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Overexpression of BCL-2 in the Intestinal Epithelium Prevents Sepsis-Induced Gut Barrier Function Via Altering Tight Junction Protein Expression.

Otani S, Oami T, Yoseph BP, Klingensmith NJ, Chen CW, Liang Z, Coopersmith C.

Shock. 2019 Oct 15. doi: 10.1097/SHK.0000000000001463. [Epub ahead of print]


Aberrant Methylation of Tumor Suppressive miRNAs in Bile from Patients With Pancreaticobiliary Diseases.

Ohtsubo K, Miyake K, Arai S, Fukuda K, Yanagimura N, Suzuki C, Otani S, Adachi Y, Tanimoto A, Nishiyama A, Yamashita K, Takeuchi S, Notohara K, Yoshimura K, Yano S.

Anticancer Res. 2019 Oct;39(10):5449-5459. doi: 10.21873/anticanres.13738.


Pseudomyogenic hemangioendothelioma of bone treated with denosumab: a case report.

Otani S, Nakayama R, Sekita T, Hirozane T, Asano N, Nishimoto K, Sasaki A, Okita H, Morioka H, Nakamura M, Matsumoto M.

BMC Cancer. 2019 Sep 3;19(1):872. doi: 10.1186/s12885-019-6072-8.


Negative impact of recipient SPRED2 deficiency on transplanted lung in a mouse model.

Hashimoto K, Yamane M, Sugimoto S, Hirano Y, Kurosaki T, Otani S, Miyoshi K, Ohara T, Okazaki M, Yoshimura T, Oto T, Matsukawa A, Toyooka S.

Transpl Immunol. 2019 Dec;57:101242. doi: 10.1016/j.trim.2019.101242. Epub 2019 Aug 22.


Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance.

Kita K, Fukuda K, Takahashi H, Tanimoto A, Nishiyama A, Arai S, Takeuchi S, Yamashita K, Ohtsubo K, Otani S, Yanagimura N, Suzuki C, Ikeda H, Tamura M, Matsumoto I, Yano S.

Cancer Sci. 2019 Oct;110(10):3215-3224. doi: 10.1111/cas.14171.


Effect of long-term clarithromycin therapy on prevention of pneumonia in older adults: A randomized, controlled trial.

Yamasue M, Komiya K, Yoshikawa H, Kohno Y, Imamura Y, Otani S, Shigenaga T, Koga H, Kishi K, Ichimiya T, Tanaka H, Hara K, Noguchi S, Yatera K, Mukae H, Hiramatsu K, Kadota JI.

Geriatr Gerontol Int. 2019 Oct;19(10):1006-1009. doi: 10.1111/ggi.13760. Epub 2019 Aug 15.


Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse.

Hirano Y, Sugimoto S, Yamamoto S, Okada M, Otani S, Ohara T, Yamane M, Matsukawa A, Oto T, Toyooka S.

Gen Thorac Cardiovasc Surg. 2019 Jul 31. doi: 10.1007/s11748-019-01181-9. [Epub ahead of print]


β-Carotene solid dispersion prepared by hot-melt technology improves its solubility in water.

Ishimoto K, Miki S, Ohno A, Nakamura Y, Otani S, Nakamura M, Nakagawa S.

J Food Sci Technol. 2019 Jul;56(7):3540-3546. doi: 10.1007/s13197-019-03793-8. Epub 2019 Jun 10.


Correction to: Concomitant aortic valve replacement, mitral valve replacement, and coronary artery bypass grafting for aortic stenosis and mitral regurgitation in a patient with relapsing polychondritis.

Kisamori E, Otani S, Yamamoto T, Nishiki M, Yamada Y, Matsumoto T.

Gen Thorac Cardiovasc Surg. 2019 Aug;67(8):728-730. doi: 10.1007/s11748-019-01166-8.


Disease-free monoculture farming by fungus-growing termites.

Otani S, Challinor VL, Kreuzenbeck NB, Kildgaard S, Krath Christensen S, Larsen LLM, Aanen DK, Rasmussen SA, Beemelmanns C, Poulsen M.

Sci Rep. 2019 Jun 19;9(1):8819. doi: 10.1038/s41598-019-45364-z.


Association between dental caries indicators and serum glycated hemoglobin-levels among patients with type 2 diabetes mellitus.

Majbauddin A, Tanimura C, Aoto H, Otani S, Parrenas MCE, Kobayashi N, Morita T, Inoue K, Masumoto T, Kurozawa Y.

J Oral Sci. 2019;61(2):335-342. doi: 10.2334/josnusd.18-0156.


Acinetobacter baumannii can be transferred from contaminated nitrile examination gloves to polypropylene plastic surfaces.

