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Anti-cancer activity of the cell membrane-permeable phytic acid prodrug.

Masunaga T, Murao N, Tateishi H, Koga R, Ohsugi T, Otsuka M, Fujita M.

Bioorg Chem. 2019 Sep 4;92:103240. doi: 10.1016/j.bioorg.2019.103240. [Epub ahead of print]


Fundamental evaluation and optimization of porous spherical silica for developing functional fine particles via fluidized bed coating.

Taki H, Kobashi A, Ishida M, Otsuka M.

Int J Pharm. 2019 Sep 9:118685. doi: 10.1016/j.ijpharm.2019.118685. [Epub ahead of print]


Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement.

Radwan MO, Ciftci HI, Ali TFS, Ellakwa DE, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Okamoto Y, Fujita M, Otsuka M.

Molecules. 2019 Sep 10;24(18). pii: E3295. doi: 10.3390/molecules24183295.


Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.

Sever B, Altıntop MD, Radwan MO, Özdemir A, Otsuka M, Fujita M, Ciftci HI.

Eur J Med Chem. 2019 Aug 28;182:111648. doi: 10.1016/j.ejmech.2019.111648. [Epub ahead of print]


Robustness of network attack strategies against node sampling and link errors.

Otsuka M, Tsugawa S.

PLoS One. 2019 Sep 4;14(9):e0221885. doi: 10.1371/journal.pone.0221885. eCollection 2019.


Feasibility of rapid on-site cytologic evaluation of lung cancer by a trained pulmonologist during bronchoscopy examination.

Umeda Y, Otsuka M, Nishikiori H, Ikeda K, Mori Y, Kobayashi T, Asai Y, Takahashi Y, Sudo Y, Kodama K, Yamada G, Chiba H, Takahashi H.

Cytopathology. 2019 Sep 3. doi: 10.1111/cyt.12771. [Epub ahead of print]


HBV-RNA, a new rule for stopping nucleos(t)ide analogues.

Otsuka M, Koike K.

Clin Gastroenterol Hepatol. 2019 Aug 29. pii: S1542-3565(19)30919-X. doi: 10.1016/j.cgh.2019.08.044. [Epub ahead of print] No abstract available.


Factors related to filtration-bleb morphology after Ex-PRESS® surgery.

Tojo N, Hayashi A, Otsuka M.

Indian J Ophthalmol. 2019 Sep;67(9):1439-1446. doi: 10.4103/ijo.IJO_2121_18.


Risk factors for acute exacerbation of idiopathic interstitial pneumonia in patients undergoing lung cancer treatment.

Taya T, Chiba H, Yamada G, Takahashi M, Ikeda K, Mori Y, Otsuka M, Takahashi H.

Jpn J Clin Oncol. 2019 Aug 14. pii: hyz115. doi: 10.1093/jjco/hyz115. [Epub ahead of print]


APOBEC3 regulates keratinocyte differentiation and expression of Notch3.

Dainichi T, Nakano Y, Wakae K, Otsuka M, Muramatsu M, Kabashima K.

Exp Dermatol. 2019 Aug 10. doi: 10.1111/exd.14019. [Epub ahead of print]


Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.

Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.

J Allergy Clin Immunol. 2019 Jul 18. pii: S0091-6749(19)30832-2. doi: 10.1016/j.jaci.2019.06.019. [Epub ahead of print]


Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.

Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y.

Cancer Sci. 2019 Aug 1. doi: 10.1111/cas.14154. [Epub ahead of print]


Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels.

Tanaka E, Miyakawa Y, Kishikawa T, Seimiya T, Iwata T, Funato K, Odawara N, Sekiba K, Yamagami M, Suzuki T, Ishibashi R, Otsuka M, Koike K.

Oncol Rep. 2019 Oct;42(4):1459-1466. doi: 10.3892/or.2019.7244. Epub 2019 Jul 19.


Accuracy of the point-of-care glucose meter for use in calves.

Nishi Y, Murakami Y, Otsuka M, Tsukano K, Ajito T, Suzuki K.

J Vet Med Sci. 2019 Jul 15. doi: 10.1292/jvms.19-0272. [Epub ahead of print]


Variations of the Dose Distribution Between CT- and CBCT-based Plans for Oropharyngeal Cancer.

Otsuka M, Monzen H, Ishikawa K, Doi H, Matsumoto K, Tamura M, Nishimura Y.

In Vivo. 2019 Jul-Aug;33(4):1271-1277. doi: 10.21873/invivo.11599.


