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Items: 20

1.

Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.

Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Marcotte D, McDowell B, Mertsching E, Negrou E, Otipoby KL, Poreci U, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M.

Bioorg Med Chem. 2019 Jul 1;27(13):2905-2913. doi: 10.1016/j.bmc.2019.05.021. Epub 2019 May 14.

PMID:
31138459
2.

BCR-dependent lineage plasticity in mature B cells.

Graf R, Seagal J, Otipoby KL, Lam KP, Ayoub S, Zhang B, Sander S, Chu VT, Rajewsky K.

Science. 2019 Feb 15;363(6428):748-753. doi: 10.1126/science.aau8475.

PMID:
30765568
3.

CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients.

Lieberman LA, Zeng W, Singh C, Wang W, Otipoby KL, Loh C, Plavina T, Gorelik L, Ransohoff RM, Cahir-McFarland E.

Neurology. 2016 Jan 26;86(4):375-81. doi: 10.1212/WNL.0000000000002314. Epub 2015 Dec 30. Erratum in: Neurology. 2016 Aug 30;87(9):960.

4.

The B-cell antigen receptor integrates adaptive and innate immune signals.

Otipoby KL, Waisman A, Derudder E, Srinivasan L, Franklin A, Rajewsky K.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12145-50. doi: 10.1073/pnas.1516428112. Epub 2015 Sep 14.

5.

Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms.

Pellerin A, Otero K, Czerkowicz JM, Kerns HM, Shapiro RI, Ranger AM, Otipoby KL, Taylor FR, Cameron TO, Viney JL, Rabah D.

EMBO Mol Med. 2015 Apr;7(4):464-76. doi: 10.15252/emmm.201404719.

6.

The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.

Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD.

Immunity. 2013 Mar 21;38(3):461-74. doi: 10.1016/j.immuni.2012.11.019. Epub 2013 Mar 14.

7.

Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.

Patterson HC, Kraus M, Wang D, Shahsafaei A, Henderson JM, Seagal J, Otipoby KL, Thai TH, Rajewsky K.

J Immunol. 2011 Sep 15;187(6):2853-8. doi: 10.4049/jimmunol.1101143. Epub 2011 Aug 12.

8.

PI3 kinase signals BCR-dependent mature B cell survival.

Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K.

Cell. 2009 Oct 30;139(3):573-86. doi: 10.1016/j.cell.2009.08.041.

9.

BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.

Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12435-8. doi: 10.1073/pnas.0805460105. Epub 2008 Aug 19.

10.

Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.

Mora JR, Iwata M, Eksteen B, Song SY, Junt T, Senman B, Otipoby KL, Yokota A, Takeuchi H, Ricciardi-Castagnoli P, Rajewsky K, Adams DH, von Andrian UH.

Science. 2006 Nov 17;314(5802):1157-60.

11.

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

Tze LE, Schram BR, Lam KP, Hogquist KA, Hippen KL, Liu J, Shinton SA, Otipoby KL, Rodine PR, Vegoe AL, Kraus M, Hardy RR, Schlissel MS, Rajewsky K, Behrens TW.

PLoS Biol. 2005 Mar;3(3):e82. Epub 2005 Mar 8.

12.

B cell receptor signal strength determines B cell fate.

Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K.

Nat Immunol. 2004 Mar;5(3):317-27. Epub 2004 Feb 1.

PMID:
14758357
13.

Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.

Oberdoerffer P, Otipoby KL, Maruyama M, Rajewsky K.

Nucleic Acids Res. 2003 Nov 15;31(22):e140.

14.

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.

Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH.

Nat Immunol. 2003 Apr;4(4):321-9. Epub 2003 Mar 3.

PMID:
12612580
15.

CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.

Otipoby KL, Draves KE, Clark EA.

J Biol Chem. 2001 Nov 23;276(47):44315-22. Epub 2001 Sep 10.

16.

B cells with the guts to switch.

Clark EA, Otipoby KL.

Nat Immunol. 2001 Jul;2(7):581-2.

PMID:
11429539
17.

Signal transduction pathways that regulate the fate of B lymphocytes.

Craxton A, Otipoby KL, Jiang A, Clark EA.

Adv Immunol. 1999;73:79-152. Review. No abstract available.

PMID:
10399006
18.

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clark EA, Goodnow CC.

Immunity. 1998 Apr;8(4):497-508.

19.

CD22 regulates thymus-independent responses and the lifespan of B cells.

Otipoby KL, Andersson KB, Draves KE, Klaus SJ, Farr AG, Kerner JD, Perlmutter RM, Law CL, Clark EA.

Nature. 1996 Dec 19-26;384(6610):634-7.

PMID:
8967951
20.

Regulation of signalling through B-lymphocyte antigen receptors by cell-cell interaction molecules.

Law CL, Craxton A, Otipoby KL, Sidorenko SP, Klaus SJ, Clark EC.

Immunol Rev. 1996 Oct;153:123-54. Review. No abstract available.

PMID:
9010722

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