. 2012 May;67(5):385-91. doi: 10.1136/thoraxjnl-2011-200880. Epub 2011 Dec 14.

24.

Nucleosome occupancy reveals regulatory elements of the CFTR promoter.

Ott CJ, Bischof JM, Unti KM, Gillen AE, Leir SH, Harris A.

Nucleic Acids Res. 2012 Jan;40(2):625-37. doi: 10.1093/nar/gkr754. Epub 2011 Sep 24.

25.

Molecular mechanisms controlling CFTR gene expression in the airway.

Zhang Z, Ott CJ, Lewandowska MA, Leir SH, Harris A.

J Cell Mol Med. 2012 Jun;16(6):1321-30. doi: 10.1111/j.1582-4934.2011.01439.x.

26.

Genomic approaches to studying CFTR transcriptional regulation.

Ott CJ, Harris A.

Methods Mol Biol. 2011;741:193-209. doi: 10.1007/978-1-61779-117-8_13.

PMID:
21594786
27.

Genomic approaches for the discovery of CFTR regulatory elements.

Ott CJ, Harris A.

Transcription. 2011 Jan-Feb;2(1):23-7. doi: 10.4161/trns.2.1.13693.

28.
29.

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.

Ott CJ, Blackledge NP, Kerschner JL, Leir SH, Crawford GE, Cotton CU, Harris A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19934-9. doi: 10.1073/pnas.0900946106. Epub 2009 Nov 6.

30.

Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression.

McCarthy VA, Ott CJ, Phylactides M, Harris A.

Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):709-18. doi: 10.1016/j.bbagrm.2009.09.005. Epub 2009 Sep 24.

31.

Novel regulatory mechanisms for the CFTR gene.

Ott CJ, Blackledge NP, Leir SH, Harris A.

Biochem Soc Trans. 2009 Aug;37(Pt 4):843-8. doi: 10.1042/BST0370843. Review.

32.

A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.

Ott CJ, Suszko M, Blackledge NP, Wright JE, Crawford GE, Harris A.

J Cell Mol Med. 2009 Apr;13(4):680-92.

33.

An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells.

Blackledge NP, Ott CJ, Gillen AE, Harris A.

Nucleic Acids Res. 2009 Mar;37(4):1086-94. doi: 10.1093/nar/gkn1056. Epub 2009 Jan 7.

34.

Mouse model for acute bacterial prostatitis in genetically distinct inbred strains.

Elkahwaji JE, Ott CJ, Janda LM, Hopkins WJ.

Urology. 2005 Oct;66(4):883-7.

PMID:
16230175
35.

Inheritance of susceptibility to induced Escherichia coli bladder and kidney infections in female C3H/HeJ mice.

Hopkins WJ, Elkahwaji JE, Heisey DM, Ott CJ.

J Infect Dis. 2003 Feb 1;187(3):418-23. Epub 2003 Jan 24.

PMID:
12552425
36.

Medical malpractice and the emergency medicine resident.

Ott CJ, Houry DE.

Ann Emerg Med. 2000 Dec;36(6):631-3. No abstract available.

PMID:
11097709

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