Kinetics Study of Cocrystal Formation Between Indomethacin and Saccharin Using High-Shear Granulation With In Situ Raman Spectroscopy.

Tanaka R, Hattori Y, Ashizawa K, Otsuka M.

J Pharm Sci. 2019 Jul 4. pii: S0022-3549(19)30422-8. doi: 10.1016/j.xphs.2019.06.019. [Epub ahead of print]


Minimum structural requirements for inhibitors of the zinc finger protein TRAF6.

Radwan MO, Koga R, Hida T, Ejima T, Kanemaru Y, Tateishi H, Okamoto Y, Inoue JI, Fujita M, Otsuka M.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2162-2167. doi: 10.1016/j.bmcl.2019.06.050. Epub 2019 Jun 27.


Additive Duloxetine for Cancer-Related Neuropathic Pain Nonresponsive or Intolerant to Opioid-Pregabalin Therapy: A Randomized Controlled Trial (JORTC-PAL08).

Matsuoka H, Iwase S, Miyaji T, Kawaguchi T, Ariyoshi K, Oyamada S, Satomi E, Ishiki H, Hasuo H, Sakuma H, Tokoro A, Shinomiya T, Otani H, Ohtake Y, Tsukuura H, Matsumoto Y, Hasegawa Y, Kataoka Y, Otsuka M, Sakai K, Matsuda Y, Morita T, Koyama A, Yamaguchi T.

J Pain Symptom Manage. 2019 Jun 26. pii: S0885-3924(19)30364-1. doi: 10.1016/j.jpainsymman.2019.06.020. [Epub ahead of print]


Applicability of quantitative flow ratio for rapid evaluation of intermediate coronary stenosis: comparison with instantaneous wave-free ratio in clinical practice.

Watarai M, Otsuka M, Yazaki K, Inagaki Y, Kahata M, Kumagai A, Inoue K, Koganei H, Enta K, Ishii Y.

Int J Cardiovasc Imaging. 2019 Jun 26. doi: 10.1007/s10554-019-01656-z. [Epub ahead of print]


A case of neutrophilic dermatosis with MEFV gene variant and abnormal activation of peripheral blood monocytes: a case report.

Otsuka M, Koga T, Sumiyoshi R, Koike Y, Furukawa K, Okamoto M, Endo Y, Tsuji S, Takatani A, Shimizu T, Igawa T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Daisuke N, Kawakami A.

Immunol Med. 2019 Mar;42(1):45-49. doi: 10.1080/25785826.2019.1625507. Epub 2019 Jun 16.


Short-term mortality and risk factors associated with reoperation after emergency amputation of the lower limbs.

Miyamoto S, Otsuka M, Hasue F, Fujiyoshi T, Kamiya K, Kiuchi H, Tanaka T, Nakamura J, Orita S, Ohtori S.

J Orthop Sci. 2019 Jun 12. pii: S0949-2658(19)30153-8. doi: 10.1016/j.jos.2019.05.018. [Epub ahead of print]


Relationship between bronchoalveolar lavage fluid and plasma endotoxin activity in calves with bronchopneumonia.

Nishi Y, Tsukano K, Otsuka M, Tsuchiya M, Suzuki K.

J Vet Med Sci. 2019 Jul 19;81(7):1043-1046. doi: 10.1292/jvms.18-0643. Epub 2019 Jun 12.


MCR-ALS analysis of IR spectroscopy and XRD for the investigation of ibuprofen - nicotinamide cocrystal formation.

Ishihara S, Hattori Y, Otsuka M.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Oct 5;221:117142. doi: 10.1016/j.saa.2019.117142. Epub 2019 May 18.


Breast cancer hormone receptor negativity, triple-negative type, mastectomy and not receiving adjuvant radiotherapy were associated with axillary recurrence after sentinel lymph node biopsy.

Sekine C, Nakano S, Mibu A, Otsuka M, Oinuma T, Takeyama H.

Asian J Surg. 2019 May 29. pii: S1015-9584(18)30808-X. doi: 10.1016/j.asjsur.2019.05.001. [Epub ahead of print]


Prognostic factors and survival in Japanese patients with brain metastasis from renal cell cancer.

Takeshita N, Otsuka M, Kamasako T, Somoto T, Uemura T, Shinozaki T, Kobayashi M, Kawana H, Itami M, Iuchi T, Komaru A, Fukasawa S.

Int J Clin Oncol. 2019 Oct;24(10):1231-1237. doi: 10.1007/s10147-019-01474-2. Epub 2019 May 28.


Surface contamination of the outer and blister packages of oral anticancer drugs: A multicenter study.

