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Gene expression over the course of schizophrenia: from clinical high-risk for psychosis to chronic stages.

Ota VK, Moretti PN, Santoro ML, Talarico F, Spindola LM, Xavier G, Carvalho CM, Marques DF, Costa GO, Pellegrino R, de Jong S, Cordeiro Q, Hakonarson H, Breen G, Noto C, Bressan RA, Gadelha A, Jesus Mari J, Belangero SI.

NPJ Schizophr. 2019 Mar 28;5(1):5. doi: 10.1038/s41537-019-0073-0.


DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis.

Belangero SI, Ota VK, Gadelha A, Berberian AA, Assunção-Leme IB, Noto C, Christofolini DM, Bellucco FT, Santoro ML, Mazzotti DR, Zugman A, Melaragno MI, Smith MAC, Pellegrino R, Hakonarson H, Cordeiro Q, Moretti PN, Bressan RA, Mari JJ, Jackowski AP.

Psychiatry Res. 2019 Apr;274:391-394. doi: 10.1016/j.psychres.2019.02.068. Epub 2019 Feb 27.


Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia.

Dal Mas C, Nani JV, Noto C, Yonamine CM, da Cunha GR, Mansur RB, Ota VK, Belangero SI, Cordeiro Q, Kapczinski F, Brietzke E, Bressan RA, Gadelha A, Hayashi MAF.

Schizophr Res. 2019 Jun;208:202-208. doi: 10.1016/j.schres.2019.02.021. Epub 2019 Mar 8.


Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders.

Carvalho CM, Pan PM, Ota VK, Spindola LM, Xavier G, Santoro ML, Mazzotti DR, Pellegrino R, Hakonarson H, Rohde LA, Miguel EC, Gadelha A, Bressan RA, Belangero SI.

Psychiatry Res. 2019 Mar;273:575-577. doi: 10.1016/j.psychres.2019.01.078. Epub 2019 Jan 29.


Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis.

Noto MN, Maes M, Nunes SOV, Ota VK, Rossaneis AC, Verri WA Jr, Cordeiro Q, Belangero SI, Gadelha A, Bressan RA, Noto C.

Eur Neuropsychopharmacol. 2019 Mar;29(3):416-431. doi: 10.1016/j.euroneuro.2018.12.008. Epub 2018 Dec 26.


Effect of male-specific childhood trauma on telomere length.

Xavier G, Spindola LM, Ota VK, Carvalho CM, Maurya PK, Tempaku PF, Moretti PN, Mazotti DR, Sato JR, Brietzke E, Miguel EC, Grassi-Oliveira R, Mari J, Bressan RA, Gadelha A, Pan PM, Belangero SI.

J Psychiatr Res. 2018 Dec;107:104-109. doi: 10.1016/j.jpsychires.2018.10.012. Epub 2018 Oct 22.


Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.

de Jong S, Diniz MJA, Saloma A, Gadelha A, Santoro ML, Ota VK, Noto C; Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Curtis C, Newhouse SJ, Patel H, Hall LS, O Reilly PF, Belangero SI, Bressan RA, Breen G.

Commun Biol. 2018 Oct 8;1:163. doi: 10.1038/s42003-018-0155-y. eCollection 2018.


Implications of an admixed Brazilian population in schizophrenia polygenic risk score.

Talarico F, Santoro M, Ota VK, Gadelha A, Pellegrino R, Hakonarson H, Bressan R, Mari JJ, Belangero S.

Schizophr Res. 2019 Feb;204:404-406. doi: 10.1016/j.schres.2018.07.026. Epub 2018 Jul 26. No abstract available.


Accessing Gene Expression in Treatment-Resistant Schizophrenia.

Moretti PN, Ota VK, Gouvea ES, Pedrini M, Santoro ML, Talarico F, Spindola LM, Carvalho CM, Noto C, Xavier G, Brietzke E, Gadelha A, Bressan R, Mari J, Belangero S.

Mol Neurobiol. 2018 Aug;55(8):7000-7008. doi: 10.1007/s12035-018-0876-4. Epub 2018 Jan 26.


Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence.

de Araujo CM, Zugman A, Swardfager W, Belangero SIN, Ota VK, Spindola LM, Hakonarson H, Pellegrino R, Gadelha A, Salum GA, Pan PM, de Moura LM, Del Aquilla M, Picon FA, Amaro E Jr, Sato JR, Brietzke E, Grassi-Oliveira R, Rohde LAP, Miguel EC, Bressan RA, Jackowski AP.

J Psychiatr Res. 2018 Mar;98:51-58. doi: 10.1016/j.jpsychires.2017.12.008. Epub 2017 Dec 20.


Leukocyte telomere length variation in different stages of schizophrenia.

Maurya PK, Rizzo LB, Xavier G, Tempaku PF, Ota VK, Santoro ML, Spíndola LM, Moretti PS, Mazzotti DR, Gadelha A, Gouvea ES, Noto C, Maes M, Cordeiro Q, Bressan RA, Brietzke E, Belangero SI.

J Psychiatr Res. 2018 Jan;96:218-223. doi: 10.1016/j.jpsychires.2017.10.016. Epub 2017 Oct 21.


Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder.

Carvalho CM, Coimbra BM, Ota VK, Mello MF, Belangero SI.

Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):671-682. doi: 10.1002/ajmg.b.32564. Epub 2017 Jul 7. Review.


Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder.

Spindola LM, Pan PM, Moretti PN, Ota VK, Santoro ML, Cogo-Moreira H, Gadelha A, Salum G, Manfro GG, Mari JJ, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel EC, Rohde LA, Sato JR, Bressan RA, Belangero SI.

J Psychiatr Res. 2017 Sep;92:24-30. doi: 10.1016/j.jpsychires.2017.03.015. Epub 2017 Mar 22.


Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.

Matsuzaka CT, Christofolini D, Ota VK, Gadelha A, Berberian AA, Noto C, Mazzotti DR, Spindola LM, Moretti PN, Smith MAC, Melaragno MI, Belangero SI, Bressan RA.

Braz J Psychiatry. 2017 Oct-Dec;39(4):302-308. doi: 10.1590/1516-4446-2016-1987. Epub 2017 Mar 2.


The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.

Gouvêa ES, Santos AF Filho, Ota VK, Mrad V, Gadelha A, Bressan RA, Cordeiro Q, Belangero SI.

Braz J Psychiatry. 2017 Apr-Jun;39(2):160-171. doi: 10.1590/1516-4446-2016-1969. Epub 2017 Jan 12. Review.


Vascular loops in the anterior inferior cerebellar artery, as identified by magnetic resonance imaging, and their relationship with otologic symptoms.

de Abreu Junior L, Kuniyoshi CH, Wolosker AB, Borri ML, Antunes A, Ota VK, Uchida D.

Radiol Bras. 2016 Sep-Oct;49(5):300-304.


Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis.

Gouvea ES, Ota VK, Noto C, Santoro ML, Spindola LM, Moretti PN, Carvalho CM, Xavier G, Rios AC, Sato JR, Hayashi MA, Brietzke E, Gadelha A, Bressan RA, Cordeiro Q, Belangero SI.

Transl Psychiatry. 2016 Oct 4;6(10):e908. doi: 10.1038/tp.2016.159.


Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity.

Gadelha A, Coleman J, Breen G, Mazzoti DR, Yonamine CM, Pellegrino R, Ota VK, Belangero SI, Glessner J, Sleiman P, Hakonarson H, Hayashi MA, Bressan RA.

Schizophr Res. 2016 Apr;172(1-3):60-7. doi: 10.1016/j.schres.2016.01.043. Epub 2016 Feb 2.


Hair cortisol in drug-naïve first-episode individuals with psychosis.

Andrade EH, Rizzo LB, Noto C, Ota VK, Gadelha A, Daruy-Filho L, Tasso Bde C, Mansur RB, Cordeiro Q, Belangero SI, Bressan RA, Grassi-Oliveira R, Brietzke E.

Braz J Psychiatry. 2016 Mar;38(1):11-6. doi: 10.1590/1516-4446-2014-1634. Epub 2016 Jan 26.


Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis.

Noto C, Ota VK, Santoro ML, Gouvea ES, Silva PN, Spindola LM, Cordeiro Q, Bressan RA, Gadelha A, Brietzke E, Belangero SI, Maes M.