Takoi H, Fujita K, Hyodo H, Matsumoto M, Otani S, Gorai M, Mano Y, Saito Y, Seike M, Furuya N, Gemma A.

Am J Infect Control. 2019 Oct;47(10):1171-1175. doi: 10.1016/j.ajic.2019.04.009. Epub 2019 May 30.


Cytokine expression profiles in cervical mucus from patients with cervical cancer and its precursor lesions.

Otani S, Fujii T, Kukimoto I, Yamamoto N, Tsukamoto T, Ichikawa R, Nishio E, Iwata A.

Cytokine. 2019 Aug;120:210-219. doi: 10.1016/j.cyto.2019.05.011. Epub 2019 May 20.


Increased attrition of memory T cells during sepsis requires 2B4.

Xie J, Chen CW, Sun Y, Laurie SJ, Zhang W, Otani S, Martin GS, Coopersmith CM, Ford ML.

JCI Insight. 2019 May 2;4(9). pii: 126030. doi: 10.1172/jci.insight.126030. eCollection 2019 May 2.


Concomitant aortic valve replacement, mitral valve replacement, and coronary artery bypass grafting for aortic stenosis and mitral regurgitation in a patient with relapsing polychondritis.

Kisamori E, Otani S, Yamamoto T, Nishiki M, Yamada Y, Matsumoto T.

Gen Thorac Cardiovasc Surg. 2019 Apr 30. doi: 10.1007/s11748-019-01130-6. [Epub ahead of print] Erratum in: Gen Thorac Cardiovasc Surg. 2019 Aug;67(8):728-730.


Imaging an intrapulmonary solitary fibrous tumor with CT and F-18 FDG PET/CT.

Shinya T, Masaoka Y, Sando M, Tanabe S, Okamoto S, Ihara H, Tanaka T, Otani S, Hiraki T, Kanazawa S.

Radiol Case Rep. 2019 Apr 4;14(6):755-758. doi: 10.1016/j.radcr.2019.03.023. eCollection 2019 Jun.


Critical illness and the role of the microbiome.

Otani S, Chihade DB, Coopersmith CM.

Acute Med Surg. 2018 Dec 27;6(2):91-94. doi: 10.1002/ams2.383. eCollection 2019 Apr. Review.


A Conceptual Model for Quality of Life Among People with Type 2 Diabetes in the Philippines.

Aoto H, Tanimura C, Majbauddin A, Kobayashi N, Morita T, Inoue K, Otani S, Fukada M, Hanaki K.

Yonago Acta Med. 2019 Mar 28;62(1):53-61. eCollection 2019 Mar.


Impact of Maximum Air Temperature on Ambulance Transports Owing to Heat Stroke During Spring and Summer in Tottori Prefecture, Japan: A Time-stratified Case-crossover Analysis.

Fujitani Y, Otani S, Majbauddin A, Amano H, Masumoto T, Kurozawa Y.

Yonago Acta Med. 2019 Mar 28;62(1):47-52. eCollection 2019 Mar.


Gut integrity in critical illness.

Otani S, Coopersmith CM.

J Intensive Care. 2019 Mar 20;7:17. doi: 10.1186/s40560-019-0372-6. eCollection 2019. Review.


Interplay between prior knowledge and communication mode on teaching effectiveness: Interpersonal neural synchronization as a neural marker.

Liu J, Zhang R, Geng B, Zhang T, Yuan D, Otani S, Li X.

Neuroimage. 2019 Jun;193:93-102. doi: 10.1016/j.neuroimage.2019.03.004. Epub 2019 Mar 7.


Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience.

Sugimoto S, Yamamoto H, Kurosaki T, Otani S, Okazaki M, Yamane M, Toyooka S, Oto T.

Surg Today. 2019 Aug;49(8):686-693. doi: 10.1007/s00595-019-01782-0. Epub 2019 Feb 21.


MR findings of uterine PEComa in patients with tuberous sclerosis: report of two cases.

Nishio N, Kido A, Minamiguchi S, Kiguchi K, Kurata Y, Nakao KK, Kuwahara R, Yajima R, Otani S, Mandai M, Togashi K, Minami M.

Abdom Radiol (NY). 2019 Apr;44(4):1256-1260. doi: 10.1007/s00261-019-01918-3.


Questionnaire survey on patient awareness of invasive rebiopsy in advanced non-small cell lung cancer.

Fukui T, Ishihara M, Kasajima M, Hiyoshi Y, Nakahara Y, Otani S, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Naoki K.

Thorac Cancer. 2019 Mar;10(3):501-507. doi: 10.1111/1759-7714.12964. Epub 2019 Jan 16.