Nomura H, Katakura N, Morita T, Sano Y, Usui H, Hiura S, Nakakuni M, Otsuka M, Akiyama E, Endo K.

J Oncol Pharm Pract. 2019 May 27:1078155219850305. doi: 10.1177/1078155219850305. [Epub ahead of print]


Analysis of degradation products of nitrogen mustards via hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Otsuka M, Miyaguchi H, Uchiyama M.

J Chromatogr A. 2019 Sep 27;1602:199-205. doi: 10.1016/j.chroma.2019.05.015. Epub 2019 May 11.


Quantitation of trace amorphous solifenacin succinate in pharmaceutical formulations by transmission Raman spectroscopy.

Terada H, Hattori Y, Sasaki T, Otsuka M.

Int J Pharm. 2019 Jun 30;565:325-332. doi: 10.1016/j.ijpharm.2019.05.017. Epub 2019 May 8.


Rheumatoid arthritis-like active synovitis with T-cell activation in a case of idiopathic multicentric Castleman disease: A case report.

Otsuka M, Koga T, Sumiyoshi R, Okamoto M, Endo Y, Tsuji S, Takatani A, Shimizu T, Igawa T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Daisuke N, Kawakami A.

Medicine (Baltimore). 2019 May;98(18):e15237. doi: 10.1097/MD.0000000000015237.


Measurement of thermal conductivity and specific heat by impedance spectroscopy of Bi2Te3 thermoelectric element.

Arisaka T, Otsuka M, Hasegawa Y.

Rev Sci Instrum. 2019 Apr;90(4):046104. doi: 10.1063/1.5079832.


Stress fracture of the midshaft clavicle associated with sternocostoclavicular hyperostosis-Case report.

Miyamoto S, Otsuka M, Hasue F, Fujiyoshi T, Kamiya K, Kiuchi H, Tanaka T, Nakamura J, Orita S, Ohtori S.

Int J Surg Case Rep. 2019;58:121-126. doi: 10.1016/j.ijscr.2019.03.059. Epub 2019 Apr 19.


Autoimmune Pulmonary Alveolar Proteinosis Diagnosed after Exposure to a Fire Extinguisher Containing Silica Powder.

Yorozuya T, Ikeda K, Chiba H, Saito A, Kuronuma K, Nishikiori H, Miyajima S, Takahashi M, Yoshikawa T, Takahashi Y, Taya T, Mori Y, Umeda Y, Otsuka M, Moriyama H, Takahashi H.

Intern Med. 2019 Jul 15;58(14):2067-2072. doi: 10.2169/internalmedicine.1557-18. Epub 2019 Apr 17.


Validity of block start performance without arm forces or by kinematics-only methods.

Otsuka M, Potthast W, Willwacher S, Goldmann JP, Kurihara T, Isaka T.

Sports Biomech. 2019 Jun;18(3):229-244. doi: 10.1080/14763141.2019.1593497. Epub 2019 Apr 16.


Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature.

I Ciftci H, G Sierra R, Yoon CH, Su Z, Tateishi H, Koga R, Kotaro K, Yumoto F, Senda T, Liang M, Wakatsuki S, Otsuka M, Fujita M, DeMirci H.

Int J Mol Sci. 2019 Apr 3;20(7). pii: E1675. doi: 10.3390/ijms20071675.


Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent Solubility Prepared by Continuous-Spray Granulator.

Tanaka R, Hattori Y, Horie Y, Kamada H, Nagato T, Otsuka M.

Pharmaceutics. 2019 Apr 3;11(4). pii: E159. doi: 10.3390/pharmaceutics11040159.


Long-term follow up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma.

Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Ihn H, Hatsumichi M, Minami H.

Cancer Sci. 2019 Jun;110(6):1995-2003. doi: 10.1111/cas.14015. Epub 2019 May 23.


Intra-athlete and inter-group comparisons: Running pace and step characteristics of elite athletes in the 400-m hurdles.

Otsuka M, Isaka T.

PLoS One. 2019 Mar 28;14(3):e0204185. doi: 10.1371/journal.pone.0204185. eCollection 2019.


New SIRT2 inhibitors: Histidine-based bleomycin spin-off.

Ali TFS, Ciftci HI, Radwan MO, Koga R, Ohsugi T, Okiyama Y, Honma T, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M.

Bioorg Med Chem. 2019 May 1;27(9):1767-1775. doi: 10.1016/j.bmc.2019.03.003. Epub 2019 Mar 2.


Identification of a neoantigen epitope in a melanoma patient with good response to anti-PD-1 antibody therapy.