Mol Neurobiol. 2016 Oct;53(8):5701-9. doi: 10.1007/s12035-015-9489-3. Epub 2015 Oct 22.


Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis.

Ota VK, Noto C, Santoro ML, Spindola LM, Gouvea ES, Carvalho CM, Santos CM, Xavier G, Higuchi CH, Yonamine C, Moretti PN, Abílio VC, Hayashi MA, Brietzke E, Gadelha A, Cordeiro Q, Bressan RA, Belangero SI.

Eur Neuropsychopharmacol. 2015 Dec;25(12):2416-25. doi: 10.1016/j.euroneuro.2015.09.013. Epub 2015 Oct 9.


Early life adversity, genomic plasticity, and psychopathology.

Turecki G, Ota VK, Belangero SI, Jackowski A, Kaufman J.

Lancet Psychiatry. 2014 Nov;1(6):461-6. doi: 10.1016/S2215-0366(14)00022-4. Epub 2014 Nov 5. Review.


Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR).

Diana MC, Santoro ML, Xavier G, Santos CM, Spindola LN, Moretti PN, Ota VK, Bressan RA, Abilio VC, Belangero SI.

Psychiatry Res. 2015 Oct 30;229(3):690-4. doi: 10.1016/j.psychres.2015.08.021. Epub 2015 Aug 12.


Oxidative stress in drug naïve first episode psychosis and antioxidant effects of risperidone.

Noto C, Ota VK, Gadelha A, Noto MN, Barbosa DS, Bonifácio KL, Nunes SO, Cordeiro Q, Belangero SI, Bressan RA, Maes M, Brietzke E.

J Psychiatr Res. 2015 Sep;68:210-6. doi: 10.1016/j.jpsychires.2015.07.003. Epub 2015 Jul 3.


High predictive value of immune-inflammatory biomarkers for schizophrenia diagnosis and association with treatment resistance.

Noto C, Maes M, Ota VK, Teixeira AL, Bressan RA, Gadelha A, Brietzke E.

World J Biol Psychiatry. 2015 Sep;16(6):422-429. doi: 10.3109/15622975.2015.1062552. Epub 2015 Jul 27.


Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naïve first episode psychosis.

Brinholi FF, Noto C, Maes M, Bonifácio KL, Brietzke E, Ota VK, Gadelha A, Cordeiro Q, Belangero SI, Bressan RA, Vargas HO, Higachi L, de Farias CC, Moreira EG, Barbosa DS.

Schizophr Res. 2015 Aug;166(1-3):225-30. doi: 10.1016/j.schres.2015.06.009. Epub 2015 Jun 27.


Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls.

Santoro ML, Gadelha A, Ota VK, Cunha GR, Asevedo E, Noto CS, Spindola LM, Pan PM, Talarico F, Mansur RB, Silva PN, Brietzke E, Cordeiro Q, Bressan RA, Belangero SI.

World J Biol Psychiatry. 2015 Sep;16(6):441-446. doi: 10.3109/15622975.2015.1048724. Epub 2015 Jun 18.


A molecular model for neurodevelopmental disorders.

Gigek CO, Chen ES, Ota VK, Maussion G, Peng H, Vaillancourt K, Diallo AB, Lopez JP, Crapper L, Vasuta C, Chen GG, Ernst C.

Transl Psychiatry. 2015 May 12;5:e565. doi: 10.1038/tp.2015.56.


Effects of depression on the cytokine profile in drug naïve first-episode psychosis.

Noto C, Ota VK, Santoro ML, Ortiz BB, Rizzo LB, Higuchi CH, Cordeiro Q, Belangero SI, Bressan RA, Gadelha A, Maes M, Brietzke E.

Schizophr Res. 2015 May;164(1-3):53-8. doi: 10.1016/j.schres.2015.01.026. Epub 2015 Feb 21.


ACE I/D genotype-related increase in ACE plasma activity is a better predictor for schizophrenia diagnosis than the genotype alone.

Gadelha A, Yonamine CM, Ota VK, Oliveira V, Sato JR, Belangero SI, Bressan RA, Hayashi MA.

Schizophr Res. 2015 May;164(1-3):109-14. doi: 10.1016/j.schres.2015.01.044. Epub 2015 Feb 17.


Effects of risperidone on cytokine profile in drug-naïve first-episode psychosis.