Sepsis erodes CD8+ memory T cell-protective immunity against an EBV homolog in a 2B4-dependent manner.

Xie J, Crepeau RL, Chen CW, Zhang W, Otani S, Coopersmith CM, Ford ML.

J Leukoc Biol. 2019 Mar;105(3):565-575. doi: 10.1002/JLB.4A0718-292R. Epub 2019 Jan 9.


SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model.

Mesaki K, Yamane M, Sugimoto S, Fujisawa M, Yoshimura T, Kurosaki T, Otani S, Miyoshi S, Oto T, Matsukawa A, Toyooka S.

Surg Today. 2019 May;49(5):443-450. doi: 10.1007/s00595-018-1753-5. Epub 2019 Jan 7.


Lung transplant candidates with idiopathic pulmonary fibrosis and long-term pirfenidone therapy: Treatment feasibility influences waitlist survival.

Tanaka S, Miyoshi K, Higo H, Kurosaki T, Otani S, Sugimoto S, Yamane M, Kiura K, Toyooka S, Oto T.

Respir Investig. 2019 Mar;57(2):165-171. doi: 10.1016/j.resinv.2018.12.002. Epub 2018 Dec 30.


Gut microbial compositions mirror caste-specific diets in a major lineage of social insects.

Otani S, Zhukova M, Koné NA, da Costa RR, Mikaelyan A, Sapountzis P, Poulsen M.

Environ Microbiol Rep. 2019 Apr;11(2):196-205. doi: 10.1111/1758-2229.12728. Epub 2019 Jan 8.


Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer.

Shirasawa M, Fukui T, Kusuhara S, Hiyoshi Y, Ishihara M, Kasajima M, Nakahara Y, Otani S, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Naoki K.

Cancer Manag Res. 2018 Nov 21;10:6039-6047. doi: 10.2147/CMAR.S181789. eCollection 2018.


Mitral valve repair versus replacement with preservation of the entire subvalvular apparatus.

Kisamori E, Otani S, Yamamoto T, Nishiki M, Yamada Y, Matsumoto T.

Gen Thorac Cardiovasc Surg. 2019 May;67(5):436-441. doi: 10.1007/s11748-018-1039-2. Epub 2018 Nov 23.


Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods.

Sugimoto S, Kurosaki T, Otani S, Tanaka S, Hikasa Y, Yamane M, Toyooka S, Kobayashi M, Oto T.

Surg Today. 2019 Mar;49(3):254-260. doi: 10.1007/s00595-018-1730-z. Epub 2018 Oct 27.


Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation.

Tanaka S, Sugimoto S, Kurosaki T, Miyoshi K, Otani S, Suzawa K, Hashida S, Yamane M, Oto T, Toyooka S.

Sci Rep. 2018 Oct 18;8(1):15366. doi: 10.1038/s41598-018-33848-3.


A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.

Yamamoto H, Sugimoto S, Tanaka S, Kurosaki T, Otani S, Yamane M, Taira N, Oto T, Toyooka S.

Surg Today. 2019 Mar;49(3):268-274. doi: 10.1007/s00595-018-1717-9. Epub 2018 Sep 18.


Lack of medical resources and public health vulnerability in Mongolia's winter disasters.

Otani S, Majbauddin A, Kurozawa Y, Shinoda M.

Rural Remote Health. 2018 Sep;18(3):4617. doi: 10.22605/RRH4617. Epub 2018 Sep 5.


The number of CD34+CD133+ hematopoietic stem cells residing in umbilical cord blood (UCB) units is not correlated with the numbers of total nucleated cells and CD34+ cells: a possible new indicator for quality evaluation of UCB units.

Matsuoka Y, Nakamura F, Hatanaka K, Fujioka T, Otani S, Kimura T, Fujimura Y, Asano H, Sonoda Y.

Int J Hematol. 2018 Dec;108(6):571-579. doi: 10.1007/s12185-018-2502-7. Epub 2018 Jul 25.


Spatial distribution of hydrogen sulfide and sulfur species in coastal marine sediments Hiroshima Bay, Japan.

Asaoka S, Umehara A, Otani S, Fujii N, Okuda T, Nakai S, Nishijima W, Takeuchi K, Shibata H, Jadoon WA, Hayakawa S.

Mar Pollut Bull. 2018 Aug;133:891-899. doi: 10.1016/j.marpolbul.2018.06.042. Epub 2018 Jun 28.


SPRED2 deficiency may lead to lung ischemia-reperfusion injury via ERK1/2 signaling pathway activation.

Okada M, Yamane M, Yamamoto S, Otani S, Miyoshi K, Sugimoto S, Matsukawa A, Toyooka S, Oto T, Miyoshi S.

