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Items: 16

1.

Reproducing human and cross-species drug toxicities using a Liver-Chip.

Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA.

Sci Transl Med. 2019 Nov 6;11(517). pii: eaax5516. doi: 10.1126/scitranslmed.aax5516.

PMID:
31694927
2.

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M.

Toxicol Sci. 2019 Aug 1;170(2):499-508. doi: 10.1093/toxsci/kfz112.

PMID:
31093666
3.

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.

Barrile R, van der Meer AD, Park H, Fraser JP, Simic D, Teng F, Conegliano D, Nguyen J, Jain A, Zhou M, Karalis K, Ingber DE, Hamilton GA, Otieno MA.

Clin Pharmacol Ther. 2018 Dec;104(6):1240-1248. doi: 10.1002/cpt.1054. Epub 2018 Apr 30.

PMID:
29484632
4.

Optimized Methods to Explore the Mechanistic and Biomarker Potential of Hepatocyte-Derived Exosomes in Drug-Induced Liver Injury.

Thacker SE, Nautiyal M, Otieno MA, Watkins PB, Mosedale M.

Toxicol Sci. 2018 May 1;163(1):92-100. doi: 10.1093/toxsci/kfy015.

PMID:
29385596
5.

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno MA, Louden CS, Hamilton GA, Flaumenhaft R, Ingber DE.

Clin Pharmacol Ther. 2018 Feb;103(2):332-340. doi: 10.1002/cpt.742. Epub 2017 Jul 14.

6.

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

Letavic MA, Savall BM, Allison BD, Aluisio L, Andres JI, De Angelis M, Ao H, Beauchamp DA, Bonaventure P, Bryant S, Carruthers NI, Ceusters M, Coe KJ, Dvorak CA, Fraser IC, Gelin CF, Koudriakova T, Liang J, Lord B, Lovenberg TW, Otieno MA, Schoetens F, Swanson DM, Wang Q, Wickenden AD, Bhattacharya A.

J Med Chem. 2017 Jun 8;60(11):4559-4572. doi: 10.1021/acs.jmedchem.7b00408. Epub 2017 May 25.

PMID:
28493698
7.

Regulatory Forum Opinion Piece*: Use and Utility of Animal Models of Disease for Nonclinical Safety Assessment: A Pharmaceutical Industry Survey.

Morgan SJ, Couch J, Guzzie-Peck P, Keller DA, Kemper R, Otieno MA, Schulingkamp RJ, Jones TW.

Toxicol Pathol. 2017 Apr;45(3):372-380. doi: 10.1177/0192623317701004. Epub 2017 Mar 28.

PMID:
28351296
8.

Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.

Otieno MA, Snoeys J, Lam W, Ghosh A, Player MR, Pocai A, Salter R, Simic D, Skaggs H, Singh B, Lim HK.

Toxicol Sci. 2018 Jun 1;163(2):374-384. doi: 10.1093/toxsci/kfx040.

PMID:
28206647
9.

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1).

Otieno MA, Bhaskaran V, Janovitz E, Callejas Y, Foster WB, Washburn W, Megill JR, Lehman-McKeeman L, Gemzik B.

Toxicol Sci. 2017 Feb;155(2):379-388. doi: 10.1093/toxsci/kfw216. Epub 2016 Oct 20.

PMID:
28025230
10.

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.

Jain A, van der Meer AD, Papa AL, Barrile R, Lai A, Schlechter BL, Otieno MA, Louden CS, Hamilton GA, Michelson AD, Frelinger AL 3rd, Ingber DE.

Biomed Microdevices. 2016 Aug;18(4):73. doi: 10.1007/s10544-016-0095-6.

11.

Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells.

Otieno MA, Bavuso N, Milano J, Foster-Brown L, Bui KH, Li Y, Hudzik T, Wescott D, Louden C, Dyroff M, Pognan F.

Toxicol Sci. 2008 Sep;105(1):221-9. doi: 10.1093/toxsci/kfn108. Epub 2008 Jun 6.

PMID:
18539914
12.
13.

Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo.

Otieno MA, Kensler TW, Guyton KZ.

Free Radic Biol Med. 2000 Mar 15;28(6):944-52.

PMID:
10802226
14.

Cysteine S-conjugates activate transcription factor NF-kappa B in cultured renal epithelial cells.

Otieno MA, Anders MW.

Am J Physiol. 1997 Jul;273(1 Pt 2):F136-43.

PMID:
9249601
16.

Immunolocalization of microsomal glutathione S-transferase in rat tissues.

Otieno MA, Baggs RB, Hayes JD, Anders MW.

Drug Metab Dispos. 1997 Jan;25(1):12-20.

PMID:
9010624

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