Noto C, Ota VK, Gouvea ES, Rizzo LB, Spindola LM, Honda PH, Cordeiro Q, Belangero SI, Bressan RA, Gadelha A, Maes M, Brietzke E.

Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu042. doi: 10.1093/ijnp/pyu042.


Changes in gene expression and methylation in the blood of patients with first-episode psychosis.

Ota VK, Noto C, Gadelha A, Santoro ML, Spindola LM, Gouvea ES, Stilhano RS, Ortiz BB, Silva PN, Sato JR, Han SW, Cordeiro Q, Bressan RA, Belangero SI.

Schizophr Res. 2014 Nov;159(2-3):358-64. doi: 10.1016/j.schres.2014.09.008. Epub 2014 Sep 28.


Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders.

Santoro ML, Santos CM, Ota VK, Gadelha A, Stilhano RS, Diana MC, Silva PN, Spíndola LM, Melaragno MI, Bressan RA, Han SW, Abílio VC, Belangero SI.

Psychiatry Res. 2014 Nov 30;219(3):674-9. doi: 10.1016/j.psychres.2014.05.034. Epub 2014 Jun 5.


Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: a follow-up study in antipsychotic-naïve patients with first-episode psychosis.

Ota VK, Noto C, Gadelha A, Santoro ML, Ortiz BB, Andrade EH, Tasso BC, Spindola LM, Silva PN, Abílio VC, Smith Mde A, Sato JR, Brietzke E, Cordeiro Q, Bressan RA, Belangero SI.

J Psychiatr Res. 2014 Sep;56:130-6. doi: 10.1016/j.jpsychires.2014.05.012. Epub 2014 Jun 4.


Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR).

Santoro ML, Ota VK, Stilhano RS, Silva PN, Santos CM, Diana MC, Gadelha A, Bressan RA, Melaragno MI, Han SW, Abílio VC, Belangero SI.

Schizophr Res. 2014 Aug;157(1-3):163-8. doi: 10.1016/j.schres.2014.05.015. Epub 2014 Jun 2.


BisQC: an operational pipeline for multiplexed bisulfite sequencing.

Chen GG, Diallo AB, Poujol R, Nagy C, Staffa A, Vaillancourt K, Lutz PE, Ota VK, Mash DC, Turecki G, Ernst C.

BMC Genomics. 2014 Apr 16;15:290. doi: 10.1186/1471-2164-15-290.


Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia.

Asevedo E, Rizzo LB, Gadelha A, Mansur RB, Ota VK, Berberian AA, Scarpato BS, Teixeira AL, Bressan RA, Brietzke E.

Physiol Behav. 2014 Apr 22;129:194-8. doi: 10.1016/j.physbeh.2014.02.032. Epub 2014 Feb 25.


PRODH polymorphisms, cortical volumes and thickness in schizophrenia.

Ota VK, Bellucco FT, Gadelha A, Santoro ML, Noto C, Christofolini DM, Assunção IB, Yamada KM, Ribeiro-dos-Santos AK, Santos S, Mari JJ, Smith MA, Melaragno MI, Bressan RA, Sato JR, Jackowski AP, Belangero SI.

PLoS One. 2014 Feb 3;9(2):e87686. doi: 10.1371/journal.pone.0087686. eCollection 2014.


Association of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort.

Mazzotti DR, Singulane CC, Ota VK, Rodrigues TP, Furuya TK, de Souza FJ, Cordeiro BG, de Oliveira Amaral CM, Chen ES, Jacomini A, de Arruda Cardoso Smith M, Borsatto-Galera B.

Gene. 2014 Feb 10;535(2):370-5. doi: 10.1016/j.gene.2013.11.040. Epub 2013 Nov 28.


Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naïve first-episode psychosis patients before and after antipsychotic treatment.

Ota VK, Noto C, Gadelha A, Santoro ML, Silva PN, Melaragno MI, Smith Mde A, Cordeiro Q, Bressan RA, Belangero SI.

Psychiatry Res. 2013 Dec 30;210(3):1290-2. doi: 10.1016/j.psychres.2013.09.016. Epub 2013 Oct 7.


Is there an association between cortical thickness, age of onset, and duration of illness in schizophrenia?