Surg Today. 2018 Dec;48(12):1089-1095. doi: 10.1007/s00595-018-1696-x. Epub 2018 Jul 18.


Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.

Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES.

Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011.


Activity of Nivolumab and Utility of Neutrophil-to-Lymphocyte Ratio as a Predictive Biomarker for Advanced Non-Small-Cell Lung Cancer: A Prospective Observational Study.

Fukui T, Okuma Y, Nakahara Y, Otani S, Igawa S, Katagiri M, Mitsufuji H, Kubota M, Hiyoshi Y, Ishihara M, Kasajima M, Sasaki J, Naoki K.

Clin Lung Cancer. 2019 May;20(3):208-214.e2. doi: 10.1016/j.cllc.2018.04.021. Epub 2018 May 5.


Low-risk donor lungs optimize the post-lung transplant outcome for high lung allocation score patients.

Kurosaki T, Miyoshi K, Otani S, Imanishi K, Sugimoto S, Yamane M, Kobayashi M, Toyooka S, Oto T.

Surg Today. 2018 Oct;48(10):928-935. doi: 10.1007/s00595-018-1670-7. Epub 2018 May 11.


Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia.

Kawai S, Fujii T, Kukimoto I, Yamada H, Yamamoto N, Kuroda M, Otani S, Ichikawa R, Nishio E, Torii Y, Iwata A.

Sci Rep. 2018 May 4;8(1):7070. doi: 10.1038/s41598-018-25310-1.


Prediction of health effects of cross-border atmospheric pollutants using an aerosol forecast model.

Onishi K, Sekiyama TT, Nojima M, Kurosaki Y, Fujitani Y, Otani S, Maki T, Shinoda M, Kurozawa Y, Yamagata Z.

Environ Int. 2018 Aug;117:48-56. doi: 10.1016/j.envint.2018.04.035. Epub 2018 May 1.


Nab-paclitaxel plus carboplatin as an effective and safe chemotherapy regimen for pulmonary carcinosarcoma with interstitial lung disease: A case report.

Niwa H, Otani S, Nakada N, Sasaki J, Saka H, Masuda N.

Respir Med Case Rep. 2018 Feb 2;23:131-135. doi: 10.1016/j.rmcr.2018.01.006. eCollection 2018.


Airway complications have a greater impact on the outcomes of living-donor lobar lung transplantation recipients than cadaveric lung transplantation recipients.

Sugimoto S, Yamane M, Otani S, Kurosaki T, Okahara S, Hikasa Y, Toyooka S, Kobayashi M, Oto T.

Surg Today. 2018 Sep;48(9):848-855. doi: 10.1007/s00595-018-1663-6. Epub 2018 Apr 21.


The diary of a nonagenarian-centenarian woman with dementia: Memory loss, life changes, and community care in Japan.

Suwa S, Otani S, Tsujimura M, Nogawa K, Shiya Y.

Int J Nurs Pract. 2018 Apr;24 Suppl 1:e12655. doi: 10.1111/ijn.12655.


Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.

Klingensmith NJ, Fay KT, Lyons JD, Chen CW, Otani S, Liang Z, Chihade DB, Burd EM, Ford ML, Coopersmith CM.

Shock. 2019 Apr;51(4):453-463. doi: 10.1097/SHK.0000000000001163.


Unilateral lung transplantation using intact bilateral upper lobes.

Otani S, Kurosaki T, Sugimoto S, Yamane M, Oto T.

J Thorac Cardiovasc Surg. 2018 Jul;156(1):e35-e38. doi: 10.1016/j.jtcvs.2018.03.003. Epub 2018 Mar 8. No abstract available.


Pneumatosis intestinalis after lung transplantation for pulmonary graft-versus-host disease.

Mesaki K, Sugimoto S, Otani S, Kurosaki T, Miyoshi K, Yamane M, Oto T.

J Thorac Dis. 2018 Jan;10(1):E42-E45. doi: 10.21037/jtd.2017.11.121.


Phase II study of bevacizumab, cisplatin, and docetaxel plus maintenance bevacizumab as first-line treatment for patients with advanced non-squamous non-small-cell lung cancer combined with exploratory analysis of circulating endothelial cells: Thoracic Oncology Research Group (TORG)1016.

Ikeda S, Kato T, Ogura T, Sekine A, Oda T, Masuda N, Igawa S, Katono K, Otani S, Yamada K, Saito H, Kondo T, Hosomi Y, Nakahara Y, Nishikawa M, Utumi K, Misumi Y, Yamanaka T, Sakamaki K, Okamoto H.

BMC Cancer. 2018 Mar 2;18(1):241. doi: 10.1186/s12885-018-4150-y.

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