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MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.

Brown AS, Meera P, Altindag B, Chopra R, Perkins EM, Paul S, Scoles DR, Tarapore E, Magri J, Huang H, Jackson M, Shakkottai VG, Otis TS, Pulst SM, Atwood SX, Oro AE.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12407-E12416. doi: 10.1073/pnas.1816177115. Epub 2018 Dec 7.


Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Review.


Optogenetic fMRI and electrophysiological identification of region-specific connectivity between the cerebellar cortex and forebrain.

Choe KY, Sanchez CF, Harris NG, Otis TS, Mathews PJ.

Neuroimage. 2018 Jun;173:370-383. doi: 10.1016/j.neuroimage.2018.02.047. Epub 2018 Feb 27.


Decreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome.

Zhang N, Peng Z, Tong X, Lindemeyer AK, Cetina Y, Huang CS, Olsen RW, Otis TS, Houser CR.

Exp Neurol. 2017 Nov;297:168-178. doi: 10.1016/j.expneurol.2017.08.008. Epub 2017 Aug 16.


Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2.

Pflieger LT, Dansithong W, Paul S, Scoles DR, Figueroa KP, Meera P, Otis TS, Facelli JC, Pulst SM.

Hum Mol Genet. 2017 Aug 15;26(16):3069-3080. doi: 10.1093/hmg/ddx191.


Antisense oligonucleotide therapy for spinocerebellar ataxia type 2.

Scoles DR, Meera P, Schneider MD, Paul S, Dansithong W, Figueroa KP, Hung G, Rigo F, Bennett CF, Otis TS, Pulst SM.

Nature. 2017 Apr 20;544(7650):362-366. doi: 10.1038/nature22044. Epub 2017 Apr 12.


Cellular and circuit mechanisms underlying spinocerebellar ataxias.

Meera P, Pulst SM, Otis TS.

J Physiol. 2016 Aug 15;594(16):4653-60. doi: 10.1113/JP271897. Epub 2016 Jun 12. Review.


The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper.

Lang EJ, Apps R, Bengtsson F, Cerminara NL, De Zeeuw CI, Ebner TJ, Heck DH, Jaeger D, Jörntell H, Kawato M, Otis TS, Ozyildirim O, Popa LS, Reeves AM, Schweighofer N, Sugihara I, Xiao J.

Cerebellum. 2017 Feb;16(1):230-252. doi: 10.1007/s12311-016-0787-8.


Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.

Tong X, Peng Z, Zhang N, Cetina Y, Huang CS, Wallner M, Otis TS, Houser CR.

J Neurosci. 2015 Dec 9;35(49):16142-58. doi: 10.1523/JNEUROSCI.2853-15.2015.


Circuit mechanisms underlying motor memory formation in the cerebellum.

Lee KH, Mathews PJ, Reeves AM, Choe KY, Jami SA, Serrano RE, Otis TS.

Neuron. 2015 Apr 22;86(2):529-40. doi: 10.1016/j.neuron.2015.03.010. Epub 2015 Apr 2.


Multifocal fluorescence microscope for fast optical recordings of neuronal action potentials.

Shtrahman M, Aharoni DB, Hardy NF, Buonomano DV, Arisaka K, Otis TS.

Biophys J. 2015 Feb 3;108(3):520-9. doi: 10.1016/j.bpj.2014.12.005.


New roles for the cerebellum in health and disease.

Reeber SL, Otis TS, Sillitoe RV.

Front Syst Neurosci. 2013 Nov 14;7:83. doi: 10.3389/fnsys.2013.00083. eCollection 2013. Review.


Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion.

Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH.

Sci Transl Med. 2013 Oct 23;5(208):208ra149. doi: 10.1126/scitranslmed.3007529.


A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons.

Peng Z, Zhang N, Wei W, Huang CS, Cetina Y, Otis TS, Houser CR.

J Neurosci. 2013 Sep 4;33(36):14392-405. doi: 10.1523/JNEUROSCI.2045-13.2013.


A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.

Santhakumar V, Meera P, Karakossian MH, Otis TS.

PLoS One. 2013 Aug 19;8(8):e72976. doi: 10.1371/journal.pone.0072976. eCollection 2013.


Repolarization matters: mutations in the Kv4.3 potassium channel cause SCA19/22.

Pulst SM, Otis TS.

Ann Neurol. 2012 Dec;72(6):829-31. doi: 10.1002/ana.23803. No abstract available.


Effects of climbing fiber driven inhibition on Purkinje neuron spiking.

Mathews PJ, Lee KH, Peng Z, Houser CR, Otis TS.

J Neurosci. 2012 Dec 12;32(50):17988-97. doi: 10.1523/JNEUROSCI.3916-12.2012.


How do climbing fibers teach?

Otis TS, Mathews PJ, Lee KH, Maiz J.

Front Neural Circuits. 2012 Nov 30;6:95. doi: 10.3389/fncir.2012.00095. eCollection 2012. No abstract available.


Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2.

Hansen ST, Meera P, Otis TS, Pulst SM.

Hum Mol Genet. 2013 Jan 15;22(2):271-83. doi: 10.1093/hmg/dds427. Epub 2012 Oct 18.


Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.

Yue L, Pawlowski M, Dellal SS, Xie A, Feng F, Otis TS, Bruzik KS, Qian H, Pepperberg DR.

Nat Commun. 2012;3:1095. doi: 10.1038/ncomms2094.


Prolonging the postcomplex spike pause speeds eyeblink conditioning.

Maiz J, Karakossian MH, Pakaprot N, Robleto K, Thompson RF, Otis TS.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16726-30. doi: 10.1073/pnas.1214274109. Epub 2012 Sep 17.


Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor.

Fink AE, Bender KJ, Trussell LO, Otis TS, DiGregorio DA.

PLoS One. 2012;7(8):e41434. doi: 10.1371/journal.pone.0041434. Epub 2012 Aug 3.


GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons.

Dellal SS, Luo R, Otis TS.

J Neurophysiol. 2012 Jun;107(11):2958-70. doi: 10.1152/jn.01028.2011. Epub 2012 Feb 29.


The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M Jr, Otis TS, Black DL.

Genes Dev. 2012 Mar 1;26(5):445-60. doi: 10.1101/gad.182477.111. Epub 2012 Feb 22.


Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.

Meera P, Wallner M, Otis TS.

J Neurophysiol. 2011 Oct;106(4):2057-64. doi: 10.1152/jn.00450.2011. Epub 2011 Jul 27.


Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.

Meera P, Olsen RW, Otis TS, Wallner M.

Mol Pharmacol. 2010 Nov;78(5):918-24. doi: 10.1124/mol.109.062687. Epub 2010 Aug 10.


Golgi in retrospect: a historiographic examination of contextual influence in tracing the constructs of neuronal organization.

Kruger L, Otis TS, Shtrahman M.

Brain Res Rev. 2011 Jan 7;66(1-2):68-74. doi: 10.1016/j.brainresrev.2010.07.001. Epub 2010 Jul 13.


Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye.

Bradley J, Luo R, Otis TS, DiGregorio DA.

J Neurosci. 2009 Jul 22;29(29):9197-209. doi: 10.1523/JNEUROSCI.1240-09.2009.


Holographic photolysis of caged neurotransmitters.

Lutz C, Otis TS, DeSars V, Charpak S, DiGregorio DA, Emiliani V.

Nat Methods. 2008 Sep;5(9):821-7. doi: 10.1038/nmeth.1241.


Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells.

Meera P, Olsen RW, Otis TS, Wallner M.

Neuropharmacology. 2009 Jan;56(1):155-60. doi: 10.1016/j.neuropharm.2008.08.011. Epub 2008 Aug 20.


Glia get excited.

Otis TS, Sofroniew MV.

Nat Neurosci. 2008 Apr;11(4):379-80. doi: 10.1038/nn0408-379. No abstract available.


Photochemical control of endogenous ion channels and cellular excitability.

Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH.

Nat Methods. 2008 Apr;5(4):331-8. doi: 10.1038/nmeth.1187. Epub 2008 Mar 2.


Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition.

Santhakumar V, Wallner M, Otis TS.

Alcohol. 2007 May;41(3):211-21. Review. Erratum in: Alcohol. 2007 Sep;41(6):461.


Whither withered Golgi? A retrospective evaluation of reticularist and synaptic constructs.

Kruger L, Otis TS.

Brain Res Bull. 2007 May 30;72(4-6):201-7. Epub 2007 Feb 15. Review.


Basis of the gabamimetic profile of ethanol.

Breese GR, Criswell HE, Carta M, Dodson PD, Hanchar HJ, Khisti RT, Mameli M, Ming Z, Morrow AL, Olsen RW, Otis TS, Parsons LH, Penland SN, Roberto M, Siggins GR, Valenzuela CF, Wallner M.

Alcohol Clin Exp Res. 2006 Apr;30(4):731-44.


Blessed are the pacemakers.

Otis TS, Jen JC.

Nat Neurosci. 2006 Mar;9(3):297-8. No abstract available.


Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.

Meera P, Dodson PD, Karakossian MH, Otis TS.

Neuropharmacology. 2005 Nov;49(6):883-9. Epub 2005 Oct 5.


Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.

Smith SL, Otis TS.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14901-6. Epub 2005 Sep 30.


Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

Hanchar HJ, Dodson PD, Olsen RW, Otis TS, Wallner M.

Nat Neurosci. 2005 Mar;8(3):339-45. Epub 2005 Feb 6.


Excitation of cerebellar interneurons by group I metabotropic glutamate receptors.

Karakossian MH, Otis TS.

J Neurophysiol. 2004 Sep;92(3):1558-65. Epub 2004 May 19.


An ultra small array of electrodes for stimulating multiple inputs into a single neuron.

Smith SL, Judy JW, Otis TS.

J Neurosci Methods. 2004 Feb 15;133(1-2):109-14.


Glycine transporters not only take out the garbage, they recycle.

Brasnjo G, Otis TS.

Neuron. 2003 Nov 13;40(4):667-9. Review.


Vesicular glutamate transporters in cognito.

Otis TS.

Neuron. 2001 Jan;29(1):11-4. Review. No abstract available.

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