Assunção Leme IB, Gadelha A, Sato JR, Ota VK, Mari JJ, Melaragno MI, Smith MA, Belangero SI, Bressan RA, Jackowski AP.

CNS Spectr. 2013 Dec;18(6):315-21. doi: 10.1017/S1092852913000333. Epub 2013 Jun 6.


Reduced dorso-lateral prefrontal cortex in treatment resistant schizophrenia.

Zugman A, Gadelha A, Assunção I, Sato J, Ota VK, Rocha DL, Mari JJ, Belangero SI, Bressan RA, Brietzke E, Jackowski AP.

Schizophr Res. 2013 Aug;148(1-3):81-6. doi: 10.1016/j.schres.2013.05.002. Epub 2013 May 28.


Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits.

Ota VK, Berberian AA, Gadelha A, Santoro ML, Ottoni GL, Matsuzaka CT, Mari JJ, Melaragno MI, Lara DR, Smith MA, Belangero SI, Bressan RA.

Psychiatry Res. 2013 Aug 30;209(1):110-3. doi: 10.1016/j.psychres.2013.03.035. Epub 2013 Apr 23.


Association of APOA1 and APOA5 polymorphisms and haplotypes with lipid parameters in a Brazilian elderly cohort.

Furuya TK, Chen ES, Ota VK, Mazzotti DR, Ramos LR, Cendoroglo MS, Araujo LQ, Burbano RR, Smith MA.

Genet Mol Res. 2013 Feb 28;12(3):3495-9. doi: 10.4238/2013.February.28.7.


Candidate genes for schizophrenia in a mixed Brazilian population using pooled DNA.

Ota VK, Gadelha A, Pellegrino R, Santoro ML, Bellucco FT, Christofolini DM, Ottoni GL, Lara DR, Ribeiro-Dos-Santos AK, Santos S, Mari JJ, Breen G, Smith MA, Bressan RA, Melaragno MI, Belangero SI.

Psychiatry Res. 2013 Jul 30;208(2):201-2. doi: 10.1016/j.psychres.2012.12.009. Epub 2013 Feb 16. No abstract available.


ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia.

Ota VK, Gadelha A, Assunção IB, Santoro ML, Christofolini DM, Bellucco FT, Santos-Filho AF, Ottoni GL, Lara DR, Mari JJ, Melaragno MI, Smith MA, Bressan RA, Belangero SI, Jackowski AP.

Schizophr Res. 2013 Apr;145(1-3):33-5. doi: 10.1016/j.schres.2013.01.011. Epub 2013 Feb 8.


Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families.

Gadelha A, Ota VK, Cano JP, Melaragno MI, Smith MA, de Jesus Mari J, Bressan RA, Belangero SI, Breen G.

PLoS One. 2012;7(12):e52262. doi: 10.1371/journal.pone.0052262. Epub 2012 Dec 31.


DRD1 rs4532 polymorphism: a potential pharmacogenomic marker for treatment response to antipsychotic drugs.

Ota VK, Spíndola LN, Gadelha A, dos Santos Filho AF, Santoro ML, Christofolini DM, Bellucco FT, Ribeiro-dos-Santos ÂK, Santos S, Mari Jde J, Melaragno MI, Bressan RA, Smith Mde A, Belangero SI.

Schizophr Res. 2012 Dec;142(1-3):206-8. doi: 10.1016/j.schres.2012.08.003. Epub 2012 Oct 1.


Assessment of 22q11.2 copy number variations in a sample of Brazilian schizophrenia patients.

Christofolini DM, Bellucco FT, Ota VK, Belangero SI, Cernach MC, Gadelha A, Mari J, Bressan RA, Smith MA, Melaragno MI.

Schizophr Res. 2011 Oct;132(1):99-100. doi: 10.1016/j.schres.2011.07.007. Epub 2011 Aug 3. No abstract available.


APOA4 polymorphism as a risk factor for unfavorable lipid serum profile and depression: a cross-sectional study.

Ota VK, Chen ES, Ejchel TF, Furuya TK, Mazzotti DR, Cendoroglo MS, Ramos LR, Araujo LQ, Burbano RR, Smith Mde A.

J Investig Med. 2011 Aug;59(6):966-70. doi: 10.2310/JIM.0b013e31822467cd.


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