Nonomura C, Otsuka M, Kondou R, Iizuka A, Miyata H, Ashizawa T, Sakura N, Yoshikawa S, Kiyohara Y, Ohshima K, Urakami K, Nagashima T, Ohnami S, Kusuhara M, Mitsuya K, Hayashi N, Nakasu Y, Mochizuki T, Yamaguchi K, Akiyama Y.

Immunol Lett. 2019 Apr;208:52-59. doi: 10.1016/j.imlet.2019.02.004. Epub 2019 Mar 14.


Clinical Outcome of Single-port Surgery in Patients With Pathologic T4 Colon Cancer.

Tei M, Otsuka M, Suzuki Y, Akamatsu H.

Surg Laparosc Endosc Percutan Tech. 2019 Mar 4. doi: 10.1097/SLE.0000000000000652. [Epub ahead of print]


Management of inguinal hernia with prolapsed ovary in very low birthweight infants during neonatal intensive care unit hospitalisation.

Kurobe M, Harada A, Sugihara T, Baba Y, Hiramatsu T, Ohashi S, Otsuka M.

J Paediatr Child Health. 2019 Mar 3. doi: 10.1111/jpc.14421. [Epub ahead of print]


Serum iron concentration as a marker of inflammation in young cows that underwent dehorning operation.

Tsukano K, Shimamori T, Fukuda T, Nishi Y, Otsuka M, Kitade Y, Suzuki K.

J Vet Med Sci. 2019 Apr 27;81(4):626-628. doi: 10.1292/jvms.19-0002. Epub 2019 Mar 1.


Factors related to improvement of cerebrovascular reserve after superficial temporal artery to middle cerebral artery anastomosis for patients with atherosclerotic steno-occlusive disease.

Otsuka M, Kikkawa Y, Kamide T, Suzuki K, Shibata A, Ikeda T, Kurita H.

Acta Neurochir (Wien). 2019 Apr;161(4):799-805. doi: 10.1007/s00701-019-03841-4. Epub 2019 Feb 18.


Novel multiple heterozygous NUDT15 variants cause an azathioprine-induced severe leukopenia in a patient with systemic lupus erythematosus.

Otsuka M, Koga T, Sumiyoshi R, Furukawa K, Okamoto M, Endo Y, Tsuji S, Takatani A, Shimizu T, Igawa T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Kawakami A.

Clin Immunol. 2019 Mar;200:64-65. doi: 10.1016/j.clim.2019.02.004. Epub 2019 Feb 8. No abstract available.


Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction.

Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K.

Cell Mol Gastroenterol Hepatol. 2019;7(2):297-312. doi: 10.1016/j.jcmgh.2018.10.010. Epub 2018 Oct 24.


[A Case of Locally Recurrent Tumor Resected by Left Hemicolectomy with Left Nephrectomy Six Years after Curative Operation for Sigmoid Colon Cancer].

Uchi R, Kawamoto J, Morinaka T, Yamada H, Etoh R, Otsuka M.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2264-2266. Japanese.


A lotus root-like appearance in a spontaneously recanalized lesion confirmed by serial coronary angiography: from optical coherence tomography study.

Dai K, Suruga K, Nakano T, Takemoto H, Hashimoto Y, Tomomori S, Higaki T, Oi K, Kawase T, Nakama Y, Suenari K, Nishioka K, Otsuka M, Masaoka Y, Shiode N, Kihara Y.

Coron Artery Dis. 2019 Mar;30(2):150-151. doi: 10.1097/MCA.0000000000000682. No abstract available.


Coronary aneurysm formation after paclitaxel-coated balloon angioplasty for in-stent restenosis of first-generation sirolimus-eluting stent implanted 9 years ago.

Kahata M, Otsuka M, Watarai M, Inagaki Y, Ishii Y.

Cardiovasc Interv Ther. 2019 Jan 12. doi: 10.1007/s12928-019-00570-4. [Epub ahead of print] No abstract available.


Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus.

Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Seimiya T, Suzuki T, Tanaka E, Ishibashi R, Funato K, Koike K.

Hepatology. 2019 May;69(5):1903-1915. doi: 10.1002/hep.30491. Epub 2019 Mar 13.


Inflammation and de-differentiation in pancreatic carcinogenesis.

Seimiya T, Otsuka M, Iwata T, Tanaka E, Suzuki T, Sekiba K, Yamagami M, Ishibashi R, Koike K.

World J Clin Cases. 2018 Dec 6;6(15):882-891. doi: 10.12998/wjcc.v6.i15.882. Review.

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